{"id":"https://openalex.org/W2589532994","doi":"https://doi.org/10.1182/blood.v120.21.3650.3650","title":"Full Dose Bendamustine (Treanda \u00ae) Can Be Safely Combined with Rituximab, Etoposide and Carboplatin (TREC): Results of a Phase I Trial in Patients with Relapsed or Refractory Lymphoma","display_name":"Full Dose Bendamustine (Treanda \u00ae) Can Be Safely Combined with Rituximab, Etoposide and Carboplatin (TREC): Results of a Phase I Trial in Patients with Relapsed or Refractory Lymphoma","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2589532994","doi":"https://doi.org/10.1182/blood.v120.21.3650.3650","mag":"2589532994"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.3650.3650","doi":"https://doi.org/10.1182/blood.v120.21.3650.3650","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.3650.3650","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082326885","display_name":"Lihua Elizabeth Budde","orcid":"https://orcid.org/0000-0003-1464-5494","observed_orcids":["https://orcid.org/0000-0003-1464-5494"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua Elizabeth Budde","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059661907","display_name":"Andrei R. Shustov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shustov R Andrei","raw_affiliation_strings":["Hematology, University of Washington, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, University of Washington, Seattle, WA, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103736457","display_name":"Gooley Ted","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gooley Ted","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008481093","display_name":"Tara L. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara L Chen","raw_affiliation_strings":["Pharmacy Services, University of Washington Medical Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Services, University of Washington Medical Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I2801852214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084492085","display_name":"Edward N. Libby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward N. Libby","raw_affiliation_strings":["Seattle Cancer Care Alliance, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA, USA,","institution_ids":["https://openalex.org/I1332479046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748961","display_name":"Maria Corinna Palanca-Wessels","orcid":"https://orcid.org/0000-0001-6187-3655","observed_orcids":["https://orcid.org/0000-0001-6187-3655"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Corinna Palanca-Wessels","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049229364","display_name":"Mary Philip","orcid":"https://orcid.org/0000-0001-7496-2630","observed_orcids":["https://orcid.org/0000-0001-7496-2630"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Philip","raw_affiliation_strings":["Medicine/Hematology, University of Washington, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine/Hematology, University of Washington, Seattle, WA, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103742696","display_name":"Daniel B. Martin","orcid":"https://orcid.org/0000-0001-8693-6528","observed_orcids":["https://orcid.org/0000-0001-8693-6528"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel B. Martin","raw_affiliation_strings":["Hematology, University of Washington, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, University of Washington, Seattle, WA, USA,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071844603","display_name":"Ryan Daniel Cassaday","orcid":"https://orcid.org/0000-0002-3424-2425","observed_orcids":["https://orcid.org/0000-0002-3424-2425"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Cassaday","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077272360","display_name":"Kiarash Kojouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800475362","display_name":"Skagit Valley Hospital","ror":"https://ror.org/04p3ja862","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800475362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiarash Kojouri","raw_affiliation_strings":["Skagit Valley Hospital Regional Cancer Care Center, Mount Vernon, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skagit Valley Hospital Regional Cancer Care Center, Mount Vernon, WA, USA,","institution_ids":["https://openalex.org/I2800475362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023180146","display_name":"Oliver W. Press","orcid":"https://orcid.org/0000-0002-3147-8037","observed_orcids":["https://orcid.org/0000-0002-3147-8037"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oliver W. Press","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004025497","display_name":"Ajay