{"id":"https://openalex.org/W2587862424","doi":"https://doi.org/10.1016/j.vaccine.2017.01.055","title":"Safety and immunogenicity of the novel H4:IC31 tuberculosis vaccine candidate in BCG-vaccinated adults: Two phase I dose escalation trials","display_name":"Safety and immunogenicity of the novel H4:IC31 tuberculosis vaccine candidate in BCG-vaccinated adults: Two phase I dose escalation trials","publication_year":2017,"publication_date":"2017-02-17","ids":{"openalex":"https://openalex.org/W2587862424","doi":"https://doi.org/10.1016/j.vaccine.2017.01.055","mag":"2587862424","pmid":"https://pubmed.ncbi.nlm.nih.gov/28216183"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2017.01.055","doi":"https://doi.org/10.1016/j.vaccine.2017.01.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2017.01.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X17301202/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0264410X17301202/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073630588","display_name":"Maria Norrby","orcid":"https://orcid.org/0000-0002-9723-6495","observed_orcids":["https://orcid.org/0000-0002-9723-6495"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maria Norrby","raw_affiliation_strings":["Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047153448","display_name":"Timo Vesikari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Timo Vesikari","raw_affiliation_strings":["Vaccine Research Center, University of Tampere, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Research Center, University of Tampere, Tampere, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lars Lindqvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars Lindqvist","raw_affiliation_strings":["Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006698445","display_name":"Markus J. Maeurer","orcid":"https://orcid.org/0000-0002-8436-8077","observed_orcids":["https://orcid.org/0000-0002-8436-8077"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Markus Maeurer","raw_affiliation_strings":["TIM, Department of Laboratory Medicine and CAST, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIM, Department of Laboratory Medicine and CAST, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110332645","display_name":"Raija K.S. Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Raija Ahmed","raw_affiliation_strings":["TIM, Department of Laboratory Medicine and CAST, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIM, Department of Laboratory Medicine and CAST, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003524409","display_name":"Shahnaz Mahdavifar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Shahnaz Mahdavifar","raw_affiliation_strings":["TIM, Department of Laboratory Medicine and CAST, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIM, Department of Laboratory Medicine and CAST, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050495873","display_name":"Sean R. Bennett","orcid":"https://orcid.org/0000-0002-4368-3652","observed_orcids":["https://orcid.org/0000-0002-4368-3652"]},"institutions":[{"id":"https://openalex.org/I1296297310","display_name":"Aeras","ror":"https://ror.org/015facm29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1296297310"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Bennett","raw_affiliation_strings":["Aeras, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aeras, Rockville, MD, USA","institution_ids":["https://openalex.org/I1296297310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110162733","display_name":"J. Bruce McClain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1296297310","display_name":"Aeras","ror":"https://ror.org/015facm29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1296297310"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bruce McClain","raw_affiliation_strings":["Aeras, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aeras, Rockville, MD, USA","institution_ids":["https://openalex.org/I1296297310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007856969","display_name":"Barbara M. Shepherd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1296297310","display_name":"Aeras","ror":"https://ror.org/015facm29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1296297310"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara M. Shepherd","raw_affiliation_strings":["Aeras, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aeras, Rockville, MD, USA","institution_ids":["https://openalex.org/I1296297310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012481334","display_name":"Daner Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1296297310","display_name":"Aeras","ror":"https://ror.org/015facm29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1296297310"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daner Li","raw_affiliation_strings":["Aeras, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aeras, Rockville, MD, USA","institution_ids":["https://openalex.org/I1296297310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027350232","display_name":"David A. Hokey","orcid":"https://orcid.org/0000-0002-6184-2485","observed_orcids":["https://orcid.org/0000-0002-6184-2485"]},"institutions":[{"id":"https://openalex.org/I1296297310","display_name":"Aeras","ror":"https://ror.org/015facm29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1296297310"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Hokey","raw_affiliation_strings":["Aeras, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aeras, Rockville, MD, USA","institution_ids":["https://openalex.org/I1296297310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080578571","display_name":"Ingrid Kromann","orcid":"https://orcid.org/0000-0002-6244-8332","observed_orcids":["https://orcid.org/0000-0002-6244-8332"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ingrid Kromann","raw_affiliation_strings":["Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078003599","display_name":"Soren Tetens Hoff","orcid":"https://orcid.org/0000-0001-8257-9340","observed_orcids":["https://orcid.org/0000-0001-8257-9340"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren T. Hoff","raw_affiliation_strings":["Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090428914","display_name":"Peter Law\u00e6tz Andersen","orcid":"https://orcid.org/0000-0002-5869-2551","observed_orcids":["https://orcid.org/0000-0002-5869-2551"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Andersen","raw_affiliation_strings":["Statens Serum Institut, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statens Serum Institut, Copenhagen, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103578533","display_name":"Adri\u00ebtte W. de Visser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Adri\u00ebtte W. de Visser","raw_affiliation_strings":["Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016521148","display_name":"Simone A. Joosten","orcid":"https://orcid.org/0000-0002-9878-0863","observed_orcids":["https://orcid.org/0000-0002-9878-0863"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Simone A. Joosten","raw_affiliation_strings":["Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004201118","display_name":"Tom H. M. Ottenhoff","orcid":"https://orcid.org/0000-0003-3706-3403","observed_orcids":["https://orcid.org/0000-0003-3706-3403"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tom