{"id":"https://openalex.org/W2590078482","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e13587","title":"Inhibition of triple-negative breast cancer (TNBC) and breast cancer stem cells (bCSC) by caffeic acid phenethyl ester (CAPE).","display_name":"Inhibition of triple-negative breast cancer (TNBC) and breast cancer stem cells (bCSC) by caffeic acid phenethyl ester (CAPE).","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2590078482","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e13587","mag":"2590078482"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.28.15_suppl.e13587","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e13587","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.e13587","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008527277","display_name":"Coral Oghenerukevwe Omene","orcid":"https://orcid.org/0000-0001-7824-1478","observed_orcids":["https://orcid.org/0000-0001-7824-1478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. O. Omene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J. Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J. A. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068136062","display_name":"Krystyna Frenkel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Frenkel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15_suppl","first_page":"e13587","last_page":"e13587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeic-acid-phenethyl-ester","display_name":"caffeic acid phenethyl ester","score":0.9639999866485596},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9020000100135803},{"id":"https://openalex.org/keywords/breast-cancer-stem-cells","display_name":"breast cancer stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/propolis","display_name":"propolis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mda-mb-231-xenograft","display_name":"MDA-MB-231 xenograft","score":0.8920000195503235},{"id":"https://openalex.org/keywords/topical-therapy","display_name":"topical treatment","score":0.38499999046325684},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.628000020980835},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mammospheres","display_name":"mammospheres","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6430000066757202},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7319999933242798},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mdr","display_name":"MDR","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.546999990940094},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2776992468","wikidata":"https://www.wikidata.org/wiki/Q15410860","display_name":"Caffeic acid phenethyl ester","level":4,"score":0.885170578956604},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7008336186408997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6311887502670288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5267968773841858},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.5240205526351929},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5220577716827393},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5163849592208862},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4624808728694916},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4513399600982666},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.44809678196907043},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.432373046875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39136210083961487},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3267097473144531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30265915393829346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2701483964920044},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.15478277206420898},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12694847583770752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09248432517051697},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.07872173190116882},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2010.28.15_suppl.e13587","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e13587","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.e13587","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030501727","https://openalex.org/W2003962972","https://openalex.org/W2333653506","https://openalex.org/W2592585741","https://openalex.org/W2747412438","https://openalex.org/W2914279563","https://openalex.org/W1183261235","https://openalex.org/W2160404781","https://openalex.org/W2285186294","https://openalex.org/W1984938785"],"abstract_inverted_index":{"e13587":[0],"Background:":[1],"TNBC":[2,71,277],"is":[3,35,130,314],"a":[4,9,18,23,60,73,253,299],"high":[5],"mortality":[6],"disease":[7],"with":[8,27,151,188,244],"paucity":[10],"of":[11,21,45,62,135,186,200,250,274,302,305,308],"therapeutics.":[12,104],"Our":[13,267],"preclinical":[14],"data":[15],"used":[16,57],"CAPE,":[17,33,259],"main":[19],"component":[20],"propolis,":[22],"honeybee":[24],"product":[25],"credited":[26],"antiinflammatory,":[28],"antioxidant,":[29],"and":[30,54,91,119,153,163,165,175,191,221,228,232,337],"antitumor":[31],"properties.":[32],"which":[34],"innocuous":[36],"to":[37,65,77,132,216,257,316,323,331,343],"normal":[38],"human":[39,63],"mammary":[40],"epithelial":[41],"cells,":[42,48,59],"inhibits":[43,116],"growth":[44,118,170,199,227,238,278],"MDA-MB-231":[46],"(231)":[47],"MDR":[49],"gene":[50],"expression,":[51],"NF-kB,":[52],"EGFR":[53],"VEGF.":[55],"We":[56,105,122],"231":[58,142,161,201,211],"model":[61],"TNBC,":[64],"show":[66,106],"that":[67,107,124,271],"CAPE":[68,108,146,152,196,205,223,247,275,296,327],"can":[69],"combat":[70],"as":[72,101,167,234,328],"therapeutic,":[74],"and/or":[75,148,281],"adjuvant":[76],"chemotherapeutic":[78],"drugs":[79],"like":[80],"Taxol.":[81],"Cancer":[82],"stem":[83],"cells":[84,162,212],"(CSC)":[85],"are":[86],"implicated":[87],"in":[88,239,252,318,334],"tumor":[89,209],"metastasis":[90,220],"recurrence,":[92],"thus,":[93],"agents":[94],"impairing":[95],"their":[96,230],"self-renewal,":[97],"could":[98,109,297],"be":[99,110,217,298],"invaluable":[100],"novel":[102],"cancer":[103,310],"such":[111],"an":[112],"agent,":[113],"because":[114],"it":[115,329],"CSC":[117,136,324,335],"self":[120],"renewal.":[121],"propose":[123],"the":[125,133,320,332],"mechanism":[126],"for":[127,219],"this":[128],"inhibition":[129,325],"due":[131],"induction":[134],"apoptosis.":[137,295],"Methods:":[138],"Nude":[139],"mice":[140],"bearing":[141],"xenografts":[143,164],"were":[144,158],"fed":[145],"diets":[147],"treated":[149],"topically":[150],"tumors":[154],"measured":[155],"2x/week.":[156],"bCSC":[157,187,214,225,251,288],"isolated":[159],"from":[160],"propagated":[166],"mammospheres.":[168],"Cell":[169],"was":[171,182,262],"analyzed":[172],"using":[173],"MTT":[174],"cell":[176],"cycle":[177],"by":[178,184,236,279,286,293,326],"flow":[179],"cytometry.":[180],"Apoptosis":[181],"determined":[183],"co-staining":[185],"Annexin":[189],"V":[190],"propidium":[192],"iodide.":[193],"Results:":[194],"Dietary":[195],"significantly":[197],"inhibited":[198,229],"xenografts.":[202],"Subsequent":[203],"topical":[204,282],"treatment":[206],"further":[207],"decreased":[208,224,237,263],"volume.":[210],"contain":[213],"thought":[215],"responsible":[218],"recurrence.":[222],"clonal":[226],"self-renewal":[231,289],"progenitors":[233],"evidenced":[235],"soft":[240],"agar":[241],"after":[242],"pretreatment":[243],"CAPE.":[245],"Further,":[246],"induced":[248],"apoptosis":[249,261],"dose-dependent":[254],"manner":[255],"up":[256],"20\u03bcM":[258],"but":[260],"at":[264,290],"40\u03bcM.":[265],"Conclusions:":[266],"results":[268],"strongly":[269],"suggest":[270],"low":[272],"doses":[273],"reduce":[276],"oral":[280],"routes,":[283],"most":[284],"likely":[285],"suppressing":[287],"least":[291],"partly":[292],"inducing":[294],"powerful":[300],"inhibitor":[301],"CSC-mediated":[303],"recurrence":[304],"aggressive":[306],"types":[307],"breast":[309],"including":[311],"TNBC.":[312],"Research":[313],"ongoing":[315],"delineate":[317],"detail":[319],"mechanism(s)":[321],"contributing":[322],"relates":[330],"changes":[333],"characteristics":[336],"differentiation.":[338],"No":[339],"significant":[340],"financial":[341],"relationships":[342],"disclose.":[344]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-03T00:00:00"}