K. Gopal","orcid":"https://orcid.org/0000-0003-3023-6834","observed_orcids":["https://orcid.org/0000-0003-3023-6834"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay K. Gopal","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42444404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"21","first_page":"3650","last_page":"3650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bendamustine","display_name":"bendamustine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.7300000190734863},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":1.0},{"id":"https://openalex.org/keywords/salvage-chemotherapy","display_name":"salvage chemotherapy","score":0.6620000004768372},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7570000290870667},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.7699999809265137},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/outpatient-chemotherapy","display_name":"outpatient chemotherapy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/g-csf-support","display_name":"G-CSF support","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cd20-positive-lymphoma","display_name":"CD20-positive lymphoma","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2781442060","wikidata":"https://www.wikidata.org/wiki/Q425745","display_name":"Bendamustine","level":4,"score":0.9115333557128906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8161894083023071},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.6472627520561218},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.5861687064170837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5647634267807007},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5339471101760864},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.5336383581161499},{"id":"https://openalex.org/C2777506904","wikidata":"https://www.wikidata.org/wiki/Q418560","display_name":"Ifosfamide","level":4,"score":0.5255818963050842},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48790690302848816},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.41767364740371704},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.4174467921257019},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33316245675086975},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.30669593811035156},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2476283311843872},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.1059369146823883}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.3650.3650","doi":"https://doi.org/10.1182/blood.v120.21.3650.3650","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.3650.3650","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2600734384","https://openalex.org/W2891826085","https://openalex.org/W6996178652","https://openalex.org/W1506536968","https://openalex.org/W636969194","https://openalex.org/W2515768560","https://openalex.org/W2093121143","https://openalex.org/W2594808694","https://openalex.org/W2559378733","https://openalex.org/W3000154643"],"abstract_inverted_index":{"Abstract":[0,1],"3650":[2],"Background:":[3],"Traditional":[4],"salvage":[5,102],"strategies":[6],"for":[7,105,254,267,563,576],"relapsed":[8,108],"lymphoma":[9,59,116,377,404],"are":[10,525,530,583],"less":[11],"effective":[12,574],"when":[13],"disease":[14,256,369,420],"recurs":[15],"after":[16],"modern":[17],"front":[18],"line":[19],"therapies":[20,347],"(e.g.":[21],"R-CHOP,":[22],"BEACOPP).":[23],"Furthermore,":[24],"typical":[25],"multi-agent":[26,101],"regimens":[27],"require":[28],"inpatient":[29],"hospitalization":[30],"and":[31,46,60,147,153,215,230,250,324,354,402,413,450,464,471,477,527,579,604],"carry":[32],"the":[33,71,93,161,212,312,427,494,507,547,560],"risk":[34],"of":[35,73,78,131,160,171,181,203,217,288,296,480,497,515,535,557,590],"significant":[36],"non-hematologic":[37,190,431],"toxicity":[38,178,572],"from":[39,220],"drugs":[40],"such":[41],"as":[42,76,187],"ifosfamide,":[43],"high-dose":[44],"cytarabine,":[45],"cisplatin.":[47],"Bendamustine":[48],"(Treanda":[49],"\u00ae,":[50],"T)":[51],"has":[52],"both":[53],"broad":[54],"spectrum":[55],"clinical":[56],"activity":[57],"in":[58,211,232,321,326,426,439,457,469,488,600],"a":[61,79,97,166,175,281,293,511],"moderate":[62],"side":[63],"effect":[64],"profile,":[65,573],"though":[66],"limited":[67],"data":[68,582,586],"exist":[69],"on":[70,227,239,245,258],"utility":[72],"this":[74],"agent":[75],"part":[77],"dose-intense":[80],"rescue":[81],"approach.":[82],"We,":[83],"thus,":[84],"hypothesized":[85],"that":[86],"bendamustine":[87,172,218],"could":[88],"safely":[89,550],"supplant":[90],"ifosfamide":[91,552],"within":[92],"RICE":[94],"regimen":[95,358,562],"yielding":[96,559],"feasible,":[98],"effective,":[99],"outpatient":[100,213,428,569],"strategy":[103],"(TREC)":[104],"patients":[106,290,317,367,409,459,524,564,601],"with":[107,174,234,272,329,461,510,553,565,602],"or":[109,119,