{"id":"https://openalex.org/W2590430429","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.243","title":"A phase Ib/IIa study of NEO-102: A therapeutic antibody to treat pancreatic and colorectal cancers.","display_name":"A phase Ib/IIa study of NEO-102: A therapeutic antibody to treat pancreatic and colorectal cancers.","publication_year":2014,"publication_date":"2014-01-20","ids":{"openalex":"https://openalex.org/W2590430429","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.243","mag":"2590430429"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.3_suppl.243","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.243","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.3_suppl.243","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070734531","display_name":"Sandip Pravin Patel","orcid":"https://orcid.org/0000-0002-8387-4840","observed_orcids":["https://orcid.org/0000-0002-8387-4840","https://orcid.org/0000-0002-4954-4944"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandip Pravin Patel","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074731037","display_name":"Michael Andrew Morse","orcid":"https://orcid.org/0000-0002-5725-4533","observed_orcids":["https://orcid.org/0000-0002-5725-4533"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Morse","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014809735","display_name":"Muhammad Shaalan Beg","orcid":"https://orcid.org/0000-0002-3754-6627","observed_orcids":["https://orcid.org/0000-0002-3754-6627"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Shaalan Beg","raw_affiliation_strings":["Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060219345","display_name":"Nilofer Saba Azad","orcid":"https://orcid.org/0000-0002-9613-3988","observed_orcids":["https://orcid.org/0000-0002-9613-3988"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilofer Saba Azad","raw_affiliation_strings":["Johns Hopkins University, School of Medicine; Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, School of Medicine; Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047349001","display_name":"Melony A. Beatson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melony A. Beatson","raw_affiliation_strings":["Precision Biologics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Biologics, Rockville, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059747639","display_name":"Sharon A. Mavroukakis","orcid":"https://orcid.org/0000-0003-4697-6474","observed_orcids":["https://orcid.org/0000-0003-4697-6474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon Mavroukakis","raw_affiliation_strings":["Precision Biologics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Biologics, Rockville, MD","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073536820","display_name":"Philip Martin Arlen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip M. Arlen","raw_affiliation_strings":["Precision Biologics, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Biologics, Rockville, MD","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"3_suppl","first_page":"243","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.19169999659061432,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muc5ac","display_name":"MUC5AC","score":0.7400000095367432},{"id":"https://openalex.org/keywords/chimeric-monoclonal-antibody","display_name":"chimeric monoclonal antibody","score":0.8980000019073486},{"id":"https://openalex.org/keywords/glycoengineered-antibody","display_name":"glycoengineered antibody","score":0.781000018119812},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/refractory-cancer","display_name":"refractory cancer","score":0.6800000071525574},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cytokine-profiling","display_name":"cytokine profiling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5120000243186951},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.3790000081062317},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5239999890327454},{"id":"https://openalex.org/keywords/stable-disease","display_name":"stable disease","score":0.859000027179718},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9429186582565308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6515398025512695},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5654285550117493},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5349600911140442},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4878871440887451},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.47412586212158203},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4378204643726349},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.43123212456703186},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.41777315735816956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28982844948768616},