{"id":"https://openalex.org/W2589099482","doi":"https://doi.org/10.1117/12.2249803","title":"Tumor margin assessment of surgical tissue specimen of cancer patients using label-free hyperspectral imaging","display_name":"Tumor margin assessment of surgical tissue specimen of cancer patients using label-free hyperspectral imaging","publication_year":2017,"publication_date":"2017-02-14","ids":{"openalex":"https://openalex.org/W2589099482","doi":"https://doi.org/10.1117/12.2249803","mag":"2589099482","pmid":"https://pubmed.ncbi.nlm.nih.gov/30294063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6169990"},"language":"en","primary_location":{"id":"doi:10.1117/12.2249803","doi":"https://doi.org/10.1117/12.2249803","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2249803","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6169990","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083707303","display_name":"Baowei Fei","orcid":"https://orcid.org/0000-0002-9123-9484","observed_orcids":["https://orcid.org/0000-0002-9123-9484"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baowei Fei","raw_affiliation_strings":["Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057729645","display_name":"Guolan Lu","orcid":"https://orcid.org/0000-0002-5023-3465","observed_orcids":["https://orcid.org/0000-0002-5023-3465"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guolan Lu","raw_affiliation_strings":["Georgia Institute of Technology (United States)","Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology (United States)","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407835","display_name":"Xu Wang","orcid":"https://orcid.org/0000-0002-0098-1238","observed_orcids":["https://orcid.org/0000-0002-0098-1238"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Wang","raw_affiliation_strings":["Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083667162","display_name":"Hongzheng Zhang","orcid":"https://orcid.org/0000-0001-8105-2256","observed_orcids":["https://orcid.org/0000-0001-8105-2256"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongzheng Zhang","raw_affiliation_strings":["Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111710908","display_name":"James V. Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James V. Little","raw_affiliation_strings":["Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066168392","display_name":"Kelly R. Magliocca","orcid":"https://orcid.org/0000-0002-3520-9694","observed_orcids":["https://orcid.org/0000-0002-3520-9694"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly R. Magliocca","raw_affiliation_strings":["Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067946910","display_name":"Amy Y. Chen","orcid":"https://orcid.org/0000-0003-3563-6343","observed_orcids":["https://orcid.org/0000-0003-3563-6343"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Y. Chen","raw_affiliation_strings":["Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7372,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.90392919,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10054","issue":null,"first_page":"100540E","last_page":"100540E"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10689","display_name":"Remote-Sensing Image Classification","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-margin-assessment","display_name":"tumor margin assessment","score":0.9990000128746033},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/spectral-properties","display_name":"spectral properties","score":0.8069999814033508},{"id":"https://openalex.org/keywords/autofluorescence-imaging","display_name":"autofluorescence imaging","score":0.9599999785423279},{"id":"https://openalex.org/keywords/image-guided-surgery","display_name":"image-guided surgery","score":0.8119999766349792},{"id":"https://openalex.org/keywords/oral-cavity","display_name":"oral cavity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/thyroid-tissue","display_name":"thyroid tissue","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C159078339","wikidata":"https://www.wikidata.org/wiki/Q959005","display_name":"Hyperspectral imaging","level":2,"score":0.9266023635864258},{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.8346060514450073},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.4626392424106598},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.4394780993461609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.384609192609787},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3362135887145996},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.20172473788261414},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19970402121543884},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19518253207206726},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10854151844978333},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1117/12.2249803","doi":"https://doi.org/10.1117/12.2249803","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2249803","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:30294063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30294063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5115890","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6169990","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6169990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6169990","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5115890","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6169990","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3541049458","display_name":"Targeted