{"id":"https://openalex.org/W2588055063","doi":"https://doi.org/10.1007/s00277-017-2938-5","title":"Ruxolitinib rechallenge in combination with hydroxyurea is effective in reverting cachexia and reducing blood transfusion demand and splenomegaly symptoms in a patient with primary myelofibrosis","display_name":"Ruxolitinib rechallenge in combination with hydroxyurea is effective in reverting cachexia and reducing blood transfusion demand and splenomegaly symptoms in a patient with primary myelofibrosis","publication_year":2017,"publication_date":"2017-02-14","ids":{"openalex":"https://openalex.org/W2588055063","doi":"https://doi.org/10.1007/s00277-017-2938-5","mag":"2588055063","pmid":"https://pubmed.ncbi.nlm.nih.gov/28197723","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5334413"},"language":"en","primary_location":{"id":"doi:10.1007/s00277-017-2938-5","doi":"https://doi.org/10.1007/s00277-017-2938-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-017-2938-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00277-017-2938-5.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs00277-017-2938-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083968415","display_name":"Claudio Cerchione","orcid":"https://orcid.org/0000-0002-9104-5436","observed_orcids":["https://orcid.org/0000-0002-9104-5436"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudio Cerchione","raw_affiliation_strings":["Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy. claudiocerc@hotmail.com","Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy. claudiocerc@hotmail.com","institution_ids":["https://openalex.org/I4210117450"]},{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy","institution_ids":["https://openalex.org/I4210117450"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ilaria Peluso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Peluso","raw_affiliation_strings":["Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy","institution_ids":["https://openalex.org/I4210117450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067001070","display_name":"Davide Nappi","orcid":"https://orcid.org/0000-0001-9776-5875","observed_orcids":["https://orcid.org/0000-0001-9776-5875"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Nappi","raw_affiliation_strings":["Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy","institution_ids":["https://openalex.org/I4210117450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112864251","display_name":"Anna Emanuele Pareto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Emanuele Pareto","raw_affiliation_strings":["Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy","institution_ids":["https://openalex.org/I4210117450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059488532","display_name":"Marco Picardi","orcid":"https://orcid.org/0000-0001-8508-2524","observed_orcids":["https://orcid.org/0000-0001-8508-2524"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Picardi","raw_affiliation_strings":["Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy","institution_ids":["https://openalex.org/I4210117450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037391469","display_name":"Vincenzo Martinelli","orcid":"https://orcid.org/0000-0001-7034-3146","observed_orcids":["https://orcid.org/0000-0001-7034-3146"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Martinelli","raw_affiliation_strings":["Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy","institution_ids":["https://openalex.org/I4210117450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057084037","display_name":"Fabrizio Pane","orcid":"https://orcid.org/0000-0003-2563-4125","observed_orcids":["https://orcid.org/0000-0003-2563-4125"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Pane","raw_affiliation_strings":["Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Azienda Ospedaliera Universitaria Federico II, Via Pansini 5, 80131, Naples, Italy","institution_ids":["https://openalex.org/I4210117450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083968415"],"corresponding_institution_ids":["https://openalex.org/I4210117450"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":2.2718,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.88322415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"96","issue":"4","first_page":"697","last_page":"699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.9539999961853027},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/rechallenge","display_name":"drug rechallenge","score":0.906000018119812},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/transfusion-requirements","display_name":"transfusion requirements","score":0.8489999771118164},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.968999981880188},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.9314655065536499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8860762715339661},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.8705295920372009},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.6646057963371277},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.5126787424087524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5026051998138428},{"id":"https://openalex.org/C2780844101","wikidata":"https://www.wikidata.org/wiki/Q2380264","display_name":"Ineffective erythropoiesis","level":4,"score":0.4941768944263458},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4391208291053772},{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.41449999809265137},{"id":"https://openalex.org/C2778740236","wikidata":"https://www.wikidata.org/wiki/Q933716","display_name":"Polycythaemia","level":2,"score":0.4144301116466522},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37479519844055176},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3724517226219177},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.3212788701057434},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.12758275866508484},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08534446358680725}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013163","descriptor_name":"Splenomegaly","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013163","descriptor_name":"Splenomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00277-017-2938-5","doi":"https://doi.org/10.1007/s00277-017-2938-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-017-2938-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00277-017-2938-5.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5334413","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5334413","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Hematol","raw_type":"Text"},{"id":"pmid:28197723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28197723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of hematology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1007/s00277-017-2938-5","doi":"https://doi.org/10.1007/s00277-017-2938-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-017-2938-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00277-017-2938-5.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2588055063.pdf","grobid_xml":"https://content.openalex.org/works/W2588055063.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1980568348","https://openalex.org/W2016111806","https://openalex.org/W2025592929","https://openalex.org/W2030356048","https://openalex.org/W2038654298","https://openalex.org/W2126532431","https://openalex.org/W2161021913","https://openalex.org/W2268545279","https://openalex.org/W2418937816"],"related_works":["https://openalex.org/W4401278266","https://openalex.org/W2794625669","https://openalex.org/W2066214315","https://openalex.org/W3082198077","https://openalex.org/W1947827851","https://openalex.org/W2907318518","https://openalex.org/W7145519621","https://openalex.org/W2952450872","https://openalex.org/W652440881","https://openalex.org/W2268545279"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-24T00:00:00"}