{"id":"https://openalex.org/W2587970063","doi":"https://doi.org/10.1182/blood.v104.11.4484.4484","title":"Adult Patients with Acute Lymphoblastic Leukemia (ALL) and Central Nervous System (CNS) Leukemia at Diagnosis May Attain Durable Complete Remissions (CR). Results from the International ALL Trial (MRC UKALL-XII/ECOG E2993).","display_name":"Adult Patients with Acute Lymphoblastic Leukemia (ALL) and Central Nervous System (CNS) Leukemia at Diagnosis May Attain Durable Complete Remissions (CR). Results from the International ALL Trial (MRC UKALL-XII/ECOG E2993).","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2587970063","doi":"https://doi.org/10.1182/blood.v104.11.4484.4484","mag":"2587970063"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.4484.4484","doi":"https://doi.org/10.1182/blood.v104.11.4484.4484","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.4484.4484","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042915360","display_name":"Hillard Michael Lazarus","orcid":"https://orcid.org/0000-0002-1159-5607","observed_orcids":["https://orcid.org/0000-0002-1159-5607"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hillard M. Lazarus","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109352890","display_name":"Sue M. Richards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue M. Richards","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113455025","display_name":"Raj Chopra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Chopra","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Litzow","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013645809","display_name":"Alan K. Burnett","orcid":"https://orcid.org/0000-0003-1734-5817","observed_orcids":["https://orcid.org/0000-0003-1734-5817"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan K. Burnett","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089619585","display_name":"Peter H. Wiernik","orcid":"https://orcid.org/0000-0003-1473-813X","observed_orcids":["https://orcid.org/0000-0003-1473-813X"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H. Wiernik","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006336720","display_name":"IAN M. FRANKLIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian M. Franklin","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001124933","display_name":"Martin S. Tallman","orcid":"https://orcid.org/0000-0002-4367-6102","observed_orcids":["https://orcid.org/0000-0002-4367-6102"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin S. Tallman","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064182313","display_name":"Georgina A. N. Buck","orcid":"https://orcid.org/0000-0001-5909-4265","observed_orcids":["https://orcid.org/0000-0001-5909-4265"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Buck","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036764019","display_name":"Jill Durrant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Durrant","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869658","display_name":"Jacob M. Rowe","orcid":"https://orcid.org/0000-0002-2016-2918","observed_orcids":["https://orcid.org/0000-0002-2016-2918"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob M. Rowe","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104206559","display_name":"Anthony H. Goldstone","orcid":"https://orcid.org/0000-0001-8179-7071","observed_orcids":["https://orcid.org/0000-0001-8179-7071"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony H. Goldstone","raw_affiliation_strings":["1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; 2 CTSU, Oxford, United Kingdom; 3 Rambam Medical Center, Haifa, Israel and 4 Eastern Cooperative Oncology Group, Brookline, MA, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.0135,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80567287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"104","issue":"11","first_page":"4484","last_page":"4484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/adult-acute-lymphoblastic-leukemia","display_name":"adult acute lymphoblastic leukemia","score":0.7200000286102295},{"id":"https://openalex.org/keywords/central-nervous-system-leukemia","display_name":"central nervous system leukemia","score":0.8330000042915344},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.9419999718666077},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.847000002861023},{"id":"https://openalex.org/keywords/matched-related-donor","display_name":"matched related donor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/matched-unrelated-donor","display_name":"matched unrelated donor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.5830000042915344},{"id":"https://openalex.org/keywords/cns-prophylaxis","display_name":"CNS