{"id":"https://openalex.org/W2590412697","doi":null,"title":"Biopharmaceutics classification system (BCS) as a framework for selective approach to bioavailability/bioequivalence (BA/BE) investigation","display_name":"Biopharmaceutics classification system (BCS) as a framework for selective approach to bioavailability/bioequivalence (BA/BE) investigation","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2590412697","mag":"2590412697"},"language":"en","primary_location":{"id":"pmh:oai:farfar.pharmacy.bg.ac.rs:123456789/737","doi":null,"is_oa":true,"landing_page_url":"https://farfar.pharmacy.bg.ac.rs/handle/123456789/737","pdf_url":"http://farfar.pharmacy.bg.ac.rs/handle/123456789/737","source":{"id":"https://openalex.org/S7407055311","display_name":"FarFar - Pharmacy Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arhiv za farmaciju","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://farfar.pharmacy.bg.ac.rs/handle/123456789/737","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049001025","display_name":"Marija Petronijevi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marija Petronijevi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111832714","display_name":"Milena Pokrajac","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milena Pokrajac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078793787","display_name":"Branislava Miljkovi\u0107","orcid":"https://orcid.org/0000-0001-5088-5976","observed_orcids":["https://orcid.org/0000-0001-5088-5976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Branislava Miljkovi\u0107","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5088-5976","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063818066","display_name":"Katarina M. Vu\u010di\u0107evi\u0107","orcid":"https://orcid.org/0000-0001-9676-5785","observed_orcids":["https://orcid.org/0000-0001-9676-5785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarina Vu\u010di\u0107evi\u0107","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9676-5785","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36120316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"1","first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biopharmaceutics-classification-system","display_name":"Biopharmaceutics Classification System","score":1.0},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.871999979019165},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.5559999942779541},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.9150000214576721},{"id":"https://openalex.org/keywords/permeability","display_name":"permeability","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dissolution","display_name":"dissolution","score":0.8389999866485596},{"id":"https://openalex.org/keywords/regulatory-requirements","display_name":"regulatory requirements","score":0.8539999723434448},{"id":"https://openalex.org/keywords/drug-development-cost-reduction","display_name":"drug development cost reduction","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.9064434766769409},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.8669021129608154},{"id":"https://openalex.org/C2910701995","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutics","level":5,"score":0.7902730703353882},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.642436146736145},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5552694201469421},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49837493896484375},{"id":"https://openalex.org/C2779652045","wikidata":"https://www.wikidata.org/wiki/Q507443","display_name":"Pharmaceutical industry","level":2,"score":0.49037599563598633},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4841928780078888},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.469255656003952},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.44458597898483276},{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.4387938976287842},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.36623263359069824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2873833179473877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.227285236120224},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1952781081199646},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:farfar.pharmacy.bg.ac.rs:123456789/737","doi":null,"is_oa":true,"landing_page_url":"https://farfar.pharmacy.bg.ac.rs/handle/123456789/737","pdf_url":"http://farfar.pharmacy.bg.ac.rs/handle/123456789/737","source":{"id":"https://openalex.org/S7407055311","display_name":"FarFar - Pharmacy Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arhiv za farmaciju","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2590412697","doi":null,"is_oa":false,"landing_page_url":"https://farfar.pharmacy.bg.ac.rs/handle/123456789/737","pdf_url":null,"source":{"id":"https://openalex.org/S4210221777","display_name":"Arhiv za farmaciju","issn_l":"0004-1963","issn":["0004-1963","2217-8767"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321453","host_organization_name":"Faculty of Agronomy in \u010ca\u010dak","host_organization_lineage":["https://openalex.org/P4310321453"],"host_organization_lineage_names":["Faculty of Agronomy in \u010ca\u010dak"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arhiv za farmaciju","raw_type":null}],"best_oa_location":{"id":"pmh:oai:farfar.pharmacy.bg.ac.rs:123456789/737","doi":null,"is_oa":true,"landing_page_url":"https://farfar.pharmacy.bg.ac.rs/handle/123456789/737","pdf_url":"http://farfar.pharmacy.bg.ac.rs/handle/123456789/737","source":{"id":"https://openalex.org/S7407055311","display_name":"FarFar - Pharmacy Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arhiv za farmaciju","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2590412697.pdf","grobid_xml":"https://content.openalex.org/works/W2590412697.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7132691859","https://openalex.org/W2492347332","https://openalex.org/W2080561646","https://openalex.org/W2000021818","https://openalex.org/W2101171473","https://openalex.org/W3211709198","https://openalex.org/W3209459277","https://openalex.org/W2896899101","https://openalex.org/W7221251687","https://openalex.org/W3210648442"],"abstract_inverted_index":{"One":[0],"of":[1,13,66,73,82,107,118,122,160],"fundamental":[2],"investigations,":[3],"that":[4],"pharmaceutical":[5,14,91,177],"industry":[6],"is":[7,24],"expected":[8,140],"to":[9,18,33,77,144,153],"conduct":[10],"during":[11],"development":[12,65,124,179],"formulation":[15],"in":[16,44,51,97,141,149,174],"order":[17],"prove":[19],"its":[20,88],"efficiency":[21],"and":[22,40,57,71,79,120,136,176],"safety,":[23],"bioavailability":[25],"(BA),":[26],"or":[27],"bioequivalence":[28],"(BE)":[29],"assessment.":[30],"Traditional":[31],"approach":[32,60],"this":[34],"investigation":[35],"entails":[36],"strictly":[37],"controlled,":[38],"expensive":[39],"time":[41,119],"consuming":[42],"study":[43],"humans.":[45],"The":[46],"potential":[47],"for":[48,104,110,116,147],"considering":[49],"drugs'":[50],"vivo":[52],"behavior":[53],"has":[54,61],"been":[55,62,129],"extended":[56],"new":[58],"selective":[59],"set":[63],"by":[64],"Biopharmaceutics":[67],"Classification":[68],"System":[69],"(BCS)":[70],"evaluation":[72],"drug":[74,123,175],"absorption":[75],"according":[76,152],"solubility":[78],"permeability":[80],"properties":[81],"the":[83,154],"drug,":[84],"as":[85,87,170],"well":[86],"dissolution":[89],"from":[90,156],"preparation.":[92],"Manufacturers":[93],"are":[94,139],"particularly":[95],"interested":[96],"creating":[98],"criteria":[99,127],"based":[100],"on":[101],"BCS":[102,164],"concept":[103],"granting":[105],"waiver":[106],"BA/BE":[108],"studies":[109],"Immediate":[111],"Release":[112],"Products":[113],"(IRP),":[114],"aiming":[115],"reduction":[117],"cost":[121],"process.":[125,180],"These":[126],"have":[128],"discussed":[130],"at":[131],"many":[132],"experts'":[133],"meetings":[134],"lately,":[135],"regulatory":[137],"agencies":[138],"near":[142],"future":[143],"consider":[145],"proposals":[146],"changes":[148],"regulative":[150],"requirements":[151],"results":[155],"practice.":[157],"If":[158],"some":[159],"them":[161],"were":[162],"accepted,":[163],"would":[165],"become":[166],"even":[167],"more":[168],"significant":[169],"a":[171],"powerful":[172],"tool":[173],"preparation":[178]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-03T00:00:00"}