{"id":"https://openalex.org/W2590932390","doi":"https://doi.org/10.1016/j.bbmt.2016.12.305","title":"Using Helper T Cell Function to Predict the Response of Chronic GVHD Patients to ECP Therapy","display_name":"Using Helper T Cell Function to Predict the Response of Chronic GVHD Patients to ECP Therapy","publication_year":2017,"publication_date":"2017-02-22","ids":{"openalex":"https://openalex.org/W2590932390","doi":"https://doi.org/10.1016/j.bbmt.2016.12.305","mag":"2590932390"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbmt.2016.12.305","doi":"https://doi.org/10.1016/j.bbmt.2016.12.305","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2016.12.305","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbmt.2016.12.305","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000369032","display_name":"Thomas M. Yankee","orcid":"https://orcid.org/0000-0002-3907-4838","observed_orcids":["https://orcid.org/0000-0002-3907-4838"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Yankee","raw_affiliation_strings":["Microbiology and Immunology, University of Kansas Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004025191","display_name":"Daisy Dai","orcid":"https://orcid.org/0000-0001-6508-7491","observed_orcids":["https://orcid.org/0000-0001-6508-7491","https://orcid.org/0000-0003-2950-036X"]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daisy Dai","raw_affiliation_strings":["Biostatistics, Children's Mercy Hospital, Kansas City, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Children's Mercy Hospital, Kansas City, MO","institution_ids":["https://openalex.org/I1328594524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081601062","display_name":"Jignesh D Dalal","orcid":"https://orcid.org/0000-0002-4418-4919","observed_orcids":["https://orcid.org/0000-0002-4418-4919"]},"institutions":[{"id":"https://openalex.org/I4210151235","display_name":"Rainbow Babies & Children's Hospital","ror":"https://ror.org/04x495f64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210151235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jignesh D. Dalal","raw_affiliation_strings":["Bone Marrow Transplantation, Pediatric Hematology/Oncology, Rainbow Babies & Childrend's Hospital, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Marrow Transplantation, Pediatric Hematology/Oncology, Rainbow Babies & Childrend's Hospital, Cleveland, OH","institution_ids":["https://openalex.org/I4210151235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112255691","display_name":"Ashraf Hassaballa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashraf Hassaballa","raw_affiliation_strings":["Immunology, Kansas University Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Kansas University Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008376636","display_name":"Siddhartha Ganguly","orcid":"https://orcid.org/0000-0003-4920-762X","observed_orcids":["https://orcid.org/0000-0003-4920-762X"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddhartha Ganguly","raw_affiliation_strings":["Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052064208","display_name":"Joseph P. McGuirk","orcid":"https://orcid.org/0000-0002-0539-4796","observed_orcids":["https://orcid.org/0000-0002-0539-4796"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph McGuirk","raw_affiliation_strings":["Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086587597","display_name":"Sunil Abhyankar","orcid":"https://orcid.org/0000-0002-8578-1226","observed_orcids":["https://orcid.org/0000-0002-8578-1226"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Abhyankar","raw_affiliation_strings":["Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS","institution_ids":["https://openalex.org/I4210097601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02521085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"3","first_page":"S358","last_page":"S360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/extracorporeal-photopheresis","display_name":"extracorporeal photopheresis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd4-t-cell-differentiation","display_name":"CD4+ T cell differentiation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/t-cell-help","display_name":"T cell help","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6759999990463257},{"id":"https://openalex.org/keywords/steroid-refractory-gvhd","display_name":"steroid-refractory GVHD","score":0.8140000104904175},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/th1-th2-cytokines","display_name":"Th1/Th2 cytokines","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cytokine-biomarkers","display_name":"cytokine biomarkers","score":0.5590000152587891},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"principal component analysis","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.922026515007019},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.6013267636299133},{"id":"https://openalex.org/C2909962264","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Extracorporeal