{"id":"https://openalex.org/W2588026145","doi":"https://doi.org/10.1007/s13361-017-1595-1","title":"Assigning Peptide Disulfide Linkage Pattern Among Regio-Isomers via Methoxy Addition to Disulfide and Tandem Mass Spectrometry","display_name":"Assigning Peptide Disulfide Linkage Pattern Among Regio-Isomers via Methoxy Addition to Disulfide and Tandem Mass Spectrometry","publication_year":2017,"publication_date":"2017-02-13","ids":{"openalex":"https://openalex.org/W2588026145","doi":"https://doi.org/10.1007/s13361-017-1595-1","mag":"2588026145","pmid":"https://pubmed.ncbi.nlm.nih.gov/28194735"},"language":"en","primary_location":{"id":"doi:10.1007/s13361-017-1595-1","doi":"https://doi.org/10.1007/s13361-017-1595-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13361-017-1595-1","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082794067","display_name":"Kirt L. Durand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirt L. Durand","raw_affiliation_strings":["Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lei Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Tan","raw_affiliation_strings":["Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055008150","display_name":"Craig A. Stinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig A. Stinson","raw_affiliation_strings":["Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014274271","display_name":"Chasity B. Love\u2010Nkansah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chasity B. Love-Nkansah","raw_affiliation_strings":["Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079252934","display_name":"Xiaoxiao Ma","orcid":"https://orcid.org/0000-0003-1205-6485","observed_orcids":["https://orcid.org/0000-0003-1205-6485"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxiao Ma","raw_affiliation_strings":["Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062534695","display_name":"Yu Xia","orcid":"https://orcid.org/0000-0001-8694-9900","observed_orcids":["https://orcid.org/0000-0001-8694-9900"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Xia","raw_affiliation_strings":["Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 47907-2084, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6746,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.59815513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"6","first_page":"1099","last_page":"1108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfide-bond-cleavage","display_name":"disulfide bond cleavage","score":0.9599999785423279},{"id":"https://openalex.org/keywords/methanol-loss","display_name":"methanol loss","score":0.625},{"id":"https://openalex.org/keywords/collision-induced-dissociation","display_name":"collision-induced dissociation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.9049999713897705},{"id":"https://openalex.org/keywords/disulfide-scrambling","display_name":"disulfide scrambling","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bovine-insulin","display_name":"bovine insulin","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9381284713745117},{"id":"https://openalex.org/C2910051704","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide Linkage","level":4,"score":0.804874062538147},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.6606738567352295},{"id":"https://openalex.org/C2775852224","wikidata":"https://www.wikidata.org/wiki/Q419800","display_name":"Dimethyl disulfide","level":3,"score":0.5933156609535217},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5590688586235046},{"id":"https://openalex.org/C2780158455","wikidata":"https://www.wikidata.org/wiki/Q411721","display_name":"Sulfenic acid","level":4,"score":0.5404077768325806},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5388118624687195},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5126746892929077},{"id":"https://openalex.org/C202235601","wikidata":"https://www.wikidata.org/wiki/Q7361732","display_name":"Structural isomer","level":2,"score":0.476578950881958},{"id":"https://openalex.org/C2778448320","wikidata":"https://www.wikidata.org/wiki/Q408395","display_name":"Sulfoxide","level":2,"score":0.41323062777519226},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3941829800605774},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3413273096084595},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22833627462387085},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20290163159370422},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.19555190205574036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10350197553634644},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07511404156684875}],"mesh":[{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007536","descriptor_name":"Isomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s13361-017-1595-1","doi":"https://doi.org/10.1007/s13361-017-1595-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13361-017-1595-1","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:28194735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28194735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1151053621","display_name":"Gas-Phase