{"id":"https://openalex.org/W2591052298","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.278","title":"PSA levels after dexamethasone withdrawal (DW) in castration resistant prostate cancer (CRPC).","display_name":"PSA levels after dexamethasone withdrawal (DW) in castration resistant prostate cancer (CRPC).","publication_year":2016,"publication_date":"2016-01-10","ids":{"openalex":"https://openalex.org/W2591052298","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.278","mag":"2591052298"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.2_suppl.278","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.278","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.2_suppl.278","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080919044","display_name":"Zafeiris Zafeiriou","orcid":"https://orcid.org/0000-0001-8059-2736","observed_orcids":["https://orcid.org/0000-0001-8059-2736"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zafeiris Zafeiriou","raw_affiliation_strings":["The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088696108","display_name":"Diletta Bianchini","orcid":"https://orcid.org/0009-0002-5071-7301","observed_orcids":["https://orcid.org/0009-0002-5071-7301"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diletta Bianchini","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012423170","display_name":"Pasquale Rescigno","orcid":"https://orcid.org/0000-0002-4668-4765","observed_orcids":["https://orcid.org/0000-0002-4668-4765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pasquale Rescigno","raw_affiliation_strings":["Department of Clinical Medicine and Surgery and Rare Tumors Reference Centre Campania Region, University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Surgery and Rare Tumors Reference Centre Campania Region, University, Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064599843","display_name":"Michael Paul Kolinsky","orcid":"https://orcid.org/0000-0002-3937-3782","observed_orcids":["https://orcid.org/0000-0002-3937-3782"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Kolinsky","raw_affiliation_strings":["The Royal Marsden, The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden, The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037380661","display_name":"Joaqu\u0131\u0301n Mateo","orcid":"https://orcid.org/0000-0001-5336-2548","observed_orcids":["https://orcid.org/0000-0001-5336-2548"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joaquin Mateo","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028760417","display_name":"David Lorente","orcid":"https://orcid.org/0000-0001-7550-0657","observed_orcids":["https://orcid.org/0000-0001-7550-0657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Lorente","raw_affiliation_strings":["Medical Oncology Department, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Valencia, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103501093","display_name":"Raquel P\u00e9rez L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raquel Perez Lopez","raw_affiliation_strings":["Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110647545","display_name":"Anurhada Jayaram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anurhada Jayaram","raw_affiliation_strings":["The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036825889","display_name":"Niven Mehra","orcid":"https://orcid.org/0000-0002-4794-1831","observed_orcids":["https://orcid.org/0000-0002-4794-1831"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Niven Mehra","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002972986","display_name":"Semini Sumanasuriya","orcid":"https://orcid.org/0000-0001-7350-8161","observed_orcids":["https://orcid.org/0000-0001-7350-8161"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Semini Sumanasuriya","raw_affiliation_strings":["The Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016057883","display_name":"Federica Recine","orcid":"https://orcid.org/0000-0002-1610-2744","observed_orcids":["https://orcid.org/0000-0002-1610-2744"]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Recine","raw_affiliation_strings":["Department of Medical Oncology, San Camillo and Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, San Camillo and Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016701763","display_name":"Spyridon Sideris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Spyridon Sideris","raw_affiliation_strings":["Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069346188","display_name":"Adam Sharp","orcid":"https://orcid.org/0000-0002-3740-1612","observed_orcids":["https://orcid.org/0000-0002-3740-1612"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam Sharp","raw_affiliation_strings":["The Institute of Cancer Research, The Royal Marsden Hospital, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research, The Royal Marsden Hospital, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111758478","display_name":"Sophia Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sophia Wong","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056339622","display_name":"Nina Tunariu","orcid":"https://orcid.org/0000-0001-6656-3699","observed_orcids":["https://orcid.org/0000-0001-6656-3699"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nina Tunariu","raw_affiliation_strings":["Institute of Cancer Research, Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research, Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000156180","display_name":"Gerhardt Attard","orcid":"https://orcid.org/0000-0002-4811-7983","observed_orcids":["https://orcid.org/0000-0002-4811-7983"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gerhardt Attard","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann S. De Bono","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"2_suppl","first_page":"278","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/psa-decline","display_name":"PSA