{"id":"https://openalex.org/W2590896632","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.415","title":"Universal screening for Lynch syndrome (LS) in colorectal cancer (CRC) and survival.","display_name":"Universal screening for Lynch syndrome (LS) in colorectal cancer (CRC) and survival.","publication_year":2014,"publication_date":"2014-01-20","ids":{"openalex":"https://openalex.org/W2590896632","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.415","mag":"2590896632"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.3_suppl.415","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.415","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.3_suppl.415","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077475730","display_name":"Sigurd\u00eds Haraldsd\u00f3ttir","orcid":"https://orcid.org/0000-0002-5050-3699","observed_orcids":["https://orcid.org/0000-0002-5050-3699"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sigurdis Haraldsdottir","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center \u2013 The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center \u2013 The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029706475","display_name":"Christina Sing-Ying Wu","orcid":"https://orcid.org/0000-0001-5922-5392","observed_orcids":["https://orcid.org/0000-0001-5922-5392"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Sing-Ying Wu","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012798070","display_name":"Heather Hampel","orcid":"https://orcid.org/0000-0001-7558-9794","observed_orcids":["https://orcid.org/0000-0001-7558-9794"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Hampel","raw_affiliation_strings":["Division of Human Genetics, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genetics, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061124226","display_name":"Wendy L. Frankel","orcid":"https://orcid.org/0000-0003-1658-1009","observed_orcids":["https://orcid.org/0000-0003-1658-1009"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Frankel","raw_affiliation_strings":["The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023681590","display_name":"Xueliang Jeff Pan","orcid":"https://orcid.org/0000-0002-2342-3212","observed_orcids":["https://orcid.org/0000-0002-2342-3212"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueliang Jeff Pan","raw_affiliation_strings":["Center for Biostatisics, The Ohio State University Comprehensive Cancer Center \u2013 The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biostatisics, The Ohio State University Comprehensive Cancer Center \u2013 The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074891676","display_name":"Tanios Bekaii\u2010Saab","orcid":"https://orcid.org/0000-0001-7721-1699","observed_orcids":["https://orcid.org/0000-0001-7721-1699","https://orcid.org/0000-0003-4653-4537"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanios S. Bekaii-Saab","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080788977","display_name":"Richard M. Goldberg","orcid":"https://orcid.org/0000-0003-0308-8223","observed_orcids":["https://orcid.org/0000-0003-0308-8223","https://orcid.org/0000-0003-3713-6895"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Goldberg","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"3_suppl","first_page":"415","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/universal-screening","display_name":"universal screening","score":0.953000009059906},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.8050000071525574},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mlh1-hypermethylation","display_name":"MLH1 hypermethylation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9030132293701172},{"id":"https://openalex.org/C2776559941","wikidata":"https://www.wikidata.org/wiki/Q783644","display_name":"Lynch syndrome","level":5,"score":0.6920565366744995},{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.6848188042640686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6310244798660278},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5844349265098572},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5560723543167114},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5102479457855225},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.46845340728759766},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4555550515651703},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4389286935329437},{"id":"https://openalex.org/C66339696","wikidata":"https://www.wikidata.org/wiki/Q6089397","display_name":"Log-rank