{"id":"https://openalex.org/W2589974507","doi":null,"title":"Small-Molecule Control of Kinesin-5 Proteins","display_name":"Small-Molecule Control of Kinesin-5 Proteins","publication_year":2008,"publication_date":"2008-03-21","ids":{"openalex":"https://openalex.org/W2589974507","mag":"2589974507"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/26579","doi":null,"is_oa":false,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-04012008-102118/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057429714","display_name":"Sarah S. Learman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah Learman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057429714"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinesin-5","display_name":"kinesin-5","score":0.9700000286102295},{"id":"https://openalex.org/keywords/kinesin-motor-protein","display_name":"kinesin motor protein","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mitotic-spindle","display_name":"mitotic spindle","score":0.8809999823570251},{"id":"https://openalex.org/keywords/microtubule-organization","display_name":"microtubule organization","score":0.8389999866485596},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/monastrol","display_name":"monastrol","score":0.984000027179718},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/microtubule-interaction","display_name":"microtubule interaction","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6309999823570251},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.929861307144165},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.44671201705932617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3831924498081207},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34444838762283325},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.33490464091300964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32887667417526245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32513561844825745},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2872772812843323},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11300572752952576}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/26579","doi":null,"is_oa":false,"landing_page_url":"http://scholar.lib.vt.edu/theses/available/etd-04012008-102118/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2589974507","doi":null,"is_oa":false,"landing_page_url":"https://vtechworks.lib.vt.edu/handle/10919/26579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":152,"referenced_works":["https://openalex.org/W130267474","https://openalex.org/W132905495","https://openalex.org/W349165566","https://openalex.org/W1491459594","https://openalex.org/W1507086201","https://openalex.org/W1507388704","https://openalex.org/W1523096427","https://openalex.org/W1540072414","https://openalex.org/W1544844054","https://openalex.org/W1569652852","https://openalex.org/W1569667199","https://openalex.org/W1813351491","https://openalex.org/W1830609257","https://openalex.org/W1931629225","https://openalex.org/W1963665010","https://openalex.org/W1963863239","https://openalex.org/W1964900539","https://openalex.org/W1965404941","https://openalex.org/W1967686200","https://openalex.org/W1969512842","https://openalex.org/W1970012919","https://openalex.org/W1970488202","https://openalex.org/W1970897399","https://openalex.org/W1972989976","https://openalex.org/W1977015596","https://openalex.org/W1977637254","https://openalex.org/W1977666960","https://openalex.org/W1978403135","https://openalex.org/W1979013550","https://openalex.org/W1980022131","https://openalex.org/W1980078657","https://openalex.org/W1985278222","https://openalex.org/W1985367444","https://openalex.org/W1985701763","https://openalex.org/W1986930199","https://openalex.org/W1987280449","https://openalex.org/W1987954645","https://openalex.org/W1987993651","https://openalex.org/W1988366540","https://openalex.org/W1988678729","https://openalex.org/W1991296405","https://openalex.org/W1992637438","https://openalex.org/W1993689973","https://openalex.org/W1995749082","https://openalex.org/W1996396451","https://openalex.org/W1997431426","https://openalex.org/W2001978459","https://openalex.org/W2003766812","https://openalex.org/W2004059254","https://openalex.org/W2004568111","https://openalex.org/W2004934711","https://openalex.org/W2006069089","https://openalex.org/W2006124934","https://openalex.org/W2009009462","https://openalex.org/W2011785555","https://openalex.org/W2014477053","https://openalex.org/W2014827729","https://openalex.org/W2017654147","https://openalex.org/W2018185036","https://openalex.org/W2019912010","https://openalex.org/W2022209597","https://openalex.org/W2024498076","https://openalex.org/W2026250491","https://openalex.org/W2027532431","https://openalex.org/W2027827275","https://openalex.org/W2029178312","https://openalex.org/W2033276495","https://openalex.org/W2033334357","https://openalex.org/W2035472375","https://openalex.org/W2040228024","https://openalex.org/W2040351161","https://openalex.org/W2040781881","https://openalex.org/W2041831801","https://openalex.org/W2042215748","https://openalex.org/W2045518803","https://openalex.org/W2047867647","https://openalex.org/W2049562205","https://openalex.org/W2052132055","https://openalex.org/W2052285203","https://openalex.org/W2052453216","https://openalex.org/W2055497692","https://openalex.org/W2055611040","https://openalex.org/W2056654738","https://openalex.org/W2057523896","https://openalex.org/W2061092318","https://openalex.org/W2061133426","https://openalex.org/W2063760