{"id":"https://openalex.org/W2588902015","doi":"https://doi.org/10.1111/dom.12906","title":"No increased risk of cardiovascular events in older adults initiating dipeptidyl peptidase\u20104 inhibitors vs therapeutic alternatives","display_name":"No increased risk of cardiovascular events in older adults initiating dipeptidyl peptidase\u20104 inhibitors vs therapeutic alternatives","publication_year":2017,"publication_date":"2017-02-14","ids":{"openalex":"https://openalex.org/W2588902015","doi":"https://doi.org/10.1111/dom.12906","mag":"2588902015","pmid":"https://pubmed.ncbi.nlm.nih.gov/28195389","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5471114"},"language":"en","primary_location":{"id":"doi:10.1111/dom.12906","doi":"https://doi.org/10.1111/dom.12906","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12906","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5471114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030404824","display_name":"Mugdha Gokhale","orcid":"https://orcid.org/0000-0003-0223-1016","observed_orcids":["https://orcid.org/0000-0003-0223-1016"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mugdha Gokhale","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","Real World Evidence, GlaxoSmithKline, Collegeville, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0003-0223-1016","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Real World Evidence, GlaxoSmithKline, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040182038","display_name":"John B. Buse","orcid":"https://orcid.org/0000-0002-9723-3876","observed_orcids":["https://orcid.org/0000-0002-9723-3876","https://orcid.org/0000-0001-6894-4110"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. Buse","raw_affiliation_strings":["Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065844636","display_name":"Michele J\u00f6nsson Funk","orcid":"https://orcid.org/0000-0002-3756-7540","observed_orcids":["https://orcid.org/0000-0002-3756-7540"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Jonsson Funk","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030530617","display_name":"Jennifer Leigh Lund","orcid":"https://orcid.org/0000-0002-1108-0689","observed_orcids":["https://orcid.org/0000-0002-1108-0689"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Lund","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036291591","display_name":"Virginia Pate","orcid":"https://orcid.org/0000-0002-2141-8882","observed_orcids":["https://orcid.org/0000-0002-2141-8882"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia Pate","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038095614","display_name":"Ross J. Simpson","orcid":"https://orcid.org/0000-0001-6938-8435","observed_orcids":["https://orcid.org/0000-0001-6938-8435"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross J. Simpson","raw_affiliation_strings":["Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043069598","display_name":"Til St\u00fcrmer\u200e","orcid":"https://orcid.org/0000-0002-9204-7177","observed_orcids":["https://orcid.org/0000-0002-9204-7177"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Til St\u00fcrmer","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030404824"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4210114143"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":null,"fwci":2.8081,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.91101171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"7","first_page":"970","last_page":"978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.9900000095367432},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7039999961853027},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7440000176429749},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9819999933242798},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.9480000138282776},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8709999918937683},{"id":"https://openalex.org/keywords/comparative-effectiveness","display_name":"comparative effectiveness","score":0.5180000066757202},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.36800000071525574},{"id":"https://openalex.org/keywords/medicare-beneficiaries","display_name":"Medicare beneficiaries","score":0.597000002861023},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"propensity score matching","score":0.6240000128746033},{"id":"https://openalex.org/keywords/competing-risk-analysis","display_name":"competing risk