{"id":"https://openalex.org/W2590858896","doi":"https://doi.org/10.1016/j.yrtph.2017.02.014","title":"Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos","display_name":"Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos","publication_year":2017,"publication_date":"2017-02-24","ids":{"openalex":"https://openalex.org/W2590858896","doi":"https://doi.org/10.1016/j.yrtph.2017.02.014","mag":"2590858896","pmid":"https://pubmed.ncbi.nlm.nih.gov/28238854"},"language":"en","primary_location":{"id":"doi:10.1016/j.yrtph.2017.02.014","doi":"https://doi.org/10.1016/j.yrtph.2017.02.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2017.02.014","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057620720","display_name":"Torka S. Poet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4389425442","display_name":"M\u00e9taphysique, histoires, transformations, actualit\u00e9s","ror":"https://ror.org/04sv5r538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I39804081","https://openalex.org/I4389425442"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Torka S. Poet","raw_affiliation_strings":["Summit Toxicology, Richland, WA, 99352, USA. Electronic address: tspoet99@gmail.com","Summit Toxicology, Richland, WA, 99352, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summit Toxicology, Richland, WA, 99352, USA. Electronic address: tspoet99@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Summit Toxicology, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I4389425442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047337288","display_name":"Charles A. Timchalk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325736334","display_name":"Battelle","ror":"https://ror.org/01h5tnr73","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1325736334"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Timchalk","raw_affiliation_strings":["Battelle, Pacific Northwest Division, Richland, WA, 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Battelle, Pacific Northwest Division, Richland, WA, 99354, USA","institution_ids":["https://openalex.org/I1325736334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113668123","display_name":"Michael J. Bartels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098568","display_name":"Laboratoire des Solides Irradi\u00e9s","ror":"https://ror.org/015x8rz21","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I2738703131","https://openalex.org/I4210098568","https://openalex.org/I4210098836","https://openalex.org/I4210145102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michael J. Bartels","raw_affiliation_strings":["ToxMetrics.com LLC, Midland, MI, 48642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxMetrics.com LLC, Midland, MI, 48642, USA","institution_ids":["https://openalex.org/I4210098568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075452344","display_name":"Jordan Ned Smith","orcid":"https://orcid.org/0000-0003-3151-2810","observed_orcids":["https://orcid.org/0000-0003-3151-2810"]},"institutions":[{"id":"https://openalex.org/I1325736334","display_name":"Battelle","ror":"https://ror.org/01h5tnr73","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1325736334"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan N. Smith","raw_affiliation_strings":["Battelle, Pacific Northwest Division, Richland, WA, 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Battelle, Pacific Northwest Division, Richland, WA, 99354, USA","institution_ids":["https://openalex.org/I1325736334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026285763","display_name":"Robin McDougal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin McDougal","raw_affiliation_strings":["Dug Safety and Metabolism, AstraZeneca, Gatehouse Park, Waltham, Boston, 02451, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dug Safety and Metabolism, AstraZeneca, Gatehouse Park, Waltham, Boston, 02451, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022827289","display_name":"Daland R. Juberg","orcid":"https://orcid.org/0000-0001-5957-8649","observed_orcids":["https://orcid.org/0000-0001-5957-8649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daland R. Juberg","raw_affiliation_strings":["Dow AgroSciences, Indianapolis, IA, 46268, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow AgroSciences, Indianapolis, IA, 46268, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018405617","display_name":"Paul S. Price","orcid":"https://orcid.org/0000-0001-5834-1025","observed_orcids":["https://orcid.org/0000-0001-5834-1025"]},"institutions":[{"id":"https://openalex.org/I4210098568","display_name":"Laboratoire des Solides Irradi\u00e9s","ror":"https://ror.org/015x8rz21","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I2738703131","https://openalex.org/I4210098568","https://openalex.org/I4210098836","https://openalex.org/I4210145102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul S. Price","raw_affiliation_strings":["ToxMetrics.com LLC, Midland, MI, 48642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxMetrics.com LLC, Midland, MI, 48642, USA","institution_ids":["https://openalex.org/I4210098568"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5057620720"],"corresponding_institution_ids":["https://openalex.org/I4389425442"],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":1.0756,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77280563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"86","issue":null,"first_page":"59","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorpyrifos","display_name":"chlorpyrifos","score":1.0},{"id":"https://openalex.org/keywords/chlorpyrifos-oxon","display_name":"chlorpyrifos