{"id":"https://openalex.org/W2589242534","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.611","title":"Determining agreement between immunohistochemistry and RT-qPCR for standard biomarkers in breast cancer: Validation on GEICAM 9906 clinical trial.","display_name":"Determining agreement between immunohistochemistry and RT-qPCR for standard biomarkers in breast cancer: Validation on GEICAM 9906 clinical trial.","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2589242534","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.611","mag":"2589242534"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.15_suppl.611","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.611","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.611","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022854192","display_name":"Philip Seth Bernard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. S. Bernard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015949324","display_name":"Colby Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110645687","display_name":"B. Mun\u00e1rriz","orcid":"https://orcid.org/0000-0002-6059-2154","observed_orcids":["https://orcid.org/0000-0002-6059-2154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Munarriz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043353796","display_name":"Inge J. Stijleman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. J. Stijleman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045301167","display_name":"Manuel Ru\u00edz\u2010Borrego","orcid":"https://orcid.org/0000-0002-1181-5622","observed_orcids":["https://orcid.org/0000-0002-1181-5622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ruiz-Borrego","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061791430","display_name":"Mark Ebbert","orcid":"https://orcid.org/0000-0001-9158-4440","observed_orcids":["https://orcid.org/0000-0001-9158-4440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. T. W. Ebbert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071202334","display_name":"\u00c1lvaro Rodr\u00edguez-Lescure","orcid":"https://orcid.org/0000-0002-6823-5290","observed_orcids":["https://orcid.org/0000-0002-6823-5290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Rodriguez-Lescure","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026298654","display_name":"Roy R. L. Bastien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. R. L. Bastien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018612347","display_name":"Carmen Crespo","orcid":"https://orcid.org/0000-0002-7634-2002","observed_orcids":["https://orcid.org/0000-0002-7634-2002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Crespo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062498736","display_name":"Charles M. Perou","orcid":"https://orcid.org/0000-0001-9827-2247","observed_orcids":["https://orcid.org/0000-0001-9827-2247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. M. Perou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113692921","display_name":"Cynthia Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Rodriguez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041691119","display_name":"Ignacio Aranda","orcid":"https://orcid.org/0000-0003-2338-2286","observed_orcids":["https://orcid.org/0000-0003-2338-2286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. I. Aranda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109172952","display_name":"Vicente Furi\u00f3","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Furi\u00f3","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008504309","display_name":"Isabel \u00c1lvarez","orcid":"https://orcid.org/0000-0001-8958-0694","observed_orcids":["https://orcid.org/0000-0001-8958-0694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Alvarez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009333628","display_name":"Miguel \u00c1ngel Segu\u00ed","orcid":"https://orcid.org/0000-0002-5103-6746","observed_orcids":["https://orcid.org/0000-0002-5103-6746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. A. Segu\u00ed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036532311","display_name":"Emilio Alba","orcid":"https://orcid.org/0000-0002-3364-2603","observed_orcids":["https://orcid.org/0000-0002-3364-2603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Alba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Anton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Anton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E. M. Carrasco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. M. Carrasco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075937719","display_name":"Rosal\u00eda Caballero","orcid":"https://orcid.org/0000-0002-6027-1748","observed_orcids":["https://orcid.org/0000-0002-6027-1748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Caballero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084517455","display_name":"Mauricio G. Mart\u00edn","orcid":"https://orcid.org/0000-0002-6326-8405","observed_orcids":["https://orcid.org/0000-0002-6326-8405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"15_suppl","first_page":"611","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rt-qpcr","display_name":"RT-qPCR","score":0.8650000095367432},{"id":"https://openalex.org/keywords/biomarker-validation","display_name":"biomarker validation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pam50-subtypes","display_name":"PAM50 molecular subtypes","score":0.6890000104904175},{"id":"https://openalex.org/keywords/esr1","display_name":"ESR1","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pgr","display_name":"PGR","score":0.9380000233650208},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.765999972820282},{"id":"https://openalex.org/keywords/mki67","display_name":"MKI67","score":0.7720000147819519},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9409999847412109},{"id":"https://openalex.org/keywords/keratin-5","display_name":"keratin 5","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cut-point-determination","display_name":"cut-point determination","score":0.5339999794960022},{"id":"https://openalex.org/keywords/her2-testing","display_name":"HER2 testing","score":0.5649999976158142},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7756264209747314},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7280058860778809},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6014838218688965},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5737446546554565},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5213940739631653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5040973424911499},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47403717041015625},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.41954368352890015},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3683151602745056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15051370859146118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2011.29.15_suppl.611","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.611","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.611","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2999877485","https://openalex.org/W2355920994","https://openalex.org/W2399421402","https://openalex.org/W2970784617","https://openalex.org/W2376996112","https://openalex.org/W2773349476","https://openalex.org/W2782824587","https://openalex.org/W2101676003","https://openalex.org/W2792951836","https://openalex.org/W2892677547"],"abstract_inverted_index":{"611":[0],"Background:":[1],"Common":[2],"practice":[3],"for":[4,30,86,100,150,172,189,201,213,251,261],"comparing":[5],"different":[6],"technologies":[7],"measuring":[8],"the":[9,60,87,112,132,162,209,224],"same":[10],"biomarker":[11],"is":[12,239],"to":[13,42,52,82,118,161,168],"establish":[14],"cut-offs":[15],"using":[16,34,59],"Receiver":[17],"Operator":[18],"Characteristic":[19],"(ROC)":[20],"curves":[21],"and":[22,40,69,97,103,116,143,166,186,194,204,211,215,243,258],"maximizing":[23],"sensitivity/specificity.":[24],"We":[25],"introduce":[26],"a":[27,174],"new":[28],"method":[29],"establishing":[31],"RT-qPCR":[32,47,164,183,220,235],"cut-points":[33,155,232],"gene":[35,62,184,257],"expression":[36,63,110,185,236,248,260,277],"across":[37,111,237,241],"biologic":[38,54,89],"subtypes":[39,55,90,115,238],"compare":[41],"standard":[43],"methods.":[44],"Methods:":[45],"A":[46],"training":[48,113],"set":[49,114,125],"was":[50,179,198],"established":[51],"identify":[53,83],"of":[56,126,140],"breast":[57,67,72,129,152,265],"cancer":[58],"PAM50":[61],"signature.":[64],"155":[65],"invasive":[66,128],"cancers":[68,130],"16":[70],"normal":[71],"samples,":[73],"procured":[74],"in":[75,121,173,264],"formalin-fixed":[76],"paraffin-embedded":[77],"tissue":[78],"blocks,":[79],"were":[80,105,159],"used":[81,117,253],"prototypic":[84],"samples":[85,217],"common":[88,262],"(Luminal":[91],"A,":[92],"Luminal":[93],"B,":[94],"HER2-enriched,":[95],"Basal-like,":[96],"Normal).":[98],"Cut-points":[99],"ESR1,":[101],"PGR,":[102],"ERBB2":[104],"determined":[106],"based":[107,233],"on":[108,234],"their":[109],"determine":[119],"sensitivity/specificity":[120],"an":[122],"independent":[123],"test":[124],"793":[127],"from":[131],"GEICAM":[133],"9906":[134],"study":[135],"(randomized":[136],"phase":[137],"III":[138],"trial":[139],"fluorouracil,":[141],"epirubicin,":[142],"cyclophosphamide":[144],"alone":[145],"or":[146],"followed":[147],"by":[148,249],"paclitaxel":[149],"early":[151],"cancer).":[153],"Fixed":[154],"(low":[156],"vs":[157,228],"intermediate/high)":[158],"applied":[160],"continuous":[163],"data":[165],"compared":[167],"IHC":[169],"scores":[170],"tested":[171],"central":[175],"facility.":[176],"Results:":[177],"There":[178],"good":[180,245],"agreement":[181,246],"between":[182,208,256],"immunohistochemistry":[187,250],"scoring":[188],"clinical":[190],"markers":[191],"ESR1/er,":[192],"PGR/pr,":[193],"ERBB2/her2.":[195],"The":[196],"accuracy":[197],"significantly":[199],"lower":[200],"MKI67/ki67,":[202],"EGFR/egfr,":[203],"KRT5/ck5/6":[205,298],"(Table).":[206],"Discrepancies":[207],"Herceptest":[210,225],"CISH":[212],"2+":[214],"3+":[216],"showed":[218],"that":[219],"agreed":[221],"better":[222],"with":[223,247],"(AUC:":[226],"0.95":[227,287],"0.93).":[229],"Conclusions:":[230],"Calling":[231],"reproducible":[240],"datasets":[242],"has":[244],"clinically":[252],"biomarkers.":[254],"Agreement":[255],"protein":[259],"biomarkers":[263],"cancer.":[266],"Accuracy":[267],"Area":[268],"under":[269],"curve":[270],"(AUC)":[271],"Sensitivity":[272],"(%)":[273,275],"Specificity":[274],"Gene/protein":[276],"ESR1/er":[278],"0.89":[279],"96":[280],"72":[281],"PGR/pr":[282],"0.90":[283],"83":[284],"86":[285],"ERBB2/her2":[286],"92":[288],"87":[289],"ki67/MKI67":[290],"0.74":[291],"71":[292,297],"62":[293],"EGFR/egfr":[294],"0.82":[295],"80":[296],"0.61":[299],"61":[300],"53":[301]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
