{"id":"https://openalex.org/W2590132913","doi":"https://doi.org/10.1016/j.fsi.2017.02.039","title":"Who needs the hotspot? The effect of temperature on the fish host immune response to Tetracapsuloides bryosalmonae the causative agent of proliferative kidney disease","display_name":"Who needs the hotspot? The effect of temperature on the fish host immune response to Tetracapsuloides bryosalmonae the causative agent of proliferative kidney disease","publication_year":2017,"publication_date":"2017-02-24","ids":{"openalex":"https://openalex.org/W2590132913","doi":"https://doi.org/10.1016/j.fsi.2017.02.039","mag":"2590132913","pmid":"https://pubmed.ncbi.nlm.nih.gov/28238860"},"language":"en","primary_location":{"id":"doi:10.1016/j.fsi.2017.02.039","doi":"https://doi.org/10.1016/j.fsi.2017.02.039","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fsi.2017.02.039","pdf_url":null,"source":{"id":"https://openalex.org/S185787987","display_name":"Fish & Shellfish Immunology","issn_l":"1050-4648","issn":["1050-4648","1095-9947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Fish & Shellfish Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.fsi.2017.02.039","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003853028","display_name":"Christyn Bailey","orcid":"https://orcid.org/0000-0002-0989-4587","observed_orcids":["https://orcid.org/0000-0002-0989-4587"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christyn Bailey","raw_affiliation_strings":["University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037830581","display_name":"Helmut E. Segner","orcid":"https://orcid.org/0000-0002-1783-1295","observed_orcids":["https://orcid.org/0000-0002-1783-1295"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Helmut Segner","raw_affiliation_strings":["University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1783-1295","affiliations":[{"raw_affiliation_string":"University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078214593","display_name":"Ayako Casanova-Nakayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ayako Casanova-Nakayama","raw_affiliation_strings":["University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000989152","display_name":"Thomas Wahli","orcid":"https://orcid.org/0000-0002-3642-4089","observed_orcids":["https://orcid.org/0000-0002-3642-4089"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Thomas Wahli","raw_affiliation_strings":["University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland. Electronic address: thomas.wahli@vetsuisse.unibe.ch","University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3642-4089","affiliations":[{"raw_affiliation_string":"University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland. Electronic address: thomas.wahli@vetsuisse.unibe.ch","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"University of Berne, Vetsuisse Faculty, Centre for Fish and Wildlife Health, L\u00e4nggassstrasse 122, CH-3012 Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000989152"],"corresponding_institution_ids":["https://openalex.org/I118564535"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":3.8013,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.94371081,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"63","issue":null,"first_page":"424","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13350","display_name":"Myxozoan Parasites in Aquatic Species","score":0.3163999915122986,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10815","display_name":"Parasite Biology and Host Interactions","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proliferative-kidney-disease","display_name":"proliferative kidney disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tetracapsuloides-bryosalmonae","display_name":"Tetracapsuloides bryosalmonae","score":1.0},{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.9869999885559082},{"id":"https://openalex.org/keywords/water-temperature","display_name":"water temperature","score":0.8059999942779541},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fish-immunology","display_name":"fish immunology","score":0.40299999713897705},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.7279999852180481},{"id":"https://openalex.org/keywords/b-cell-response","display_name":"B cell response","score":0.9549999833106995},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/immune-related-gene-expression","display_name":"immune gene expression","score":0.7200000286102295},{"id":"https://openalex.org/keywords/pathogen-load","display_name":"pathogen load","score":0.6159999966621399},{"id":"https://openalex.org/keywords/salmonid-diseases","display_name":"salmonid diseases","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8666075468063354},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8573609590530396},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5417135953903198},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5347221493721008},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4973953068256378},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4791352450847626},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4147164225578308},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17798170447349548}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005393","descriptor_name":"Fish Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005393","descriptor_name":"Fish Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010273","descriptor_name":"Parasitic