{"id":"https://openalex.org/W2590911405","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.7279","title":"A phase II study of combination therapy with liposomal doxorubicin and carboplatin (CBDCA) in patients (pts) with previously untreated small cell lung cancer (SCLC)","display_name":"A phase II study of combination therapy with liposomal doxorubicin and carboplatin (CBDCA) in patients (pts) with previously untreated small cell lung cancer (SCLC)","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2590911405","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.7279","mag":"2590911405"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2005.23.16_suppl.7279","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.7279","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.7279","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018701322","display_name":"Daniel Vorobiof","orcid":"https://orcid.org/0000-0002-5892-7568","observed_orcids":["https://orcid.org/0000-0002-5892-7568"]},"institutions":[{"id":"https://openalex.org/I4210089752","display_name":"The Medical Oncology Centre of Rosebank","ror":"https://ror.org/00cpjch55","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210089752"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"D. A. Vorobiof","raw_affiliation_strings":["Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa","institution_ids":["https://openalex.org/I4210089752","https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043177871","display_name":"Bernardo Leon Rapoport","orcid":"https://orcid.org/0000-0001-7610-3653","observed_orcids":["https://orcid.org/0000-0001-7610-3653"]},"institutions":[{"id":"https://openalex.org/I4210089752","display_name":"The Medical Oncology Centre of Rosebank","ror":"https://ror.org/00cpjch55","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210089752"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"B. L. Rapoport","raw_affiliation_strings":["Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa","institution_ids":["https://openalex.org/I4210089752","https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041129078","display_name":"Coenraad Frederik Slabber","orcid":"https://orcid.org/0009-0006-1167-1848","observed_orcids":["https://orcid.org/0009-0006-1167-1848"]},"institutions":[{"id":"https://openalex.org/I4210089752","display_name":"The Medical Oncology Centre of Rosebank","ror":"https://ror.org/00cpjch55","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210089752"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"C. F. Slabber","raw_affiliation_strings":["Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa","institution_ids":["https://openalex.org/I4210089752","https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109174690","display_name":"Adina Alberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089752","display_name":"The Medical Oncology Centre of Rosebank","ror":"https://ror.org/00cpjch55","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210089752"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"A. S. Alberts","raw_affiliation_strings":["Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa","institution_ids":["https://openalex.org/I4210089752","https://openalex.org/I69552723"]}]},{"author_position":"last","author":{"id":null,"display_name":"A. Uys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089752","display_name":"The Medical Oncology Centre of Rosebank","ror":"https://ror.org/00cpjch55","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210089752"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"A. Uys","raw_affiliation_strings":["Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandton Oncology Ctr, Johannesburg, South Africa; The Medcl Oncology Ctr of Rosebank, Johannesburg, South Africa; Dept of Medcl Oncology, Univ of Pretoria, Pretoria, South Africa; Wilgers Oncology Ctr, Pretoria, South Africa","institution_ids":["https://openalex.org/I4210089752","https://openalex.org/I69552723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"16_suppl","first_page":"7279","last_page":"7279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pegylated-liposomal-doxorubicin","display_name":"pegylated liposomal doxorubicin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.6639999747276306},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.48399999737739563},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7350000143051147},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8370000123977661},{"id":"https://openalex.org/keywords/stage-iv-disease","display_name":"stage IV