089","https://openalex.org/W2064921309","https://openalex.org/W2064986217","https://openalex.org/W2068328402","https://openalex.org/W2068522691","https://openalex.org/W2071411646","https://openalex.org/W2075277027","https://openalex.org/W2076619368","https://openalex.org/W2077056852","https://openalex.org/W2081721965","https://openalex.org/W2082631326","https://openalex.org/W2083097340","https://openalex.org/W2084158611","https://openalex.org/W2085849675","https://openalex.org/W2086081719","https://openalex.org/W2089340266","https://openalex.org/W2090025948","https://openalex.org/W2090427843","https://openalex.org/W2091566818","https://openalex.org/W2093718967","https://openalex.org/W2099618082","https://openalex.org/W2099687412","https://openalex.org/W2101176165","https://openalex.org/W2101919995","https://openalex.org/W2104643398","https://openalex.org/W2106416580","https://openalex.org/W2108376231","https://openalex.org/W2108887630","https://openalex.org/W2111827360","https://openalex.org/W2115777487","https://openalex.org/W2115833182","https://openalex.org/W2116146706","https://openalex.org/W2116895384","https://openalex.org/W2118722623","https://openalex.org/W2120060428","https://openalex.org/W2121567293","https://openalex.org/W2122450219","https://openalex.org/W2126588926","https://openalex.org/W2126969704","https://openalex.org/W2127762987","https://openalex.org/W2128653554","https://openalex.org/W2132284632","https://openalex.org/W2132917859","https://openalex.org/W2133492742","https://openalex.org/W2134869983","https://openalex.org/W2135416062","https://openalex.org/W2146314877","https://openalex.org/W2146551941","https://openalex.org/W2151687898","https://openalex.org/W2152913480","https://openalex.org/W2155004688","https://openalex.org/W2160059044","https://openalex.org/W2162632054","https://openalex.org/W2163978496","https://openalex.org/W2165419593","https://openalex.org/W2165864728","https://openalex.org/W2166088282","https://openalex.org/W2171884409","https://openalex.org/W2175270698","https://openalex.org/W2181147749","https://openalex.org/W2235700303","https://openalex.org/W2387988997","https://openalex.org/W2407629009","https://openalex.org/W2409773342","https://openalex.org/W2410153161","https://openalex.org/W2605393866"],"related_works":["https://openalex.org/W1964258277","https://openalex.org/W2060127952","https://openalex.org/W1966553673","https://openalex.org/W1949283845","https://openalex.org/W2472051164","https://openalex.org/W1480853534","https://openalex.org/W7146248659","https://openalex.org/W4411275484","https://openalex.org/W3176627018","https://openalex.org/W1985800372"],"abstract_inverted_index":{"Mitosis,":[0],"or":[1,35],"cell":[2,108,170],"division,":[3],"is":[4,12],"the":[5,17,32,37,40,50,64,91,123,154,166,192,240],"mechanism":[6],"by":[7],"which":[8],"cells":[9],"divide":[10],"and":[11,19,67,106,172,196,203],"an":[13],"intricate":[14],"process":[15],"requiring":[16],"action":[18],"control":[20,169],"of":[21,60,96,102,115,149,199,213,225,242],"numerous":[22],"proteins.":[23],"Such":[24,130],"proteins":[25,75,160,202,217],"serve":[26],"either":[27],"as":[28,229,231],"structural":[29],"entities":[30],"within":[31,39,49,63],"mitotic":[33,65,93],"spindle,":[34],"perform":[36],"\"work\"":[38],"apparatus.":[41],"In":[42],"particular,":[43],"Kinesin-5":[44,97,128,136,144,150,201,226],"motor":[45,52],"proteins,":[46],"a":[47,103,112,210,222],"subset":[48],"kinesin":[51],"protein":[53,227],"superfamily,":[54],"are":[55,68],"primarily":[56],"responsible":[57],"for":[58,71],"organization":[59],"microtubules":[61],"(MTs)":[62],"apparatus,":[66],"consequently":[69],"vital":[70],"efficient":[72],"mitosis.":[73],"These":[74],"utilize":[76],"energy":[77],"from":[78],"ATP":[79],"hydrolysis":[80],"in":[81,100,178,219],"order":[82],"to":[83,125,142,156,168,190,209,239],"\"walk\"":[84],"along":[85],"antiparallel":[86],"MTs,":[87],"positioning":[88],"them":[89],"into":[90],"bipolar":[92],"spindle.":[94],"Loss":[95],"activity":[98,195,228],"results":[99],"formation":[101],"monoastral":[104],"spindle":[105],"subsequent":[107],"cycle":[109],"arrest.":[110],"Recently,":[111],"wide":[113],"variety":[114],"small":[116,162,188],"molecules":[117,189],"have":[118,139,175],"been":[119,140],"identified":[120],"that":[121,186,206],"possess":[122],"ability":[124,155],"inhibit":[126],"certain":[127],"motors.":[129],"compounds,":[131,236],"including":[132],"monastrol":[133],"(the":[134],"first":[135],"inhibitor":[137],"identified),":[138],"employed":[141],"study":[143],"activity.":[145],"A":[146],"thorough":[147],"understanding":[148,212],"function,":[151],"combined":[152],"with":[153,161,234],"specifically":[157],"target":[158],"these":[159],"molecules,":[163],"may":[164,173,237],"provide":[165],"capability":[167],"division":[171],"therefore":[174],"significant":[176],"implications":[177],"anti-cancer":[179,247],"therapies.":[180],"The":[181],"following":[182],"dissertation":[183],"describes":[184],"research":[185],"utilizes":[187],"probe":[191],"function":[193,218],"(ATPase":[194],"MT":[197],"interactions)":[198],"various":[200],"provides":[204],"information":[205],"will":[207],"lead":[208,238],"better":[211],"exactly":[214],"how":[215],"such":[216],"vivo.":[220],"Further,":[221],"greater":[223],"knowledge":[224],"well":[230],"specific":[232],"interactions":[233],"small-molecule":[235],"development":[241],"more":[243],"potent,":[244],"less":[245],"toxic":[246],"drugs.":[248]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-03T00:00:00"}
