{"id":"https://openalex.org/W2590169740","doi":"https://doi.org/10.1002/cmdc.201700037","title":"Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists","display_name":"Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists","publication_year":2017,"publication_date":"2017-02-20","ids":{"openalex":"https://openalex.org/W2590169740","doi":"https://doi.org/10.1002/cmdc.201700037","mag":"2590169740","pmid":"https://pubmed.ncbi.nlm.nih.gov/28218498"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201700037","doi":"https://doi.org/10.1002/cmdc.201700037","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201700037","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030476450","display_name":"Margarida Espadinha","orcid":"https://orcid.org/0000-0002-7053-0475","observed_orcids":["https://orcid.org/0000-0002-7053-0475"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Margarida Espadinha","raw_affiliation_strings":["Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016577026","display_name":"Jorge Dourado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jorge Dourado","raw_affiliation_strings":["Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087348082","display_name":"Roc\u00edo Lajar\u00edn-Cuesta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rocio Lajarin\u2010Cuesta","raw_affiliation_strings":["Instituto Te\u00f3filo Hernando, Facultad de Medicina Universidad Autonoma de Madrid C/ Arzobispo Morcillo, 4 28029 Madrid Spain","Instituto de Investigacion Sanitaria, Hospital Universitario de la Princesa  28006 Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando, Facultad de Medicina Universidad Autonoma de Madrid C/ Arzobispo Morcillo, 4 28029 Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto de Investigacion Sanitaria, Hospital Universitario de la Princesa  28006 Madrid Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052533073","display_name":"Clara Herrera\u2010Arozamena","orcid":"https://orcid.org/0000-0002-5894-128X","observed_orcids":["https://orcid.org/0000-0002-5894-128X"]},"institutions":[{"id":"https://openalex.org/I4210121842","display_name":"Instituto de Qu\u00edmica M\u00e9dica","ror":"https://ror.org/02vznxv75","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210121842"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Clara Herrera\u2010Arozamena","raw_affiliation_strings":["Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC)  C/ Juan de la Cierva, 3 28006 Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC)  C/ Juan de la Cierva, 3 28006 Madrid Spain","institution_ids":["https://openalex.org/I4210121842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026345203","display_name":"L\u00eddia Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-6799-2740","observed_orcids":["https://orcid.org/0000-0002-6799-2740"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lidia M. D. Gon\u00e7alves","raw_affiliation_strings":["Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057649982","display_name":"Mar\u00eda Isabel Rodr\u00edguez-Franco","orcid":"https://orcid.org/0000-0002-6500-792X","observed_orcids":["https://orcid.org/0000-0002-6500-792X"]},"institutions":[{"id":"https://openalex.org/I4210121842","display_name":"Instituto de Qu\u00edmica M\u00e9dica","ror":"https://ror.org/02vznxv75","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210121842"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Isabel Rodr\u00edguez\u2010Franco","raw_affiliation_strings":["Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC)  C/ Juan de la Cierva, 3 28006 Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC)  C/ Juan de la Cierva, 3 28006 Madrid Spain","institution_ids":["https://openalex.org/I4210121842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080800757","display_name":"Crist\u00f3bal de los R\u00edos","orcid":"https://orcid.org/0000-0002-6456-7589","observed_orcids":["https://orcid.org/0000-0002-6456-7589"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristobal de\u2005los\u2005Rios","raw_affiliation_strings":["Instituto Te\u00f3filo Hernando, Facultad de Medicina Universidad Autonoma de Madrid C/ Arzobispo Morcillo, 4 28029 Madrid Spain","Instituto de Investigacion Sanitaria, Hospital Universitario de la Princesa  28006 Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando, Facultad de Medicina Universidad Autonoma de Madrid C/ Arzobispo Morcillo, 4 28029 Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto de Investigacion Sanitaria, Hospital Universitario de la Princesa  28006 Madrid Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063797318","display_name":"Maria M. M. Santos","orcid":"https://orcid.org/0000-0002-2239-9353","observed_orcids":["https://orcid.org/0000-0002-2239-9353"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Maria M. M. Santos","raw_affiliation_strings":["Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-2239-9353","affiliations":[{"raw_affiliation_string":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063797318"],"corresponding_institution_ids":["https://openalex.org/I141596103"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4617,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53657822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"12","issue":"7","first_page":"537","last_page":"545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bicyclic-lactams","display_name":"bicyclic lactams","score":0.9819999933242798},{"id":"https://openalex.org/keywords/enantiopure-compounds","display_name":"enantiomerically pure compounds","score":0.8640000224113464},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9430000185966492},{"id":"https://openalex.org/keywords/brain-permeability","display_name":"brain