{"id":"https://openalex.org/W2590510465","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.440","title":"Metformin use and outcome of sunitinib treatment in diabetic patients with metastatic renal cell carcinoma.","display_name":"Metformin use and outcome of sunitinib treatment in diabetic patients with metastatic renal cell carcinoma.","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W2590510465","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.440","mag":"2590510465"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2015.33.7_suppl.440","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.440","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.7_suppl.440","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049181473","display_name":"Daniel Keizman","orcid":"https://orcid.org/0000-0002-1087-1147","observed_orcids":["https://orcid.org/0000-0002-1087-1147"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2801839060","display_name":"Meir Medical Center","ror":"https://ror.org/04pc7j325","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801839060"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel Keizman","raw_affiliation_strings":["Genitourinary Oncology Service, Division of Oncology, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar-Saba, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genitourinary Oncology Service, Division of Oncology, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar-Saba, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2801839060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062639024","display_name":"Maya Ish\u2010Shalom","orcid":"https://orcid.org/0000-0002-3960-3066","observed_orcids":["https://orcid.org/0000-0002-3960-3066"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2801839060","display_name":"Meir Medical Center","ror":"https://ror.org/04pc7j325","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801839060"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Maya Ish-Shalom","raw_affiliation_strings":["Genitourinary Oncology Service, Division of Oncology, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar-Saba, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genitourinary Oncology Service, Division of Oncology, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar-Saba, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2801839060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114046173","display_name":"Avivit Peer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avivit Peer","raw_affiliation_strings":["Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039952118","display_name":"Maya Gottfried","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801839060","display_name":"Meir Medical Center","ror":"https://ror.org/04pc7j325","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801839060"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Maya Gottfried","raw_affiliation_strings":["Lung Cancer Unit, Meir Medical Center, Kfar Saba, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Cancer Unit, Meir Medical Center, Kfar Saba, Israel","institution_ids":["https://openalex.org/I2801839060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103085920","display_name":"Hans J. Hammers","orcid":"https://orcid.org/0000-0002-6224-4559","observed_orcids":["https://orcid.org/0000-0002-6224-4559"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans J. Hammers","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012074439","display_name":"Mario A. Eisenberger","orcid":"https://orcid.org/0000-0002-8787-3271","observed_orcids":["https://orcid.org/0000-0002-8787-3271"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario A. Eisenberger","raw_affiliation_strings":["The Johns Hopkins Medical Institutions, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Medical Institutions, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108621863","display_name":"Victoria J. Sinibaldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria J. Sinibaldi","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024357764","display_name":"Victoria Neiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Victoria Neiman","raw_affiliation_strings":["Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020715864","display_name":"Eli Rosenbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eli Rosenbaum","raw_affiliation_strings":["Department of Oncology, Rabin Medical Center, Petah Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Rabin Medical Center, Petah Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026901306","display_name":"David Leonid Sarid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"David Sarid","raw_affiliation_strings":["Division of Oncology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089230523","display_name":"Eli Gez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eli Gez","raw_affiliation_strings":["Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068955417","display_name":"Wilmosh Mermershtain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800633300","display_name":"Soroka Medical Center","ror":"https://ror.org/003sphj24","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800633300","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Wilmosh Mermershtain","raw_affiliation_strings":["Soroka Medical Center, Beersheba, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soroka Medical Center, Beersheba, Israel","institution_ids":["https://openalex.org/I2800633300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084245628","display_name":"Keren Rouvinov","orcid":"https://orcid.org/0000-0002-8273-4723","observed_orcids":["https://orcid.org/0000-0002-8273-4723"]},"institutions":[{"id":"https://openalex.org/I2800633300","display_name":"Soroka Medical Center","ror":"https://ror.org/003sphj24","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800633300","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Keren Rouvinov","raw_affiliation_strings":["Soroka Medical Center, Beersheba, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soroka Medical Center, Beersheba, Israel","institution_ids":["https://openalex.org/I2800633300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062199973","display_name":"Raanan Berger","orcid":"https://orcid.org/0000-0002-2788-0971","observed_orcids":["https://orcid.org/0000-0002-2788-0971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raanan Berger","raw_affiliation_strings":["Uro-oncologist, Tel Hashomer, Tel Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uro-oncologist, Tel