analysis","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.8160073757171631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7760334014892578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6923576593399048},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.6248592734336853},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5863058567047119},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5684195756912231},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5667830109596252},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.5070343017578125},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5039247870445251},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4759678244590759},{"id":"https://openalex.org/C2778763485","wikidata":"https://www.wikidata.org/wiki/Q419770","display_name":"Dipeptidyl peptidase-4 inhibitor","level":4,"score":0.47585198283195496},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.46349358558654785},{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.4600095748901367},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.45957064628601074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32871270179748535},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.27711886167526245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25889062881469727},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.22530660033226013},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.1456528604030609},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06778526306152344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0627993643283844},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0571194589138031},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006278","descriptor_name":"Medicare","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058065","descriptor_name":"Diabetic Cardiomyopathies","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D058065","descriptor_name":"Diabetic Cardiomyopathies","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D058065","descriptor_name":"Diabetic Cardiomyopathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1111/dom.12906","doi":"https://doi.org/10.1111/dom.12906","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12906","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},{"id":"pmid:28195389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28195389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, obesity & metabolism","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:4973109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5471114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5471114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5471114","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetes Obes Metab","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:n583z1696","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/7tyt-7b61","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, Obesity and Metabolism, 19(7)","raw_type":"Article"},{"id":"doi:10.17615/7tyt-7b61","doi":"https://doi.org/10.17615/7tyt-7b61","is_oa":true,"landing_page_url":"https://doi.org/10.17615/7tyt-7b61","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4973109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5471114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1471178749","display_name":"Methods for Estimating Sex Differences in Safety and Effectiveness of Drugs","funder_award_id":"R01HL118255","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3534060070","display_name":"Patterns of use, comparative effectiveness, and safety of rotavirus vaccines","funder_award_id":"R21HD080214","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3969538665","display_name":"North Carolina Translational & Clinical Sciences Institute (NC TraCS)","funder_award_id":"UL1TR001111","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4152050977","display_name":"UNC Oncology K12","funder_award_id":"2k12ca120780-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4720334866","display_name":null,"funder_award_id":"K12-CA120780","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6628848920","display_name":"North Carolina Translational and Clinical Science Institute (NC TraCS)","funder_award_id":"UL1TR002489","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7441241992","display_name":"PROMIS Validation in Prospective Population-based Prostate Cancer Research Study","funder_award_id":"R01CA174453","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8013340669","display_name":"Propensity Scores and Preventive Drug Use in the Elderly","funder_award_id":"R01AG023178","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8025455098","display_name":"North Carolina Translational & Clinical Sciences Institute (NC