{"id":"https://openalex.org/W2589533643","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.522","title":"Updated analysis: Observational cohort study of first-line bevacizumab combined with chemotherapy in metastatic colorectal cancer (HGCSG0802)\u2014Sub-group analysis by KRAS Exon2 status.","display_name":"Updated analysis: Observational cohort study of first-line bevacizumab combined with chemotherapy in metastatic colorectal cancer (HGCSG0802)\u2014Sub-group analysis by KRAS Exon2 status.","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2589533643","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.522","mag":"2589533643"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.4_suppl.522","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.522","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.4_suppl.522","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045950776","display_name":"Michio Nakamura","orcid":"https://orcid.org/0000-0002-1509-9811","observed_orcids":["https://orcid.org/0000-0002-1509-9811"]},"institutions":[{"id":"https://openalex.org/I4210147254","display_name":"Sapporo City General Hospital","ror":"https://ror.org/0498kr054","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210147254"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Nakamura","raw_affiliation_strings":["Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210147254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698940","display_name":"Satoshi Yuki","orcid":"https://orcid.org/0000-0002-2039-3062","observed_orcids":["https://orcid.org/0000-0002-2039-3062"]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Yuki","raw_affiliation_strings":["Hokkaido University Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023876278","display_name":"Kentaro Sawada","orcid":"https://orcid.org/0000-0001-7952-2765","observed_orcids":["https://orcid.org/0000-0001-7952-2765"]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Sawada","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073718992","display_name":"Ayane Oba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147254","display_name":"Sapporo City General Hospital","ror":"https://ror.org/0498kr054","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210147254"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayane Oba","raw_affiliation_strings":["Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Sapporo City General Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210147254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104134720","display_name":"Atsushi Sat\u014d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Sato","raw_affiliation_strings":["Department of Medical Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063744320","display_name":"Takashi Kato","orcid":"https://orcid.org/0000-0003-4430-9678","observed_orcids":["https://orcid.org/0000-0003-4430-9678"]},"institutions":[{"id":"https://openalex.org/I4405257923","display_name":"Hokkaido Gastroenterology Hospital","ror":"https://ror.org/05tq2c590","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405257923"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Kato","raw_affiliation_strings":["Department of Internal Medicine, Hokkaido Gastroenterology Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hokkaido Gastroenterology Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4405257923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113541735","display_name":"Takashi Meguro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257923","display_name":"Hokkaido Gastroenterology Hospital","ror":"https://ror.org/05tq2c590","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405257923"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Meguro","raw_affiliation_strings":["Department of Internal Medicine, Hokkaido Gastroenterology Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hokkaido Gastroenterology Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4405257923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013280808","display_name":"Nobuyuki Ehira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284453","display_name":"Japanese Red Cross Kitami Hospital","ror":"https://ror.org/03k1mwm48","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284453"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Ehira","raw_affiliation_strings":["Department of Gastroenterology, Japanese Red Cross Kitami Hospital, Kitami, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Japanese Red Cross Kitami Hospital, Kitami, Japan","institution_ids":["https://openalex.org/I4405284453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102350543","display_name":"Miki Tateyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miki Tateyama","raw_affiliation_strings":["Department of Medical Oncology, Tomakomai Nisshou Hospital, Tomakomai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Tomakomai Nisshou Hospital, Tomakomai, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080229788","display_name":"Kazuteru Hatanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254357","display_name":"Hakodate Municipal Hospital","ror":"https://ror.org/01q9jet09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuteru Hatanaka","raw_affiliation_strings":["Department of Gastroenterology, Hakodate Municipal Hospital, Hakodate, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hakodate Municipal Hospital, Hakodate, Japan","institution_ids":["https://openalex.org/I4405254357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110659379","display_name":"Kazunori