permeability","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7379999756813049},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.858532190322876},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5956641435623169},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5726009607315063},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.5718712210655212},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4529407024383545},{"id":"https://openalex.org/C2778851735","wikidata":"https://www.wikidata.org/wiki/Q407324","display_name":"Phencyclidine","level":4,"score":0.4392154812812805},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.42740607261657715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42327481508255005},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.41710638999938965},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3571842312812805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2800036072731018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2757549583911896},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2147125005722046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17143025994300842},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07732591032981873}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001643","descriptor_name":"Bridged Bicyclo Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cmdc.201700037","doi":"https://doi.org/10.1002/cmdc.201700037","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201700037","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:28218498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28218498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/149788","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/149788","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2574980881","display_name":null,"funder_award_id":"IF/00732/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3651614218","display_name":"Instituto de Investiga\u00e7\u00e3o do Medicamento","funder_award_id":"UID/DTP/04138/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5820894357","display_name":"Design, synthesis and biological evaluation of novel p53 activators by targeting p53 protein-protein interactions","funder_award_id":"SFRH/BD/117931/2016","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6104999892","display_name":null,"funder_award_id":"PIE-201580E109","funder_id":"https://openalex.org/F4320334857","funder_display_name":"Consejo Superior de Investigaciones Cient\u00edficas"},{"id":"https://openalex.org/G7547231035","display_name":"S\u00edntese enantioselectiva de alcal\u00f3ides ind\u00f3licos e a sua aplica\u00e7\u00e3o como antagonistas de NMDA","funder_award_id":"PTDC/QUI-QUI/111664/2009","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G767553682","display_name":"La proteina fosfatasa 2A como diana terap\u00e9utica para el desarrollo de nuevos f\u00e1rmacos para el tratamiento de enfermedades neurodegenerativas","funder_award_id":"PI13/00789","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G959905082","display_name":null,"funder_award_id":"SAF2015-64948-C2-1-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320334857","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1561114541","https://openalex.org/W1930557746","https://openalex.org/W1966556202","https://openalex.org/W1986170848","https://openalex.org/W1986964147","https://openalex.org/W2009560845","https://openalex.org/W2015859691","https://openalex.org/W2017744581","https://openalex.org/W2024380057","https://openalex.org/W2026976753","https://openalex.org/W2027844417","https://openalex.org/W2049055721","https://openalex.org/W2064800259","https://openalex.org/W2070963592","https://openalex.org/W2073962317","https://openalex.org/W2089094370","https://openalex.org/W2099853010","https://openalex.org/W2114163624","https://openalex.org/W2141682133","https://openalex.org/W2150333097","https://openalex.org/W2160934472","https://openalex.org/W2162454135","https://openalex.org/W2205882274","https://openalex.org/W2467235541","https://openalex.org/W2470498206","https://openalex.org/W2949166776"],"related_works":["https://openalex.org/W2922478903","https://openalex.org/W3013670343","https://openalex.org/W2767306497","https://openalex.org/W2157943555","https://openalex.org/W2017744581","https://openalex.org/W2064800259","https://openalex.org/W2000747055","https://openalex.org/W2088700160","https://openalex.org/W2775569439","https://openalex.org/W7160821371"],"abstract_inverted_index":{"Abstract":[0],"N\u2010Methyl\u2010d\u2010aspartate":[1],"(NMDA)":[2],"receptors":[3,28],"are":[4],"fundamental":[5],"for":[6,99,136],"the":[7,11,66,74,83,100,137,143],"normal":[8],"function":[9],"of":[10,26,65,86,90,102,139,145],"central":[12],"nervous":[13],"system":[14],"(CNS),":[15],"and":[16,23,45,58,73,121],"play":[17],"an":[18,79,92,117],"important":[19],"role":[20],"in":[21,96,118],"memory":[22],"learning.":[24],"Over\u2010activation":[25],"these":[27,124],"leads":[29],"to":[30],"neuronal":[31],"loss":[32],"associated":[33,141],"with":[34,142],"major":[35],"neurological":[36],"disorders":[37],"such":[38],"as":[39,60,88],"Parkinson's":[40],"disease,":[41,43],"Alzheimer's":[42,103],"schizophrenia,":[44],"epilepsy.":[46],"In":[47],"this":[48,110],"study,":[49],"22":[50],"novel":[51],"enantiopure":[52],"bicyclic":[53],"lactams":[54],"were":[55],"designed,":[56],"synthesized,":[57],"evaluated":[59],"NMDA":[61,70,93,146],"receptor":[62,71,94],"antagonists.":[63],"Most":[64],"new":[67],"compounds":[68],"displayed":[69],"antagonism,":[72],"most":[75],"promising":[76],"compound":[77,111],"showed":[78],"IC50":[80],"value":[81],"on":[82],"same":[84],"order":[85],"magnitude":[87],"that":[89,109,127],"memantine,":[91],"antagonist":[95],"clinical":[97],"use":[98],"treatment":[101,138],"disease.":[104],"Further":[105],"biological":[106],"evaluation":[107],"indicated":[108],"is":[112,132],"brain":[113],"permeable":[114],"(determined":[115],"by":[116],"vitro":[119],"assay)":[120],"non\u2010hepatotoxic.":[122],"All":[123],"results":[125],"indicate":[126],"(3S,7aS)\u20107a\u2010(4\u2010chlorophenyl)\u20103\u2010(4\u2010hydroxybenzyl)tetrahydropyrrolo[2,1\u2010b]oxazol\u20105(6H)\u2010one":[128],"(compound":[129],"5":[130],"b)":[131],"a":[133],"potential":[134],"candidate":[135],"pathologies":[140],"over\u2010activation":[144],"receptors.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-03-03T00:00:00"}