{"id":"https://openalex.org/W2590911684","doi":"https://doi.org/10.1200/jco.2013.31.6_suppl.123","title":"A randomized phase II trial of dexamethasone versus prednisolone as secondary hormonal therapy in CRPC.","display_name":"A randomized phase II trial of dexamethasone versus prednisolone as secondary hormonal therapy in CRPC.","publication_year":2013,"publication_date":"2013-02-20","ids":{"openalex":"https://openalex.org/W2590911684","doi":"https://doi.org/10.1200/jco.2013.31.6_suppl.123","mag":"2590911684"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.6_suppl.123","doi":"https://doi.org/10.1200/jco.2013.31.6_suppl.123","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.6_suppl.123","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016488980","display_name":"Ramachandran Venkitaraman","orcid":"https://orcid.org/0000-0002-6296-6033","observed_orcids":["https://orcid.org/0000-0002-6296-6033"]},"institutions":[{"id":"https://openalex.org/I4210160269","display_name":"Ipswich Hospital","ror":"https://ror.org/05m3qrs33","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210101239","https://openalex.org/I4210160269"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ramachandran Venkitaraman","raw_affiliation_strings":["Ipswich Hospital NHS, Ipswich, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipswich Hospital NHS, Ipswich, United Kingdom","institution_ids":["https://openalex.org/I4210160269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033672260","display_name":"Karen Thomas","orcid":"https://orcid.org/0000-0001-7548-4466","observed_orcids":["https://orcid.org/0000-0001-7548-4466"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen Thomas","raw_affiliation_strings":["The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049692975","display_name":"Vedang Murthy","orcid":"https://orcid.org/0000-0001-6011-9319","observed_orcids":["https://orcid.org/0000-0001-6011-9319"]},"institutions":[{"id":"https://openalex.org/I4210157422","display_name":"Advanced Centre for Treatment, Research and Education in Cancer","ror":"https://ror.org/05b9pgt88","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698","https://openalex.org/I4210157422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vedang Murthy","raw_affiliation_strings":["ACTREC, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACTREC, Mumbai, India","institution_ids":["https://openalex.org/I4210157422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057348233","display_name":"Ruth Woode\u2010Amissah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Woode-Amissah","raw_affiliation_strings":["Institute of Cancer Research, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025921361","display_name":"David Paul Dearnaley","orcid":"https://orcid.org/0000-0002-3954-2806","observed_orcids":["https://orcid.org/0000-0002-3954-2806"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Paul Dearnaley","raw_affiliation_strings":["Institute of Cancer Research/Royal Marsden Hospital, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research/Royal Marsden Hospital, Sutton, United Kingdom","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063051257","display_name":"Alan Horwich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Horwich","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London and Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London and Surrey, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047234703","display_name":"Robert Anthony Huddart","orcid":"https://orcid.org/0000-0003-3604-1990","observed_orcids":["https://orcid.org/0000-0003-3604-1990"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Anthony Huddart","raw_affiliation_strings":["Institute of Cancer Research, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research, Surrey, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann Sebastian De Bono","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101420072","display_name":"Chris C. Parker","orcid":"https://orcid.org/0000-0001-6512-124X","observed_orcids":["https://orcid.org/0000-0001-6512-124X","https://orcid.org/0000-0001-7724-9486"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Parker","raw_affiliation_strings":["The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"6_suppl","first_page":"123","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":1.0},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8069999814033508},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/psa-response","display_name":"PSA