{"id":"https://openalex.org/W2590956055","doi":null,"title":"Therapeutic Exploitation of Metabolic Checkpoints In Cancer Cells","display_name":"Therapeutic Exploitation of Metabolic Checkpoints In Cancer Cells","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2590956055","mag":"2590956055"},"language":"en","primary_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-2777","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/1774","pdf_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=2777&context=gc_etds","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=2777&context=gc_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059983831","display_name":"Deven Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Deven Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059983831"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.24449999630451202,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.5979999899864197},{"id":"https://openalex.org/keywords/metabolic-checkpoint","display_name":"metabolic checkpoint","score":0.6570000052452087},{"id":"https://openalex.org/keywords/g1-cell-cycle-progression","display_name":"G1 cell cycle progression","score":0.7649999856948853},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.7400000095367432},{"id":"https://openalex.org/keywords/essential-amino-acids","display_name":"essential amino acids","score":0.7329999804496765},{"id":"https://openalex.org/keywords/aminooxyacetic-acid","display_name":"aminooxyacetic acid","score":0.8650000095367432},{"id":"https://openalex.org/keywords/s-phase-arrest","display_name":"S phase arrest","score":0.9120000004768372},{"id":"https://openalex.org/keywords/replicative-stress","display_name":"replicative stress","score":0.8519999980926514},{"id":"https://openalex.org/keywords/aspartate","display_name":"aspartic acid","score":0.8980000019073486},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5554905533790588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3178119659423828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15162229537963867}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-2777","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/1774","pdf_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=2777&context=gc_etds","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},{"id":"mag:2590956055","doi":null,"is_oa":false,"landing_page_url":"http://academicworks.cuny.edu/cgi/viewcontent.cgi?article=2777&context=gc_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-2777","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/1774","pdf_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=2777&context=gc_etds","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2590956055.pdf","grobid_xml":"https://content.openalex.org/works/W2590956055.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W1506043671","https://openalex.org/W1512819804","https://openalex.org/W1526058397","https://openalex.org/W1544564404","https://openalex.org/W1547033864","https://openalex.org/W1553978925","https://openalex.org/W1590458072","https://openalex.org/W1905915630","https://openalex.org/W1918384196","https://openalex.org/W1932780354","https://openalex.org/W1966181655","https://openalex.org/W1967442806","https://openalex.org/W1967482096","https://openalex.org/W1968113908","https://openalex.org/W1969210627","https://openalex.org/W1975319922","https://openalex.org/W1975887477","https://openalex.org/W1976979132","https://openalex.org/W1978625554","https://openalex.org/W1979861893","https://openalex.org/W1980502224","https://openalex.org/W1982501876","https://openalex.org/W1982789056","https://openalex.org/W1983698019","https://openalex.org/W1984621921","https://openalex.org/W1984736455","https://openalex.org/W1985046929","https://openalex.org/W1986896225","https://openalex.org/W1989830594","https://openalex.org/W1991386861","https://openalex.org/W1992170852","https://openalex.org/W1992903441","https://openalex.org/W1994937757","https://openalex.org/W1996121326","https://openalex.org/W1996365670","https://openalex.org/W1997053429","https://openalex.org/W1999547245","https://openalex.org/W2000731858","https://openalex.org/W2001568034","https://openalex.org/W2002226709","https://openalex.org/W2004006939","https://openalex.org/W2004582874