Hashomer, Tel Hashomer, Israel","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001783218","display_name":"Michael Anthony Carducci","orcid":"https://orcid.org/0000-0002-7908-1215","observed_orcids":["https://orcid.org/0000-0002-7908-1215"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Anthony Carducci","raw_affiliation_strings":["The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"7_suppl","first_page":"440","last_page":"440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":1.0},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9200000166893005},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.6650000214576721},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7310000061988831},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8029999732971191},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.7229999899864197},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.5339999794960022},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6110000014305115},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6150000095367432},{"id":"https://openalex.org/keywords/renin-angiotensin-system-inhibitors","display_name":"renin-angiotensin system inhibitors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9617703557014465},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.8759438395500183},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6926291584968567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6789621114730835},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.5981875061988831},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5539372563362122},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5203249454498291},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4571341276168823},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4515473246574402},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.4448031187057495},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1372901201248169}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2015.33.7_suppl.440","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.440","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.7_suppl.440","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2596517027","https://openalex.org/W2404104112","https://openalex.org/W2462521029","https://openalex.org/W2590944242","https://openalex.org/W2591165238","https://openalex.org/W3163868693","https://openalex.org/W2123290833","https://openalex.org/W2116054512","https://openalex.org/W2070009707","https://openalex.org/W2065232530"],"abstract_inverted_index":{"440":[0],"Background:":[1],"Sunitinib":[2],"(Su)":[3],"is":[4,49],"a":[5,73,137],"standard":[6],"treatment":[7],"(tx)":[8],"for":[9],"metastatic":[10,211],"renal":[11],"cell":[12],"carcinoma":[13],"(mRCC).":[14],"Pre-clinical":[15],"and":[16,105,122,140,149,157,160,188,236,307,338],"clinical":[17],"studies":[18],"in":[19,47,64,90,248],"several":[20],"cancer":[21],"types":[22],"suggest":[23],"that":[24,357],"the":[25,42,54,60,165,198,266,293,350],"antidiabetic":[26],"agent":[27],"metformin":[28],"(Met)":[29],"has":[30],"antitumor":[31],"activity.":[32,38],"Met":[33,57,103,107,112,158,184,319,346],"may":[34,348],"negatively":[35],"regulate":[36],"mTOR":[37],"Its":[39],"effect":[40,55,110],"on":[41,59,114],"outcome":[43,61,161],"of":[44,56,76,80,111,130,152,221,270,292,352],"targeted":[45,216],"therapies":[46],"mRCC":[48,176,208,356],"poorly":[50],"defined.":[51],"We":[52,71],"analyzed":[53],"use":[58,113,220,320,347],"sunitinib":[62],"tx":[63,271],"diabetic":[65,81,173,353],"patients":[66],"(pts)":[67],"with":[68,83,88,128,175,179,300,316,355,360],"mRCC.":[69],"Methods:":[70],"performed":[72,163],"retrospective":[74],"study":[75],"an":[77],"unselected":[78],"cohort":[79,296],"pts":[82,174,354],"mRCC,":[84],"who":[85],"were":[86,97,162,177,182,195,302,318],"treated":[87,178,359],"Su":[89,237],"7":[91],"centers":[92],"across":[93],"2":[94,100,253],"countries.":[95],"Pts":[96],"divided":[98],"into":[99],"groups:":[101],"(1)":[102],"users":[104,185],"(2)":[106],"naive.":[108],"The":[109,193],"response":[115,244],"rate":[116],"(RR),":[117],"progression":[118,264],"free":[119],"survival":[120,124],"(PFS)":[121],"overall":[123],"(OS),":[125],"was":[126,254,275,283],"tested":[127],"adjustment":[129],"other":[131],"known":[132],"confounding":[133],"risk":[134,325],"factors":[135,156,298],"using":[136,164],"chisquare":[138],"test":[139,143],"partial":[141],"likelihood":[142],"from":[144],"Cox":[145],"model.":[146],"Furthermore,":[147],"univariate":[148],"multivariate":[150,290],"analyses":[151,291],"association":[153],"between":[154],"clinicopathologic":[155,200],"use,":[159],"entire":[166,294],"pt":[167,295],"cohort.":[168],"Results:":[169],"Between":[170],"2004-2014,":[171],"108":[172],"sunitinib.":[180],"There":[181],"52":[183],"(group":[186,191],"1)":[187],"56":[189],"nonusers":[190],"2).":[192],"groups":[194],"balanced":[196],"regarding":[197],"following":[199],"factors:":[201],"age,":[202],"gender,":[203],"HENG":[204,324],"risk,":[205],"past":[206],"nephrectomy,":[207],"histology,":[209],"\u22652":[210],"sites,":[212],"lung/liver/bone":[213],"metastasis,":[214],"prior":[215],"tx,":[217],"smoking":[218,304,330],"status,":[219],"angiotensin":[222],"system":[223],"inhibitors":[224],"(ASIs),":[225],"pre-tx":[226,308,339],"neutrophil":[227],"to":[228],"lymphocyte":[229],"ratio":[230],"(NLR)":[231],">3,":[232],"Su-induced":[233],"hypertension":[234],"(HTN),":[235],"dose":[238],"reduction/tx":[239],"interruption.":[240],"Clinical":[241],"benefit":[242],"(partial":[243],"+":[245],"stable":[246],"disease)":[247],"group":[249,252],"1":[250],"vs.":[251,256,260,277,285],"96%":[255],"84%,":[257],"while":[258],"4%":[259],"16%":[261],"had":[262],"disease":[263],"within":[265],"first":[267],"3":[268],"months":[269,279,287],"(p=0.054).":[272],"Median":[273,281],"PFS":[274,301],"15":[276],"11.5":[278],"(p=0.1).":[280],"OS":[282,317,351],"32":[284],"21":[286],"(p=0.001).":[288],"In":[289],"(n=108),":[297],"associated":[299,315],"active":[303,329],"(HR=2.7,":[305],"p<0.0001)":[306],"NLR":[309,340],">3":[310,341],"(HR":[311,321,326,335,342],"1.8,":[312,336],"p=0.012).":[313],"Factors":[314],"0.2,":[322],"p<0.0001),":[323,332],"3.3,":[327,343],"p=0.008),":[328],"(HR=2.9,":[331],"liver":[333],"metastases":[334],"p=0.004),":[337],"p<0.0001).":[344],"Conclusions:":[345],"improve":[349],"are":[358],"Su.":[361]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-03-03T00:00:00"}