{"id":"https://openalex.org/W2589313592","doi":"https://doi.org/10.3390/genes8030086","title":"Systematic Identification and Assessment of Therapeutic Targets for Breast Cancer Based on Genome-Wide RNA Interference Transcriptomes","display_name":"Systematic Identification and Assessment of Therapeutic Targets for Breast Cancer Based on Genome-Wide RNA Interference Transcriptomes","publication_year":2017,"publication_date":"2017-02-24","ids":{"openalex":"https://openalex.org/W2589313592","doi":"https://doi.org/10.3390/genes8030086","mag":"2589313592","pmid":"https://pubmed.ncbi.nlm.nih.gov/28245581","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5368690"},"language":"en","primary_location":{"id":"doi:10.3390/genes8030086","doi":"https://doi.org/10.3390/genes8030086","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes8030086","pdf_url":"https://www.mdpi.com/2073-4425/8/3/86/pdf?version=1487944660","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4425/8/3/86/pdf?version=1487944660","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100355920","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0002-0166-3944","observed_orcids":["https://orcid.org/0000-0002-0166-3944"]},"institutions":[{"id":"https://openalex.org/I4210105491","display_name":"302 Military Hospital of China","ror":"https://ror.org/01pd66220","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Research Center for Clinical & Translational Medicine, Beijing 302 Hospital, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Clinical & Translational Medicine, Beijing 302 Hospital, Beijing 100039, China","institution_ids":["https://openalex.org/I4210105491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072518075","display_name":"Xiaoyao Yin","orcid":"https://orcid.org/0000-0002-8207-2512","observed_orcids":["https://orcid.org/0000-0002-8207-2512"]},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyao Yin","raw_affiliation_strings":["Science and technology on Parallel and Distributed Processing Laboratory, National University of Defense Technology, Changsha 410073, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science and technology on Parallel and Distributed Processing Laboratory, National University of Defense Technology, Changsha 410073, China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084494795","display_name":"Jing Zhong","orcid":"https://orcid.org/0000-0003-4593-4897","observed_orcids":["https://orcid.org/0000-0003-4593-4897","https://orcid.org/0009-0001-7022-5059"]},"institutions":[{"id":"https://openalex.org/I4210105567","display_name":"Huzhou Central Hospital","ror":"https://ror.org/01czx1v82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105567","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhong","raw_affiliation_strings":["Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China","institution_ids":["https://openalex.org/I4210105567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103181621","display_name":"Naiyang Guan","orcid":"https://orcid.org/0000-0001-9314-2929","observed_orcids":["https://orcid.org/0000-0001-9314-2929"]},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Naiyang Guan","raw_affiliation_strings":["Science and technology on Parallel and Distributed Processing Laboratory, National University of Defense Technology, Changsha 410073, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science and technology on Parallel and Distributed Processing Laboratory, National University of Defense Technology, Changsha 410073, China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061811574","display_name":"Zhigang Luo","orcid":"https://orcid.org/0000-0002-7552-201X","observed_orcids":["https://orcid.org/0000-0002-7552-201X"]},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Luo","raw_affiliation_strings":["Science and technology on Parallel and Distributed Processing Laboratory, National University of Defense Technology, Changsha 410073, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science and technology on Parallel and Distributed Processing Laboratory, National University of Defense Technology, Changsha 410073, China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100530746","display_name":"Lishan Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105567","display_name":"Huzhou Central Hospital","ror":"https://ror.org/01czx1v82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105567","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lishan Min","raw_affiliation_strings":["Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China","institution_ids":["https://openalex.org/I4210105567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057538485","display_name":"Xing Yao","orcid":"https://orcid.org/0000-0003-2761-3221","observed_orcids":["https://orcid.org/0000-0003-2761-3221"]},"institutions":[{"id":"https://openalex.org/I4210105567","display_name":"Huzhou Central Hospital","ror":"https://ror.org/01czx1v82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105567","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Yao","raw_affiliation_strings":["Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China","institution_ids":["https://openalex.org/I4210105567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045958734","display_name":"Xiaochen Bo","orcid":"https://orcid.org/0000-0003-1911-7922","observed_orcids":["https://orcid.org/0000-0003-1911-7922","https://orcid.org/0000-0003-3490-5812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaochen Bo","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044485259","display_name":"Licheng