","https://openalex.org/W2005066107","https://openalex.org/W2005496215","https://openalex.org/W2006896973","https://openalex.org/W2007044718","https://openalex.org/W2007505836","https://openalex.org/W2007725129","https://openalex.org/W2008825756","https://openalex.org/W2010413317","https://openalex.org/W2011282245","https://openalex.org/W2014058353","https://openalex.org/W2014988241","https://openalex.org/W2015012139","https://openalex.org/W2020151423","https://openalex.org/W2023012828","https://openalex.org/W2024104654","https://openalex.org/W2030801461","https://openalex.org/W2030977583","https://openalex.org/W2031918765","https://openalex.org/W2033408767","https://openalex.org/W2041855679","https://openalex.org/W2042499074","https://openalex.org/W2045795713","https://openalex.org/W2046982981","https://openalex.org/W2052146604","https://openalex.org/W2053580956","https://openalex.org/W2056040807","https://openalex.org/W2057106513","https://openalex.org/W2058648933","https://openalex.org/W2059086985","https://openalex.org/W2060905299","https://openalex.org/W2063013559","https://openalex.org/W2064412858","https://openalex.org/W2064670731","https://openalex.org/W2065825082","https://openalex.org/W2065887259","https://openalex.org/W2066659565","https://openalex.org/W2069524101","https://openalex.org/W2072451938","https://openalex.org/W2074437785","https://openalex.org/W2075209047","https://openalex.org/W2075511135","https://openalex.org/W2076767106","https://openalex.org/W2078603028","https://openalex.org/W2080099280","https://openalex.org/W2080100938","https://openalex.org/W2080810925","https://openalex.org/W2081920342","https://openalex.org/W2086393402","https://openalex.org/W2086816631","https://openalex.org/W2087136249","https://openalex.org/W2090406819","https://openalex.org/W2092545031","https://openalex.org/W2094518946","https://openalex.org/W2094817491","https://openalex.org/W2097259163","https://openalex.org/W2098912234","https://openalex.org/W2101083009","https://openalex.org/W2101572834","https://openalex.org/W2101579411","https://openalex.org/W2102148658","https://openalex.org/W2102888099","https://openalex.org/W2105575738","https://openalex.org/W2106130068","https://openalex.org/W2110443482","https://openalex.org/W2111341684","https://openalex.org/W2112481873","https://openalex.org/W2114859236","https://openalex.org/W2114956843","https://openalex.org/W2117028091","https://openalex.org/W2117692326","https://openalex.org/W2120320496","https://openalex.org/W2120356140","https://openalex.org/W2121233961","https://openalex.org/W2123977090","https://openalex.org/W2124598062","https://openalex.org/W2126783165","https://openalex.org/W2127063807","https://openalex.org/W2127624416","https://openalex.org/W2128252882","https://openalex.org/W2129920232","https://openalex.org/W2131734657","https://openalex.org/W2133684121","https://openalex.org/W2135546443","https://openalex.org/W2136676465","https://openalex.org/W2137737048","https://openalex.org/W2139126860","https://openalex.org/W2139987952","https://openalex.org/W2140804609","https://openalex.org/W2142544392","https://openalex.org/W2143632660","https://openalex.org/W2148603246","https://openalex.org/W2148931486","https://openalex.org/W2149218373","https://openalex.org/W2149687593","https://openalex.org/W2150091603","https://openalex.org/W2153708110","https://openalex.org/W2156144699","https://openalex.org/W2158612356","https://openalex.org/W2160159824","https://openalex.org/W2161594264","https://openalex.org/W2163583831","https://openalex.org/W2167737594","https://openalex.org/W2169625143","https://openalex.org/W2170801131","https://openalex.org/W2277073486","https://openalex.org/W2319386786","https://openalex.org/W2503851771"],"related_works":["https://openalex.org/W2277073486","https://openalex.org/W1526058397","https://openalex.org/W7073537172","https://openalex.org/W1980502224","https://openalex.org/W19631770","https://openalex.org/W2469786665","https://openalex.org/W2041855679","https://openalex.org/W2070710923","https://openalex.org/W4307003099","https://openalex.org/W2046982981"],"abstract_inverted_index":{"During":[0],"the":[1,5,28,49,59,90,169,209,213,234,255,284,292,323,366,372,392],"G1":[2,40,71,92,309,343,359,412],"phase":[3],"of":[4,38,62,97,127,172,236,240,298,303,