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2757256031036377},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2532293200492859},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.11064526438713074}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.3_suppl.243","doi":"https://doi.org/10.1200/jco.2014.32.3_suppl.243","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.3_suppl.243","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2908221867","https://openalex.org/W2249986218","https://openalex.org/W2013645270","https://openalex.org/W2890337375","https://openalex.org/W2484253333","https://openalex.org/W2806818170","https://openalex.org/W2591494309","https://openalex.org/W2589453705","https://openalex.org/W4256507697","https://openalex.org/W2082709824"],"abstract_inverted_index":{"243":[0],"Background:":[1],"We":[2],"have":[3,280],"developed":[4],"a":[5,12,94],"chimeric":[6],"monoclonal":[7],"antibody":[8],"(ab)":[9],"that":[10,16],"targets":[11],"variant":[13],"of":[14,41,58,67,85,97,137,159,162,180,227,244,283,289],"MUC5AC":[15],"is":[17,118,247,325],"expressed":[18],"specifically":[19],"by":[20,135],"human":[21],"pancreatic":[22],"(P)":[23],"and":[24,63,75,102,124,141,150,157,168,185,203,297,310,338,350],"colorectal":[25],"(C)":[26],"tumors":[27],"with":[28,99,116,121,206,277,295,353],"minimal":[29],"reactivity":[30],"to":[31,128,172,198,316,334,336,346],"normal":[32],"GI":[33],"mucosa.":[34],"In":[35,240],"the":[36,42,173,190,220,224,245,269,305,317,328],"phase":[37],"(ph)":[38],"I":[39],"trial":[40,115,357],"initial":[43],"formulation":[44],"NEO-101,":[45],"5/19":[46],"patients":[47,311],"(pts)":[48],"had":[49],"stable":[50],"disease":[51,80,290],"(SD)":[52],"after":[53],"completing":[54],"their":[55],"1st":[56],"course":[57],"treatment":[59],"(tx)":[60],"(4":[61],"doses)":[62],"overall":[64],"survival":[65],"(OS)":[66],">12":[68],"months":[69],"(mos)":[70],"observed":[71,326],"in":[72,219,291],"3":[73,216],"C":[74,125,298],"2":[76,256,270,318],"P":[77,123,296],"pts":[78,120,217,246,257,294],"despite":[79],"progression":[81],"on":[82,215,287],"standard":[83],"(std)":[84],"care":[86],"tx":[87,354],"regimens.":[88],"The":[89,254],"current":[90,329],"study":[91],"utilizes":[92],"NEO-102,":[93],"glycoengineered":[95],"form":[96],"NEO-101":[98],"improved":[100],"stability":[101],"decreased":[103],"RBC":[104],"agglutination.":[105],"Methods:":[106],"A":[107],"Ph":[108],"Ib/IIa":[109],"open":[110],"label,":[111],"multi-center":[112],"dose-escalation":[113],"clinical":[114,147,207,284],"NEO-102":[117,278],"enrolling":[119],"advanced":[122],"cancer":[126],"refractory":[127],"std":[129],"therapy.":[130],"Primary":[131],"objective:":[132],"measure":[133],"efficacy":[134],"analysis":[136,211],"CT":[138],"scans":[139],"pre-":[140],"post-therapy":[142],"using":[143],"RECIST":[144],"criteria,":[145],"OS,":[146],"laboratory":[148],"tests,":[149],"physical":[151],"examinations.":[152],"Secondary":[153],"objectives:":[154],"a.determine":[155],"safety":[156],"tolerability":[158],"escalating":[160],"doses":[161],"NEO-102;":[163],"b.":[164],"assess":[165,199],"pharmacokinetics":[166],"(PK)":[167],"select":[169],"immune":[170,186],"responses":[171],"ab":[174,279],"at":[175,223,251,268,304,327],"each":[176],"dose":[177,225,235,272,308,320,330],"level.":[178,273,321],"Analyses":[179],"pt":[181],"PBMCs":[182],"for":[183,200,204,249,260],"ADCC":[184,349],"cytokine":[187,351],"profiling":[188],"utilizing":[189],"Milliplex":[191],"MAP":[192],"Human":[193],"Cytokine/Chemokine":[194],"Panel":[195],"are":[196,258,264,312,344],"planned":[197],"immunologic":[201],"outcome,":[202],"correlation":[205],"benefit.":[208],"Results:":[209],"Safety":[210,300],"has":[212,301],"been":[213,302],"performed":[214],"enrolled":[218],"first":[221],"cohort":[222],"level":[226,309],"1.5":[228,306],"mg/kg":[229,271,307,319],"IV":[230],"q2weeks.":[231],"There":[232],"were":[233],"no":[234,323],"limiting":[236],"toxicities":[237],"(DLT)":[238],"observed.":[239],"this":[241],"cohort,":[242],"one":[243],"evaluable":[248],"SD":[250],"4":[252],"mos.":[253],"other":[255],"scheduled":[259],"restaging":[261],"scans.":[262],"Pts":[263],"currently":[265,313],"being":[266,314],"accrued":[267,315],"Conclusions:":[274],"Preliminary":[275],"results":[276],"demonstrated":[281],"signs":[282],"activity":[285],"based":[286],"stabilization":[288],"heavily":[292],"pretreated":[293],"cancer.":[299],"established":[303],"If":[322],"DLT":[324],"level,":[331],"we":[332],"plan":[333],"escalate":[335],"3mg/kg":[337],"4mg/kg":[339],"respectively.":[340],"Immune":[341],"biomarker":[342],"analyses":[343],"underway":[345],"correlate":[347],"PBMC":[348],"profile":[352],"response.":[355],"Clinical":[356],"information:":[358],"NCT01040000.":[359]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2017-03-03T00:00:00"}
