{"id":"https://openalex.org/W2590695706","doi":"https://doi.org/10.1111/ajt.14234","title":"Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation","display_name":"Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation","publication_year":2017,"publication_date":"2017-02-22","ids":{"openalex":"https://openalex.org/W2590695706","doi":"https://doi.org/10.1111/ajt.14234","mag":"2590695706","pmid":"https://pubmed.ncbi.nlm.nih.gov/28226413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5519442"},"language":"en","primary_location":{"id":"doi:10.1111/ajt.14234","doi":"https://doi.org/10.1111/ajt.14234","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.14234","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.14234","source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.14234","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029981005","display_name":"Miriam Manook","orcid":"https://orcid.org/0000-0002-6474-6122","observed_orcids":["https://orcid.org/0000-0002-6474-6122"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"M. Manook","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","Renal and Transplant Department, Guy's and St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Renal and Transplant Department, Guy's and St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007319566","display_name":"Jean Kwun","orcid":"https://orcid.org/0000-0002-8563-5472","observed_orcids":["https://orcid.org/0000-0002-8563-5472"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kwun","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012052292","display_name":"Christopher K. Burghuber","orcid":"https://orcid.org/0000-0002-5758-7549","observed_orcids":["https://orcid.org/0000-0002-5758-7549"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C. Burghuber","raw_affiliation_strings":["Division of Transplantation, Department of Surgery, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplantation, Department of Surgery, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020295262","display_name":"Kannan P. Samy","orcid":"https://orcid.org/0000-0001-8272-5694","observed_orcids":["https://orcid.org/0000-0001-8272-5694"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Samy","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090425910","display_name":"Michael S. Mulvihill","orcid":"https://orcid.org/0000-0002-8122-1483","observed_orcids":["https://orcid.org/0000-0002-8122-1483"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Mulvihill","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030923472","display_name":"Janghoon Yoon","orcid":"https://orcid.org/0000-0001-8543-194X","observed_orcids":["https://orcid.org/0000-0001-8543-194X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Yoon","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073028134","display_name":"He Xu","orcid":"https://orcid.org/0000-0003-4887-4279","observed_orcids":["https://orcid.org/0000-0003-4887-4279"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Xu","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071247321","display_name":"Andrea L. MacDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.L. MacDonald","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090334068","display_name":"Kyle Freischlag","orcid":"https://orcid.org/0000-0002-0234-5235","observed_orcids":["https://orcid.org/0000-0002-0234-5235"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Freischlag","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":"https://orcid.org/0000-0002-0234-5235","affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090312330","display_name":"Verna Curfman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Curfman","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051928243","display_name":"Earl L. Branum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Branum","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021750333","display_name":"David N. Howell","orcid":"https://orcid.org/0000-0001-7257-1767","observed_orcids":["https://orcid.org/0000-0001-7257-1767"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Howell","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073283527","display_name":"Alton B. Farris","orcid":"https://orcid.org/0000-0001-5534-7763","observed_orcids":["https://orcid.org/0000-0001-5534-7763"]},"institutions":[{"id":"https://openalex.org/I2800556163","display_name":"Emory University Hospital","ror":"https://ror.org/05dm4ck87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I2800556163"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.B. Farris","raw_affiliation_strings":["Department of Pathology, Emory University Hospital, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Emory University Hospital, Atlanta, GA","institution_ids":["https://openalex.org/I2800556163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074196179","display_name":"Richard Anthony Smith","orcid":"https://orcid.org/0000-0001-8038-3045","observed_orcids":["https://orcid.org/0000-0001-8038-3045"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R.A. Smith","raw_affiliation_strings":["MRC Centre for