response","score":0.8840000033378601},{"id":"https://openalex.org/keywords/time-to-psa-progression","display_name":"time to PSA progression","score":0.8489999771118164},{"id":"https://openalex.org/keywords/radiological-response","display_name":"radiological response","score":0.8619999885559082},{"id":"https://openalex.org/keywords/drug-comparison","display_name":"drug comparison","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.922348141670227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8960045576095581},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.794886589050293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5958884954452515},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5802333354949951},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5511958003044128},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.4983255863189697},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3623429536819458},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24805963039398193}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.6_suppl.123","doi":"https://doi.org/10.1200/jco.2013.31.6_suppl.123","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.6_suppl.123","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5299999713897705,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131146826","https://openalex.org/W2303420095","https://openalex.org/W1536887651","https://openalex.org/W1974657326","https://openalex.org/W3196396019","https://openalex.org/W2790922327","https://openalex.org/W1997327310","https://openalex.org/W2565791917","https://openalex.org/W2065024194","https://openalex.org/W7096129091"],"abstract_inverted_index":{"123":[0],"Background:":[1],"Dexamethasone":[2],"and":[3,116,179,183],"prednisolone":[4,70,98,139,158,203,244,264],"are":[5,233],"glucocorticosteroids":[6],"used":[7,260],"as":[8],"second":[9],"line":[10],"hormonal":[11],"treatment":[12,247],"for":[13,181,210],"castration":[14,51],"refractory":[15],"prostate":[16,53],"cancer":[17,54],"(CRPC).":[18],"The":[19,77,231],"biochemical":[20],"response":[21,83,111,125,172,223],"rates":[22],"in":[23,128,245,261,265],"cohort":[24],"studies":[25],"suggest":[26],"that":[27,238],"dexamethasone":[28,45,74,133,152,182,225,239,257],"may":[29],"be":[30,259],"the":[31,87,171,215,236,246,251],"more":[32,241],"active":[33,242],"agent.":[34],"We":[35],"conducted":[36],"an":[37],"open":[38],"label,":[39],"randomised":[40],"phase":[41],"II":[42],"trial":[43,269],"of":[44,214,248,253],"versus":[46],"prednisolone.":[47,229],"Methods:":[48],"Patients":[49,93],"with":[50,55,94,168,235],"resistant":[52],"progressive":[56],"disease":[57],"on":[58,97,132,138,151,157,202,228],"androgen":[59],"deprivation":[60],"therapy":[61],"were":[62,65,121,192,208],"eligible.":[63],"They":[64],"randomized":[66],"to":[67,86,101,107,135,145,154,204,224,263],"receive":[68],"either":[69],"10mg":[71],"daily":[72],"or":[73],"0.5mg":[75],"daily.":[76],"main":[78],"endpoint":[79],"was":[80,126,148,177],"confirmed":[81,221],"PSA":[82,88,95,108,124,146,211,222],"rate":[84,112,173],"according":[85],"Working":[89],"Group":[90],"2":[91],"criteria.":[92],"progression":[96,147,201,227],"crossed":[99,198],"over":[100,199],"dexamethasone.":[102],"Secondary":[103],"endpoints":[104],"included":[105],"time":[106,144],"progression,":[109],"radiologic":[110],"using":[113],"RECIST":[114,175],"criteria,":[115],"safety.":[117],"Results:":[118],"Seventy-five":[119],"patients":[120,130,167,196,207,217],"randomized.":[122],"Confirmed":[123],"achieved":[127],"12/39":[129],"(31%)":[131],"compared":[134,153],"6/36":[136],"(17%)":[137],"(p":[140,186],"=":[141,187],"0.153).":[142],"Median":[143],"9.7":[149],"months":[150,156],"5.1":[155],"(HR":[159],"1.57,":[160],"95%":[161],"CI":[162],"0.90":[163],"-2.75).":[164],"In":[165,250],"43":[166],"measurable":[169],"disease,":[170],"by":[174],"criteria":[176],"15%":[178],"6%":[180],"prednisolone,":[184],"respectively":[185],"0.606).":[188],"Clinically":[189],"significant":[190],"toxicities":[191],"rare.":[193],"Of":[194],"23":[195],"who":[197],"at":[200],"dexamethasone,":[205],"19":[206,216],"evaluable":[209],"response.":[212],"Seven":[213],"(37%)":[218],"had":[219],"a":[220],"after":[226],"Conclusions:":[230],"data":[232],"consistent":[234],"hypothesis":[237],"is":[240],"than":[243],"CRPC.":[249],"absence":[252],"definitive,":[254],"larger":[255],"trials,":[256],"should":[258],"preference":[262],"this":[266],"setting.":[267],"Clinical":[268],"information:":[270],"2005-006018-16.":[271]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-03-03T00:00:00"}