Dai","orcid":"https://orcid.org/0000-0002-2391-6885","observed_orcids":["https://orcid.org/0000-0002-2391-6885"]},"institutions":[{"id":"https://openalex.org/I4210105567","display_name":"Huzhou Central Hospital","ror":"https://ror.org/01czx1v82","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105567","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Licheng Dai","raw_affiliation_strings":["Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China","institution_ids":["https://openalex.org/I4210105567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018758426","display_name":"Hui Bai","orcid":"https://orcid.org/0000-0002-9013-7873","observed_orcids":["https://orcid.org/0000-0002-9013-7873","https://orcid.org/0009-0007-3402-5117"]},"institutions":[{"id":"https://openalex.org/I4210088839","display_name":"People 's Liberation Army 451 Hospital","ror":"https://ror.org/007w9h140","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088839"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Bai","raw_affiliation_strings":["Beijing Institute of Radiation Medicine, Beijing 100850, China","No. 451 Hospital of PLA, Xi\u2019an 710054, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Radiation Medicine, Beijing 100850, China","institution_ids":[]},{"raw_affiliation_string":"No. 451 Hospital of PLA, Xi\u2019an 710054, China","institution_ids":["https://openalex.org/I4210088839","https://openalex.org/I4210160531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018758426","https://openalex.org/A5044485259"],"corresponding_institution_ids":["https://openalex.org/I4210088839","https://openalex.org/I4210105567","https://openalex.org/I4210160531"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.555,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.57565984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"3","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.14900000393390656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.12060000002384186,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/tcga-breast-cancer","display_name":"TCGA breast cancer","score":0.5490000247955322},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8889999985694885},{"id":"https://openalex.org/keywords/druggable-proteins","display_name":"druggable proteins","score":0.9459999799728394},{"id":"https://openalex.org/keywords/small-molecule-modulators","display_name":"small molecule modulators","score":0.9470000267028809},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/luminal-a-subtype","display_name":"luminal A","score":0.8029999732971191},{"id":"https://openalex.org/keywords/luminal-b","display_name":"luminal B","score":1.0},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8270000219345093},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.7922900915145874},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7036138772964478},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6982195377349854},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6815924644470215},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6528975963592529},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.544141948223114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4834778904914856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47689321637153625},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46863651275634766},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4631907641887665},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4239062964916229},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4106861352920532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24853456020355225},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.24756211042404175},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22276750206947327},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.09871187806129456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.059590697288513184}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/genes8030086","doi":"https://doi.org/10.3390/genes8030086","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes8030086","pdf_url":"https://www.mdpi.com/2073-4425/8/3/86/pdf?version=1487944660","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},{"id":"pmid:28245581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28245581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5368690","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5368690/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3c31887053b34a64b3a44548bd707520","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c31887053b34a64b3a44548bd707520","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genes, Vol 8, Iss 3, p 86 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/genes8030086","doi":"https://doi.org/10.3390/genes8030086","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes8030086","pdf_url":"https://www.mdpi.com/2073-4425/8/3/86/pdf?version=1487944660","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G391715649","display_name":null,"funder_award_id":"U1435222","funder_id":"https://openalex.org/F4320335577","funder_display_name":"Major Research Plan"},{"id":"https://openalex.org/G4111034471","display_name":null,"funder_award_id":"U1435222","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8710076561","display_name":null,"funder_award_id":"2015AA020108","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335577","display_name":"Major Research Plan","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2589313592.pdf","grobid_xml":"https://content.openalex.org/works/W2589313592.