prophylaxis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.6690000295639038},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.37299999594688416},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.878746509552002},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.605401337146759},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.46484655141830444},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4608997106552124},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41827917098999023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41694456338882446},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.4106194078922272}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.4484.4484","doi":"https://doi.org/10.1182/blood.v104.11.4484.4484","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.4484.4484","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125486570","https://openalex.org/W2128491464","https://openalex.org/W4252037816","https://openalex.org/W248850316","https://openalex.org/W2587522587","https://openalex.org/W2530508747","https://openalex.org/W2092369026","https://openalex.org/W2590101487","https://openalex.org/W1989937920","https://openalex.org/W2511212664"],"abstract_inverted_index":{"Abstract":[0],"In":[1,263],"1993,":[2],"we":[3,266,275],"initiated":[4],"an":[5,66,77,93],"international":[6],"trial":[7],"in":[8,57,71,95,146,186,207,217,249,313,331,338],"newly":[9],"diagnosed":[10],"adult":[11],"(age":[12],"15\u201360":[13],"years)":[14],"ALL":[15,288],"patients.":[16,100],"1637":[17],"patients":[18,30,103,121,138,142,168,184,202,289],"have":[19,60],"been":[20],"entered":[21],"and":[22,37,68,84,116,134,152,158,179,196,212,257],"data":[23],"analyzed":[24],"as":[25,45,302,304],"of":[26,35,171,174,177,271,279],"June":[27],"2004.":[28],"All":[29],"receive":[31],"two":[32],"induction":[33,129],"phases":[34],"therapy":[36,41],"CNS":[38,43,105,272,284,291],"prophylaxis":[39],"(or":[40],"if":[42],"involved)":[44],"assessed":[46],"by":[47],"lumbar":[48],"puncture":[49],"for":[50,164,230],"cytospin.":[51],"Patients":[52],"age":[53,111],"\u2264":[54],"50":[55],"yr":[56],"CR1":[58,72,124,147,332,339],"who":[59],"a":[61,221,268],"matched-related":[62],"donor":[63,89],"(MRD)":[64],"undergo":[65],"allograft,":[67],"the":[69],"remainder":[70],"are":[73],"randomized":[74],"either":[75],"to":[76,189,282],"autograft":[78,258],"or":[79],"4":[80],"cycles":[81],"intensive":[82],"consolidation":[83],"maintenance":[85],"chemotherapy.":[86,306],"Matched":[87],"unrelated":[88],"(MUD)":[90],"allograft":[91,237,243],"is":[92],"option":[94],"Philadelphia":[96],"chromosome":[97],"(Ph)":[98],"positive":[99],"46":[101,357],"(3%)":[102],"had":[104],"leukemia":[106,273,292],"at":[107,209,220,293],"presentation.":[108],"Median":[109],"(range)":[110],"was":[112],"29":[113],"(16\u201356)":[114],"years,":[115],"5":[117,153,350],"were":[118,162],"Ph+.":[119],"Five":[120],"never":[122],"attained":[123,139],"(3":[125],"died":[126,185],"early":[127],"during":[128],"on":[130],"days":[131],"4,":[132],"25":[133],"36).":[135],"41/46":[136],"(89%)":[137],"CR1.":[140,166],"23":[141],"underwent":[143],"transplant,":[144],"17":[145],"(10":[148],"MRD,":[149],"2":[150,324,333,336],"MUD,":[151],"autografts),":[154],"while":[155],"3":[156,159,176,318,344],"MUD":[157,242,325,330,334],"MRD":[160,236,337,342],"allografts":[161],"performed":[163,248],">":[165],"31/46":[167],"died,":[169],"12":[170,183],"leukemia,":[172],"8":[173,180],"infection,":[175],"GVHD":[178,194],"other":[181],"causes.":[182],"remission":[187,321,327],"due":[188,281],"infection":[190],"(5),":[191],"bleeding":[192],"(2),":[193],"(3),":[195],"visceral":[197],"organ":[198],"failure":[199],"(2).":[200],"15":[201,232],"remain":[203,216],"alive,":[204],"one":[205],"Ph+":[206],"relapse":[208],"58":[210,345],"mo":[211,226],"14":[213],"(30%)":[214],"Ph-":[215,287],"continuous":[218],"CR":[219,314],"median":[222],"67":[223,246,329],"(range:":[224],"2\u2013133)":[225],"after":[227],"diagnosis.":[228],"Treatments":[229],"these":[231],"long-term":[233,297],"survivors":[234],"were:":[235],"(6":[238,253],"@":[239,245,254,260],"45,53,63,67,98,120":[240,341],"mo),":[241],"(1":[244,259],"mo;":[247],"relapse),":[250],"chemotherapy":[251],"only":[252],"2,55,87,98,125,133":[255,355],"mo)":[256],"31":[261,351],"mo).":[262],"this":[264],"study":[265],"noted":[267],"low":[269],"incidence":[270],"but":[274],"cannot":[276],"exclude":[277],"avoidance":[278],"enrollment":[280],"suspected":[283],"involvement.":[285],"Adult":[286],"with":[290],"diagnosis":[294],"can":[295],"attain":[296],"disease-free":[298],"survivorship":[299],"using":[300],"transplantation":[301],"well":[303],"conventional":[305],"Therapy":[307],"(and":[308],"status)":[309],"No.":[310],"Pts":[311],"Survivors":[312],"(mo)":[315],"Induction":[316],"death":[317],"Died:":[319],"no":[320],"(resistant":[322],"disease)":[323],"without":[326],"1":[328],"post-relapse":[335],"10":[340],">CR1":[343],"(in":[346],"relapse)":[347],"Auto":[348],"(CR1)":[349,353],"Chemotherapy":[352],"18":[354],"Total":[356]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-02-24T00:00:00"}