{"id":"https://openalex.org/W2590129600","doi":"https://doi.org/10.1200/jco.2011.29.7_suppl.49","title":"Alkaline phosphatase (ALP) normalization and overall survival in patients with bone metastases from castration-resistant prostate cancer (CRPC) treated with radium-223.","display_name":"Alkaline phosphatase (ALP) normalization and overall survival in patients with bone metastases from castration-resistant prostate cancer (CRPC) treated with radium-223.","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2590129600","doi":"https://doi.org/10.1200/jco.2011.29.7_suppl.49","mag":"2590129600"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.7_suppl.49","doi":"https://doi.org/10.1200/jco.2011.29.7_suppl.49","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.7_suppl.49","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101420072","display_name":"Chris C. Parker","orcid":"https://orcid.org/0000-0001-6512-124X","observed_orcids":["https://orcid.org/0000-0001-6512-124X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"C. Parker","raw_affiliation_strings":["The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057471734","display_name":"Charles Gillies O'Bryan-Tear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"C. G. O'Bryan-Tear","raw_affiliation_strings":["The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014460763","display_name":"B. Bolstad","orcid":"https://orcid.org/0009-0007-9064-932X","observed_orcids":["https://orcid.org/0009-0007-9064-932X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"B. Bolstad","raw_affiliation_strings":["The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009120349","display_name":"A. Lokna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"A. Lokna","raw_affiliation_strings":["The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112235154","display_name":"Sten F. Nilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"S. Nilsson","raw_affiliation_strings":["The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Marsden Hospital, Surrey, United Kingdom; Algeta ASA, Oslo, Norway; Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"7_suppl","first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.3564000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radium-223","display_name":"radium-223","score":0.9330000281333923},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8980000019073486},{"id":"https://openalex.org/keywords/alpha-emitting-radiopharmaceuticals","display_name":"alpha-emitting radiopharmaceuticals","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6299999952316284},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.9190000295639038},{"id":"https://openalex.org/keywords/alsympca-trial","display_name":"ALSYMPCA trial","score":0.7170000076293945},{"id":"https://openalex.org/keywords/treatment-biomarkers","display_name":"treatment biomarkers","score":0.3840000033378601},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5929999947547913},{"id":"https://openalex.org/keywords/bone-marrow-sparing","display_name":"bone marrow sparing","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8582123517990112},{"id":"https://openalex.org/C2780737065","wikidata":"https://www.wikidata.org/wiki/Q18888805","display_name":"Radium-223","level":5,"score":0.8209003210067749},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6275445222854614},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5599631667137146},{"id":"https://openalex.org/C550196577","wikidata":"https://www.wikidata.org/wiki/Q1128","display_name":"Radium","level":2,"score":0.48441794514656067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4507637917995453},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4446665048599243},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.44150015711784363},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.40707695484161377},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.2866869568824768},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2576855421066284},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2011.29.7_suppl.49","doi":"https://doi.org/10.1200/jco.2011.29.7_suppl.49","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.7_suppl.49","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3134766907","https://openalex.org/W4247733065","https://openalex.org/W3094492307","https://openalex.org/W2766005351","https://openalex.org/W2017722713","https://openalex.org/W4252574288","https://openalex.org/W3005906688","https://openalex.org/W2038735381","https://openalex.org/W2513382730","https://openalex.org/W4233890944"],"abstract_inverted_index":{"49":[0],"Background:":[1],"Radium-223":[2,23],"(Alpharadin)":[3],"is":[4,52],"a":[5,25,55,76,198],"first-in-class":[6],"alpha-pharmaceutical.":[7],"It":[8],"targets":[9],"bone":[10,21,32,39,64,232],"metastases":[11,40,65,233],"with":[12,38,54,61,121,147,153,188,194,228,235,241],"high-energy":[13],"alpha-radiation":[14],"of":[15,31,79,151,258],"extremely":[16],"short":[17],"range":[18],"that":[19,131],"spares":[20],"marrow.":[22],"has":[24],"profound":[26],"effect":[27,51],"on":[28],"serum":[29],"markers":[30],"metabolism,":[33],"including":[34],"ALP,":[35],"in":[36,68,142,175,181],"patients":[37,145,206,211],"from":[41],"CRPC.":[42],"In":[43,136,169],"an":[44],"exploratory":[45],"analysis,":[46],"we":[47],"studied":[48],"whether":[49],"this":[50],"associated":[53,240],"meaningful":[56],"clinical":[57],"benefit.":[58],"Methods:":[59],"Patients":[60],"CRPC":[62,230],"and":[63,127,154,161,191,208,218,231],"were":[66,110,123,158,215],"treated":[67,146,234],"2":[69],"randomized":[70],"phase":[71,255],"II":[72],"studies.":[73],"BC1-02":[74],"was":[75,140,173,239],"placebo-controlled":[77],"study":[78],"radium-223":[80,91,122],"(50":[81],"kBq/kg)":[82,96],"every":[83,97],"4":[84],"weeks":[85,99,160,217],"for":[86,100,203,251],"12":[87,101],"weeks.":[88,102],"BC1-04":[89],"evaluated":[90],"(25,":[92],"50,":[93],"or":[94],"80":[95,195],"6":[98],"Baseline":[103],"total":[104],"ALP":[105,138,156,171,213,237],"values":[106],">":[107],"128":[108,117],"U/L":[109,118],"considered":[111],"elevated;":[112],"those":[113,128,152],"decreasing":[114],"to":[115],"below":[116],"during":[119],"treatment":[120],"defined":[124],"as":[125,133],"normalized,":[126],"remaining":[129],"above":[130],"value":[132],"non-normalized.":[134],"Results:":[135],"BC1-02,":[137],"normalization":[139,157,172,214,238],"seen":[141,174],"12/26":[143],"(46%)":[144],"radium-223.":[148,259],"Median":[149,201],"survivals":[150,202],"without":[155],"102":[159,216],"42":[162],"weeks,":[163,220],"respectively":[164,221],"(log-rank":[165,222],"P":[166,223],"<":[167],"0.001).":[168],"BC1-04,":[170],"25/75":[176],"(33%)":[177],"cases:":[178],"5/29":[179],"(17%)":[180],"the":[182,204,209,249,252],"25":[183,205],"kBq/kg":[184],"group,":[185],"10/25":[186],"(40%)":[187],"50":[189,210],"kBq/kg,":[190,196],"10/21":[192],"(48%)":[193],"indicating":[197],"dose-response":[199],"relationship.":[200],"with,":[207],"without,":[212],"58":[219],"=":[224],"0.0086).":[225],"Conclusions:":[226],"Inpatients":[227],"metastatic":[229],"radium-223,":[236],"significantly":[242],"better":[243],"overall":[244],"survival.":[245],"These":[246],"data":[247],"support":[248],"rationale":[250],"ongoing":[253],"ALSYMPCA":[254],"III":[256],"trial":[257],"[Table:":[260],"see":[261],"text]":[262]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-03-03T00:00:00"}
