{"id":"https://openalex.org/W2590002157","doi":"https://doi.org/10.1016/j.bioorg.2017.02.012","title":"Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives","display_name":"Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives","publication_year":2017,"publication_date":"2017-02-21","ids":{"openalex":"https://openalex.org/W2590002157","doi":"https://doi.org/10.1016/j.bioorg.2017.02.012","mag":"2590002157","pmid":"https://pubmed.ncbi.nlm.nih.gov/28242062"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2017.02.012","doi":"https://doi.org/10.1016/j.bioorg.2017.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2017.02.012","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0045206817300330-fx1_lrg.jpg","source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0045206817300330-fx1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082105084","display_name":"\u0130smail Ak\u00e7ok","orcid":"https://orcid.org/0000-0002-5444-3929","observed_orcids":["https://orcid.org/0000-0002-5444-3929"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130smail Ak\u00e7ok","raw_affiliation_strings":["\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: ismailakcok@gmail.com","\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: ismailakcok@gmail.com","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008074406","display_name":"Derya Mete","orcid":"https://orcid.org/0000-0002-9966-0222","observed_orcids":["https://orcid.org/0000-0002-9966-0222"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Derya Mete","raw_affiliation_strings":["\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: deryabostanbas@iyte.edu.tr","\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: deryabostanbas@iyte.edu.tr","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062409344","display_name":"Ayhan \u015een","orcid":"https://orcid.org/0000-0002-1327-4567","observed_orcids":["https://orcid.org/0000-0002-1327-4567"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ayhan \u015een","raw_affiliation_strings":["\u0130zmir Institute of Technology, Faculty of Science, Department of Molecular Biology and Genetics, Urla 35430, \u0130zmir, Turkey. Electronic address: ayhansen65@gmail.com","\u0130zmir Institute of Technology, Faculty of Science, Department of Molecular Biology and Genetics, Urla 35430, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Molecular Biology and Genetics, Urla 35430, \u0130zmir, Turkey. Electronic address: ayhansen65@gmail.com","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Molecular Biology and Genetics, Urla 35430, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065834539","display_name":"P\u0131nar Kasaplar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"P\u0131nar Kasaplar","raw_affiliation_strings":["\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: pinarkasaplar@gmail.com","\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: pinarkasaplar@gmail.com","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078031429","display_name":"Kemal Korkmaz","orcid":"https://orcid.org/0000-0003-4040-2568","observed_orcids":["https://orcid.org/0000-0003-4040-2568"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kemal S. Korkmaz","raw_affiliation_strings":["Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering, Ege University, Bornova, \u0130zmir, Turkey. Electronic address: ks_korkmaz@yahoo.com","Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering, Ege University, Bornova, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering, Ege University, Bornova, \u0130zmir, Turkey. Electronic address: ks_korkmaz@yahoo.com","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering, Ege University, Bornova, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028240343","display_name":"Ali \u00c7a\u011f\u0131r","orcid":"https://orcid.org/0000-0003-0347-6656","observed_orcids":["https://orcid.org/0000-0003-0347-6656"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ali \u00c7a\u011f\u0131r","raw_affiliation_strings":["\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: alicagir@iyte.edu.tr","\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey. Electronic address: alicagir@iyte.edu.tr","institution_ids":["https://openalex.org/I120217413"]},{"raw_affiliation_string":"\u0130zmir Institute of Technology, Faculty of Science, Department of Chemistry, Urla 35430, \u0130zmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028240343"],"corresponding_institution_ids":["https://openalex.org/I120217413"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":0.5845,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60826525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"71","issue":null,"first_page":"275","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.45680001378059387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.45680001378059387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.40700000524520874,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-beta-unsaturated-delta-lactones","display_name":"\u03b1,\u03b2-unsaturated \u03b4-lactones","score":0.9750000238418579},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/racemic-synthesis","display_name":"racemic synthesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibition","display_name":"topoisomerase I inhibition","score":0.8619999885559082},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.6809999942779541},{"id":"https://openalex.org/keywords/heteroatom-substitution","display_name":"heteroatom substitution","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9338643550872803},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7395402193069458},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.682466447353363},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43361419439315796},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3872464895248413},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3686829209327698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3087354600429535},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2122851312160492},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.11023873090744019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bioorg.2017.02.012","doi":"https://doi.org/10.1016/j.bioorg.2017.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2017.02.012","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0045206817300330-fx1_lrg.jpg","source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:28242062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28242062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:gcris.iyte.edu.tr:11147/6369","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11147/6369","pdf_url":"http://gcris.iyte.edu.tr/bitstreams/817943ee-1c3c-492b-bb26-4e3dea82352d/download","source":{"id":"https://openalex.org/S4377196445","display_name":"IYTE GCRIS Database (Izmir Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:openaccess.iyte.edu.tr:11147/6369","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11147/6369","pdf_url":null,"source":{"id":"https://openalex.org/S4306400894","display_name":"\u0130YTE (\u0130ZM\u0130R Y\u00dcKSEK TEKNOLOJ\u0130 ENST\u0130T\u00dcS\u00dc)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bioorg.2017.02.012","doi":"https://doi.org/10.1016/j.bioorg.2017.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2017.02.012","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S0045206817300330-fx1_lrg.jpg","source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6083863281","display_name":null,"funder_award_id":"110T782","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322259","display_name":"\u0130zmir Y\u00fcksek Teknoloji Enstit\u00fcs\u00fc","ror":"https://ror.org/03stptj97"},{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2590002157.pdf","grobid_xml":"https://content.openalex.org/works/W2590002157.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W115080944","https://openalex.org/W1530401629","https://openalex.org/W1978968240","https://openalex.org/W1986861947","https://openalex.org/W1992340564","https://openalex.org/W1993533171","https://openalex.org/W1999748098","https://openalex.org/W1999760120","https://openalex.org/W2005496979","https://openalex.org/W2009876821","https://openalex.org/W2015058407","https://openalex.org/W2022692463","https://openalex.org/W2023835194","https://openalex.org/W2025007043","https://openalex.org/W2035296243","https://openalex.org/W2038351155","https://openalex.org/W2039175138","https://openalex.org/W2047676254","https://openalex.org/W2056460218","https://openalex.org/W2062367950","https://openalex.org/W2073298943","https://openalex.org/W2076234505","https://openalex.org/W2076549897","https://openalex.org/W2077389084","https://openalex.org/W2079092659","https://openalex.org/W2124525518","https://openalex.org/W2146274229","https://openalex.org/W2315970392","https://openalex.org/W2408913764","https://openalex.org/W2953232152"],"related_works":["https://openalex.org/W3080449168","https://openalex.org/W2648874330","https://openalex.org/W6982675673","https://openalex.org/W2054089531","https://openalex.org/W2051724300","https://openalex.org/W2984821361","https://openalex.org/W2473922752","https://openalex.org/W4220959939","https://openalex.org/W2030135253","https://openalex.org/W3033033440"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2017-03-03T00:00:00"}