Transplantation, King's College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Transplantation, King's College, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080698950","display_name":"Steven Howard Sacks","orcid":"https://orcid.org/0000-0001-6361-9095","observed_orcids":["https://orcid.org/0000-0001-6361-9095"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Sacks","raw_affiliation_strings":["MRC Centre for Transplantation, King's College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Transplantation, King's College, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002570839","display_name":"Anthony Dorling","orcid":"https://orcid.org/0000-0003-3102-2600","observed_orcids":["https://orcid.org/0000-0003-3102-2600"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Dorling","raw_affiliation_strings":["MRC Centre for Transplantation, King's College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Transplantation, King's College, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043616920","display_name":"Nizam Mamode","orcid":"https://orcid.org/0000-0001-8549-9098","observed_orcids":["https://orcid.org/0000-0001-8549-9098"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Mamode","raw_affiliation_strings":["Renal and Transplant Department, Guy's and St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal and Transplant Department, Guy's and St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078530019","display_name":"Stuart J. Knechtle","orcid":"https://orcid.org/0000-0002-1625-385X","observed_orcids":["https://orcid.org/0000-0002-1625-385X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S.J. Knechtle","raw_affiliation_strings":["Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078530019"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":0.7351,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.66280917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"17","issue":"8","first_page":"2055","last_page":"2064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.19699999690055847,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/thromboelastography","display_name":"thromboelastography","score":0.8569999933242798},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7260000109672546},{"id":"https://openalex.org/keywords/porcine-islets","display_name":"porcine islets","score":0.8519999980926514},{"id":"https://openalex.org/keywords/organ-preservation-solutions","display_name":"organ preservation solutions","score":0.5789999961853027},{"id":"https://openalex.org/keywords/glomerulitis","display_name":"glomerulitis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/peritubular-capillaritis","display_name":"peritubular capillaritis","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9416713714599609},{"id":"https://openalex.org/C2777878052","wikidata":"https://www.wikidata.org/wiki/Q3312044","display_name":"Thrombotic microangiopathy","level":3,"score":0.917705774307251},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.6022516489028931},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.5369213819503784},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5183842778205872},{"id":"https://openalex.org/C2776513394","wikidata":"https://www.wikidata.org/wiki/Q1412400","display_name":"Microangiopathy","level":3,"score":0.48317089676856995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3975660502910614},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3391057252883911},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07105550169944763},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.05678457021713257},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05437692999839783}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057049","descriptor_name":"Thrombotic Microangiopathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/ajt.14234","doi":"https://doi.org/10.1111/ajt.14234","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.14234","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.14234","source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},{"id":"pmid:28226413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28226413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/f6178c29-5a06-4947-b42b-38fedffed544","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/f6178c29-5a06-4947-b42b-38fedffed544","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:5017256","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5519442","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5519442","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5519442","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Transplant","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/ajt.14234","doi":"https://doi.org/10.1111/ajt.14234","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.14234","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.14234","source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1908936996","display_name":null,"funder_award_id":"J006742/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2090214858","display_name":"King\u2019s College London Confidence