TraCS)","funder_award_id":"TL1TR001110","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W103558615","https://openalex.org/W1411550797","https://openalex.org/W1854036179","https://openalex.org/W1898250390","https://openalex.org/W1914121615","https://openalex.org/W1963542379","https://openalex.org/W1968315455","https://openalex.org/W1968749935","https://openalex.org/W1973420370","https://openalex.org/W1998418707","https://openalex.org/W2033102245","https://openalex.org/W2064130493","https://openalex.org/W2064262728","https://openalex.org/W2067495573","https://openalex.org/W2068376155","https://openalex.org/W2076859422","https://openalex.org/W2081294423","https://openalex.org/W2090369799","https://openalex.org/W2102279107","https://openalex.org/W2110201971","https://openalex.org/W2114437291","https://openalex.org/W2116616880","https://openalex.org/W2122532950","https://openalex.org/W2125436438","https://openalex.org/W2127854619","https://openalex.org/W2131830909","https://openalex.org/W2132761689","https://openalex.org/W2133980496","https://openalex.org/W2142830692","https://openalex.org/W2150291618","https://openalex.org/W2151947272","https://openalex.org/W2154595662","https://openalex.org/W2158639332","https://openalex.org/W2160088494","https://openalex.org/W2164595809","https://openalex.org/W2172923077","https://openalex.org/W2222285657","https://openalex.org/W2346794292","https://openalex.org/W2468732910"],"related_works":["https://openalex.org/W2554491899","https://openalex.org/W2963886491","https://openalex.org/W3093311241","https://openalex.org/W2901680512","https://openalex.org/W4415103975","https://openalex.org/W2795857566","https://openalex.org/W2290062540","https://openalex.org/W3196047236","https://openalex.org/W2400880207","https://openalex.org/W2067495573"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"compare":[2],"the":[3,35,47,52,82,113,150,167,192,207,288,292],"cardiovascular":[4],"(CV)":[5],"risk":[6,77,86,263,301],"associated":[7],"with":[8,307],"dipeptidyl":[9],"peptidase-4":[10],"(DPP-4)":[11],"inhibitors":[12,187,309],"relative":[13],"to":[14,23,46],"sulphonylureas":[15],"(SUs)":[16],"and":[17,63,88,103,126,140,177,188,191,201,220,237,268,281],"thiazolidinediones":[18],"(TZDs).":[19],"METHODS:":[20],"During":[21],"2007":[22],"2013,":[24],"using":[25],"Medicare":[26],"data":[27],"for":[28,75,93,99,149,185,264,269],"beneficiaries":[29],"aged":[30],">65":[31],"years,":[32,136,233],"we":[33,80],"identified":[34],"following":[36],"2":[37],"cohorts":[38],"of":[39,163,170,258,302],"new-users,":[40],"who":[41],"had":[42,142,239],"not":[43],"been":[44],"exposed":[45],"drugs":[48],"being":[49],"compared":[50],"in":[51,277],"6":[53],"months":[54],"before":[55],"initiation:":[56],"(1)":[57],"DPP-4":[58,65,114,123,186,208,217,279,308],"inhibitor":[59,66,115,124,209,218,280],"vs":[60,67,116,210,310],"SU":[61,117,129],"initiators":[62,125,219,224],"(2)":[64],"TZD":[68,211,223,282],"initiators.":[69,130,283],"Using":[70],"propensity-score-adjusted":[71],"Cox":[72],"models":[73],"accounting":[74],"competing":[76],"by":[78,287],"death,":[79],"estimated":[81],"hazard":[83],"ratios":[84],"(HRs),":[85],"differences":[87],"95%":[89],"confidence":[90],"intervals":[91],"(CIs)":[92],"myocardial":[94],"infarction":[95],"(MI),":[96],"stroke,":[97,108],"hospitalization":[98],"heart":[100],"failure":[101],"(HF),":[102],"a":[104,143,159,240,254],"combined":[105],"outcome":[106,152,246],"(MI,":[107],"all-cause":[109],"mortality).":[110],"RESULTS:":[111],"In":[112],"comparison,":[118,212],"there":[119,213,296],"were":[120,138,172,196,214,235],"30":[121],"130":[122],"68":[127],"382":[128],"Their":[131,228],"mean":[132,229],"age":[133,230],"was":[134,153,231,248,266,272],"75":[135],"41%":[137],"men":[139,236],"55%":[141],"baseline":[144,241],"CV":[145,242],"condition.":[146],"The":[147,244,261],"HR":[148,247],"composite":[151,245],"0.75":[154],"(95%":[155,174,179,198,203,250],"CI":[156,175,180,199,204,251],"0.72-0.79)":[157],"over":[158,253],"median":[160,255],"treatment":[161,256,290],"duration":[162,257],"1":[164,259],"year,":[165],"but":[166],"1-year":[168,262],"risks":[169,195],"MI":[171,265],"1.00":[173],"0.89-1.12)":[176],"1.47":[178],"1.38-1.56)":[181],"per":[182,274],"100":[183,275],"patients":[184,276],"SUs,":[189],"respectively,":[190],"corresponding":[193],"stroke":[194,270,304],"0.98":[197],"0.87-1.10)":[200],"1.09":[202],"1.01-1.17).":[205],"For":[206],"20":[215],"596":[216],"13":[221],"526":[222],"without":[225],"previous":[226],"HF.":[227],"74":[232],"42%":[234],"30%":[238],"event.":[243],"0.94":[249],"0.86-1.02)":[252],"year.":[260],"~0.90":[267],"it":[271],"~0.80":[273],"both":[278],"CONCLUSION:":[284],"Although":[285],"limited":[286],"short":[289],"period,":[291],"present":[293],"study":[294],"suggests":[295],"is":[297],"no":[298],"increased":[299],"short-term":[300],"MI,":[303],"or":[305],"HF":[306],"SUs/TZDs.":[311]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-24T00:00:00"}