{"id":"https://openalex.org/W2589175865","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.393","title":"Intraoperative radiotherapy (IORT) in the era of intensive neoadjuvant chemotherapy and chemoradiotherapy for locally advanced and borderline resectable adenocarcinoma of the pancreas (PDAC).","display_name":"Intraoperative radiotherapy (IORT) in the era of intensive neoadjuvant chemotherapy and chemoradiotherapy for locally advanced and borderline resectable adenocarcinoma of the pancreas (PDAC).","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2589175865","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.393","mag":"2589175865"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.4_suppl.393","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.393","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.4_suppl.393","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070093254","display_name":"Florence K. Keane","orcid":"https://orcid.org/0000-0002-0351-7959","observed_orcids":["https://orcid.org/0000-0002-0351-7959"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florence K. Keane","raw_affiliation_strings":["Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074136628","display_name":"Jennifer Yon-Li Wo","orcid":"https://orcid.org/0000-0001-9872-5912","observed_orcids":["https://orcid.org/0000-0001-9872-5912"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Yon-Li Wo","raw_affiliation_strings":["Massachusetts General Hospital, Waban, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Waban, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061627885","display_name":"Cristina Rosa Ferrone","orcid":"https://orcid.org/0000-0002-6295-1085","observed_orcids":["https://orcid.org/0000-0002-6295-1085"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Ferrone","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088474933","display_name":"Jeffrey William Clark","orcid":"https://orcid.org/0000-0001-9524-3600","observed_orcids":["https://orcid.org/0000-0001-9524-3600"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Clark","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081543892","display_name":"Lawrence Scott Blaszkowsky","orcid":"https://orcid.org/0000-0002-9437-2977","observed_orcids":["https://orcid.org/0000-0002-9437-2977"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Scott Blaszkowsky","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112197691","display_name":"Jill N. Allen","orcid":"https://orcid.org/0000-0002-1446-2981","observed_orcids":["https://orcid.org/0000-0002-1446-2981"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill N. Allen","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108626576","display_name":"Eunice Lee Kwak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunice Lee Kwak","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070720153","display_name":"David P. Ryan","orcid":"https://orcid.org/0000-0002-9685-673X","observed_orcids":["https://orcid.org/0000-0002-9685-673X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Ryan","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051782291","display_name":"Keith D. Lillemoe","orcid":"https://orcid.org/0009-0004-5057-3875","observed_orcids":["https://orcid.org/0009-0004-5057-3875","https://orcid.org/0000-0003-4283-8437"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith D Lillemoe","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019690020","display_name":"Carlos F. Fernandez-del Castillo","orcid":"https://orcid.org/0000-0001-5975-7225","observed_orcids":["https://orcid.org/0000-0001-5975-7225"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Fernandez-del Castillo","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044225007","display_name":"Theodore Sunki Hong","orcid":"https://orcid.org/0000-0001-8481-6581","observed_orcids":["https://orcid.org/0000-0001-8481-6581"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore S. Hong","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"4_suppl","first_page":"393","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraoperative-radiotherapy","display_name":"intraoperative radiotherapy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/locally-advanced-pancreatic-cancer","display_name":"locally advanced pancreatic cancer","score":0.8730000257492065},{"id":"https://openalex.org/keywords/borderline-resectable-pancreatic-cancer","display_name":"borderline resectable pancreatic cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/folfirinox","display_name":"FOLFIRINOX","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9369999766349792},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.675000011920929},{"id":"https://openalex.org/keywords/positive-surgical-margins","display_name":"positive