{"id":"https://openalex.org/W2590345936","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.2543","title":"Effects of the P-glycoprotein (Pgp) antagonist tariquidar (XR-9576; TQD) on Pgp function as well as the toxicity and efficacy of combined chemotherapy in patients with metastatic adrenocortical cancer (mACC)","display_name":"Effects of the P-glycoprotein (Pgp) antagonist tariquidar (XR-9576; TQD) on Pgp function as well as the toxicity and efficacy of combined chemotherapy in patients with metastatic adrenocortical cancer (mACC)","publication_year":2008,"publication_date":"2008-05-20","ids":{"openalex":"https://openalex.org/W2590345936","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.2543","mag":"2590345936"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2008.26.15_suppl.2543","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.2543","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.2543","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066423217","display_name":"Michael E. Menefee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. E. Menefee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005085650","display_name":"Hongyun Huang","orcid":"https://orcid.org/0000-0002-3723-8966","observed_orcids":["https://orcid.org/0000-0002-3723-8966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008898573","display_name":"Maureen Edgerly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Edgerly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110266399","display_name":"Herbert L. Kotz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Kotz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111888064","display_name":"Maria J. Merino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Merino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. M. Balis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034880174","display_name":"C. C. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. C. Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071864090","display_name":"R. Brooks Robey","orcid":"https://orcid.org/0000-0001-5059-3965","observed_orcids":["https://orcid.org/0000-0001-5059-3965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Robey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013592290","display_name":"Susan Elaine Bates","orcid":"https://orcid.org/0000-0001-6708-0330","observed_orcids":["https://orcid.org/0000-0001-6708-0330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. E. Bates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047856599","display_name":"Antonio Tito Fojo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. T. Fojo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"15_suppl","first_page":"2543","last_page":"2543"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tariquidar","display_name":"tariquidar","score":0.9229999780654907},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibition","display_name":"P-glycoprotein inhibition","score":0.9559999704360962},{"id":"https://openalex.org/keywords/metastatic-adrenocortical-carcinoma","display_name":"metastatic adrenocortical carcinoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mitotane","display_name":"mitotane","score":0.843999981880188},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9620000123977661},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5860000252723694},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/99mtc-sestamibi","display_name":"99mTc-sestamibi","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cd56-cells","display_name":"CD56+ cells","score":0.6880000233650208},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.32100000977516174},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8919628858566284},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6409363746643066},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.583149790763855},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5825318694114685},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5798551440238953},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.577843189239502},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5641873478889465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5039798617362976},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4705256223678589},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4421636462211609},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.43068230152130127},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3927730