Diseases, Animal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010273","descriptor_name":"Parasitic Diseases, Animal","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D017686","descriptor_name":"Oncorhynchus mykiss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055764","descriptor_name":"Myxozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.fsi.2017.02.039","doi":"https://doi.org/10.1016/j.fsi.2017.02.039","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fsi.2017.02.039","pdf_url":null,"source":{"id":"https://openalex.org/S185787987","display_name":"Fish & Shellfish Immunology","issn_l":"1050-4648","issn":["1050-4648","1095-9947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Fish & Shellfish Immunology","raw_type":"journal-article"},{"id":"pmid:28238860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28238860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fish & shellfish immunology","raw_type":"Journal Article"},{"id":"pmh:doi:10.7892/boris.112091","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/199775","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:112091","doi":null,"is_oa":false,"landing_page_url":"https://boris.unibe.ch/112091/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401747","display_name":"BORIS (University Library Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210103840","host_organization_name":"Nakuru County Council","host_organization_lineage":["https://openalex.org/I4210103840"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bailey, Christyn John; Segner, Helmut; Casanova, Ayako; Wahli, Thomas (2017). Who needs the hotspot? The effect of temperature on the fish host immune response to Tetracapsuloides bryosalmonae the causative agent of proliferative kidney disease. Fish & shellfish immunology, 63, pp. 424-437. Elsevier Science 10.1016/j.fsi.2017.02.039 <http://dx.doi.org/10.1016/j.fsi.2017.02.039>","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.fsi.2017.02.039","doi":"https://doi.org/10.1016/j.fsi.2017.02.039","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.fsi.2017.02.039","pdf_url":null,"source":{"id":"https://openalex.org/S185787987","display_name":"Fish & Shellfish Immunology","issn_l":"1050-4648","issn":["1050-4648","1095-9947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Fish & Shellfish Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2526077595","display_name":"Proliferative Kidney Disease (PKD) of salmonids: an emerging disease \u2013 investigation of the temperature dependent host response against the parasite Tetracapsuloides bryosalmonae","funder_award_id":"138310","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1528387991","https://openalex.org/W1891788702","https://openalex.org/W1966226308","https://openalex.org/W1966922404","https://openalex.org/W1967115552","https://openalex.org/W1976251589","https://openalex.org/W1977302333","https://openalex.org/W1983734758","https://openalex.org/W1986686460","https://openalex.org/W1992622482","https://openalex.org/W1997981022","https://openalex.org/W1998387067","https://openalex.org/W2003405010","https://openalex.org/W2008318356","https://openalex.org/W2011312974","https://openalex.org/W2019900700","https://openalex.org/W2032307425","https://openalex.org/W2033289727","https://openalex.org/W2040830490","https://openalex.org/W2043479124","https://openalex.org/W2043823681","https://openalex.org/W2046659585","https://openalex.org/W2053207181","https://openalex.org/W2059787136","https://openalex.org/W2060267424","https://openalex.org/W2069696396","https://openalex.org/W2070365250","https://openalex.org/W2072698367","https://openalex.org/W2081870862","https://openalex.org/W2082450387","https://openalex.org/W2084560704","https://openalex.org/W2090611184","https://openalex.org/W2091826024","https://openalex.org/W2093412276","https://openalex.org/W2094439235","https://openalex.org/W2095791743","https://openalex.org/W2100303227","https://openalex.org/W2107277218","https://openalex.org/W2109274279","https://openalex.org/W2116394003","https://openalex.org/W2117970813","https://openalex.org/W2123211402","https://openalex.org/W2124002196","https://openalex.org/W2129784602","https://openalex.org/W2150216599","https://openalex.org/W2162098634","https://openalex.org/W2180665518","https://openalex.org/W2221113357","https://openalex.org/W2282382969","https://openalex.org/W2294234775"],"related_works":["https://openalex.org/W2754944889","https://openalex.org/W1966922404","https://openalex.org/W6921650719","https://openalex.org/W2069696396","https://openalex.org/W2085441658","https://openalex.org/W1983423611","https://openalex.org/W6978079406","https://openalex.org/W3133934391","https://openalex.org/W2433904364","https://openalex.org/W2040800694"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-03-03T00:00:00"}