disease","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271222352981567},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7410982251167297},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.7113416194915771},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6439809203147888},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6064916253089905},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5622572302818298},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5597655177116394},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5520723462104797},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5351577401161194},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.490011602640152},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4819174110889435},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4682130813598633},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4501854181289673},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.4363234341144562},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.09838840365409851}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2005.23.16_suppl.7279","doi":"https://doi.org/10.1200/jco.2005.23.16_suppl.7279","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2005.23.16_suppl.7279","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2281158280","https://openalex.org/W2116664839","https://openalex.org/W1927113581","https://openalex.org/W7095764024","https://openalex.org/W2091582167","https://openalex.org/W4214920520","https://openalex.org/W2338842857","https://openalex.org/W2135705146","https://openalex.org/W2246168085","https://openalex.org/W2070263945"],"abstract_inverted_index":{"7279":[0],"Background:":[1],"SCLC":[2,329],"remains":[3],"an":[4,132,318],"aggressive":[5],"disease":[6,215],"with":[7,12,51,77,84,131,149,161,308],"a":[8,71,162],"poor":[9],"survival.":[10],"Combinations":[11],"doxorubicin":[13],"and":[14,31,47,66,114,192,206,216,241,266,284,320],"CBDCA":[15,78,304],"are":[16,97,111,176],"the":[17,22,140,173],"standard":[18,52],"chemotherapy":[19,326],"regimen":[20],"for":[21,178,198,328],"treatment":[23],"of":[24,29,57,68,73,92,127,135,146,155,164],"SCLC.":[25],"A":[26,90,153],"wide":[27],"variety":[28],"dose":[30,72],"schedules":[32],"have":[33,105,158,213,295],"been":[34,106,159,296],"employed":[35],"when":[36],"managing":[37],"these":[38],"patients.":[39,330],"Pegylated":[40],"liposomal":[41],"doxorubicin,":[42],"has":[43],"shown":[44],"anti-tumour":[45],"activity":[46],"reduced":[48],"toxicity":[49,67,221,258,294],"compared":[50],"doxorubicin.":[53],"Methods:":[54],"The":[55,117,125,331],"objective":[56],"this":[58,170],"phase":[59,300],"II":[60,271,301],"study":[61,302,332],"is":[62,120,195,333],"to":[63,108,187,316,339],"determine":[64],"efficacy":[65],"Caelyx":[69,309],"at":[70],"50mg/m2":[74],"in":[75,82,272,312],"combination":[76],"(AUC":[79,305],"=":[80,306],"5),":[81],"patients":[83,104,128,147,175,212,218],"chemo-na\u00efve":[85],"small":[86],"cell":[87],"lung":[88],"cancer.":[89],"total":[91,154],"6":[93,230],"-":[94,137,270],"8":[95,207,226,278],"cycles":[96,157,166],"repeated":[98],"every":[99],"28":[100],"days.":[101],"Results:":[102],"Twenty-four":[103],"entered":[107],"date.":[109],"There":[110],"17":[112],"males":[113],"7":[115,273],"females.":[116],"median":[118,163],"age":[119],"63":[121],"years":[122],"(range":[123,167],"42\u201373).":[124],"majority":[126],"(79%)":[129],"presented":[130,148],"ECOG":[133],"PS":[134],"0":[136],"1,":[138],"despite":[139],"fact":[141],"that":[142],"more":[143],"than":[144],"80%":[145],"stage":[150,171],"IV":[151],"disease.":[152],"108":[156],"administered,":[160],"4":[165,203,249],"1\u20138).":[168],"At":[169],"21of":[172],"24":[174],"evaluable":[177],"response.":[179],"One":[180,251],"patient":[181,194,252],"withdrew":[182],"consent,":[183],"one":[184],"died":[185],"due":[186],"pneumonia":[188],"after":[189],"1":[190,193,282],"cycle":[191],"too":[196],"early":[197],"evaluation.":[199],"Documented":[200],"responses":[201],"include":[202],"(19%)":[204],"complete":[205],"(38%)":[208],"partial":[209],"responses.":[210],"Four":[211],"stable":[214],"5":[217,239],"progressed.":[219],"Haematological":[220],"includes":[222,259],"anaemia":[223],"(grade":[224,233,243,261,268,276,286],"I-II:":[225,234,244,262],"patients;":[227,236,246,279],"grade":[228,237,247,280],"III:":[229],"patients),":[231,264,274],"neutropenia":[232],"15":[235,288],"III-IV:":[238,248,281],"patients)":[240],"thrombocytopenia":[242],"10":[245],"patients).":[250,289],"developed":[253],"febrile":[254],"neutropenia.":[255],"Non":[256],"haematological":[257],"PPE":[260],"14":[263],"nausea":[265],"vomiting":[267],"I":[269],"stomatitis":[275],"I-III:":[277,287],"patient)":[283],"fatigue":[285],"No":[290,335],"cardiac":[291],"or":[292],"renal":[293],"observed.":[297],"Conclusions:":[298],"This":[299],"combining":[303],"5)":[307],"(50mg/m2),":[310],"conducted":[311],"South":[313],"Africa":[314],"appears":[315],"be":[317],"active":[319],"very":[321],"well":[322],"tolerated":[323],"first":[324],"line":[325],"regime":[327],"ongoing.":[334],"significant":[336],"financial":[337],"relationships":[338],"disclose.":[340]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-03-03T00:00:00"}