{"id":"https://openalex.org/W2590931442","doi":"https://doi.org/10.1016/j.bbmt.2016.12.096","title":"Autologous Transplantation (autoHCT) is Associated with Improved Overall Survival (OS) in Follicular Lymphoma (FL) Patients (Pts) Experiencing Early Therapy Failure after Frontline Chemo-Immunotherapy: A National Lymphocare Study (NLCS) & CIBMTR Analysis","display_name":"Autologous Transplantation (autoHCT) is Associated with Improved Overall Survival (OS) in Follicular Lymphoma (FL) Patients (Pts) Experiencing Early Therapy Failure after Frontline Chemo-Immunotherapy: A National Lymphocare Study (NLCS) & CIBMTR Analysis","publication_year":2017,"publication_date":"2017-02-22","ids":{"openalex":"https://openalex.org/W2590931442","doi":"https://doi.org/10.1016/j.bbmt.2016.12.096","mag":"2590931442"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbmt.2016.12.096","doi":"https://doi.org/10.1016/j.bbmt.2016.12.096","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2016.12.096","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbmt.2016.12.096","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064738578","display_name":"Carla Casulo","orcid":"https://orcid.org/0000-0003-4998-9932","observed_orcids":["https://orcid.org/0000-0003-4998-9932","https://orcid.org/0000-0001-9993-5065"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Casulo","raw_affiliation_strings":["Wilmot Cancer Institute, University of Rochester, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmot Cancer Institute, University of Rochester, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038526399","display_name":"Jonathan W. Friedberg","orcid":"https://orcid.org/0000-0002-1420-5563","observed_orcids":["https://orcid.org/0000-0002-1420-5563"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan W. Friedberg","raw_affiliation_strings":["Wilmot Cancer Institute, University of Rochester, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmot Cancer Institute, University of Rochester, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000705580","display_name":"Kwang Woo Ahn","orcid":"https://orcid.org/0000-0003-4567-8037","observed_orcids":["https://orcid.org/0000-0003-4567-8037"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwang Woo Ahn","raw_affiliation_strings":["CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI","Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050493084","display_name":"Alessandro Digilio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa DiGilio","raw_affiliation_strings":["CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077430940","display_name":"Anna Maria Sureda","orcid":"https://orcid.org/0000-0002-1238-6970","observed_orcids":["https://orcid.org/0000-0002-1238-6970"]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]},{"id":"https://openalex.org/I4210143012","display_name":"Duran i Reynals Hospital","ror":"https://ror.org/03qwghy04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210143012"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anna Sureda","raw_affiliation_strings":["Servei d'Hematologica, Institut Catal\u00e0 d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servei d'Hematologica, Institut Catal\u00e0 d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain","institution_ids":["https://openalex.org/I4210107147","https://openalex.org/I4210143012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069393942","display_name":"Timothy S. Fenske","orcid":"https://orcid.org/0000-0001-7069-0025","observed_orcids":["https://orcid.org/0000-0001-7069-0025"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy S. Fenske","raw_affiliation_strings":["Department of Medicine, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005159945","display_name":"Sonali M. Smith","orcid":"https://orcid.org/0000-0002-9893-4949","observed_orcids":["https://orcid.org/0000-0002-9893-4949"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonali M. Smith","raw_affiliation_strings":["Section of Hematology/Oncology, The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011030256","display_name":"Mehdi Hamadani","orcid":"https://orcid.org/0000-0001-5372-510X","observed_orcids":["https://orcid.org/0000-0001-5372-510X"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehdi Hamadani","raw_affiliation_strings":["Department of Medicine, Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":1.0776,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74785999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"3","first_page":"S46","last_page":"S47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8379999995231628},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.4269999861717224},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cibmtr","display_name":"CIBMTR","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mortality-risk-stratification","display_name":"mortality risk