test","level":3,"score":0.4277645945549011},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.337451696395874}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.3_suppl.415","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.415","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.3_suppl.415","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2913159935","https://openalex.org/W3121999460","https://openalex.org/W3203090514","https://openalex.org/W2913026422","https://openalex.org/W2801758966","https://openalex.org/W2590507993","https://openalex.org/W2886418574","https://openalex.org/W4401362246","https://openalex.org/W2586923628","https://openalex.org/W2980346929"],"abstract_inverted_index":{"415":[0],"Background:":[1],"It":[2,304],"has":[3],"been":[4],"argued":[5],"that":[6,307,319],"universal":[7,77,286],"screening":[8,22,54,78,287],"for":[9,55,124,130,137,268],"LS":[10,23,336],"should":[11],"be":[12],"performed":[13],"on":[14,64,193,223],"all":[15,65],"patients":[16,200,207,214,230],"(pts)":[17],"diagnosed":[18,102,203],"with":[19,79,107,147,204,242,288],"CRC":[20,66,100],"because":[21],"pts":[24,96,101,146,191,296,311],"and":[25,32,114,133,174,212,260,271,310,322],"their":[26,115],"relatives":[27],"can":[28],"detect":[29],"early":[30],"cancers":[31],"improve":[33],"outcomes.":[34],"This":[35,70],"approach":[36],"is":[37,305],"being":[38],"adopted":[39],"by":[40,61,82,184],"many":[41],"comprehensive":[42],"cancer":[43],"centers":[44],"around":[45],"the":[46,134,143,168,187,332],"country.":[47],"The":[48,256],"Ohio":[49],"State":[50],"University":[51],"(OSU)":[52],"began":[53],"deficient":[56],"mismatch":[57],"repair":[58],"(dMMR)":[59],"proteins":[60],"immunohistochemistry":[62],"(IHC)":[63],"cases":[67],"in":[68,87,331],"2006.":[69],"retrospective":[71],"study":[72,188],"aims":[73],"to":[74,123,141,194,219,240,295,326,339],"assess":[75],"whether":[76],"IHC":[80,111,185,244,289,300],"followed":[81],"conclusive":[83,149,196,232,281],"testing":[84,109,150,197,233,247,272,282],"(BRAF":[85],"mutation":[86],"setting":[88,333],"of":[89,162,178,334],"MLH1":[90],"deficiency,":[91],"and/or":[92],"gene":[93,224],"sequencing)":[94],"affects":[95],"survival.":[97],"Methods:":[98],"All":[99],"at":[103],"OSU":[104],"from":[105,167],"3/2006-6/2012":[106],"dMMR":[108,183],"per":[110],"were":[112,117,164,202,216],"included,":[113],"charts":[116],"reviewed.":[118],"Chi-square":[119],"test":[120,136],"was":[121,128,258],"used":[122,129],"categorical":[125],"parameters,":[126],"t-test":[127],"continuous":[131],"variables,":[132],"log-rank":[135],"overall":[138],"survival":[139,237,314],"(OS)":[140],"compare":[142],"difference":[144,257],"between":[145],"full":[148,154],"vs":[151],"those":[152,241],"without":[153,245,301],"testing.":[155,303],"Patients":[156,278],"who":[157,279,297],"expired":[158],"within":[159],"4":[160],"weeks":[161],"diagnosis":[163,337],"excluded":[165],"(n=10)":[166],"OS":[169,228,249,293],"analysis.":[170],"Results:":[171],"One":[172],"hundred":[173],"twenty-two":[175],"tumors":[176,180],"(15.7%":[177],"777":[179],"tested)":[181],"had":[182,209,234,280,290,298],"during":[186],"period.":[189],"Fifty-one":[190],"went":[192],"have":[195,220],"done;":[198],"thirteen":[199],"(25.5%)":[201],"LS,":[205],"29":[206],"(56.9%)":[208],"MLH1-hypermethylated":[210],"tumors,":[211],"9":[213],"(17.6%)":[215],"not":[217,250],"found":[218],"MMR":[221],"mutations":[222],"sequencing.":[225],"In":[226],"an":[227],"analysis,":[229],"undergoing":[231],"significantly":[235,291],"longer":[236,292],"as":[238],"compared":[239,294],"abnormal":[243,285,299],"further":[246],"(median":[248],"reached":[251],"vs.":[252],"38":[253],"months,":[254],"p=0.04).":[255],"similar":[259],"remained":[261],"marginally":[262],"significant":[263],"(p=":[264],"0.04-0.09)":[265],"after":[266,283],"correcting":[267],"age,":[269],"stage":[270,321],"date":[273],"using":[274],"different":[275],"models.":[276],"Conclusions:":[277],"initial":[284],"follow-up":[302],"possible":[306],"ascertainment":[308],"bias":[309],"compliance":[312],"influenced":[313],"so":[315],"larger":[316],"prospective":[317],"studies":[318],"document":[320],"treatment":[323],"are":[324],"needed":[325],"determine":[327],"if":[328],"increased":[329],"surveillance":[330],"a":[335],"leads":[338],"better":[340],"OS.":[341]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-03-03T00:00:00"}