{"id":"https://openalex.org/W2591051471","doi":"https://doi.org/10.1111/aji.12654","title":"Microbiome, autoimmunity, allergy, and helminth infection: The importance of the pregnancy period","display_name":"Microbiome, autoimmunity, allergy, and helminth infection: The importance of the pregnancy period","publication_year":2017,"publication_date":"2017-02-21","ids":{"openalex":"https://openalex.org/W2591051471","doi":"https://doi.org/10.1111/aji.12654","mag":"2591051471","pmid":"https://pubmed.ncbi.nlm.nih.gov/28224678"},"language":"en","primary_location":{"id":"doi:10.1111/aji.12654","doi":"https://doi.org/10.1111/aji.12654","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aji.12654","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067920379","display_name":"Xian Chen","orcid":"https://orcid.org/0000-0002-6827-2841","observed_orcids":["https://orcid.org/0000-0002-6827-2841"]},"institutions":[{"id":"https://openalex.org/I4210157741","display_name":"Shenzhen Zhongshan Urological Hospital","ror":"https://ror.org/0502tm991","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210157741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian Chen","raw_affiliation_strings":["Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210157741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376819","display_name":"Su Liu","orcid":"https://orcid.org/0000-0001-5805-5643","observed_orcids":["https://orcid.org/0000-0001-5805-5643"]},"institutions":[{"id":"https://openalex.org/I4210157741","display_name":"Shenzhen Zhongshan Urological Hospital","ror":"https://ror.org/0502tm991","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210157741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su Liu","raw_affiliation_strings":["Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210157741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068435105","display_name":"Qiao Ye Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157741","display_name":"Shenzhen Zhongshan Urological Hospital","ror":"https://ror.org/0502tm991","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210157741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiao Tan","raw_affiliation_strings":["Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210157741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074738902","display_name":"Yehuda Shoenfeld","orcid":"https://orcid.org/0000-0003-2802-4090","observed_orcids":["https://orcid.org/0000-0003-2802-4090","https://orcid.org/0000-0003-0185-9637"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Yehuda Shoenfeld","raw_affiliation_strings":["Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Tel-Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Tel-Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031470604","display_name":"Yong Zeng","orcid":"https://orcid.org/0000-0002-6264-283X","observed_orcids":["https://orcid.org/0000-0002-6264-283X"]},"institutions":[{"id":"https://openalex.org/I4210157741","display_name":"Shenzhen Zhongshan Urological Hospital","ror":"https://ror.org/0502tm991","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210157741"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Zeng","raw_affiliation_strings":["Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-6264-283X","affiliations":[{"raw_affiliation_string":"Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210157741"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031470604","https://openalex.org/A5074738902"],"corresponding_institution_ids":["https://openalex.org/I2799810450","https://openalex.org/I4210157741"],"apc_list":{"value":4460,"currency":"USD","value_usd":4460},"apc_paid":null,"fwci":0.2328,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.19294167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"78","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.04879999905824661,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-microbiome","display_name":"maternal microbiome","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/allergy","display_name":"allergy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/helminth-infection","display_name":"helminthiasis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.949999988079071},{"id":"https://openalex.org/keywords/gestational-weight-gain","display_name":"gestational weight gain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neonatal-health","display_name":"newborn health","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.9037874341011047},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.8239044547080994},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5928323268890381},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5661890506744385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5650800466537476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5250161290168762},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4892835319042206},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3218510150909424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29184263944625854},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.13240477442741394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006373","descriptor_name":"Helminthiasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/aji.12654","doi":"https://doi.org/10.1111/aji.12654","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aji.12654","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},{"id":"pmid:28224678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28224678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of