oxon","score":0.9940000176429749},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.40299999713897705},{"id":"https://openalex.org/keywords/metabolic-clearance","display_name":"metabolic clearance","score":0.5350000262260437},{"id":"https://openalex.org/keywords/uncertainty-factors","display_name":"uncertainty factors","score":0.6600000262260437},{"id":"https://openalex.org/keywords/human-health-risk-assessment","display_name":"human health risk assessment","score":0.8600000143051147},{"id":"https://openalex.org/keywords/organophosphorus-insecticides","display_name":"organophosphate insecticides","score":0.7680000066757202},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.47200000286102295},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.9583647847175598},{"id":"https://openalex.org/C2776304672","wikidata":"https://www.wikidata.org/wiki/Q414915","display_name":"Chlorpyrifos","level":3,"score":0.6140066385269165},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4855353832244873},{"id":"https://openalex.org/C2776542393","wikidata":"https://www.wikidata.org/wiki/Q7115738","display_name":"Oxon","level":2,"score":0.48110049962997437},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.44410327076911926},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.41658270359039307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4036028981208801},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3746774196624756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3720804452896118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3462301790714264},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3457674980163574},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.17841240763664246},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.10922130942344666},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09045034646987915},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004390","descriptor_name":"Chlorpyrifos","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.yrtph.2017.02.014","doi":"https://doi.org/10.1016/j.yrtph.2017.02.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2017.02.014","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:28238854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28238854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory toxicology and pharmacology : RTP","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333845","display_name":"Dow AgroSciences","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W112731556","https://openalex.org/W117546959","https://openalex.org/W575556124","https://openalex.org/W1892194869","https://openalex.org/W1921982455","https://openalex.org/W1965230909","https://openalex.org/W1967113939","https://openalex.org/W1969894558","https://openalex.org/W1977109232","https://openalex.org/W1980227425","https://openalex.org/W1981646537","https://openalex.org/W1983645416","https://openalex.org/W1984102717","https://openalex.org/W1984574841","https://openalex.org/W1987072296","https://openalex.org/W1988542296","https://openalex.org/W1988649077","https://openalex.org/W1996506894","https://openalex.org/W2005907102","https://openalex.org/W2009114511","https://openalex.org/W2018115535","https://openalex.org/W2020389566","https://openalex.org/W2024660130","https://openalex.org/W2030571309","https://openalex.org/W2031452828","https://openalex.org/W2042720508","https://openalex.org/W2046087193","https://openalex.org/W2048693988","https://openalex.org/W2049412648","https://openalex.org/W2051773722","https://openalex.org/W2055526313","https://openalex.org/W2058891183","https://openalex.org/W2066595038","https://openalex.org/W2070287219","https://openalex.org/W2075358273","https://openalex.org/W2078782061","https://openalex.org/W2080284133","https://openalex.org/W2089538550","https://openalex.org/W2094400497","https://openalex.org/W2094968514","https://openalex.org/W2107288346","https://openalex.org/W2110403403","https://openalex.org/W2111463499","https://openalex.org/W2112945045","https://openalex.org/W2114328384","https://openalex.org/W2114623273","https://openalex.org/W2119330677","https://openalex.org/W2120103204","https://openalex.org/W2128574710","https://openalex.org/W2132341968","https://openalex.org/W2140268893","https://openalex.org/W2141301177","https://openalex.org/W2146860134","https://openalex.org/W2150416321","https://openalex.org/W2162610690","https://openalex.org/W2163602949","https://openalex.org/W2187761001","https://openalex.org/W2225273737","https://openalex.org/W2340629065","https://openalex.org/W2774658375","https://openalex.org/W4285719527","https://openalex.org/W6619666350","https://openalex.org/W6674223019","https://openalex.org/W6705117348"],"related_works":["https://openalex.org/W2111463499","https://openalex.org/W2066595038","https://openalex.org/W2024660130","https://openalex.org/W2952027546","https://openalex.org/W2072138663","https://openalex.org/W2496523899","https://openalex.org/W4220654740","https://openalex.org/W2018115535","https://openalex.org/W1988649077","https://openalex.org/W2051773722"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-03T00:00:00"}