{"id":"https://openalex.org/W2588095744","doi":"https://doi.org/10.1093/neuonc/now212.564","title":"NIMG-53. PREDICTIVE CYTOLOGICAL TOPOGRAPHY MAPS REGIONS OF PATHOLOGICALLY CONFIRMED NON-ENHANCING HYPERCELLULAR TUMOR IN GLIOBLASTOMA PATIENTS","display_name":"NIMG-53. PREDICTIVE CYTOLOGICAL TOPOGRAPHY MAPS REGIONS OF PATHOLOGICALLY CONFIRMED NON-ENHANCING HYPERCELLULAR TUMOR IN GLIOBLASTOMA PATIENTS","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2588095744","doi":"https://doi.org/10.1093/neuonc/now212.564","mag":"2588095744"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/now212.564","doi":"https://doi.org/10.1093/neuonc/now212.564","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/now212.564","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi136/9643685/now212.564.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi136/9643685/now212.564.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025448851","display_name":"Sarah L. Hurrell","orcid":"https://orcid.org/0000-0002-2519-3473","observed_orcids":["https://orcid.org/0000-0002-2519-3473"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Hurrell","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080491768","display_name":"Sean D. McGarry","orcid":"https://orcid.org/0000-0003-4937-2780","observed_orcids":["https://orcid.org/0000-0003-4937-2780"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean McGarry","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102988345","display_name":"Elizabeth J. Cochran","orcid":"https://orcid.org/0000-0003-3642-6532","observed_orcids":["https://orcid.org/0000-0003-3642-6532"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Cochran","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091546375","display_name":"Jennifer Connelly","orcid":"https://orcid.org/0000-0002-6122-8573","observed_orcids":["https://orcid.org/0000-0002-6122-8573"]},"institutions":[{"id":"https://openalex.org/I1310546135","display_name":"Froedtert Hospital","ror":"https://ror.org/01nhrc260","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310546135"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Connelly","raw_affiliation_strings":["Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I1310546135","https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030778015","display_name":"Scott D. Rand","orcid":"https://orcid.org/0000-0002-4136-9352","observed_orcids":["https://orcid.org/0000-0002-4136-9352"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Rand","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077147996","display_name":"Joseph A. Bovi","orcid":"https://orcid.org/0000-0002-3686-1940","observed_orcids":["https://orcid.org/0000-0002-3686-1940"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Bovi","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032574031","display_name":"Peter S. LaViolette","orcid":"https://orcid.org/0000-0002-9602-6891","observed_orcids":["https://orcid.org/0000-0002-9602-6891"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter S. LaViolette","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029623067","display_name":"Kathleen M. Schmainda","orcid":"https://orcid.org/0000-0001-6402-2602","observed_orcids":["https://orcid.org/0000-0001-6402-2602"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M. Schmainda","raw_affiliation_strings":["Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025635958","display_name":"Amy L. Kaczmarowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Kaczmarowski","raw_affiliation_strings":["Medical College of Wisconsin, Wawautosa, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Wawautosa, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"suppl_6","first_page":"vi136","last_page":"vi136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-cellularity","display_name":"tumor cellularity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/nuclei-segmentation","display_name":"nuclei segmentation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.42500001192092896},{"id":"https://openalex.org/keywords/treatment-response-assessment","display_name":"treatment response assessment","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6340723037719727},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6208322048187256},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.5814873576164246},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5426201820373535},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47017616033554077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45324981212615967},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.38407301902770996},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3458218574523926},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3289673924446106},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31333690881729126},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/neuonc/now212.564","doi":"https://doi.org/10.1093/neuonc/now212.564","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/now212.564","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi136/9643685/now212.564.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/neuonc/now212.564","doi":"https://doi.org/10.1093/neuonc/now212.564","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/now212.564","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi136/9643685/now212.564.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6100000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2588095744.pdf","grobid_xml":"https://content.openalex.org/works/W2588095744.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3153595864","https://openalex.org/W4411504666","https://openalex.org/W4224090425","https://openalex.org/W2767968186","https://openalex.org/W2768026344","https://openalex.org/W4205536357","https://openalex.org/W2962522375","https://openalex.org/W3044448414","https://openalex.org/W2593808165","https://openalex.org/W4408448734"],"abstract_inverted_index":{"Clinical":[0],"imaging":[1,16,57],"is":[2],"important":[3],"in":[4,27,182],"the":[5],"detection":[6],"and":[7,22,41,58,81,96,104,117,126,164,206],"treatment":[8,33,204],"of":[9,32,90,146,179],"glioblastoma":[10],"(GBM),":[11],"where":[12],"different":[13],"magnetic":[14],"resonance":[15],"(MRI)":[17],"contrasts":[18],"to":[19,60,76,113,132,142,161],"classify":[20],"tumor":[21,37,195],"plan":[23],"treatment.":[24],"Despite":[25],"advances":[26],"modern":[28],"MRI":[29,115,124],"technology,":[30],"differentiation":[31],"effects":[34],"from":[35,85,157],"infiltrative":[36],"remains":[38],"a":[39,48,134,188],"difficult":[40],"clinically":[42],"relevant":[43],"problem.":[44],"This":[45,200],"study":[46],"uses":[47],"new":[49,158,189],"technique,":[50],"predictive":[51],"cytological":[52],"topography":[53],"(PiCT),":[54],"which":[55,138],"combines":[56],"histology":[59],"address":[61],"this":[62],"issue.":[63],"Thirteen":[64],"patients":[65],"with":[66],"GBM":[67],"were":[68,73,83,101,107,110,130,155],"assessed":[69,121],"at":[70],"autopsy.":[71],"Brains":[72],"sliced":[74],"axially":[75],"match":[77],"pre-mortem":[78],"MR":[79],"images":[80],"samples":[82,100,154],"collected":[84],"various":[86],"locations":[87],"(e.g.,":[88],"center":[89],"tumor,":[91],"surrounding":[92],"rim,":[93],"normal":[94],"white":[95],"gray":[97],"matter).":[98],"The":[99,123],"then":[102,111,140],"digitized":[103],"cell":[105,118,128,147],"nuclei":[106],"segmented.":[108],"Samples":[109],"co-registered":[112],"matching":[114],"slices":[116],"count":[119],"was":[120,139,167],"voxel-wise.":[122],"values":[125],"corresponding":[127],"counts":[129],"used":[131],"train":[133],"machine":[135],"learning":[136],"algorithm":[137],"applied":[141],"generate":[143],"PiCT":[144],"maps":[145,175],"density.":[148],"To":[149],"validate":[150],"these":[151],"maps,":[152],"tissue":[153],"taken":[156],"regions":[159,178],"predicted":[160],"contain":[162],"hypercellularity":[163,181],"evaluated.":[165],"Hypercellularity":[166],"defined":[168],"by":[169],"our":[170],"board":[171],"certified":[172],"pathologist.":[173],"Predictive":[174],"correctly":[176],"identified":[177],"non-enhancing":[180],"all":[183],"13":[184],"patients.":[185],"We":[186],"present":[187],"method":[190],"for":[191],"predictively":[192],"mapping":[193],"brain":[194],"cellularity":[196],"beyond":[197],"contrast":[198],"enhancement.":[199],"technique":[201],"could":[202],"improve":[203],"planning":[205],"disease":[207],"monitoring.":[208]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-02-24T00:00:00"}