{"id":"https://openalex.org/W2590109313","doi":"https://doi.org/10.1182/blood.v122.21.501.501","title":"Overview Of The Genomic Landscape Of High Risk Diffuse Large B-Cell Lymphoma Using Targeted DNA and RNA Sequencing","display_name":"Overview Of The Genomic Landscape Of High Risk Diffuse Large B-Cell Lymphoma Using Targeted DNA and RNA Sequencing","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2590109313","doi":"https://doi.org/10.1182/blood.v122.21.501.501","mag":"2590109313"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.501.501","doi":"https://doi.org/10.1182/blood.v122.21.501.501","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.501.501","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056410481","display_name":"Michelle K. Nahas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michelle Nahas","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101967195","display_name":"Anthony R. Mato","orcid":"https://orcid.org/0000-0002-0435-8611","observed_orcids":["https://orcid.org/0000-0002-0435-8611"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony R Mato","raw_affiliation_strings":["Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017525817","display_name":"Amy L. Donahue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy L Donahue","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685161","display_name":"Jie He","orcid":"https://orcid.org/0000-0002-0285-5403","observed_orcids":["https://orcid.org/0000-0002-0285-5403","https://orcid.org/0000-0001-6961-8421"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie He","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066068230","display_name":"Geoff A. Otto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoff A Otto","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029183165","display_name":"Doron Lipson","orcid":"https://orcid.org/0009-0004-2738-5702","observed_orcids":["https://orcid.org/0009-0004-2738-5702"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Doron Lipson","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079433880","display_name":"Roman Yelensky","orcid":"https://orcid.org/0000-0002-5356-0111","observed_orcids":["https://orcid.org/0000-0002-5356-0111"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roman Yelensky","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039434063","display_name":"Jeff S. Ross","orcid":"https://orcid.org/0000-0001-8770-6425","observed_orcids":["https://orcid.org/0000-0001-8770-6425"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeff Ross","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060859065","display_name":"Phil J. Stephens","orcid":"https://orcid.org/0000-0002-0840-4996","observed_orcids":["https://orcid.org/0000-0002-0840-4996"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Phil Stephens","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112254892","display_name":"Kar Fai Chow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kar Fai Chow","raw_affiliation_strings":["Department of Pathology, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059656794","display_name":"Tania Zielonka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tania Zielonka","raw_affiliation_strings":["Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038375065","display_name":"Pritish K. Bhattacharyya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pritish K. Bhattacharyya","raw_affiliation_strings":["Department of Pathology, The John Theurer Cancer Center at Hackensack University Medical Center, Hackesack, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The John Theurer Cancer Center at Hackensack University Medical Center, Hackesack, NJ, USA,","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005083651","display_name":"Ewelina Protomastro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ewelina Protomastro","raw_affiliation_strings":["Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013717203","display_name":"Tatyana A. Feldman","orcid":"https://orcid.org/0000-0002-4458-2896","observed_orcids":["https://orcid.org/0000-0002-4458-2896"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatyana Feldman","raw_affiliation_strings":["Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma Division, The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA,","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033513950","display_name":"Andrew L. Pecora","orcid":"https://orcid.org/0000-0002-8368-0632","observed_orcids":["https://orcid.org/0000-0002-8368-0632"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew L. Pecora","raw_affiliation_strings":["John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA,","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101897436","display_name":"Vincent Miller","orcid":"https://orcid.org/0000-0002-5511-1328","observed_orcids":["https://orcid.org/0000-0002-5511-1328"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vincent Miller","raw_affiliation_strings":["Foundation Medicine, Inc, Cambridge, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc, Cambridge, MA, USA,","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089882481","display_name":"Andre Henri Goy","orcid":"https://orcid.org/0000-0001-5125-6522","observed_orcids":["https://orcid.org/0000-0001-5125-6522"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andre