{"id":"https://openalex.org/W2589984114","doi":"https://doi.org/10.1136/ebmed-2016-110632","title":"Both a stage shift and changes in stage-specific survival have contributed to reductions in breast cancer mortality","display_name":"Both a stage shift and changes in stage-specific survival have contributed to reductions in breast cancer mortality","publication_year":2017,"publication_date":"2017-02-22","ids":{"openalex":"https://openalex.org/W2589984114","doi":"https://doi.org/10.1136/ebmed-2016-110632","mag":"2589984114","pmid":"https://pubmed.ncbi.nlm.nih.gov/28228386"},"language":"en","primary_location":{"id":"doi:10.1136/ebmed-2016-110632","doi":"https://doi.org/10.1136/ebmed-2016-110632","is_oa":false,"landing_page_url":"http://doi.org/10.1136/ebmed-2016-110632","pdf_url":null,"source":{"id":"https://openalex.org/S157733732","display_name":"BMJ Evidence-Based Medicine","issn_l":"1356-5524","issn":["1356-5524","1473-6810","2515-446X","2515-4478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-20","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence Based Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074904688","display_name":"S.W. Duffy","orcid":"https://orcid.org/0000-0003-4901-7922","observed_orcids":["https://orcid.org/0000-0003-4901-7922"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen W Duffy","raw_affiliation_strings":["Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064344218","display_name":"Ruth Etzioni","orcid":"https://orcid.org/0000-0002-9164-6370","observed_orcids":["https://orcid.org/0000-0002-9164-6370"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Etzioni","raw_affiliation_strings":["Fred Hutchinson Cancer Research Centre, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Centre, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025868896","display_name":"Peter David Sasieni","orcid":"https://orcid.org/0000-0003-1509-8744","observed_orcids":["https://orcid.org/0000-0003-1509-8744"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Sasieni","raw_affiliation_strings":["Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1326,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49761505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"22","issue":"2","first_page":"76","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-mortality","display_name":"breast cancer mortality","score":0.9319999814033508},{"id":"https://openalex.org/keywords/screening-mammography","display_name":"mammography screening","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.6439999938011169},{"id":"https://openalex.org/keywords/overdiagnosis","display_name":"overdiagnosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/stage-shift","display_name":"stage shift","score":0.6420000195503235},{"id":"https://openalex.org/keywords/stage-specific-survival","display_name":"stage-specific survival","score":0.9459999799728394},{"id":"https://openalex.org/keywords/breast-cancer-incidence","display_name":"breast cancer incidence","score":0.6240000128746033},{"id":"https://openalex.org/keywords/screening-effectiveness","display_name":"screening effectiveness","score":0.6209999918937683},{"id":"https://openalex.org/keywords/treatment-improvement","display_name":"treatment improvement","score":0.3330000042915344},{"id":"https://openalex.org/keywords/women-over-40","display_name":"women over 40","score":0.7710000276565552},{"id":"https://openalex.org/keywords/case-fatality","display_name":"case fatality","score":0.4659999907016754},{"id":"https://openalex.org/keywords/breast-cancer-incidence-trends","display_name":"breast cancer incidence trends","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2779377019","wikidata":"https://www.wikidata.org/wiki/Q956131","display_name":"Overdiagnosis","level":2,"score":0.8612359762191772},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8022098541259766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7641143202781677},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4778406322002411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46876853704452515},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.46497535705566406},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4548547565937042},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.45463886857032776},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3992632329463959},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34730446338653564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.053278446197509766},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1136/ebmed-2016-110632","doi":"https://doi.org/10.1136/ebmed-2016-110632","is_oa":false,"landing_page_url":"http://doi.org/10.1136/ebmed-2016-110632","pdf_url":null,"source":{"id":"https://openalex.org/S157733732","display_name":"BMJ Evidence-Based Medicine","issn_l":"1356-5524","issn":["1356-5524","1473-6810","2515-446X","2515-4478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-20","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence Based Medicine","raw_type":"journal-article"},{"id":"pmid:28228386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28228386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based medicine","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/a63425b4-a95a-4989-8d13-452c5296bcb3","doi":null,"is_oa":false,"landing_page_url":"https://ebm.bmj.com/content/22/2/76","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Duffy, S W, Etzioni, R & Sasieni, P 2017, 'Both a stage shift and changes in stage-specific survival have contributed to reductions in breast cancer mortality', Evidence-based Medicine, vol. 22, no. 2, pp. 76-76. https://doi.org/10.1136/ebmed-2016-110632","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:open-archive.highwire.org:ebmed:22/2/76","doi":null,"is_oa":false,"landing_page_url":"http://ebm.bmj.com/cgi/content/short/22/2/76","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/25766","doi":null,"is_oa":false,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/25766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3665625494","display_name":null,"funder_award_id":"16892","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G7935303170","display_name":"Estimating Overdiagnosis in Cancer Screening Studies","funder_award_id":"R01CA192402","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2123885847","https://openalex.org/W2155356134","https://openalex.org/W2399727781","https://openalex.org/W2529908594","https://openalex.org/W3170143802","https://openalex.org/W4235739337"],"related_works":["https://openalex.org/W2531066577","https://openalex.org/W2001732456","https://openalex.org/W2045255249","https://openalex.org/W1567193719","https://openalex.org/W2471141161","https://openalex.org/W162781829","https://openalex.org/W1852752264","https://openalex.org/W2912508873","https://openalex.org/W1983438838","https://openalex.org/W2059300111"],"abstract_inverted_index":{"Commentary":[0],"on:":[1],"Welch":[2],"HG,":[3],"Prorok":[4],"PC,":[5],"O'Malley":[6],"AJ,":[7],"et":[8,124],"al.":[9],"Breast-cancer":[10],"tumor":[11],"size,":[12],"overdiagnosis,":[13],"and":[14,44,68,84,92],"mammography":[15],"screening":[16,37,67],"effectiveness.":[17],"N":[18],"Engl":[19],"J":[20],"Med":[21],"2016;375:1438\u201347.[OpenUrl][1][CrossRef][2][PubMed][3]":[22],"Since":[23],"randomised":[24],"trials":[25],"demonstrated":[26],"a":[27,119],"reduction":[28,64],"in":[29,41,51,57,73,87,94,130],"breast":[30,47,81],"cancer":[31,48,82],"mortality":[32,45,63],"with":[33,106],"mammographic":[34],"screening,":[35],"such":[36],"has":[38,49],"become":[39],"widespread":[40],"developed":[42],"countries,":[43],"from":[46],"declined":[50],"recent":[52],"decades.1":[53],"There":[54],"is":[55],"interest":[56],"quantifying":[58],"the":[59,95],"proportion":[60],"of":[61,80],"this":[62],"attributable":[65,70],"to":[66,71,122],"that":[69,128],"improvements":[72],"treatment.":[74],"This":[75],"paper":[76],"reported":[77],"on":[78],"analysis":[79],"incidence":[83],"case":[85,115],"death":[86],"women":[88],"aged":[89],"40":[90],"years":[91],"over":[93],"USA":[96],"by":[97],"tumour":[98],"size.":[99],"The":[100],"authors":[101],"compared":[102],"prescreening":[103],"results":[104],"(1975\u20131979)":[105],"postscreening":[107],"(2008\u20132012":[108],"for":[109,113],"size":[110],"distribution,":[111],"2000\u20132002":[112],"10-year":[114],"death).":[116],"They":[117],"used":[118],"similar":[120],"approach":[121],"Duffy":[123],"al":[125],"2":[126],"positing":[127],"reductions":[129],"\u2026":[131],"[1]:":[132],"{openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D375%26rft.spage%253D1438%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1600249%26rft_id%253Dinfo%253Apmid%252F27732805%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx":[133],"[2]:":[134],"/lookup/external-ref?access_num=10.1056/NEJMoa1600249&link_type=DOI":[135],"[3]:":[136],"/lookup/external-ref?access_num=27732805&link_type=MED&atom=%2Febmed%2F22%2F2%2F76.atom":[137]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-03-03T00:00:00"}