in Concept","funder_award_id":"MC_PC_15031","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4388919642","display_name":null,"funder_award_id":"J006742/1","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G474998974","display_name":"MRC Centre for Transplantation","funder_award_id":"MR/J006742/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8086106190","display_name":"Resource fo Nonhuman Primate Cell Depleting Antibodies","funder_award_id":"R24OD010976","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8303857989","display_name":null,"funder_award_id":"MR/J006742/1","funder_id":"https://openalex.org/F4320320285","funder_display_name":"King's College London"},{"id":"https://openalex.org/G8897047347","display_name":"Transplant Tolerance in Non-Human Primates","funder_award_id":"U19AI051731","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000920145","display_name":"Nonhuman Primate Reagent Resource","funder_award_id":"U24AI126683","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2590695706.pdf","grobid_xml":"https://content.openalex.org/works/W2590695706.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1533163737","https://openalex.org/W1575662510","https://openalex.org/W1632113953","https://openalex.org/W1686008017","https://openalex.org/W1737600104","https://openalex.org/W1923404879","https://openalex.org/W1976249816","https://openalex.org/W1978499921","https://openalex.org/W1982003857","https://openalex.org/W1984433766","https://openalex.org/W2007016555","https://openalex.org/W2032299365","https://openalex.org/W2046550253","https://openalex.org/W2077857883","https://openalex.org/W2085256639","https://openalex.org/W2097802875","https://openalex.org/W2111185199","https://openalex.org/W2146073039","https://openalex.org/W2180848613","https://openalex.org/W2209423354","https://openalex.org/W2221834647","https://openalex.org/W2270588421","https://openalex.org/W2321281162","https://openalex.org/W2334576688","https://openalex.org/W2398624859","https://openalex.org/W2463403896","https://openalex.org/W2808707072","https://openalex.org/W4255648413","https://openalex.org/W4292630397","https://openalex.org/W4302374199"],"related_works":["https://openalex.org/W2025518428","https://openalex.org/W2916856959","https://openalex.org/W2330858257","https://openalex.org/W2172198943","https://openalex.org/W2785967297","https://openalex.org/W1992778921","https://openalex.org/W2588030731","https://openalex.org/W2062464221","https://openalex.org/W2908504582","https://openalex.org/W7140099589"],"abstract_inverted_index":{"Early":[0],"activation":[1],"of":[2,11,114,129,141,146,189],"coagulation":[3],"is":[4,24],"an":[5],"important":[6],"factor":[7],"in":[8,65,91,137,182],"the":[9,50,183],"initiation":[10],"innate":[12],"immunity,":[13],"as":[14,170,172],"characterized":[15],"by":[16,119],"thrombotic":[17],"microangiopathy":[18],"(TMA).":[19],"In":[20,126],"transplantation,":[21],"systemic":[22],"anticoagulation":[23],"difficult":[25],"due":[26],"to":[27,49,58,61,96,110,153,157],"bleeding.":[28],"A":[29],"novel":[30],"\"cytotopic\"":[31],"agent,":[32],"thrombalexin":[33],"(TLN),":[34],"combines":[35],"a":[36,130,138],"cell-membrane-bound":[37],"(myristoyl":[38],"tail)":[39,77],"anti-thrombin":[40],"(hirudin-like":[41],"peptide":[42],"[HLL]),":[43],"which":[44],"can":[45],"be":[46,154],"perfused":[47],"directly":[48],"donor":[51],"organ":[52],"or":[53,86],"cells.":[54],"Thromboelastography":[55],"was":[56,117,151,163,195],"used":[57],"measure":[59],"time":[60,109],"clot":[62,111],"formation":[63],"(r-time)":[64],"both":[66],"rhesus":[67,85],"and":[68,83,104,121,167],"human":[69,87,101],"blood,":[70],"comparing":[71],"TLN":[72,116,147,150],"versus":[73,78],"HLL":[74],"(without":[75],"cytotopic":[76],"negative":[79],"control.":[80],"Both":[81],"TLN-":[82],"HLL-treated":[84],"whole":[88],"blood":[89],"result":[90],"significantly":[92],"prolonged":[93,108],"r-time":[94],"compared":[95],"kaolin":[97],"controls.":[98],"Only":[99],"TLN-treated":[100,184],"endothelial":[102],"cells":[103],"neonatal":[105],"porcine":[106],"islets":[107],"formation.":[112],"Detection":[113],"membrane-bound":[115],"confirmed":[118],"immunohistochemistry":[120],"fluorescence":[122],"activated":[123],"cell":[124],"sorter.":[125],"vivo,":[127],"perfusion":[128],"nonhuman":[131],"primate":[132],"kidney":[133],"TLN-supplemented":[134],"preservation":[135],"solution":[136],"sensitized":[139],"model":[140],"transplantation":[142],"demonstrated":[143],"no":[144,164,192],"evidence":[145,188],"systemically.":[148],"Histologically,":[149],"shown":[152],"present":[155],"up":[156],"4":[158],"days":[159],"after":[160],"transplantation.":[161],"There":[162],"platelet":[165],"deposition,":[166],"TMA":[168],"severity,":[169],"well":[171],"microvascular":[173],"injury":[174],"scores":[175],"(glomerulitis":[176],"+":[177],"peritubular":[178],"capillaritis),":[179],"were":[180],"less":[181],"animals.":[185],"Despite":[186],"promising":[187],"localized":[190],"efficacy,":[191],"survival":[193],"benefit":[194],"demonstrated.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-03-03T00:00:00"}