fusion biopsy using anti-[18F]FACBC PET/CT and real-time 3D ultrasound g","funder_award_id":"R21CA176684","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3692936707","display_name":"MOLECULAR IMAGING DIRECTED, 3D ULTRASOUND-GUIDED, BIOPSY SYSTEM","funder_award_id":"R01CA156775","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4945154444","display_name":"ACADEMIC-INDUSTRIAL PARTNERSHIP FOR TRANSLATION OF PET/TRUS GUIDED INTERVENTION","funder_award_id":"R01CA204254","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000881663","display_name":"Winship Cancer Institute Cancer Center Support Grant","funder_award_id":"P30CA138292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333204","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1558937864","https://openalex.org/W1570518064","https://openalex.org/W1571903778","https://openalex.org/W1585160280","https://openalex.org/W1635961389","https://openalex.org/W1934042091","https://openalex.org/W1935362880","https://openalex.org/W1967873088","https://openalex.org/W1971637299","https://openalex.org/W1975631571","https://openalex.org/W1975956815","https://openalex.org/W1977066218","https://openalex.org/W1977791453","https://openalex.org/W1978498174","https://openalex.org/W1980956174","https://openalex.org/W1983114140","https://openalex.org/W1988386267","https://openalex.org/W1992620675","https://openalex.org/W1996554297","https://openalex.org/W2019338222","https://openalex.org/W2032790167","https://openalex.org/W2037236246","https://openalex.org/W2046817177","https://openalex.org/W2047033241","https://openalex.org/W2048976066","https://openalex.org/W2053950384","https://openalex.org/W2055289219","https://openalex.org/W2064079563","https://openalex.org/W2065686227","https://openalex.org/W2065829098","https://openalex.org/W2067910955","https://openalex.org/W2073124504","https://openalex.org/W2079934168","https://openalex.org/W2082686355","https://openalex.org/W2086820800","https://openalex.org/W2094562601","https://openalex.org/W2096631226","https://openalex.org/W2099697510","https://openalex.org/W2104988701","https://openalex.org/W2106235642","https://openalex.org/W2109816469","https://openalex.org/W2113242816","https://openalex.org/W2124705288","https://openalex.org/W2155758341","https://openalex.org/W2161271315","https://openalex.org/W2168478992","https://openalex.org/W2169636029","https://openalex.org/W2171222245","https://openalex.org/W2189916683","https://openalex.org/W2217602394","https://openalex.org/W2332643428","https://openalex.org/W2497599701","https://openalex.org/W2682360066","https://openalex.org/W2747983114","https://openalex.org/W4238067071","https://openalex.org/W4249313277","https://openalex.org/W4251509404","https://openalex.org/W4251522022","https://openalex.org/W6634221970"],"related_works":["https://openalex.org/W2755701658","https://openalex.org/W2747983114","https://openalex.org/W4327565101","https://openalex.org/W2793251974","https://openalex.org/W3133026608","https://openalex.org/W4313295370","https://openalex.org/W2625073279","https://openalex.org/W2922276536","https://openalex.org/W2973216789","https://openalex.org/W2945204448"],"abstract_inverted_index":{"We":[0,44,53,68,85],"are":[1,29],"developing":[2],"label-free":[3,180],"hyperspectral":[4,111,181,202],"imaging":[5,112,163,166,169,182,203],"(HSI)":[6],"for":[7,50,60,186,207],"tumor":[8,187],"margin":[9,188],"assessment.":[10],"HSI":[11,38,51,58],"data,":[12],"hypercube":[13],"(x,y,\u03bb),":[14],"consists":[15],"of":[16,19,22,26,63,132,135,139,153,156,160,194,200],"a":[17],"series":[18],"high-resolution":[20],"images":[21,93],"the":[23,37,61,99,145,147,201],"same":[24],"field":[25],"view":[27],"that":[28,179],"acquired":[30,86],"at":[31],"different":[32],"wavelengths.":[33],"Every":[34],"pixel":[35],"on":[36],"image":[39],"has":[40,183],"an":[41,107,129,150],"optical":[42],"spectrum.":[43],"developed":[45],"preprocessing":[46],"and":[47,65,80,91,96,113,122,137,158],"classification":[48,62,114],"methods":[49],"data.":[52],"used":[54],"spectral":[55],"features":[56],"from":[57,73,98,125,144],"data":[59],"cancer":[64,83,121,196],"benign":[66],"tissue.":[67],"collected":[69],"surgical":[70,191],"tissue":[71,124,142,192],"specimens":[72,143,193],"16":[74],"human":[75],"patients":[76],"who":[77],"underwent":[78],"head":[79],"neck":[81],"(H&N)":[82],"surgery.":[84,212],"both":[87],"HSI,":[88],"autofluorescence":[89,165],"images,":[90],"fluorescence":[92,168],"with":[94,128,170],"2-NBDG":[95],"proflavine":[97],"specimens.":[100],"Digitized":[101],"histologic":[102],"slides":[103],"were":[104],"examined":[105],"by":[106],"H&N":[108,195],"pathologist.":[109],"The":[110],"method":[115,148],"was":[116],"able":[117],"to":[118],"distinguish":[119],"between":[120],"normal":[123],"oral":[126],"cavity":[127],"average":[130,151],"accuracy":[131,152],"90\u00b18%,":[133],"sensitivity":[134,155],"89\u00b19%,":[136],"specificity":[138,159],"91\u00b16%.":[140],"For":[141],"thyroid,":[146],"achieved":[149],"94\u00b16%,":[154,157],"95\u00b16%.":[161],"Hyperspectral":[162],"outperformed":[164],"or":[167,174],"vital":[171],"dye":[172],"(2-NBDG":[173],"proflavine).":[175],"This":[176],"study":[177],"suggests":[178],"great":[184],"potential":[185],"assessment":[189],"in":[190,210],"patients.":[197],"Further":[198],"development":[199],"technology":[204],"is":[205],"warranted":[206],"its":[208],"application":[209],"image-guided":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-24T00:00:00"}