Goy","raw_affiliation_strings":["The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA","institution_ids":["https://openalex.org/I1324520350"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017525817","https://openalex.org/A5029183165","https://openalex.org/A5038375065","https://openalex.org/A5039434063","https://openalex.org/A5056410481","https://openalex.org/A5059656794","https://openalex.org/A5060859065","https://openalex.org/A5066068230","https://openalex.org/A5079433880","https://openalex.org/A5100685161","https://openalex.org/A5101897436","https://openalex.org/A5112254892"],"corresponding_institution_ids":["https://openalex.org/I1324520350","https://openalex.org/I4392738181"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3387724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"501","last_page":"501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/high-risk-dlbcl","display_name":"high-risk DLBCL","score":0.8339999914169312},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.5849999785423279},{"id":"https://openalex.org/keywords/mutational-landscape","display_name":"mutational landscape","score":0.7720000147819519},{"id":"https://openalex.org/keywords/double-hit-lymphoma","display_name":"double-hit lymphoma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/myc-rearrangement","display_name":"MYC rearrangement","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bcl2-rearrangement","display_name":"BCL2 rearrangement","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bcl6-rearrangement","display_name":"BCL6 rearrangement","score":0.8790000081062317},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/myd88-mutation","display_name":"MYD88 mutation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/card11-mutation","display_name":"CARD11 mutation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cd79b-mutation","display_name":"CD79B mutation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/abc-subtype","display_name":"ABC subtype","score":0.5320000052452087},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.5640000104904175},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.5730000138282776},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5630000233650208},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6600000262260437},{"id":"https://openalex.org/keywords/molecular-heterogeneity","display_name":"molecular heterogeneity","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.7162294387817383},{"id":"https://openalex.org/C2777537477","wikidata":"https://www.wikidata.org/wiki/Q17847411","display_name":"BCL6","level":5,"score":0.5490378737449646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5108070373535156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.510398805141449},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.45605677366256714},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4345543384552002},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.4330441951751709},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.41052132844924927},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.32192760705947876},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3051415681838989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2610663175582886},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2532806992530823},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.2317364513874054},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.22049552202224731},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.15607383847236633},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13757023215293884},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.10178729891777039},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.501.501","doi":"https://doi.org/10.1182/blood.v122.21.501.501","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.501.501","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4300000071525574,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389244042","https://openalex.org/W2985021406","https://openalex.org/W4379981845","https://openalex.org/W4379981829","https://openalex.org/W2985949593","https://openalex.org/W3010064674","https://openalex.org/W4417005927","https://openalex.org/W2611911991","https://openalex.org/W7137565873","https://openalex.org/W6902021607"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,127],"implementation":[3],"of":[4,12,64,68,96,130,139,163,210,242,286,297,314,356,387,391,400,440,448,452,477,486,498],"chemoimmunotherapy":[5],"(R-CHOP)":[6],"has":[7,133],"dramatically":[8],"improved":[9],"the":[10,36,65,87,140,330,413,436],"outcome":[11,156,438],"B-cell":[13],"NHL":[14],"particularly":[15,112],"DLBCL":[16,69,150,157,374,418,453],"(>":[17],"50%":[18,386],"OS":[19,162],"at":[20,410],"5":[21],"years":[22],"with":[23,45,54,114,159,338,458,507],"very":[24,154],"few":[25],"late":[26],"relapses).":[27],"Most":[28],"failures":[29],"to":[30,195,265,282],"R-CHOP":[31],"occur":[32],"early":[33],"(80%":[34],"in":[35,86,116,124,143,183,301,312,369,373,396,405,500,504],"1st":[37],"18":[38],"months),":[39],"are":[40,50],"not":[41,51],"easily":[42],"salvageable":[43],"even":[44],"high":[46,266],"dose":[47],"therapy-ASCT":[48],"and":[49,75,98,171,190,203,217,227,246,253,276,326,347,352,365,380,389,407,423,474,488,502,510],"reliably":[52],"predicted":[53],"current":[55],"available":[56],"prognostic":[57],"models.":[58],"There":[59],"is":[60],"a":[61,135,160,175,184,459,484,494],"growing":[62],"awareness":[63],"molecular