Eto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256273","display_name":"Tomakomai City Hospital","ror":"https://ror.org/03znejq22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Eto","raw_affiliation_strings":["Department of Gastroenterology, Tomakomai City Hospital, Tomakomai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tomakomai City Hospital, Tomakomai, Japan","institution_ids":["https://openalex.org/I4405256273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048919337","display_name":"Hiroyuki Okuda","orcid":"https://orcid.org/0000-0001-8452-6189","observed_orcids":["https://orcid.org/0000-0001-8452-6189"]},"institutions":[{"id":"https://openalex.org/I4210124731","display_name":"Keiyukai Sapporo Hospital","ror":"https://ror.org/02thnee40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124731"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Okuda","raw_affiliation_strings":["Department of Medical Oncology, Keiyukai Sapporo Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Keiyukai Sapporo Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210124731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110212518","display_name":"Yoshimitsu Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimitsu Kobayashi","raw_affiliation_strings":["Hokkaido University Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053092940","display_name":"Osamu Muto","orcid":"https://orcid.org/0000-0003-3965-1962","observed_orcids":["https://orcid.org/0000-0003-3965-1962"]},"institutions":[{"id":"https://openalex.org/I4210135494","display_name":"Akita Red Cross Hospital","ror":"https://ror.org/043h2w593","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210135494"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Muto","raw_affiliation_strings":["Department of Medical Oncology, Japanese Red Cross Akita Hospital, Akita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Japanese Red Cross Akita Hospital, Akita, Japan","institution_ids":["https://openalex.org/I4210135494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103160157","display_name":"Masakazu Ab\u00e9","orcid":"https://orcid.org/0000-0002-8508-3997","observed_orcids":["https://orcid.org/0000-0002-8508-3997"]},"institutions":[{"id":"https://openalex.org/I4210121725","display_name":"Sapporo Kosei General Hospital","ror":"https://ror.org/029jhw134","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210121725"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Abe","raw_affiliation_strings":["Department of Medical Oncology, Sapporo Kosei General Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Sapporo Kosei General Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210121725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108789136","display_name":"Kanji Kato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanji Kato","raw_affiliation_strings":["Department of Gastroenterology, Iwamizawa Municipal General Hospital, Iwamizawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Iwamizawa Municipal General Hospital, Iwamizawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103529757","display_name":"Mineo Kudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113341","display_name":"Sapporo Hokuyu Hospital","ror":"https://ror.org/024czvm93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210113341"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mineo Kudo","raw_affiliation_strings":["Department of Gastroenterology, Sapporo Hokuyu Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Sapporo Hokuyu Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210113341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109053899","display_name":"Kencho Miyashita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kencho Miyashita","raw_affiliation_strings":["Department of Gastroenterology, Aiiku Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Aiiku Hospital, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109310451","display_name":"Yuh Sakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112590","display_name":"Misawa City Hospital","ror":"https://ror.org/02ahcqm31","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210112590"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuh Sakata","raw_affiliation_strings":["Misawa City Hospital, Misawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Misawa City Hospital, Misawa, Japan","institution_ids":["https://openalex.org/I4210112590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054182211","display_name":"Yoshito Komatsu","orcid":"https://orcid.org/0000-0002-1570-6802","observed_orcids":["https://orcid.org/0000-0002-1570-6802","https://orcid.org/0000-0001-5448-6403"]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshito Komatsu","raw_affiliation_strings":["Hokkaido University Hospital Cancer Center, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University Hospital Cancer Center, Sapporo, Japan","institution_ids":["https://openalex.org/I4210141669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"4_suppl","first_page":"522","last_page":"522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9750000238418579},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/kras-exon-2-mutation","display_name":"KRAS exon 2 