stratification","score":0.3869999945163727},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9418716430664062},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.9374144077301025},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.6902139186859131},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.5504745244979858},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5052304863929749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47608983516693115},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45155274868011475},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3396793603897095},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.23017165064811707},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1444094181060791}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bbmt.2016.12.096","doi":"https://doi.org/10.1016/j.bbmt.2016.12.096","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2016.12.096","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bbmt.2016.12.096","doi":"https://doi.org/10.1016/j.bbmt.2016.12.096","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2016.12.096","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2623533834","https://openalex.org/W2774937907","https://openalex.org/W2803131717","https://openalex.org/W2890734861","https://openalex.org/W2773672544","https://openalex.org/W2121651984","https://openalex.org/W3183608863","https://openalex.org/W2590630390","https://openalex.org/W2888730183","https://openalex.org/W2960149403"],"abstract_inverted_index":{"Introduction:":[0],"FL":[1,38,71,110,134,159,176,248,368],"pts":[2,39,49,72,111,135,177,183,194,249,301,369],"experiencing":[3,40,370],"therapy":[4,23,42,81,365],"failure":[5,82,87],"within":[6,52,103,186],"2":[7],"years":[8],"(yrs)":[9],"of":[10,19,22,34,54,66,70,105,126,189,208,229,259,290,298,309,330,339],"a":[11,92,256,274,335],"frontline":[12,55],"rituximab-based":[13,151,373],"chemoimmunotherapy":[14,56,99,152],"have":[15],"poor":[16],"OS":[17,33,228,317,379],"regardless":[18],"the":[20,113,123,139,142,307],"type":[21],"or":[24,100,212],"rituximab":[25],"maintenance":[26],"use.":[27],"A":[28,286],"recent":[29],"NLCS":[30,114,182,354],"reported":[31],"5-yr":[32],"only":[35],"50%":[36],"in":[37,48,112,223,247,367],"early":[41,80,303,328,362],"failure,":[43],"compared":[44],"to":[45,88,163,210,383],"90%":[46],"survival":[47],"not":[50,74,119,195,253],"progressing":[51],"2-yrs":[53,104],"(Casulo":[57],"C.":[58],"JCO":[59],"2015).":[60],"Whether":[61],"autoHCT":[62,121,137,143,232,246,299,319,331,359],"can":[63],"improve":[64],"outcomes":[65],"this":[67,78,127],"high-risk":[68],"subgroup":[69,288],"is":[73,375],"known.":[75],"Methods:":[76],"In":[77],"study,":[79],"(ETF)":[83],"was":[84,161,168,203,234,252,332],"defined":[85],"as":[86,153],"achieve":[89],"at":[90,158,174],"least":[91],"partial":[93],"response":[94],"(PR)":[95],"after":[96,372],"first":[97,107,154],"line":[98,108,155],"disease":[101],"relapse/progression":[102],"starting":[106],"chemoimmunotherapy.":[109],"fulfilling":[115],"these":[116,385],"criteria":[117],"and":[118,231,355],"receiving":[120,302],"represent":[122,141],"non-HCT":[124,230,291],"cohort":[125,144,292,300],"analysis":[128,244,289],"(n":[129,145,293],"=":[130,146,240,262,266,279,284,294,312,324,342,347],"174);":[131],"while":[132],"ETF":[133,190,209,251,371],"undergoing":[136],"from":[138,206,306,364],"CIBMTR":[140,356],"175).":[147],"All":[148],"patients":[149],"received":[150],"treatment.":[156],"Age":[157],"diagnosis":[160],"restricted":[162],"18-70":[164],"yrs,":[165],"but":[166],"there":[167],"no":[169],"upper":[170],"limit":[171],"for":[172,199,273],"age":[173,269],"autoHCT.":[175],"with":[178,250,255,318,334,377],"transformation":[179],"were":[180,191],"excluded.":[181],"who":[184],"died":[185],"4":[187],"months":[188],"excluded":[192],"(ie,":[193],"surviving":[196],"long":[197],"enough":[198],"salvage/autoHCT).":[200],"Primary":[201],"objective":[202],"OS;":[204],"measured":[205],"date":[207],"death":[211],"last":[213],"follow":[214],"up":[215],"(left":[216],"truncated).":[217],"Results:":[218],"Baseline":[219],"characteristics":[220],"are":[221,387],"shown":[222],"Table":[224],"1.":[225],"The":[226],"3-yr":[227,316],"cohorts":[233],"60%":[235],"versus":[236,296,321],"67%":[237],"respectively":[238],"(P":[239],".16).":[241],"On":[242,326],"multivariate":[243],"(MVA)":[245],"associated":[254,333,376],"reduced":[257,337],"risk":[258,277,338],"mortality":[260,276,340],"(HR":[261,278,341],".88,":[263],"95%CI:.61-1.26,":[264],"P":[265,283,323,346],".49).":[267],"Only":[268],"\u226560":[270],"yrs":[271],"predicted":[272],"higher":[275,315],"2.49,":[280],"95%CI:":[281,344],"1.18-5.25,":[282],".002).":[285],"planned":[287],"174)":[295],"subset":[297],"HCT":[304],"(\u22641-yr":[305,363],"time":[308],"ETF;":[310],"n":[311],"123)":[313],"showed":[314],"(60%":[320],"73%,":[322],".02).":[325,348],"MVA":[327],"application":[329],"significantly":[336],".63,":[343],".42-.94,":[345],"Conclusion:":[349],"This":[350],"unique":[351],"collaboration":[352],"between":[353],"suggests":[357],"that":[358],"when":[360],"performed":[361],"failure)":[366],"chemoimmunotherapy,":[374],"an":[378],"benefit.":[380],"Prospective":[381],"trials":[382],"confirm":[384],"findings":[386],"urgently":[388],"needed.Tabled":[389],"1":[390]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2017-03-03T00:00:00"}