":[66],"heterogeneity":[67],"beyond":[70],"well-established":[71],"germinal":[72],"center":[73],"(GC)":[74],"non-GC":[76],"subtypes.":[77],"Additional":[78],"genomic":[79,178,191,287,293,450],"alterations":[80,83,192,404,499],"include":[81],"structural":[82],"(such":[84],"as":[85,119],"\u201cdouble-hit\u201d":[88],"lymphoma":[89],"(DHL)":[90],"(harboring":[91],"rearrangements":[92,479],"or":[93,100,106,122,308,341,350],"additional":[94],"copies":[95],"MYC":[97],"BCL2":[99,340],"less":[101],"commonly":[102],"BCL6);":[103],"predominantly":[104],"deregulated":[105],"activated":[107],"driving":[108],"pathways":[109,370],"(ex":[110],"NF-\u03baB":[111,381,401],"associated":[113],"mutations":[115,310,395],"genes":[117,245,248,255],"such":[118],"CARD11,":[120],"CD79B":[121],"MYD88":[123],"ABC":[125],"subtype).":[126],"recent":[128],"use":[129],"high-resolution":[131],"technologies":[132],"revealed":[134],"much":[136],"higher":[137],"complexity":[138],"mutational":[141],"landscape":[142],"NHL.":[144],"Methods":[145],"Here,":[146],"we":[147],"studied":[148],"35":[149,331],"primary":[151],"tumors":[152],"from":[153,208,212,454],"poor":[155,437],"patients":[158],"median":[161],"8.4":[164],"months":[165],"(range":[166],".3-44.5":[167],"months).":[168],"Targeted":[169],"DNA":[170,202,235,275,487],"RNA":[172,205,489],"sequencing":[173,223],"using":[174,232,483],"NGS":[176],"based":[177],"profiling":[179,451],"assay":[180],"was":[181,206],"performed":[182],"CLIA":[185],"certified":[186],"laboratory":[187],"(Foundation":[188],"Medicine)":[189],"were":[193,225,263],"compared":[194],"those":[196],"previously":[197,371,415],"published":[198],"for":[199,251,258,274,280,417,466,469],"DLBCL:":[200],"Genomic":[201],"total":[204,278],"isolated":[207],"40\u00b5m":[209],"tissue":[211],"archived":[213],"clinical":[214,455],"formalin":[215],"fixed":[216],"paraffin-embedded":[218],"(FFPE)":[219],"blocks.":[220],"Illumina":[221],"adaptor-ligated":[222],"libraries":[224,262],"created":[226],"captured":[228,261],"by":[229],"solution":[230],"hybridization":[231],"two":[233],"custom":[234],"oligonucleotide":[236],"baitsets":[237],"targeting":[238],"all":[239],"coding":[240],"exons":[241],"374":[243],"cancer-related":[244],"24":[247],"frequently":[249,256],"rearranged":[250,257],"DNA-seq,":[252],"272":[254],"RNA-seq.":[259],"All":[260],"sequenced":[264],"depth":[267],"(Illumina":[268],"HiSeq),":[269],"averaging":[270],">810X":[271],"unique":[272,472],"coverage":[273,473],">20,000,000":[277],"pairs":[279],"RNA,":[281],"enable":[283],"accurate":[284],"detection":[285,355,476],"alterations.":[288],"Results":[289],"We":[290,444,491],"identified":[291],"214":[292],"alterations,":[294],"an":[295],"average":[296],"6.1":[298],"per":[299],"sample,":[300],"71":[302],"genes:":[303],"87":[304],"substitutions/indels,":[305],"85":[306],"nonsense":[307],"frameshifting":[309],"resulting":[311],"truncation":[313],"known":[315],"tumor":[316],"suppressor":[317],"genes,":[318,398],"4":[319,357],"gene":[320,324],"amplifications,":[321],"15":[322],"homozygous":[323],"deletions,":[325],"25":[327],"translocations.":[328],"In":[329],"samples,":[332],"12":[333],"harbored":[334],"immunoglobulin":[335],"(Ig)":[336],"translocations":[337],"MYC,":[339],"BCL6":[342,360],"(2":[343],"MYC/IgH,":[344],"7":[345],"BCL2/IgH,":[346],"6":[348],"BCL6/IgH":[349],"IgL)":[351],"RNA-seq":[353],"allowed":[354],"non-Ig":[358],"partner":[359],"fusions,":[361],"including":[362,376],"RHOH-BCL6,":[363],"ST6GAL1-BCL6,":[364],"GAPDH-BCL6.":[366],"Alterations":[367],"aggregated":[368],"implicated":[372],"pathogenesis,":[375],"chromatin":[377],"modification":[378],"(18%)":[379],"signaling":[382],"(16%).":[383],"More":[384],"than":[385],"ABC-DLBCL":[388],"27%":[390],"GCB-DLBCL":[392],"carry":[393],"somatic":[394],"multiple":[397,478],"regulators":[399],"signaling.":[402],"Intriguingly,":[403],"TP53":[406],"MLL2":[408,503],"occurred":[409],"approximately":[411],"double":[412],"frequency":[414],"reported":[416],"overall":[419,461],"(32%":[420],"vs.":[421],"17%":[422],"47%":[424],"vs":[425],"24%,":[426],"respectively,":[427],"Pasqualucci":[428],"et":[429],"al,":[430],"Nature":[431],"Genetics,":[432],"2011),":[433],"reflecting":[434],"likely":[435],"population":[439],"our":[441],"cohort.":[442],"Conclusions":[443],"demonstrate":[445],"technical":[446],"feasibility":[447],"comprehensive":[449],"FFPE":[456],"specimens,":[457],"low":[460],"failure":[462],"rate":[463],"(1/36":[464],"samples":[465],"DNA,":[467],"2/36":[468],"RNA),":[470],"deep":[471],"simultaneous":[475],"(BCL2,":[480],"BCL6,":[481],"Myc)":[482],"combination":[485],"sequencing.":[490],"additionally":[492],"observe":[493],"potentially":[495],"interesting":[496],"enrichment":[497],"P53":[501],"aggressive":[505],"disease,":[506],"cohort":[508],"expansion":[509],"more":[511],"detailed":[512],"genotype/phenotype":[513],"correlative":[514],"analysis":[515],"ongoing.":[516],"Disclosures:":[517],"Wang:":[518],"Foundation":[519],"Medicine:":[520,523,526,529,544,551],"Employment.":[521,524,527,530,534,538,542,545,549,552],"Nahas:Foundation":[522],"Donahue:Foundation":[525],"He:Foundation":[528],"Otto:Foundation":[531],"Medicine,":[532,540,547],"Inc:":[533,537,541,548],"Lipson:Foundation":[535],"Medincine,":[536],"Yelensky:Foundation":[539],"Ross:Foundation":[543],"Stephens:Foundation":[546],"Miller:Foundation":[550]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2017-03-03T00:00:00"}