reproductive immunology (New York, N.Y. : 1989)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329791","display_name":"Shenzhen Fundamental Research Program","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W49611453","https://openalex.org/W900681215","https://openalex.org/W1494283037","https://openalex.org/W1509578356","https://openalex.org/W1590369543","https://openalex.org/W1678648653","https://openalex.org/W1763618179","https://openalex.org/W1929744752","https://openalex.org/W1932402193","https://openalex.org/W1963501720","https://openalex.org/W1968105193","https://openalex.org/W1970031113","https://openalex.org/W1978740926","https://openalex.org/W1979696706","https://openalex.org/W1979914317","https://openalex.org/W1983086029","https://openalex.org/W1983480534","https://openalex.org/W1983972858","https://openalex.org/W1984283801","https://openalex.org/W1990339279","https://openalex.org/W1993804685","https://openalex.org/W1994310214","https://openalex.org/W1994900790","https://openalex.org/W1996067516","https://openalex.org/W2005507128","https://openalex.org/W2006923731","https://openalex.org/W2007910255","https://openalex.org/W2014605450","https://openalex.org/W2020885659","https://openalex.org/W2021926390","https://openalex.org/W2023506796","https://openalex.org/W2026597738","https://openalex.org/W2030571305","https://openalex.org/W2032096424","https://openalex.org/W2040475339","https://openalex.org/W2041136224","https://openalex.org/W2041867846","https://openalex.org/W2043239636","https://openalex.org/W2044027004","https://openalex.org/W2045285843","https://openalex.org/W2045466539","https://openalex.org/W2048672502","https://openalex.org/W2053039168","https://openalex.org/W2053141800","https://openalex.org/W2053703074","https://openalex.org/W2056270090","https://openalex.org/W2056782822","https://openalex.org/W2058739008","https://openalex.org/W2060485250","https://openalex.org/W2062011235","https://openalex.org/W2062580847","https://openalex.org/W2069388628","https://openalex.org/W2070223844","https://openalex.org/W2071610511","https://openalex.org/W2073822675","https://openalex.org/W2074974657","https://openalex.org/W2079266218","https://openalex.org/W2085818612","https://openalex.org/W2088108149","https://openalex.org/W2090925778","https://openalex.org/W2095874292","https://openalex.org/W2096324249","https://openalex.org/W2096891797","https://openalex.org/W2100318919","https://openalex.org/W2100503784","https://openalex.org/W2103318681","https://openalex.org/W2103761010","https://openalex.org/W2104610549","https://openalex.org/W2106047413","https://openalex.org/W2112589439","https://openalex.org/W2118001436","https://openalex.org/W2118869408","https://openalex.org/W2119911499","https://openalex.org/W2121933003","https://openalex.org/W2122931228","https://openalex.org/W2123151198","https://openalex.org/W2124686802","https://openalex.org/W2128168864","https://openalex.org/W2131536322","https://openalex.org/W2132622748","https://openalex.org/W2135989088","https://openalex.org/W2139285189","https://openalex.org/W2143777796","https://openalex.org/W2144109968","https://openalex.org/W2146678259","https://openalex.org/W2149515881","https://openalex.org/W2149573313","https://openalex.org/W2160934677","https://openalex.org/W2161099242","https://openalex.org/W2161564173","https://openalex.org/W2166223274","https://openalex.org/W2166535711","https://openalex.org/W2167520830","https://openalex.org/W2169733549","https://openalex.org/W2171286410","https://openalex.org/W2319459971","https://openalex.org/W2413500664","https://openalex.org/W2472593842"],"related_works":["https://openalex.org/W2026597738","https://openalex.org/W4415815349","https://openalex.org/W2765965774","https://openalex.org/W3010012148","https://openalex.org/W4213029075","https://openalex.org/W4392757800","https://openalex.org/W2958346395","https://openalex.org/W3088316412","https://openalex.org/W6902489863","https://openalex.org/W3110995469"],"abstract_inverted_index":{"Pregnancy":[0],"is":[1,50],"a":[2,12,74],"special":[3],"physical":[4],"period":[5],"in":[6,90],"reproductive":[7],"age":[8],"women,":[9],"which":[10,70],"has":[11,23],"beneficial":[13],"influence":[14,96],"on":[15],"the":[16,28,55,85,113,127],"course":[17],"of":[18,54,87,106,115,129],"certain":[19],"autoimmune":[20],"diseases.":[21],"It":[22],"been":[24],"recently":[25],"suggested":[26],"that":[27,35],"microbiome":[29,46,89,116],"undergoes":[30],"profound":[31],"changes":[32],"during":[33,48,123,132],"pregnancy":[34,49,91],"are":[36,71],"associated":[37],"with":[38,117],"host":[39],"physiological":[40],"and":[41,63,67,98,108,121,125],"immunological":[42,68],"adaptations.":[43],"The":[44],"maternal":[45,88],"remodeling":[47],"an":[51],"active":[52],"response":[53],"mother,":[56],"possibly":[57],"to":[58,64,82,94],"alter":[59],"immune":[60],"system":[61],"status":[62],"facilitate":[65],"metabolic":[66],"adaptations,":[69],"needed":[72],"for":[73],"successful":[75],"pregnancy.":[76,133],"In":[77],"this":[78],"review,":[79],"we":[80],"attempt":[81],"discuss":[83],"(i)":[84],"role":[86],"outcomes":[92],"known":[93],"adversely":[95],"neonatal":[97],"infant":[99],"health,":[100],"including":[101],"preterm":[102],"birth,":[103],"cardiometabolic":[104],"complications":[105],"pregnancy,":[107],"gestational":[109],"weight":[110],"gain;":[111],"(ii)":[112],"association":[114],"autoimmunity,":[118],"allergy":[119],"diseases,":[120],"asthma":[122],"pregnancy;":[124],"(iii)":[126],"impact":[128],"helminth":[130],"infection":[131]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-03T00:00:00"}