Ion Chemistry of Peptide Radical Ions and Applications in Protein Characterization","funder_award_id":"1308114","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1023657295","https://openalex.org/W1966647910","https://openalex.org/W1973656620","https://openalex.org/W1973899747","https://openalex.org/W1978617991","https://openalex.org/W1990581038","https://openalex.org/W1994635189","https://openalex.org/W2000359698","https://openalex.org/W2002222610","https://openalex.org/W2002242532","https://openalex.org/W2012619004","https://openalex.org/W2017163455","https://openalex.org/W2017172725","https://openalex.org/W2018252822","https://openalex.org/W2023586084","https://openalex.org/W2029180439","https://openalex.org/W2039691000","https://openalex.org/W2043742342","https://openalex.org/W2048527293","https://openalex.org/W2057706980","https://openalex.org/W2062013025","https://openalex.org/W2064183803","https://openalex.org/W2066606332","https://openalex.org/W2072934848","https://openalex.org/W2077427812","https://openalex.org/W2089529549","https://openalex.org/W2141023695","https://openalex.org/W2143946237","https://openalex.org/W2153138530","https://openalex.org/W2156249239","https://openalex.org/W2157681460","https://openalex.org/W2161307259","https://openalex.org/W2165998358","https://openalex.org/W2166524375","https://openalex.org/W2169057680","https://openalex.org/W2312264339","https://openalex.org/W2312979167","https://openalex.org/W2320591750","https://openalex.org/W2949320474","https://openalex.org/W4211175230","https://openalex.org/W4255127518"],"related_works":["https://openalex.org/W1973656620","https://openalex.org/W315307182","https://openalex.org/W2903225226","https://openalex.org/W2046385014","https://openalex.org/W3209884531","https://openalex.org/W2058561450","https://openalex.org/W2167684345","https://openalex.org/W1973899747","https://openalex.org/W2012913970","https://openalex.org/W2784470807"],"abstract_inverted_index":{"Pinpointing":[0],"disulfide":[1,16,27,37,46,71,132,171,203,208,221,225],"linkage":[2,204,226],"pattern":[3],"is":[4],"critical":[5],"in":[6,50,184,206],"the":[7,91,148,159,176,185],"characterization":[8],"of":[9,14,69,75,147,161],"proteins":[10],"and":[11,29,57,73,86,125,138,223,230],"peptides":[12],"consisting":[13],"multiple":[15],"bonds.":[17],"Herein,":[18],"we":[19],"report":[20],"a":[21,40,44,55,70,87,105],"method":[22,41],"based":[23,189],"on":[24,43,190],"coupling":[25],"online":[26],"modification":[28],"tandem":[30],"mass":[31],"spectrometry":[32],"(MS/MS)":[33],"to":[34,66,175,215],"distinguish":[35],"peptide":[36,207,217],"regio-isomers.":[38,209],"Such":[39],"relies":[42],"new":[45],"bond":[47,72,133],"cleavage":[48,68],"reaction":[49,64,167],"solution,":[51],"involving":[52],"methanol":[53,107],"as":[54,120,156],"reactant":[56],"254":[58],"nm":[59],"ultraviolet":[60],"(UV)":[61],"irradiation.":[62],"This":[63,210],"leads":[65],"selective":[67],"formation":[74],"sulfenic":[76,100],"methyl":[77,101,126],"ester":[78,102],"(\u2013SOCH":[79],"3":[80,129,196],")":[81],"at":[82,90],"one":[83],"cysteine":[84,99],"residue":[85],"thiol":[88],"(\u2013SH)":[89],"other.":[92],"Under":[93],"low":[94],"energy":[95],"collision-induced":[96],"dissociation":[97],"(CID),":[98],"motif":[103],"produces":[104],"signature":[106],"loss":[108],"(\u201332":[109],"Da),":[110],"allowing":[111],"its":[112],"identification":[113],"from":[114],"other":[115],"possible":[116],"isomeric":[117],"structures":[118],"such":[119],"S-hydroxylmethyl":[121],"(\u2013SCH":[122],"2":[123,145],"OH)":[124],"sulfoxide":[127],"(\u2013S(O)-CH":[128],").":[130],"Since":[131],"can":[134],"be":[135],"selectively":[136],"cleaved":[137],"modified":[139],"upon":[140],"methoxy":[141,149,191],"addition,":[142],"subsequent":[143],"MS":[144,195],"CID":[146,197],"addition":[150,192],"product":[151],"provides":[152],"enhanced":[153],"sequence":[154],"coverage":[155],"demonstrated":[157],"by":[158,194],"analysis":[160],"bovine":[162],"insulin.":[163],"More":[164],"importantly,":[165],"this":[166],"does":[168],"not":[169,182],"induce":[170],"scrambling,":[172],"likely":[173],"due":[174],"fact":[177],"that":[178],"radical":[179],"intermediates":[180],"are":[181],"involved":[183],"process.":[186],"An":[187],"approach":[188],"followed":[193],"has":[198],"been":[199],"developed":[200],"for":[201],"assigning":[202],"patterns":[205],"methodology":[211],"was":[212],"successfully":[213],"applied":[214],"characterizing":[216],"systems":[218],"having":[219],"two":[220],"bonds":[222],"three":[224],"isomers:":[227],"side-by-side,":[228],"overlapped,":[229],"looped-within-a-loop":[231],"configurations.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-24T00:00:00"}