{"id":"https://openalex.org/W2590984159","doi":"https://doi.org/10.1002/mp.12177","title":"Theoretical effectiveness of cell survival in fractionated radiotherapy with hypoxia\u2010targeted dose escalation","display_name":"Theoretical effectiveness of cell survival in fractionated radiotherapy with hypoxia\u2010targeted dose escalation","publication_year":2017,"publication_date":"2017-02-25","ids":{"openalex":"https://openalex.org/W2590984159","doi":"https://doi.org/10.1002/mp.12177","mag":"2590984159","pmid":"https://pubmed.ncbi.nlm.nih.gov/28236652"},"language":"en","primary_location":{"id":"doi:10.1002/mp.12177","doi":"https://doi.org/10.1002/mp.12177","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mp.12177","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108491054","display_name":"Alexei V. Chvetsov","orcid":"https://orcid.org/0009-0006-5479-1962","observed_orcids":["https://orcid.org/0009-0006-5479-1962"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexei V. Chvetsov","raw_affiliation_strings":["Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904741","display_name":"Joseph G. Rajendran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph G. Rajendran","raw_affiliation_strings":["Department of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062492688","display_name":"Jing Zeng","orcid":"https://orcid.org/0000-0001-7388-8926","observed_orcids":["https://orcid.org/0000-0001-7388-8926"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Zeng","raw_affiliation_strings":["Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104111803","display_name":"Shilpen A. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilpen A. Patel","raw_affiliation_strings":["Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080374314","display_name":"Stephen R. Bowen","orcid":"https://orcid.org/0000-0001-7581-770X","observed_orcids":["https://orcid.org/0000-0001-7581-770X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Bowen","raw_affiliation_strings":["Departments of Radiation Oncology and Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiation Oncology and Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087491523","display_name":"Edward Y. Kim","orcid":"https://orcid.org/0000-0002-6055-2283","observed_orcids":["https://orcid.org/0000-0002-6055-2283"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Y. Kim","raw_affiliation_strings":["Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195-6043 USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108491054"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":1.5471,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79838185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"5","first_page":"1975","last_page":"1982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.1363999992609024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fractionated-radiotherapy","display_name":"fractionated radiotherapy","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.8410000205039978},{"id":"https://openalex.org/keywords/linear-quadratic-model","display_name":"linear-quadratic model","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/reoxygenation","display_name":"reoxygenation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/delivery-errors","display_name":"delivery errors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7599999904632568},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/hypoxic-fraction","display_name":"hypoxic fraction","score":0.5270000100135803},{"id":"https://openalex.org/keywords/tumor-control-probability","display_name":"tumor control probability","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7089920043945312},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.5897431373596191},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.5316299200057983},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5211389064788818},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.5121734142303467},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.4894215166568756},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.47196710109710693},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.47003883123397827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45422154664993286},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4456164836883545},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.41207608580589294},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3796721398830414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25027433037757874},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.20608994364738464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18601319193840027},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15618619322776794},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.12276414036750793},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011853","descriptor_name":"Radiobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mp.12177","doi":"https://doi.org/10.1002/mp.12177","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mp.12177","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},{"id":"pmid:28236652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28236652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical physics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W610388639","https://openalex.org/W620802985","https://openalex.org/W1776569623","https://openalex.org/W1966591251","https://openalex.org/W1969907047","https://openalex.org/W1976996553","https://openalex.org/W1978370833","https://openalex.org/W1990793341","https://openalex.org/W1994134155","https://openalex.org/W1997208081","https://openalex.org/W2000156247","https://openalex.org/W2008408031","https://openalex.org/W2011310004","https://openalex.org/W2021027913","https://openalex.org/W2026900109","https://openalex.org/W2027652813","https://openalex.org/W2030009220","https://openalex.org/W2037183541","https://openalex.org/W2039769803","https://openalex.org/W2057290654","https://openalex.org/W2057976445","https://openalex.org/W2061434030","https://openalex.org/W2065191153","https://openalex.org/W2068011562","https://openalex.org/W2069240289","https://openalex.org/W2070394361","https://openalex.org/W2077679212","https://openalex.org/W2088255270","https://openalex.org/W2093062284","https://openalex.org/W2094011295","https://openalex.org/W2134637206","https://openalex.org/W2302071074"],"related_works":["https://openalex.org/W1973426146","https://openalex.org/W1995287452","https://openalex.org/W2039769803","https://openalex.org/W1998579228","https://openalex.org/W4313437333","https://openalex.org/W2891683124","https://openalex.org/W4403507023","https://openalex.org/W2054210405","https://openalex.org/W2108866483","https://openalex.org/W2058081325"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,34,106,132,358],"goal":[2],"of":[3,41,65,85,128,157,163,170,209,237,250,257,273,311,319,383,400,406],"this":[4,362],"article":[5],"is":[6,36,52,200,275],"to":[7,21,68,160,240],"compute":[8],"the":[9,62,91,96,104,152,167,205,217,228,241,247,261,271,280,284,289,309,317,329,339,349,354,381,398,401,404,428],"cell":[10,22,73,114,134,158,192,224,242,295,331,345,374],"survival":[11,23,92,115,135,159,193,258,296,332],"during":[12,204,353,427],"fractionated":[13],"radiotherapy":[14,42,69,164,210,323,384],"with":[15,29,43,90,148,211,324,385],"non-uniform":[16,195,285,313,340,366,389,416],"hypoxia-targeted":[17,312,367,417],"dose":[18,27,47,142,174,198,219,248,286,291,314,326,341,351,368,378,390,395,418,425],"distribution":[19,28,220,272,292,352,396],"relative":[20,113,133,168,191,294,330],"for":[24,38,109,112,125,138,151,194,227],"a":[25,55,117,145,222,254],"uniform":[26,197,218,290,350,377,394,424],"equal":[30,229],"integral":[31,230],"tumor":[32,57,66,263],"dose.":[33,231],"analysis":[35,51],"performed":[37],"different":[39,161],"parameters":[40,150,162],"conventional":[44,139,212,386],"and":[45,75,87,140,178,186,196,253,293,303,408],"hypofractionated":[46,141,322,414],"regimens.":[48],"METHODS:":[49],"Our":[50,184],"done":[53],"using":[54,77],"parsimonious":[56],"response":[58,67],"model":[59,100,107,146],"that":[60,190,216,365],"describes":[61],"major":[63],"components":[64],"such":[70,165],"as":[71,78,81,166],"radiosensitivity,":[72],"proliferation,":[74],"hypoxia":[76],"few":[79,207,282],"variables":[80],"possible.":[82],"Two":[83],"levels":[84],"oxygenated":[86,262],"hypoxic":[88,171],"cells":[89],"curves":[93],"described":[94],"by":[95,397],"linear":[97,238],"quadratic":[98],"(LQ)":[99],"are":[101,370,411,420],"implemented":[102],"in":[103,116,144,246,260,361],"model.":[105],"allows":[108],"analytical":[110,187],"solutions":[111],"single":[118],"fraction":[119],"simulation":[120],"which":[121,337],"can":[122,267,306,392],"be":[123],"used":[124],"additional":[126],"validation":[127],"our":[129],"numerical":[130],"simulations.":[131],"was":[136,181,333],"computed":[137],"regimens":[143],"problem":[147],"radiobiological":[149],"non-small-cell":[153],"lung":[154],"cancer.":[155],"Sensitivity":[156],"volume":[169],"fraction,":[172],"boost":[173],"ratio,":[175],"re-oxygenation":[176,302,407],"rate,":[177],"delivery":[179,304,409],"errors":[180,305,410],"investigated.":[182],"RESULTS:":[183],"computational":[185],"results":[188],"show":[189],"distributions":[199,287,315,342,369,379,391,419,426],"larger":[201],"than":[202,299,348,376,423],"1.0":[203],"first":[206,281],"fractions":[208],"fractionation.":[213,387],"This":[214,232,265],"indicates":[215],"produces":[221],"higher":[223,344],"killing":[225,243,346,375],"effect":[226,244,266,347],"may":[233],"stem":[234],"from":[235],"domination":[236],"contribution":[239],"seen":[245],"range":[249],"1-2":[251],"Gy":[252],"steeper":[255],"slope":[256],"curve":[259],"region.":[264],"only":[268],"happen":[269],"if":[270,403],"clonogens":[274],"nearly":[276],"uniform;":[277],"therefore,":[278],"after":[279],"fractions,":[283],"outperform":[288,393],"becomes":[297],"less":[298,371],"1.0.":[300],"However,":[301],"also":[307],"reduce":[308],"effectiveness":[310],"toward":[316],"end":[318,399],"treatment.":[320,356,430],"For":[321],"fractional":[325],">3":[327],"Gy,":[328],"always":[334],"below":[335],"1.0,":[336],"means":[338],"produced":[343],"entire":[355,429],"CONCLUSION:":[357],"data":[359],"obtained":[360],"work":[363],"suggest":[364],"effective":[372],"at":[373,380],"beginning":[382],"However;":[388],"treatment":[402],"effects":[405],"reduced.":[412],"In":[413],"radiotherapy,":[415],"more":[421],"efficient":[422]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-03T00:00:00"}
