{"id":"https://openalex.org/W2589370262","doi":"https://doi.org/10.1200/jco.2014.32.31_suppl.191","title":"Preliminary results from a phase I study of substance P-saporin in terminal cancer patients with intractable pain.","display_name":"Preliminary results from a phase I study of substance P-saporin in terminal cancer patients with intractable pain.","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2589370262","doi":"https://doi.org/10.1200/jco.2014.32.31_suppl.191","mag":"2589370262"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.31_suppl.191","doi":"https://doi.org/10.1200/jco.2014.32.31_suppl.191","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.31_suppl.191","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085248404","display_name":"Arthur E. Frankel","orcid":"https://orcid.org/0000-0001-6201-8802","observed_orcids":["https://orcid.org/0000-0001-6201-8802"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur E. Frankel","raw_affiliation_strings":["The University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077390750","display_name":"Hugh Nymeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugh Nymeyer","raw_affiliation_strings":["The University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082922778","display_name":"Douglas A. Lappi","orcid":"https://orcid.org/0000-0003-4239-7387","observed_orcids":["https://orcid.org/0000-0003-4239-7387"]},"institutions":[{"id":"https://openalex.org/I4210105971","display_name":"Advanced Targeting Systems (United States)","ror":"https://ror.org/01tzmft44","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105971"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A. Lappi","raw_affiliation_strings":["Advanced Targeting Systems, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Targeting Systems, San Diego, CA","institution_ids":["https://openalex.org/I4210105971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028849975","display_name":"Denise Higgins","orcid":"https://orcid.org/0000-0002-5274-7494","observed_orcids":["https://orcid.org/0000-0002-5274-7494"]},"institutions":[{"id":"https://openalex.org/I4210105971","display_name":"Advanced Targeting Systems (United States)","ror":"https://ror.org/01tzmft44","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105971"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Higgins","raw_affiliation_strings":["Advanced Targeting Systems, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Targeting Systems, San Diego, CA","institution_ids":["https://openalex.org/I4210105971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026905234","display_name":"Chul Woo Ahn","orcid":"https://orcid.org/0000-0002-2997-9203","observed_orcids":["https://orcid.org/0000-0002-2997-9203"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chul Ahn","raw_affiliation_strings":["The University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018576610","display_name":"Carl Edward Noe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Noe","raw_affiliation_strings":["McDermott Center for Pain Management, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McDermott Center for Pain Management, Dallas, TX","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"31_suppl","first_page":"191","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.3732999861240387,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intractable-cancer-pain","display_name":"intractable cancer pain","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neurokinin-1-receptor","display_name":"neurokinin-1 receptor","score":0.6840000152587891},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.5049999952316284},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.7620000243186951},{"id":"https://openalex.org/keywords/targeted-toxins","display_name":"targeted toxins","score":0.7369999885559082},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.39500001072883606},{"id":"https://openalex.org/keywords/terminally-ill-cancer-patients","display_name":"terminal cancer patients","score":0.6209999918937683},{"id":"https://openalex.org/keywords/bone-pain","display_name":"bone pain","score":0.39899998903274536},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.6029999852180481},{"id":"https://openalex.org/keywords/allodynia","display_name":"allodynia","score":0.4950000047683716},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.7009999752044678},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.5720000267028809},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.3199999928474426},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8149313926696777},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.7153558135032654},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.49654608964920044},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.4901912808418274},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.46602392196655273},{"id":"https://openalex.org/C157820659","wikidata":"https://www.wikidata.org/wiki/Q1320251","display_name":"Intrathecal","level":2,"score":0.4475652277469635},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