{"id":"https://openalex.org/W2590821171","doi":null,"title":"Isolation and Characterization of Reactive Heme -Oxygen Intermediates in Cytochrome P450 Catalysis","display_name":"Isolation and Characterization of Reactive Heme -Oxygen Intermediates in Cytochrome P450 Catalysis","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2590821171","mag":"2590821171"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/85436","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2142/85436","pdf_url":null,"source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053309916","display_name":"Thomas M. Makris","orcid":"https://orcid.org/0000-0001-7927-620X","observed_orcids":["https://orcid.org/0000-0001-7927-620X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas M. Makris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053309916"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35784032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.925000011920929},{"id":"https://openalex.org/keywords/reactive-intermediates","display_name":"reactive intermediates","score":0.6940000057220459},{"id":"https://openalex.org/keywords/heme-oxygenase","display_name":"heme oxygenase","score":0.6710000038146973},{"id":"https://openalex.org/keywords/heme-oxygenation","display_name":"heme oxygenation","score":0.4230000078678131},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.5839999914169312},{"id":"https://openalex.org/keywords/intermediate-isolation","display_name":"intermediate isolation","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6457292437553406},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.626312792301178},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5677690505981445},{"id":"https://openalex.org/C192937433","wikidata":"https://www.wikidata.org/wiki/Q2134627","display_name":"Reactive intermediate","level":3,"score":0.5090315341949463},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4841097593307495},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.43483203649520874},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.4216736853122711},{"id":"https://openalex.org/C20705724","wikidata":"https://www.wikidata.org/wiki/Q902628","display_name":"Hemeprotein","level":4,"score":0.4171905517578125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28440672159194946},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24975448846817017},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.13237637281417847},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11785882711410522},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0912477970123291}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/85436","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2142/85436","pdf_url":null,"source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2590821171","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/85436","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037545821","https://openalex.org/W172213682","https://openalex.org/W1136140286","https://openalex.org/W2043758058","https://openalex.org/W1991402003","https://openalex.org/W2005145448","https://openalex.org/W1795233226","https://openalex.org/W2110627335","https://openalex.org/W1963882934","https://openalex.org/W384344890"],"abstract_inverted_index":{"The":[0],"P450":[1,62,76,145],"monooxygenases,":[2],"and":[3,38,121,133],"specifically":[4],"the":[5,10,28,36,71,75,79,92,97,116,125,139,144],"intermediate":[6],"species":[7,99],"formed":[8],"within":[9],"course":[11],"of":[12,20,24,40,45,74,81,94,107,118,129],"their":[13,58],"reaction":[14,140],"cycle,":[15],"are":[16],"formidable":[17],"oxidants,":[18],"capable":[19],"a":[21,32,43,66,105],"diverse":[22],"range":[23,44],"chemical":[25],"reactions.":[26,63],"As":[27],"cryoradiolytic":[29],"methodologies":[30],"prove":[31],"convenient":[33],"tool":[34],"for":[35,70],"isolation":[37],"stabilization":[39],"heme-oxygen":[41],"intermediates,":[42,96,132],"substrate":[46],"probes":[47],"has":[48],"been":[49,102],"coupled":[50],"to":[51,56,90,114,135,138],"these":[52,95,130,137],"studies":[53],"in":[54,60,84,104,112,124],"order":[55,89,113],"assess":[57,91,115],"role":[59,117],"known":[61],"This":[64],"provides":[65],"template":[67],"not":[68],"only":[69],"assorted":[72],"reactivity":[73],"superfamily,":[77],"but":[78],"utilization":[80],"related":[82],"intermediates":[83],"other":[85,108],"metalloenzyme":[86],"systems.":[87],"In":[88],"commonality":[93],"ferric-peroxo":[98],"have":[100],"also":[101],"generated":[103],"number":[106],"heme":[109],"enzyme":[110],"systems":[111],"proximal":[119],"ligand":[120],"distal":[122],"pocket":[123],"proton":[126],"mediated":[127],"functionalization":[128],"reactive":[131],"thus,":[134],"compare":[136],"mechanism":[141],"associated":[142],"with":[143],"monoxygenases.":[146]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2017-03-03T00:00:00"}