321884155},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32601553201675415},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.3092355728149414}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2008.26.15_suppl.2543","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.2543","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.2543","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2225998796","https://openalex.org/W2107542049","https://openalex.org/W2164543086","https://openalex.org/W2268812775","https://openalex.org/W2910724606","https://openalex.org/W1791352086","https://openalex.org/W6986313040","https://openalex.org/W2138851039","https://openalex.org/W2103394810","https://openalex.org/W2033751185"],"abstract_inverted_index":{"2543":[0],"Background:":[1],"ACC":[2,10],"is":[3],"a":[4,20,134,226,249,263,339],"rare":[5],"tumor":[6],"optimally":[7],"treated":[8],"surgically.":[9],"expresses":[11,293],"high":[12],"levels":[13],"of":[14,22,37,123,137,142,162,164,188,203,207,222,230,232,266,290,305,315,328],"Pgp.":[15,291],"We":[16],"added":[17],"TQD":[18,89,205,283,316,329],"to":[19,33,100,320,358],"regimen":[21,46,307],"daily":[23,56],"oral":[24],"mitotane":[25,57],"with":[26,53,133,144,159,225,247,262,345],"infusional":[27,63],"doxorubicin,":[28],"vincristine,":[29],"and":[30,42,61,70,87,91,109,115,213,236,243,271,287,296,330,347],"etoposide":[31,67],"(MAVE)":[32],"assess":[34,101],"the":[35,44,140,253,326],"efficacy":[36],"Pgp":[38,102,208,224,278,295,340,352],"inhibition":[39,206,221,265,279,289],"in":[40,139,186,195,200,209,240,252,280,285,323,342],"mACC":[41,54,241,292],"whether":[43],"MAVE":[45],"could":[47],"be":[48,299],"improved.":[49],"Methods:":[50],"46":[51,105],"pts":[52,75,106,143,148,156,168],"received":[55],"(mean":[58],"3.99":[59],"g/day)":[60],"96-hour":[62],"doxorubicin":[64],"(8":[65],"mg/m2/day),":[66,69],"(60":[68],"vincristine":[71],"(0.24":[72],"mg/m2/day).":[73],"Six":[74],"underwent":[76],"surgery":[77],"after":[78,88],"achieving":[79],"best":[80],"chemotherapy":[81],"response.":[82],"99mTc-sestamibi":[83,218,231],"scans":[84,219],"obtained":[85],"before":[86],"administration":[90],"rhodamine":[92],"efflux":[93,256],"from":[94,257],"CD56+":[95,258],"mononuclear":[96],"cells":[97,259],"were":[98,107,126],"used":[99],"inhibition.":[103],"Results:":[104],"enrolled":[108],"44":[110],"are":[111,351],"evaluable":[112],"for":[113],"response":[114,129,163],"toxicity.":[116],"54%":[117],"had":[118,157,169],"functional":[119,223,294],"tumors.":[120],"A":[121],"total":[122],"210":[124],"cycles":[125],"administered.":[127],"The":[128,172,180,303,313],"rate":[130],"was":[131,177,184,193,211,260,308],"8.7%":[132],"median":[135,173,227,264],"shrinkage":[136],"13%":[138],"14%":[141],"measurable":[145],"shrinkage.":[146],"Two":[147,155],"have":[149],"ongoing":[150],"CRs":[151],"over":[152],"3":[153],"years.":[154],"PR":[158],"mean":[160],"duration":[161],"15":[165],"weeks;":[166],"25":[167],"stable":[170],"disease.":[171],"overall":[174],"survival":[175],"(OS)":[176],"13.7":[178],"months.":[179],"predominant":[181],"G3/4":[182],"toxicity":[183],"neutropenia":[185],"80%":[187],"first":[189],"cycles.":[190,197,204],"Pegylated":[191],"G-CSF":[192,311],"given":[194],"subsequent":[196],"Fever":[198],"occurred":[199],"only":[201,248],"4.7%":[202],"vivo":[210],"marked":[212],"sustained":[214,288,332],"as":[215,338],"evidenced":[216],"by":[217,301,310],"demonstrating":[220,276],"increase":[228],"accumulation":[229],"133%":[233],"(range":[234,238],"10\u2013240%)":[235],"179%":[237],"38\u2013424%)":[239],"lesions":[242],"normal":[244],"liver,":[245],"respectively,":[246],"2%":[250],"change":[251],"heart.":[254],"Rhodamine":[255],"blocked":[261,300],"92%":[267],"at":[268,273],"24":[269],"hours":[270],"81%":[272],"48":[274],"hours,":[275],"excellent":[277],"vivo.":[281],"Conclusions:":[282],"results":[284],"potent":[286],"this":[297,306],"can":[298],"TQD.":[302],"myelotoxicity":[304],"resolved":[309],"administration.":[312],"addition":[314],"does":[317],"not":[318],"appear":[319],"prolong":[321],"OS":[322],"mACC.":[324],"However,":[325],"safety":[327],"its":[331,335],"potency":[333],"warrant":[334],"further":[336],"investigation":[337],"antagonist":[341],"future":[343],"studies":[344],"cytotoxic":[346],"novel":[348],"agents":[349],"that":[350],"substrates.":[353],"No":[354],"significant":[355],"financial":[356],"relationships":[357],"disclose.":[359]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2017-03-03T00:00:00"}