325,394,410],"cell":[6,72,344,382,421],"cycle,":[7],"normal":[8],"cells":[9,85,115,126,146,355,387],"respond":[10],"to":[11,17,20,159,166,174,223,226,316,389,401],"growth":[12,29],"factors":[13],"and":[14,56,99,161,188,258,280,289,312,369],"nutrients":[15],"prior":[16],"entering":[18],"S-phase":[19,120,190,199,214,219,267,293],"replicate":[21,390],"its":[22],"genome.":[23],"We":[24,81,216,347],"previously":[25],"reported":[26],"that":[27,69,83,218,321,349,415,426],"factor-mediated":[30],"restriction":[31],"point":[32],"is":[33,135,156,164,273,281,378,424],"distinguishable":[34],"from":[35,365,371],"a":[36,107,137,150,202,274,361,408],"series":[37,409],"late":[39,91,117,308,358,411],"metabolic":[41,305,413],"checkpoints":[42,306,320,414,429],"mediated":[43],"by":[44,182,283,296],"essential":[45,51],"amino":[46,52],"acids":[47],"(EAAs),":[48],"conditionally":[50],"acid":[53],"glutamine":[54,299],"(Gln),":[55],"mTOR":[57,373],"\u2013":[58,192],"mammalian":[60],"target":[61],"rapamycin.":[63,111,197],"Mutations":[64],"in":[65,77,102,116,119,132,140,233,246,307,352,357,380,391,418,432],"genes":[66],"encoding":[67],"proteins":[68],"regulate":[70],"cycle":[73,345],"progression":[74],"are":[75,330,416,430,436],"observed":[76,82],"virtually":[78],"all":[79],"cancers.":[80],"cancer":[84,145,420,433],"with":[86,168],"K-Ras":[87],"mutations":[88],"bypass":[89],"Gln":[93,98,128,148,155,186,241,313,367],"checkpoint":[94,368,377],"when":[95,350,427],"deprived":[96],"instead":[100],"arrest":[101,191,200,220,294,356],"S-phase.":[103],"Significantly,":[104],"this":[105,134,376],"created":[106,201],"synthetic":[108,194,203],"lethality":[109,195,204],"for":[110,196,205,212,230,277,310,318,332,342,439],"Whereas":[112],"rapamycin":[113,121],"arrests":[114],"G1,":[118],"induces":[122],"apoptosis.":[123],"While":[124],"depriving":[125],"can":[129,179],"be":[130,180],"achieved":[131],"culture,":[133],"not":[136],"viable":[138],"option":[139],"an":[141,224],"animal.":[142],"However,":[143],"K-Ras-driven":[144],"utilize":[147],"via":[149],"novel":[151,437],"transaminase":[152,285],"reaction":[153,178,286],"whereby":[154],"first":[157],"deaminated":[158],"glutamate":[160,163,288],"then":[162],"deamidated":[165],"a-ketoglutarate,":[167],"concomitant":[170],"conversion":[171],"oxaloacetate":[173],"aspartate.":[175],"This":[176],"transamination":[177],"inhibited":[181],"aminooxyacetate,":[183],"which":[184,245,265,272],"mimics":[185],"deprivation":[187],"causes":[189],"creating":[193],"Since":[198,328],"rapamycin,":[206],"we":[207,335,405],"investigated":[208,336],"molecular":[210],"basis":[211],"arrest.":[215,268],"found":[217,348],"was":[221],"due":[222],"inability":[225],"generate":[227],"deoxynucleotides":[228,243,278],"needed":[229],"DNA":[231,262],"synthesis":[232],"absence":[235,393],"glutamine.":[237],"The":[238,251,301],"lack":[239],"suppressed":[242],"biosynthesis,":[244,334],"turn":[247],"induced":[248],"replicative":[249,252],"stress.":[250],"stress":[253],"activated":[254],"ataxia":[256],"telangiectasia":[257],"Rad3-related":[259],"protein":[260],"(ATR)-mediated":[261],"damage":[263],"pathway,":[264],"caused":[266,295],"Of":[269],"significance,":[270],"aspartate,":[271],"critical":[275,326,331],"metabolite":[276],"biosynthesis":[279],"generated":[282],"between":[287],"oxaloacetate,":[290],"rescued":[291],"inhibition":[297],"utilization.":[300],"presence":[302,324],"distinct":[304,362],"EAAs":[311],"led":[314],"us":[315],"look":[317],"additional":[319],"monitor":[322],"nutrients.":[327],"lipids":[329,339,395],"membrane":[333],"whether":[337],"serum":[338],"were":[340],"important":[341],"progression.":[346],"put":[351],"delipidated":[353],"serum,":[354],"at":[360],"site":[363],"downstream":[364],"upstream":[370],"site.":[374],"Intriguingly,":[375],"dysregulated":[379,417,431],"clear":[381],"renal":[383],"carcinoma":[384],"cells.":[385],"These":[386],"continue":[388],"until":[396],"they":[397],"ultimately":[398],"starve":[399],"themselves":[400],"death.":[402],"In":[403],"summary,":[404],"have":[406],"identified":[407],"specific":[419],"lines.":[422],"It":[423],"speculated":[425],"these":[428],"cells,":[434],"there":[435],"opportunities":[438],"therapeutic":[440],"intervention.":[441]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-03T00:00:00"}