{"id":"https://openalex.org/W2590986103","doi":"https://doi.org/10.1055/s-2005-862325","title":"Canalicular Immunostaining of Aminopeptidase N (CD13) as a Diagnostic Marker for Hepatocellular Carcinomas","display_name":"Canalicular Immunostaining of Aminopeptidase N (CD13) as a Diagnostic Marker for Hepatocellular Carcinomas","publication_year":2005,"publication_date":"2005-01-14","ids":{"openalex":"https://openalex.org/W2590986103","doi":"https://doi.org/10.1055/s-2005-862325","mag":"2590986103"},"language":"en","primary_location":{"id":"doi:10.1055/s-2005-862325","doi":"https://doi.org/10.1055/s-2005-862325","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2005-862325","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024583139","display_name":"Christoph R\u00f6cken","orcid":"https://orcid.org/0000-0002-6989-8002","observed_orcids":["https://orcid.org/0000-0002-6989-8002"]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C R\u00f6cken","raw_affiliation_strings":["Institut f\u00fcr Pathologie der Universit\u00e4t Magdeburg, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pathologie der Universit\u00e4t Magdeburg, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034992183","display_name":"Jonathan D. Licht","orcid":"https://orcid.org/0000-0002-3942-1369","observed_orcids":["https://orcid.org/0000-0002-3942-1369"]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Licht","raw_affiliation_strings":["Institut f\u00fcr Pathologie der Universit\u00e4t Magdeburg, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pathologie der Universit\u00e4t Magdeburg, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071266689","display_name":"Albert Roessner","orcid":"https://orcid.org/0000-0003-1015-3177","observed_orcids":["https://orcid.org/0000-0003-1015-3177"]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Roessner","raw_affiliation_strings":["Institut f\u00fcr Pathologie der Universit\u00e4t Magdeburg, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pathologie der Universit\u00e4t Magdeburg, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95793202"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40097486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cd13","display_name":"CD13","score":0.9509999752044678},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.675000011920929},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cd10","display_name":"CD10","score":0.8040000200271606},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.8980000019073486},{"id":"https://openalex.org/keywords/heppar-1","display_name":"HepPar1","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.924836277961731},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7446860671043396},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6432273387908936},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6149988770484924},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6036879420280457},{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.484937459230423},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4656655788421631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40747523307800293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2034861147403717},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06452932953834534}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2005-862325","doi":"https://doi.org/10.1055/s-2005-862325","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2005-862325","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2146087788","https://openalex.org/W2070322837","https://openalex.org/W1951191190","https://openalex.org/W1981420563","https://openalex.org/W3030917752","https://openalex.org/W2036585421","https://openalex.org/W2049734857","https://openalex.org/W2137111114","https://openalex.org/W2045972849","https://openalex.org/W4244658047"],"abstract_inverted_index":{"Neprilysin":[0],"(CD13)":[1],"is":[2,157,177],"expressed":[3],"in":[4,52,95,100,106,113,118,180],"both":[5],"normal":[6],"and":[7,29,59,81,103,116,132,134,172,184],"neoplastic":[8],"liver":[9,65,142],"tissue,":[10],"where":[11],"it":[12,166],"exhibits":[13],"a":[14,87],"characteristic":[15],"canalicular":[16,88,153],"pattern":[17,90],"(CD13":[18],"can":[19,51,127,130,176],")":[20],"similar":[21],"to":[22,45,63,140],"the":[23,47,64,84,123],"one":[24],"observed":[25],"with":[26,33,72],"anti-CD10":[27],"antibodies":[28,31,73],"when":[30],"cross-react":[32],"biliary":[34],"glycoprotein":[35],"I":[36],"(p-CEA).":[37],"The":[38],"aim":[39],"of":[40,49,162],"this":[41],"retrospective":[42],"study":[43],"was":[44,70,91,111,138],"investigate":[46],"use":[48],"CD13":[50,94,126,156,175],"differentiating":[53,181],"between":[54,170,182],"hepatocellular":[55],"(HCC;":[56],"53":[57],"specimens)":[58],"non-hepatocellular":[60],"carcinomas":[61],"metastatic":[62],"(non-HCC;":[66],"34":[67],"specimens).":[68],"Immunostaining":[69],"performed":[71],"directed":[74],"against":[75],"CD10,":[76],"CD13,":[77],"p-CEA,":[78,133],"a-fetoprotein":[79],"(AFP),":[80],"HepPar1.":[82],"In":[83,122],"HCC":[85,183],"group,":[86,125],"staining":[89,154],"found":[92,112],"for":[93,98,104,136,155],"48":[96],"(91%),":[97],"p-CEA":[99],"43":[101],"(81%),":[102],"CD10":[105,129],"30":[107],"(57%)":[108],"specimens.":[109],"HepPar1":[110],"29":[114],"(55%)":[115],"AFP":[117],"17":[119],"(32%)":[120],"HCCs.":[121],"non-HCC":[124,145],",":[128,131],"immunostaining":[135],"AFP,":[137],"confined":[139],"non-neoplastic":[141],"tissue.":[143],"Two":[144],"cases":[146],"showed":[147],"HepPar1-immunostaining.":[148],"Our":[149],"results":[150],"demonstrate":[151],"that":[152],"another":[158],"highly":[159],"specific":[160],"marker":[161],"hepatocytic":[163],"differentiation.":[164],"Although":[165],"does":[167],"not":[168],"differentiate":[169],"benign":[171],"malignant":[173],"lesions,":[174],"clearly":[178],"useful":[179],"non-HCC.":[185]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-03-03T00:00:00"}
