{"id":"https://openalex.org/W25908605","doi":null,"title":"Hypopituitarism and HIV-infection: a new comorbidity in the HAART era?","display_name":"Hypopituitarism and HIV-infection: a new comorbidity in the HAART era?","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W25908605","mag":"25908605","pmid":"https://pubmed.ncbi.nlm.nih.gov/19020383"},"language":"en","primary_location":{"id":"pmid:19020383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19020383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Evaluation Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/619301","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015290971","display_name":"Lucia Zirilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Zirilli","raw_affiliation_strings":["Chair of Endocrinology, Integrated Department of Medicine, Endocrinology, Metabolism, and Geriatrics, University of Modena and Reggio Emilia, 41100 Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Endocrinology, Integrated Department of Medicine, Endocrinology, Metabolism, and Geriatrics, University of Modena and Reggio Emilia, 41100 Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072405681","display_name":"Gabriella Orlando","orcid":"https://orcid.org/0000-0002-4590-9045","observed_orcids":["https://orcid.org/0000-0002-4590-9045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Orlando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009628447","display_name":"Chiara Diazzi","orcid":"https://orcid.org/0000-0002-6259-2481","observed_orcids":["https://orcid.org/0000-0002-6259-2481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Diazzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053850536","display_name":"Nicola Squillace","orcid":"https://orcid.org/0000-0002-7608-6045","observed_orcids":["https://orcid.org/0000-0002-7608-6045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Squillace","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019760526","display_name":"Cesare Carani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Carani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006204124","display_name":"Giovanni Guaraldi","orcid":"https://orcid.org/0000-0002-5724-3914","observed_orcids":["https://orcid.org/0000-0002-5724-3914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Guaraldi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091324311","display_name":"Vincenzo Rochira","orcid":"https://orcid.org/0000-0001-8169-0696","observed_orcids":["https://orcid.org/0000-0001-8169-0696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Rochira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8737,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.74009114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"31","issue":"9 Suppl","first_page":"33","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.2809999883174896,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.8169999718666077},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.8500000238418579},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.890999972820282},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.8550000190734863},{"id":"https://openalex.org/keywords/waist-to-hip-ratio","display_name":"waist-to-hip ratio","score":0.7590000033378601},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6119999885559082},{"id":"https://openalex.org/keywords/metabolic-and-endocrine-disorders","display_name":"endocrine-metabolic disorders","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2780941825","wikidata":"https://www.wikidata.org/wiki/Q1538213","display_name":"Lipodystrophy","level":5,"score":0.8190860748291016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6495949029922485},{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.6299971342086792},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6215897798538208},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6117308139801025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.559341549873352},{"id":"https://openalex.org/C2779546735","wikidata":"https://www.wikidata.org/wiki/Q3500973","display_name":"Lipoatrophy","level":5,"score":0.552942156791687},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.54563969373703},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4802687168121338},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.39530766010284424},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.3698968291282654},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3307960331439972},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.27768373489379883},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.27296245098114014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23274412751197815}],"mesh":[{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004700","descriptor_name":"Endocrine System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004700","descriptor_name":"Endocrine System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19020383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19020383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Evaluation Study"},{"id":"pmh:oai:iris.unimore.it:11380/619301","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/619301","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:25908605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19020383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/619301","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/619301","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W144868573","https://openalex.org/W1675957369","https://openalex.org/W1767400858","https://openalex.org/W1966456165","https://openalex.org/W1969304309","https://openalex.org/W1975244513","https://openalex.org/W1977757546","https://openalex.org/W1994523830","https://openalex.org/W1997795602","https://openalex.org/W1998594561","https://openalex.org/W2014387233","https://openalex.org/W2023723955","https://openalex.org/W2028657303","https://openalex.org/W2044121333","https://openalex.org/W2053216237","https://openalex.org/W2064279436","https://openalex.org/W2081299887","https://openalex.org/W2098099009","https://openalex.org/W2105755717","https://openalex.org/W2120902327","https://openalex.org/W2157497584","https://openalex.org/W2320082926"],"related_works":["https://openalex.org/W2590663652","https://openalex.org/W2183218213","https://openalex.org/W2014387233","https://openalex.org/W140015901","https://openalex.org/W340156401","https://openalex.org/W4293262662","https://openalex.org/W2883485499","https://openalex.org/W2034711245","https://openalex.org/W2155047027","https://openalex.org/W2134702438"],"abstract_inverted_index":{"Several":[0],"comorbidities":[1],"are":[2],"associated":[3,73],"with":[4,74],"the":[5,12,16,20,35,52,56,111,124],"HIV":[6],"infection":[7],"and":[8,37,82,126,155],"may":[9],"involve":[10],"also":[11,45],"endocrine-metabolic":[13],"system.":[14],"Consistently,":[15],"recent":[17],"development":[18],"of":[19,40,64,93,116,180,191],"therapeutic":[21],"regimen":[22],"highly":[23],"active":[24],"antiretroviral":[25],"therapy":[26],"(HAART)":[27],"ruled":[28],"out":[29],"a":[30,164,177,189],"significant":[31],"improvement":[32],"both":[33,80],"in":[34,60,76,97,135,139,194],"prognosis":[36],"life":[38],"expectancy":[39],"HIV-infected":[41,65,136,195],"patients,":[42],"but":[43,103],"disclosed":[44],"new":[46],"serious":[47],"drug-related":[48],"toxicity.":[49],"Of":[50],"these,":[51],"lipodystrophy":[53,71],"syndrome":[54],"is":[55,72],"most":[57],"frequent,":[58],"occurring":[59],"up":[61],"to":[62,100,106,123,131,146,150,169,184],"83%":[63],"patients":[66,141,161],"under":[67],"HAART.":[68],"The":[69,114],"HIV-related":[70],"alterations":[75],"GH":[77,84,95,118,143,166,181],"dynamics,":[78],"affecting":[79],"basal":[81],"stimulated":[83],"secretion.":[85],"This":[86],"GHIGF-":[87],"I":[88],"secretive":[89],"pattern":[90],"resembles":[91],"that":[92],"severe":[94],"deficiency":[96,167],"adulthood":[98],"due":[99,130,168,183],"pituitary":[101,117,142,172],"diseases,":[102],"without":[104],"leading":[105],"IGF-I":[107],"serum":[108],"levels":[109],"below":[110],"normal":[112],"range.":[113],"impairment":[115],"secretion":[119,144,182],"has":[120],"been":[121],"ascribed":[122],"hormonal":[125],"metabolic":[127],"inhibitory":[128],"effect":[129],"adipose":[132,152],"tissue":[133,153],"redistribution":[134],"males,":[137],"since":[138],"these":[140,160],"appeared":[145],"be":[147],"inversely":[148],"related":[149],"visceral":[151,185],"accumulation":[154],"waist":[156],"to-hip-ratio.":[157],"However,":[158],"whether":[159],"suffer":[162],"from":[163],"true":[165],"an":[170],"intrinsic":[171],"failure":[173],"or":[174],"display":[175],"only":[176],"functional":[178],"reduction":[179],"adiposity":[186],"remains":[187],"still":[188],"matter":[190],"debate,":[192],"especially":[193],"females.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}