Photopheresis","level":4,"score":0.598110020160675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5299317240715027},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.514537513256073},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.48555251955986023},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.46711477637290955},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4470067024230957},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4399362802505493},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41800886392593384},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41672849655151367},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2968258261680603}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bbmt.2016.12.305","doi":"https://doi.org/10.1016/j.bbmt.2016.12.305","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2016.12.305","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bbmt.2016.12.305","doi":"https://doi.org/10.1016/j.bbmt.2016.12.305","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2016.12.305","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087974519","https://openalex.org/W2332996798","https://openalex.org/W2012341055","https://openalex.org/W1767759161","https://openalex.org/W2984620319","https://openalex.org/W1938252555","https://openalex.org/W2152802537","https://openalex.org/W1899396321","https://openalex.org/W3212896757","https://openalex.org/W2586736557"],"abstract_inverted_index":{"Chronic":[0],"graft-versus":[1],"host":[2],"disease":[3],"(GvHD)":[4],"affects":[5],"approximately":[6],"30-70%":[7],"of":[8,39,50,99,181,335,355,360,379],"patients":[9,27,41,64,94],"undergoing":[10],"hematopoietic":[11],"stem":[12],"cell":[13,78],"transplantation.":[14],"Extracorporeal":[15],"photopheresis":[16],"(ECP)":[17],"therapy":[18,25,52,107,382],"has":[19],"emerged":[20],"as":[21,82,231,233,264,266],"a":[22,59,83,170,203,291,333,343,375],"promising":[23],"second-line":[24],"for":[26,112,152,213,246,277,310,353],"with":[28,143,296,326],"steroid-refractory":[29],"chronic":[30,385],"GvHD.":[31],"However,":[32],"ECP":[33,51,68,100,106,381],"is":[34,44],"only":[35],"successful":[36,380],"in":[37,56,188,198,279,285,312,329,383],"50-80%":[38],"these":[40],"and":[42,53,115,140,148,160,173,184,193,221,226,254,259,338],"there":[43],"considerable":[45],"delay":[46],"between":[47],"the":[48,97,189,196,218,239,251,272,317,327,356],"onset":[49],"clinical":[54],"improvement":[55],"symptoms.":[57],"Thus,":[58],"method":[60],"to":[61,96,195,302],"predict":[62],"which":[63],"might":[65,80],"benefit":[66],"from":[67,90],"would":[69],"be":[70,374],"highly":[71],"valuable.":[72],"To":[73],"determine":[74],"whether":[75],"CD4+":[76,85,132,370],"T":[77,86,133,371],"differentiation":[79],"serve":[81],"predictor,":[84],"cells":[87,134,372],"were":[88,135,141,158,167,186],"isolated":[89],"ten":[91],"steroid-resistant":[92,384],"GvHD":[93,199,386],"prior":[95],"initiation":[98],"therapy.":[101],"Patients":[102],"(Table":[103,130],"1)":[104],"underwent":[105],"two":[108,117],"times":[109,118],"per":[110,119],"week":[111,120],"four":[113],"weeks":[114],"then":[116],"every":[121],"other":[122],"week.":[123],"CGVHD":[124],"was":[125],"scored":[126],"using":[127,169,175],"NIH":[128,200,219,252,280,313,330],"criteria":[129],"2).":[131],"purified":[136],"via":[137],"negative":[138],"selection":[139],"stimulated":[142],"plate-bound":[144],"anti-CD3":[145],"10":[146],"mg/ml":[147,151],"anti-CD28":[149],"5":[150],"five":[153,349],"days.":[154],"Tissue":[155],"culture":[156,191],"supernatants":[157],"collected":[159,168],"stored":[161],"at":[162,224,257],"\u221280\u00b0C":[163],"until":[164],"analysis,":[165],"Data":[166],"Luminex":[171],"200":[172],"analyzed":[174],"MILLIPLEX\u00ae":[176],"Analyst":[177],"software":[178],"(Millipore).The":[179],"production":[180,368],"42":[182],"cytokines":[183,321],"chemokines":[185],"measured":[187],"tissue":[190],"supernatant":[192],"compared":[194],"change":[197,278,311,328],"score":[201,220,253,314,331],"over":[202],"six-month":[204],"period.Table":[205],"1Patient":[206],"demographics.Table":[207],"2The":[208,241],"immunosuppressive":[209,235,242,268],"agents":[210,243],"are":[211,229,244,262,283,300],"shown":[212,245],"each":[214,247],"patient.":[215,248],"In":[216,249,288,341],"addition,":[217,250,342],"prednisone":[222,255],"dose":[223,256],"baseline":[225,258],"6":[227,260],"months":[228,261],"shown,":[230,263],"well":[232,265],"any":[234,267],"drugs":[236,269],"added":[237,270],"during":[238,271],"study.Table":[240],"study.":[273],"The":[274,304,320,358],"scatter":[275,289],"plots":[276],"versus":[281],"cytokine":[282,318,367],"presented":[284],"Figure":[286],"1.":[287],"plots,":[290],"linear":[292,305],"regression":[293,306],"line":[294,307],"along":[295],"95%":[297],"confidence":[298],"band":[299],"fitted":[301],"data.":[303],"provides":[308],"prediction":[309],"based":[315],"on":[316],"values.":[319],"that":[322,348,366],"correlated":[323],"most":[324],"strongly":[325],"included":[332],"mixture":[334],"Th1,":[336],"Th2,":[337],"Th9":[339],"cytokines.":[340],"principal":[344,350],"component":[345],"analysis":[346],"showed":[347],"components":[351],"accounted":[352],"90%":[354],"variation.":[357],"results":[359],"our":[361],"small":[362],"pilot":[363],"study":[364],"suggest":[365],"by":[369],"may":[373],"useful":[376],"prognostic":[377],"indicator":[378],"patients.":[387]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2017-03-03T00:00:00"}