196,262],"refractory":[110,355],"lymphoma.":[111,567],"Methods:":[112],"Eligibility":[113],"included:":[114],"relapsed/refractory":[115,566],"(untreated":[117],"T-NHL":[118,394],"MCL":[120],"was":[121,163,185,209,283,301,486],"allowed":[122],"during":[123],"stage":[124,322,327],"1),":[125,241],"age":[126,337],"\u226518":[127],"years,":[128,344],"performance":[129],"status":[130],"0\u20132,":[132],"measurable":[133],"disease,":[134],"no":[135,150,154,330],"active":[136,151],"CNS":[137],"involvement,":[138],"ANC":[139],"3":[140,143,435],"1,500/\u03bcL,":[141],"platelets":[142],"100,000/\u03bcL,":[144],"adequate":[145],"hepatic":[146],"renal":[148],"function,":[149],"arrhythmias,":[152],"known":[155],"HIV.":[156],"The":[157,442,568],"primary":[158],"objective":[159],"study":[162],"to":[164,198,206,223,248,269,292,356,419,549],"define":[165],"maximally":[167],"tolerated":[168],"dose":[169,176,277,295],"(MTD)":[170],"associated":[173],"limiting":[177],"(DLT)":[179],"rate":[180],"\u226425%.":[182],"A":[183],"DLT":[184,282],"defined":[186],"any":[188],"related":[189,445],"grade":[191,434],"\u22654":[192],"adverse":[193],"event":[194],"(AE),":[195],"inability":[197],"complete":[199],"one":[200,414],"full":[201],"cycle":[202,417,496],"therapy":[204],"due":[205,418],"toxicity.":[207],"Therapy":[208],"delivered":[210],"setting":[214],"consisted":[216],"ranging":[219],"60":[221],"mg/m2":[222,225,244],"120":[224],"daily":[226],"days":[228,246,266],"1":[229,247,349,416],"2":[231,261,270,328,411,518,556],"combination":[233],"carboplatin":[235],"(AUC":[236],"=":[237,338,348,359,380,387,392,396,400,406],"5":[238],"day":[240,260],"etoposide":[242],"(100":[243],"3)":[249,263],"rituximab":[251],"(375":[252],"mg/m2,":[253],"CD20+":[255],"only":[257],"either":[259],"every":[264],"21":[265],"up":[268,291,514],"cycles":[271,412,423],"G-CSF":[273],"support.":[274],"Single":[275],"patient":[276],"escalation":[278],"occurred":[279],"until":[280],"observed,":[284],"followed":[285],"by":[286,303],"cohorts":[287,596],"4":[289,320],"maximum":[294],"120mg/m2":[297,554],"\u00d7":[298,555],"2.":[299],"Response":[300,467],"measured":[302],"standard":[304],"criteria":[305],"(Cheson":[306],"2007).":[307],"AEs":[308,432],"were":[309,318,424,437,447,455,473],"graded":[310],"using":[311],"CTCAE":[313],"v4.0":[314],"Results:":[315],"Twenty-four":[316],"treated,":[319],"1,":[323],"20":[325],"DLTs":[331],"observed.":[332],"Baseline":[333],"features":[334],"included":[335,375],"median":[336,345,512],"58":[339],"(range":[340,350,517],"18":[341],"\u2013":[342,352,504,519],"72)":[343],"prior":[346,372],"0":[351],"2),":[353,393,397,401],"last":[357,508],"16":[360,458],"(of":[361],"22":[362],"evaluable,":[363],"73%).":[364],"All":[365,422],"B-NHL":[366],"had":[368],"progression":[370,531],"following":[371,493],"rituximab.":[373],"Histologies":[374],"Hodgkin":[376],"(HL,":[378],"n":[379,386],"8),":[381],"diffuse":[382],"large":[383],"B-cell":[384],"(DLBCL,":[385],"9),":[388],"mantle":[389],"cell":[390],"(n":[391,395,399,405],"follicular":[398],"lymphoplasmacytic":[403],"1).":[407],"Twenty-three":[408],"received":[410,415],"progression.":[421],"given":[425],"settings.":[429],"Thirteen":[430],"\u2265":[433],"(SAEs)":[436],"observed":[438,456],"9":[440,462],"patients.":[441],"most":[443],"common":[444],"SAEs":[446],"dehydration":[448],"(2),":[449],"febrile":[451],"neutropenia":[452],"(2).":[453],"Responses":[454],"(67%)":[460],"CR,":[463],"7":[465],"PR.":[466],"rates":[468],"HL":[470],"DLBCL":[472,603],"88%":[474],"(6CR,":[475],"1PR),":[476],"56%.":[478],"Mobilization":[479],"peripheral":[481],"blood":[482],"stem":[483],"cells":[484],"(PBSC)":[485],"successful":[487],"all":[489],"15":[490],"attempts":[491],"immediately":[492],"second":[495],"T(R)EC":[498],"(median":[499],"yield:":[500],"5.58\u00d7106CD34/kg,":[501],"range":[502],"3.96":[503],"11.68).":[505],"At":[506],"update":[509],"follow":[513],"8":[516],"18)":[520],"months,":[521],"19":[522],"(79%)":[523],"alive,":[526],"13":[528],"(54%)":[529],"free,":[532],"including":[533,592],"10":[534],"12":[536],"who":[537],"subsequently":[538],"underwenttransplant.":[539],"Conclusions:":[540],"This":[541],"multicenter":[542],"phase":[543],"I":[544],"trial":[545],"confirms":[546],"ability":[548],"replace":[551],"bendamustine,":[558],"TREC":[561],"administration,":[570],"manageable":[571],"use":[575],"PBSC":[577],"mobilization,":[578],"preliminary":[580],"response":[581],"encouraging.":[584],"These":[585],"support":[587],"future":[588],"evaluation":[589],"TREC,":[591],"our":[593],"ongoing":[594],"expansion":[595],"further":[597],"investigating":[598],"outcomes":[599],"HL.":[605],"Disclosures:":[606],"Budde:":[607],"Teva:":[608],"Research":[609,612],"Funding.":[610,613],"Gopal:TEVA:":[611]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-03-03T00:00:00"}