mutation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8399999737739563},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.5730000138282776},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.6579999923706055},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.625},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7229999899864197},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6309999823570251},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.6069999933242798},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.6940000057220459},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.3330000042915344},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9398670196533203},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8465442657470703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7734465599060059},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.741748571395874},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6035423278808594},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5126342177391052},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48216456174850464},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4692269265651703},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.46915900707244873},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4370863437652588},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.43340760469436646},{"id":"https://openalex.org/C191093355","wikidata":"https://www.wikidata.org/wiki/Q9250577","display_name":"Exact test","level":2,"score":0.41223251819610596},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38838377594947815},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3748738467693329},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.34680330753326416},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32746729254722595},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.325047105550766}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.4_suppl.522","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.522","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.4_suppl.522","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2589568546","https://openalex.org/W2590570006","https://openalex.org/W2034020560","https://openalex.org/W2054122365","https://openalex.org/W2591156492","https://openalex.org/W2601520795","https://openalex.org/W2525371782","https://openalex.org/W2891098128","https://openalex.org/W2589301513","https://openalex.org/W2080651866"],"abstract_inverted_index":{"522":[0],"Background:":[1],"A":[2],"few":[3],"reports":[4],"have":[5],"shown":[6],"the":[7,14,28,285,309],"efficacy":[8],"of":[9,13,51],"bevacizumab":[10,327],"(BV)":[11],"independent":[12],"KRAS":[15,26,139,256,286,310,315],"Exon2":[16,287,311,316],"mutational":[17,288,317],"status":[18,318],"(KRAS).":[19],"We":[20],"performed":[21,105,112],"a":[22,321],"sub-group":[23],"analysis":[24,99,127,299],"by":[25],"from":[27],"HGCSG0802":[29,52],"observational":[30],"cohort":[31],"study":[32],"that":[33,301],"investigated":[34],"115":[35],"patients":[36],"(pts)":[37],"treated":[38],"with":[39,72,113,154,157],"1st":[40,329],"line":[41,330],"BV":[42,200],"for":[43,100,133,163,205],"metastatic":[44],"colorectal":[45],"cancer":[46],"(mCRC).":[47],"Methods:":[48],"The":[49,67,149,218,297],"objective":[50],"was":[53,188,223],"to":[54,199],"evaluate":[55],"progression-free":[56],"survival":[57,60],"(PFS),":[58],"overall":[59],"(OS),":[61],"response":[62],"rate":[63],"(RR),":[64],"and":[65,88,97,102,116,142,156,175,221,225,232,244,262,271,303,323],"safety.":[66],"key":[68],"eligibility":[69],"criteria":[70],"were":[71,90,104,111,131,159,201,293,305],"evaluable":[73,132],"lesions,":[74],"older":[75],"than":[76],"20":[77],"years,":[78],"ECOG":[79],"PS":[80,164],"0-2.":[81],"In":[82,252,280],"this":[83,281],"analysis,":[84,255],"pts":[85,124,130,136,144,150],"characteristics,":[86],"RR":[87,187],"safety":[89],"compared":[91],"using":[92,106],"Fisher\u2019s":[93],"exact":[94],"test.":[95],"Univariate":[96],"multivariate":[98,254,298],"PFS":[101,220,261,302],"OS":[103,222,245,263,272,304],"patient":[107],"characteristics.":[108],"Survival":[109],"analyses":[110],"Kaplan-Meier":[114],"method":[115],"Cox":[117,253],"proportional":[118],"hazards":[119],"model.":[120],"Results:":[121],"Of":[122],"108":[123],"(the":[125],"full":[126],"set),":[128],"99":[129],"KRAS.":[134],"Sixty-two":[135],"(62.6%)":[137],"had":[138,146],"wild-type":[140,312],"(wt)":[141],"37":[143],"(37.4%)":[145],"mutation":[147],"(mt).":[148],"characteristics":[151],"between":[152],"those":[153],"wt":[155,191,229],"mt":[158,236,257],"generally":[160],"balanced":[161,203],"except":[162,204],"0":[165],"(91.9%":[166],"in":[167,170,179,182,190,194,210,213,228,235,308,326],"wt,":[168,180,211],"75.7%":[169],"mt;":[171,183,214],"p":[172,184,215,241,249,268,276],"=":[173,185,216,242,250,269,277],"0.036)":[174],"lung":[176],"metastasis":[177],"(33.9%":[178],"62.2%":[181],"0.007).":[186],"70.0%":[189],"versus":[192,230],"65.7%":[193],"mt.":[195],"Adverse":[196],"events":[197,292],"related":[198],"almost":[202],"bleeding":[206],"(any":[207],"grade)":[208],"(30.6%":[209],"13.5%":[212],"0.088).":[217],"median":[219],"9.9":[224],"26.8":[226],"months":[227,234],"7.9":[231],"17.5":[233],"(PFS":[237,264],";":[238,246,265,273],"HR":[239,247,266,274],"1.519,":[240],"0.064":[243],"1.944,":[248],"0.005).":[251,278],"showed":[258,300],"significantly":[259,306],"shorter":[260],"1.637,":[267],"0.045":[270],"2.132,":[275],"Conclusions:":[279],"cohort,":[282],"depending":[283],"on":[284],"status,":[289],"severe":[290],"adverse":[291],"no":[294],"significant":[295],"difference.":[296],"longer":[307],"patients.":[313],"So,":[314],"can":[319],"be":[320],"predictive":[322],"prognostic":[324],"marker":[325],"combined":[328],"chemotherapy.":[331],"Clinical":[332],"trial":[333],"information:":[334],"UMIN000018935.":[335]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2017-03-03T00:00:00"}