decline","score":0.6790000200271606},{"id":"https://openalex.org/keywords/psa-progression","display_name":"PSA progression","score":0.5239999890327454},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/antiandrogen-withdrawal","display_name":"antiandrogen withdrawal","score":0.6340000033378601},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.32100000977516174},{"id":"https://openalex.org/keywords/urinary-symptoms","display_name":"urinary symptoms","score":0.7310000061988831},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.4350000023841858},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.39800000190734863},{"id":"https://openalex.org/keywords/response-magnitude","display_name":"response magnitude","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9511392116546631},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6750457882881165},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5661225318908691},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5263796448707581},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.49785470962524414},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4803537130355835},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.4548625648021698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4481467604637146},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43023431301116943},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33233433961868286}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.2_suppl.278","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.278","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.2_suppl.278","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2103728005","https://openalex.org/W1974657326","https://openalex.org/W2790922327","https://openalex.org/W3196396019","https://openalex.org/W2590911684","https://openalex.org/W2065024194","https://openalex.org/W1977957095","https://openalex.org/W2131146826","https://openalex.org/W2303420095","https://openalex.org/W2890336344"],"abstract_inverted_index":{"278":[0],"Background:":[1],"PSA":[2,37,85,140,170,205],"decline":[3],"(PSAD)":[4],"in":[5,47,225,242,254,355,371],"CRPC":[6,52],"after":[7,39,286,348],"withdrawal":[8],"of":[9,36,73,100,106,138,162,204,209,274,304,313,344,358,374],"antiandrogens":[10],"and":[11,23,34,65,81,130,237,245,251,253,325,332,366],"steroid":[12],"related":[13],"drugs":[14],"is":[15],"well":[16,25],"established.":[17],"DW":[18,64,299,308,351],"responses":[19,171,317,352],"have":[20],"been":[21],"anecdotal":[22],"not":[24,173,319],"characterized.":[26],"In":[27,271,291],"this":[28],"study":[29],"we":[30],"investigated":[31],"the":[32,48,136,199,201,258,372],"frequency":[33,312],"magnitude":[35],"changes":[38],"DW.":[40,349],"Methods:":[41],"We":[42],"retrospectively":[43],"identified":[44,157],"patients":[45,107,155,227,247,323],"treated":[46],"Royal":[49],"Marsden":[50],"for":[51,98,135,175],"with":[53,93,113,194,264,300,324],"D":[54,94,97,161,168],"monotherapy.":[55],"Patients":[56,87],"were":[57,102,156,165,172],"considered":[58,370],"evaluable":[59],"if":[60],"they":[61],"had":[62,159,183],"between":[63,127,322],"their":[66],"next":[67,278],"treatment":[68,92,169,210,279],"or":[69,95],"radiotherapy":[70,90],"an":[71],"interval":[72],"at":[74,82],"least":[75,83],"7":[76],"days,":[77],"no":[78],"other":[79],"intervention":[80],"one":[84,256,292],"reading.":[86,197],"who":[88,158],"received":[89,96,160],"during":[91,298],"palliation":[99],"symptoms":[101,347],"excluded.":[103],"The":[104,311],"number":[105],"showing":[108],"PSAD":[109,187,222,232,261],"was":[110,121,143,189,213,223,240,280,295,318],"recorded":[111],"together":[112],"its":[114],"percentage":[115],"change":[116],"from":[117,207,307],"baseline.":[118],"Chi-square":[119,335],"test":[120,336],"used":[122],"to":[123,146,211,218,288,309,329,368],"compare":[124],"response":[125,206,302,328],"rates":[126],"different":[128,321],"groups":[129],"95%":[131,229],"confidence":[132],"intervals":[133],"(CI)":[134],"description":[137],"frequencies.":[139],"progression":[141],"(PSAP)":[142],"defined":[144],"according":[145],"Prostate":[147],"Cancer":[148],"Working":[149],"Group":[150],"2":[151,246],"criteria.":[152],"Results:":[153],"200":[154],"which":[163,188],"50":[164],"evaluable.":[166],"During":[167],"available":[174],"5":[176,272],"patients,":[177],"while":[178],"16":[179],"(35%,":[180],"95%CI":[181],"[20%-50%])":[182],"a":[184,191,195,265,268,283,301,356],"\u2265":[185,233,235,238,259,275,314],"50%":[186,239],"confirmed":[190,263],"month":[192,269],"later":[193],"second":[196,266],"For":[198],"responders,":[200],"median":[202],"duration":[203,303],"initiation":[208],"PSAP":[212,296],"293":[214],"days":[215,306],"(range:":[216],"219":[217],"1063).":[219],"After":[220],"DW,":[221],"observed":[224,241,354],"12":[226],"(24%,":[228],"CI":[230],"[12%,36%]).":[231],"25%,":[234],"30%":[236,260],"6,":[243],"3":[244],"respectively":[248],"(12%,":[249],"6%":[250,331],"4%)":[252],"only":[255,294],"could":[257],"be":[262,369],"reading":[267],"later.":[270],"cases":[273],"25%":[276,315],"PSAD,":[277],"initiated":[281],"despite":[282],"dropping":[284],"PSA,":[285],"8":[287],"43":[289],"days.":[290],"case":[293],"reached":[297],"53":[305],"PSAP.":[310],"PSAW":[316],"significantly":[320],"without":[326],"prior":[327],"dexamethasone:":[330],"17%":[333],"respectively,":[334],"p":[337],"=":[338],"0.29.":[339],"One":[340],"patient":[341],"reported":[342],"improvement":[343],"his":[345],"urinary":[346],"Conclusions:":[350],"are":[353],"minority":[357],"patients.":[359],"This":[360],"phenomenon":[361],"merits":[362],"further":[363],"prospective":[364],"characterization":[365],"needs":[367],"design":[373],"clinical":[375],"trials.":[376]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-03-03T00:00:00"}