4238319993019104},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33815014362335205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3129904270172119},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29008567333221436},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.20668381452560425}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2014.32.31_suppl.191","doi":"https://doi.org/10.1200/jco.2014.32.31_suppl.191","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.31_suppl.191","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982110011","https://openalex.org/W2049912867","https://openalex.org/W2408938541","https://openalex.org/W2085739574","https://openalex.org/W1976105490","https://openalex.org/W1974004037","https://openalex.org/W1973434522","https://openalex.org/W4388166241","https://openalex.org/W2045091557","https://openalex.org/W2004197608"],"abstract_inverted_index":{"191":[0],"Background:":[1],"For":[2],"10-15%":[3],"of":[4,60,82,100,181,186,203,228,237,245,258,316,323],"cancer":[5,246],"patients,":[6],"pain":[7,188,217,274,336],"cannot":[8],"be":[9],"controlled":[10],"using":[11],"existing":[12,342],"therapies":[13],"(Zech":[14],"et":[15,107,114,121,129,150,164],"al.,":[16,108,115,122,130,151,165],"Pain,":[17],"63,":[18],"65-76,":[19],"1995).":[20],"SP-SAP":[21,34,83,182,238,300,347],"is":[22,239,355],"the":[23,61,78,140,184,242,309,312,317],"first":[24,313],"targeted":[25],"toxin":[26,69],"to":[27,52,222],"undergo":[28],"phase":[29,318],"I":[30,57,319],"testing":[31],"for":[32,146,160,183,293,302,335,350],"pain.":[33,251],"(Wiley":[35],"and":[36,58,64,76,94,192,266,284,286,296,299],"Lappi,":[37],"Neurosci":[38],"Lett,":[39],"230,":[40],"97-100,":[41],"1997)":[42],"covalently":[43],"linkes":[44],"substance":[45],"P":[46],"(SP),":[47],"a":[48,67,200],"neuromodulator":[49],"that":[50,70,73,199],"binds":[51],"NK1":[53,75],"receptors":[54],"on":[55],"laminae":[56],"X":[59],"dorsal":[62],"horn,":[63],"saporin":[65],"(SAP),":[66],"ribosomal":[68],"ablates":[71],"cells":[72],"express":[74],"endocytose":[77],"toxin.":[79],"Intrathecal":[80],"injections":[81,138],"in":[84,189],"rats":[85],"reduce":[86],"chemically":[87],"or":[88,103,157,175,209,226,325,327],"thermally":[89],"induced":[90],"pain,":[91],"thermal":[92],"hyperalgesia,":[93],"mechanical":[95],"allodynia,":[96],"with":[97,248,357],"no":[98,172],"signs":[99],"motor,":[101],"sensory,":[102],"behavioral":[104],"dysfunction":[105],"(Mantyh":[106],"Science,":[109,116],"278,":[110],"275-9,":[111],"1997;":[112],"Nichols":[113],"286,":[117],"1558-61,":[118],"1999;":[119],"Suzuki":[120],"Nature":[123],"Neurosci,":[124,131],"5,":[125],"139-26,":[126],"2002;":[127],"Vierck":[128],"199,":[132,195],"223-32,":[133],"2003).":[134],"In":[135],"canines,":[136],"intrathecal":[137,235],"into":[139],"lumbar":[141],"region":[142],"\u2013":[143,170],"45":[144],"mcg":[145,159,205,211],"10-15":[147],"kg":[148,162],"(Allen":[149],"Toxicol":[152],"Sci,":[153],"91,":[154],"286-98,":[155],"2006)":[156],"15":[158],"8-12":[161],"(Wiese":[163],"Anesthesiol,":[166,194],"119,":[167],"1163-77,":[168],"2013)":[169,197],"produce":[171],"neurological,":[173],"behavioral,":[174],"histological":[176],"deficits.":[177],"A":[178,233],"double-blinded":[179],"RCT":[180],"treatment":[185],"bone":[187],"canines":[190,229],"(Brown":[191],"Agnello,":[193],"1178-85,":[196],"showed":[198],"single":[201,234],"injection":[202,236],"60":[204],"(above":[206],"30":[207,213],"kg)":[208,214],"40":[210],"(below":[212],"significantly":[215],"reduced":[216],"as":[218],"measured":[219],"by":[220,273],"time":[221],"owner":[223],"unblinding":[224],"(p=0.002)":[225],"number":[227],"unblended":[230],"(p=0.001).":[231],"Methods:":[232],"made":[240],"at":[241,256],"L5-S1":[243],"interspace":[244],"patients":[247],"intractable":[249],"sub-umbilical":[250],"Single":[252],"subject":[253],"cohorts":[254],"are":[255,271,291],"doses":[257,343],"1,":[259],"2,":[260],"4,":[261],"8,":[262],"16,":[263],"32,":[264],"64,":[265],"90":[267],"mcg.":[268],"Primary":[269],"outcomes":[270],"assessed":[272],"survey":[275],"(VAS":[276],"\u201cbothersome":[277],"pain\u201d,":[278],"VAS":[279],"\u201cpain":[280],"intensity\u201d,":[281],"ODI,":[282],"EQ-5D,":[283],"BDI)":[285],"medication":[287],"use":[288],"log.":[289],"Patients":[290],"monitored":[292],"toxicity,":[294],"neurological":[295,326],"cardiac":[297,328],"abnormalities,":[298],"antibodies":[301],"6":[303],"months.":[304],"Results:":[305],"This":[306],"report":[307],"presents":[308],"results":[310],"from":[311],"three":[314],"subjects":[315],"study.":[320],"No":[321,332],"evidence":[322,334],"toxicity":[324],"abnormalities":[329],"were":[330],"found.":[331],"clear":[333],"reduction":[337],"was":[338],"observed.":[339],"Conclusions:":[340],"At":[341],"(<":[344],"4":[345],"mcg),":[346],"appears":[348],"safe":[349],"human":[351],"use.":[352],"The":[353],"study":[354],"continuing":[356],"dose":[358],"escalation.":[359],"Clinical":[360],"trial":[361],"information:":[362],"NCT02036281.":[363]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}