surgical margins","score":0.6570000052452087},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8009999990463257},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9269999861717224},{"id":"https://openalex.org/keywords/postoperative-morbidity","display_name":"postoperative morbidity","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9709764719009399},{"id":"https://openalex.org/C2777148230","wikidata":"https://www.wikidata.org/wiki/Q17144959","display_name":"FOLFIRINOX","level":5,"score":0.6125513911247253},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.533787190914154},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.500816822052002},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4690200388431549},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4350530505180359},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.42017436027526855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25892120599746704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1823977828025818},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.16628116369247437},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.4_suppl.393","doi":"https://doi.org/10.1200/jco.2016.34.4_suppl.393","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.4_suppl.393","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2529956502","https://openalex.org/W2529232938","https://openalex.org/W2990820147","https://openalex.org/W2949308270","https://openalex.org/W3118632059","https://openalex.org/W3211349133","https://openalex.org/W2027075372","https://openalex.org/W7166050442","https://openalex.org/W2729457578","https://openalex.org/W1975276209"],"abstract_inverted_index":{"393":[0],"Background:":[1],"Improved":[2],"outcomes":[3,50],"with":[4,8,54,69,79,230,245,267,274,292,303],"FOLFIRINOX":[5],"or":[6,161,260,276,294],"gemcitabine":[7],"nab-paclitaxel":[9],"in":[10,58,87,156,164,182,191,206,257,272,284],"the":[11,199,213],"treatment":[12,24,78],"of":[13,19,25,56,66,136,202,215,227,287,298],"metastatic":[14],"PDAC":[15,74],"have":[16,132],"prompted":[17],"incorporation":[18],"these":[20],"regimens":[21],"into":[22],"neoadjuvant":[23,37,77,120,280],"PDAC.":[26],"While":[27],"some":[28],"patients":[29,68,138,165,183,192,207,229,291,302],"are":[30,40,47],"still":[31],"found":[32,130],"to":[33,42,48,98,106,131,220],"be":[34],"unresectable":[35,231,304],"after":[36,119,279],"treatment,":[38,121],"others":[39],"able":[41],"undergo":[43],"resection.":[44],"Our":[45],"aims":[46],"evaluate":[49],"and":[51,126,169,188,196,211,297],"toxicities":[52],"associated":[53,244,266],"use":[55],"IORT":[57,143,170,242,263,282],"this":[59],"setting.":[60],"Methods:":[61],"We":[62],"retrospectively":[63],"analyzed":[64],"records":[65],"85":[67,113],"locally":[70],"advanced/":[71],"borderline":[72],"resectable":[73],"who":[75,139,166,173,184,193,208,222],"received":[76,142,235],"chemotherapy":[80],"and/or":[81],"chemoradiotherapy":[82],"followed":[83],"by":[84],"surgical":[85,100,277],"exploration":[86,234,278],"an":[88],"IORT-equipped":[89],"operating":[90],"suite":[91],"between":[92],"2010-2015.":[93],"Descriptive":[94],"statistics":[95],"were":[96,124,129,218],"used":[97,105,271],"compare":[99],"outcomes.":[101],"Survival":[102],"analysis":[103],"was":[104,152,179,239,243],"calculate":[107],"overall":[108],"survival":[109],"(OS).":[110],"Results:":[111],"Of":[112],"patients,":[114],"49":[115,137],"(57.6%)":[116],"underwent":[117,140,167,174,185,194,209,223],"resection":[118,141,168,175,186,195,210,224,275],"27":[122,228],"(31.8%)":[123],"unresectable,":[125],"9":[127],"(10.6%)":[128],"distant":[133],"metastases.":[134],"24":[135],"for":[144,290,301],"close/positive":[145],"margins":[146,205,296],"on":[147],"intraoperative":[148],"frozen":[149],"section.":[150],"There":[151],"no":[153,254],"significant":[154,255],"difference":[155,256],"operative":[157,162,258],"times,":[158],"postoperative":[159],"complications,":[160],"morbidity":[163],"vs":[171],"those":[172,221],"alone.":[176,225],"Median":[177,237],"OS":[178,238,286],"31.1":[180],"months":[181,190,289,300],"alone":[187],"35.1":[189],"IORT.":[197,236],"Despite":[198],"increased":[200,246,268],"incidence":[201],"close/":[203],"positive":[204,295],"IORT,":[212],"rates":[214],"local":[216],"recurrence":[217],"similar":[219],"26":[226],"disease":[232],"upon":[233],"20.5":[240,299],"months.":[241],"hospital":[247],"stay":[248],"(4":[249],"vs.":[250],"3.5":[251],"d),":[252],"but":[253],"time":[259],"morbidity.":[261],"Conclusions:":[262],"is":[264],"not":[265],"toxicity":[269],"when":[270],"conjunction":[273],"therapy.":[281],"resulted":[283],"median":[285],"35":[288],"close":[293],"disease.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-03-03T00:00:00"}
