{"id":"https://openalex.org/W2589346271","doi":"https://doi.org/10.1200/jco.2011.29.4_suppl.374","title":"Role of obesity in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas.","display_name":"Role of obesity in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas.","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W2589346271","doi":"https://doi.org/10.1200/jco.2011.29.4_suppl.374","mag":"2589346271"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.4_suppl.374","doi":"https://doi.org/10.1200/jco.2011.29.4_suppl.374","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.4_suppl.374","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/7xp62201","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112774793","display_name":"Bruce Shih-Li Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. S. Lin","raw_affiliation_strings":["University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005918843","display_name":"Jason A. Zell","orcid":"https://orcid.org/0000-0003-2661-904X","observed_orcids":["https://orcid.org/0000-0003-2661-904X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Zell","raw_affiliation_strings":["University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045617341","display_name":"Nikki Madson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Madson","raw_affiliation_strings":["University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103071787","display_name":"Christine E. McLaren","orcid":"https://orcid.org/0000-0002-7932-9903","observed_orcids":["https://orcid.org/0000-0002-7932-9903"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. E. McLaren","raw_affiliation_strings":["University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108364106","display_name":"Eugene W. Gerner","orcid":"https://orcid.org/0000-0002-9906-8501","observed_orcids":["https://orcid.org/0000-0002-9906-8501"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. W. Gerner","raw_affiliation_strings":["University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060872059","display_name":"Frank Louis Meyskens","orcid":"https://orcid.org/0000-0002-8827-4334","observed_orcids":["https://orcid.org/0000-0002-8827-4334"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. L. Meyskens","raw_affiliation_strings":["University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Orange, CA; Gastrointestinal Cancer Program, Arizona Cancer Center, Tucson, AZ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"4_suppl","first_page":"374","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.11320000141859055,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/difluoromethylornithine","display_name":"difluoromethylornithine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/sulindac","display_name":"sulindac","score":0.9900000095367432},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8519999980926514},{"id":"https://openalex.org/keywords/metachronous-adenomas","display_name":"metachronous adenomas","score":0.8190000057220459},{"id":"https://openalex.org/keywords/adenoma-recurrence","display_name":"adenoma recurrence","score":0.7889999747276306},{"id":"https://openalex.org/keywords/high-risk-adenomas","display_name":"high-risk adenomas","score":0.7379999756813049},{"id":"https://openalex.org/keywords/multiple-adenomas","display_name":"multiple adenomas","score":0.7580000162124634},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7200000286102295},{"id":"https://openalex.org/keywords/colorectal-cancer-prevention","display_name":"colorectal cancer prevention","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8801286220550537},{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.6946743726730347},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6813133955001831},{"id":"https://openalex.org/C2776241388","wikidata":"https://www.wikidata.org/wiki/Q963093","display_name":"Sulindac","level":3,"score":0.6628286242485046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.623404860496521},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5815920233726501},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4812747836112976},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42440545558929443},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32029247283935547},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.31132400035858154},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19560730457305908},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1535964012145996},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.2011.29.4_suppl.374","doi":"https://doi.org/10.1200/jco.2011.29.4_suppl.374","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.4_suppl.374","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7xp62201","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7xp62201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology, vol 29, iss 4_suppl","raw_type":"article"},{"id":"pmh:qt7xp62201","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/7xp62201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lin, BS; Zell, JA; Madson, N; McLaren, CE; Gerner, EW; &amp; Meyskens, FL. (2011). Role of obesity in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas.. JOURNAL OF CLINICAL ONCOLOGY, 29(4). doi: 10.1200/jco.2011.29.4_suppl.374. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7xp62201","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt7xp62201","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7xp62201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology, vol 29, iss 4_suppl","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113834939","https://openalex.org/W7095931323","https://openalex.org/W2097235831","https://openalex.org/W2944307022","https://openalex.org/W2331881548","https://openalex.org/W1990656498","https://openalex.org/W2008033210","https://openalex.org/W2399781571","https://openalex.org/W2151172259","https://openalex.org/W2992427983"],"abstract_inverted_index":{"374":[0],"Background:":[1],"Chemoprevention":[2],"with":[3,21,45,100,119,134,164,183,200],"difluoromethylornithine":[4],"(DFMO)":[5],"plus":[6,47,67,166,202],"sulindac":[7,48,68,167,203],"markedly":[8],"reduces":[9],"risk":[10,22,40,114,196],"of":[11,23,41,115,181],"recurrence":[12,42,161],"in":[13,57],"colorectal":[14,26],"adenoma":[15,118,136,160,185],"(CRA)":[16],"patients.":[17],"Obesity":[18,156],"is":[19],"associated":[20,133],"CRA":[24,35,61,195],"and":[25,39,90,151],"cancer":[27],"(CRC).":[28],"This":[29],"study":[30],"investigates":[31],"how":[32],"obesity":[33,75,103,131,182,190],"influences":[34],"characteristics":[36,99],"at":[37,81,187],"baseline":[38,98],"after":[43,162,198],"treatment":[44,163,199],"DFMO":[46,66,165,201],"vs.":[49,69,204],"placebo.":[50,70,205],"Methods:":[51],"Our":[52,173],"analysis":[53,107],"included":[54],"subjects":[55],"enrolled":[56],"a":[58],"phase":[59],"III":[60],"prevention":[62],"clinical":[63],"trial":[64],"investigating":[65],"Patients":[71],"were":[72,94],"classified":[73],"by":[74],"(BMI":[76],">":[77],"30":[78],"kg/m2)":[79],"status":[80],"baseline.":[82],"Pearson's":[83],"\u03c72":[84],"statistic":[85],"or":[86,122,168],"Fisher's":[87],"exact":[88],"test":[89,93],"Mann-Whitney":[91],"U":[92],"used":[95,109],"to":[96,102,110],"compare":[97],"regard":[101],"status.":[104],"Log-binomial":[105],"regression":[106],"was":[108,132],"determine":[111],"the":[112,179],"relative":[113],"metachronous":[116],"adenoma,":[117],"advanced":[120,143],"histology,":[121],"multiple":[123],"adenomas,":[124],"adjusted":[125],"for":[126,178],"covariates.":[127],"Results:":[128],"At":[129],"baseline,":[130],"increased":[135],"number":[137],"(p":[138,141,145,149,154,170],"=0.017),":[139],"size":[140],"=0.003),":[142],"histology":[144],"=0.042),":[146],"high-risk":[147,184],"adenomas":[148,153],"=0.0002),":[150],"distal":[152],"=0.038).":[155],"did":[157],"not":[158,192],"modify":[159,194],"placebo":[169],"=0.80).":[171],"Conclusions:":[172],"results":[174],"provide":[175],"supporting":[176],"evidence":[177],"association":[180],"features":[186],"baseline;":[188],"however,":[189],"does":[191],"substantially":[193],"reduction":[197],"[Table:":[206,209],"see":[207,210],"text]":[208,211]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-03-03T00:00:00"}