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W7419881","https://openalex.org/W28705092","https://openalex.org/W145633305","https://openalex.org/W203925562","https://openalex.org/W1656241491","https://openalex.org/W1857266517","https://openalex.org/W1967717472","https://openalex.org/W1969346276","https://openalex.org/W1972841107","https://openalex.org/W1978739865","https://openalex.org/W1988548899","https://openalex.org/W1989625924","https://openalex.org/W1989814127","https://openalex.org/W1993188287","https://openalex.org/W1994930469","https://openalex.org/W1996822667","https://openalex.org/W1996940506","https://openalex.org/W2004946118","https://openalex.org/W2005303413","https://openalex.org/W2032516771","https://openalex.org/W2034451570","https://openalex.org/W2037207156","https://openalex.org/W2042051990","https://openalex.org/W2044702943","https://openalex.org/W2056040742","https://openalex.org/W2056402768","https://openalex.org/W2066655755","https://openalex.org/W2066815158","https://openalex.org/W2067530106","https://openalex.org/W2072167545","https://openalex.org/W2073569331","https://openalex.org/W2075438156","https://openalex.org/W2083491663","https://openalex.org/W2088126934","https://openalex.org/W2092714850","https://openalex.org/W2096027508","https://openalex.org/W2097255042","https://openalex.org/W2098737737","https://openalex.org/W2102140136","https://openalex.org/W2107554353","https://openalex.org/W2108559088","https://openalex.org/W2114735994","https://openalex.org/W2118605519","https://openalex.org/W2124729407","https://openalex.org/W2130410032","https://openalex.org/W2131277831","https://openalex.org/W2132619562","https://openalex.org/W2135630508","https://openalex.org/W2140056178","https://openalex.org/W2144378472","https://openalex.org/W2145480262","https://openalex.org/W2146278300","https://openalex.org/W2146512944","https://openalex.org/W2147415463","https://openalex.org/W2157285286","https://openalex.org/W2157840751","https://openalex.org/W2158217645","https://openalex.org/W2161837289","https://openalex.org/W2164229713","https://openalex.org/W2165745669","https://openalex.org/W2170146596","https://openalex.org/W2223549218","https://openalex.org/W2235523093","https://openalex.org/W2259802687","https://openalex.org/W2261992653","https://openalex.org/W2463471218","https://openalex.org/W2917837889","https://openalex.org/W3041047318","https://openalex.org/W6605944285"],"related_works":["https://openalex.org/W4413894313","https://openalex.org/W2538234063","https://openalex.org/W1999287489","https://openalex.org/W2800035847","https://openalex.org/W2885175476","https://openalex.org/W4297907116","https://openalex.org/W2956427550","https://openalex.org/W2289961779","https://openalex.org/W4366284235","https://openalex.org/W1991888125"],"abstract_inverted_index":{"With":[0],"accumulating":[1],"public":[2],"omics":[3],"data,":[4],"great":[5],"efforts":[6],"have":[7,189],"been":[8,190],"made":[9],"to":[10,43,54,73,165,170,195,240],"characterize":[11],"the":[12,24,27,44,66,88,111,129,154,167,196],"genetic":[13],"heterogeneity":[14],"of":[15,30,46,104,107,123,144,156,198,207],"breast":[16,94,112,125,157,214,226],"cancer.":[17,227],"However,":[18],"identifying":[19],"novel":[20],"targets":[21,32,78,173,210,245],"and":[22,49,52,69,76,82,110,183,223,242],"selecting":[23],"best":[25],"from":[26,93,120],"sizeable":[28],"lists":[29],"candidate":[31,208,244],"is":[33],"still":[34],"a":[35,105,142,204,234],"key":[36],"challenge":[37],"for":[38,79,174,211,237,246],"targeted":[39],"therapy,":[40],"largely":[41],"owing":[42],"lack":[45],"economical,":[47],"efficient":[48],"systematic":[50],"discovery":[51,197],"assessment":[53,72,164],"prioritize":[55,77,171,243],"potential":[56,172],"therapeutic":[57,83,209],"targets.":[58],"Here,":[59],"we":[60,140,202],"describe":[61],"an":[62],"approach":[63,231],"that":[64,147,188],"combines":[65],"computational":[67],"evaluation":[68],"objective,":[70],"multifaceted":[71,163],"systematically":[74],"identify":[75,184,241],"biological":[80],"validation":[81],"exploration.":[84],"We":[85,160,177],"first":[86],"establish":[87],"reference":[89],"gene":[90,136,168,175],"expression":[91],"profiles":[92],"cancer":[95,113,126,158,215],"cell":[96],"line":[97],"MCF7":[98],"upon":[99],"genome-wide":[100],"RNA":[101],"interference":[102],"(RNAi)":[103],"total":[106],"3689":[108],"genes,":[109],"query":[114],"signatures":[115],"using":[116],"RNA-seq":[117],"data":[118],"generated":[119],"tissue":[121],"samples":[122],"clinical":[124],"patients":[127],"in":[128],"Cancer":[130],"Genome":[131],"Atlas":[132],"(TCGA).":[133],"Based":[134],"on":[135],"set":[137,143,169],"enrichment":[138],"analysis,":[139],"identified":[141],"510":[145],"genes":[146],"when":[148],"knocked":[149],"down":[150],"could":[151],"significantly":[152],"reverse":[153],"transcriptome":[155],"state.":[159],"then":[161],"perform":[162],"analyze":[166],"therapy.":[176],"also":[178],"propose":[179],"drug":[180],"repurposing":[181],"opportunities":[182],"potentially":[185],"druggable":[186],"proteins":[187],"poorly":[191],"explored":[192],"with":[193],"regard":[194],"small-molecule":[199],"modulators.":[200],"Finally,":[201],"obtained":[203],"small":[205],"list":[206],"four":[212],"major":[213],"subtypes,":[216],"i.e.,":[217],"luminal":[218,220],"A,":[219],"B,":[221],"HER2+":[222],"triple":[224],"negative":[225],"This":[228],"RNAi":[229],"transcriptome-based":[230],"can":[232],"be":[233],"helpful":[235],"paradigm":[236],"relevant":[238],"researches":[239],"experimental":[247],"validation.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-03-03T00:00:00"}