H.M. Ottenhoff","raw_affiliation_strings":["Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078542779","display_name":"Jan Andersson","orcid":"https://orcid.org/0000-0003-0316-3860","observed_orcids":["https://orcid.org/0000-0003-0316-3860","https://orcid.org/0009-0005-7276-8056"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Andersson","raw_affiliation_strings":["Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden","Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden","Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069208310","display_name":"Susanna Brighenti","orcid":"https://orcid.org/0000-0001-8540-153X","observed_orcids":["https://orcid.org/0000-0001-8540-153X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Susanna Brighenti","raw_affiliation_strings":["Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden. Electronic address: susanna.brighenti@ki.se","Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden. Electronic address: susanna.brighenti@ki.se","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Center for Infectious Medicine (CIM), Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5069208310"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":{"value":2063,"currency":"EUR","value_usd":2224},"fwci":4.8302,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.95686536,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"35","issue":"12","first_page":"1652","last_page":"1661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-vaccine","display_name":"tuberculosis vaccine","score":0.8399999737739563},{"id":"https://openalex.org/keywords/ag85b","display_name":"Ag85B","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tb10-4","display_name":"TB10.4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.8759999871253967},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cd4-t-cell-responses","display_name":"CD4+ T cell responses","score":0.972000002861023},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8220000267028809},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.6589999794960022},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/fusion-protein-vaccine","display_name":"fusion protein vaccine","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.8144386410713196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8105885982513428},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8006372451782227},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7125008702278137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.636658251285553},{"id":"https://openalex.org/C2779078216","wikidata":"https://www.wikidata.org/wiki/Q7850848","display_name":"Tuberculosis vaccines","level":4,"score":0.568733274936676},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5211301445960999},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5096189975738525},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4561126232147217},{"id":"https://openalex.org/C2778288313","wikidata":"https://www.wikidata.org/wiki/Q798309","display_name":"BCG vaccine","level":3,"score":0.43646347522735596},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.33219510316848755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24280020594596863},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05712363123893738}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032581","descriptor_name":"Tuberculosis Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D032581","descriptor_name":"Tuberculosis Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D032581","descriptor_name":"Tuberculosis Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1016/j.vaccine.2017.01.055","doi":"https://doi.org/10.1016/j.vaccine.2017.01.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2017.01.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X17301202/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:28216183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28216183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:tampub.uta.fi:10024/100919","doi":null,"is_oa":true,"landing_page_url":"http://tampub.uta.fi/handle/10024/100919","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"publishedVersion"},{"id":"pmh:oai:alma.31UKB_LEU:9940751522402711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/114401","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/114401/1?col=81522199330002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccine, Vol. 35, no. 12, p. 1652-1661","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3000690","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/114401","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccine, 35(12), 1652 - 1661","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/114401","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/114401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"35","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3000690","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/114401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccine","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:trepo.tuni.fi:10024/100919","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/100919","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"publishedVersion"}],"best_oa_location":{"id":"doi:10.1016/j.vaccine.2017.01.055","doi":"https://doi.org/10.1016/j.vaccine.2017.01.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2017.01.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X17301202/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311178","display_name":"Aeras Global Tuberculosis Vaccine Foundation","ror":"https://ror.org/015facm29"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2587862424.pdf","grobid_xml":"https://content.openalex.org/works/W2587862424.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W373525439","https://openalex.org/W631768487","https://openalex.org/W1535079286","https://openalex.org/W1552600293","https://openalex.org/W1874438006","https://openalex.org/W1971947249","https://openalex.org/W1974433492","https://openalex.org/W1977575192","https://openalex.org/W1983763479","https://openalex.org/W2004908730","https://openalex.org/W2006091616","https://openalex.org/W2007149567","https://openalex.org/W2011183326","https://openalex.org/W2014816257","https://openalex.org/W2020340820","https://openalex.org/W2027455101","https://openalex.org/W2035214942","https://openalex.org/W2035651986","https://openalex.org/W2045693101","https://openalex.org/W2047219566","https://openalex.org/W2049675690","https://openalex.org/W2057731649","https://openalex.org/W2066738380","https://openalex.org/W2075241883","https://openalex.org/W2089226849","https://openalex.org/W2107876252","https://openalex.org/W2112503375","https://openalex.org/W2116616469","https://openalex.org/W2117522110","https://openalex.org/W2130388209","https://openalex.org/W2137285612","https://openalex.org/W2153271703","https://openalex.org/W2156436209","https://openalex.org/W2160925670","https://openalex.org/W2345333765","https://openalex.org/W2408473116","https://openalex.org/W2614214796","https://openalex.org/W4205161959"],"related_works":["https://openalex.org/W631768487","https://openalex.org/W2086707243","https://openalex.org/W2556974178","https://openalex.org/W926099720","https://openalex.org/W7096671530","https://openalex.org/W4393387660","https://openalex.org/W6901519464","https://openalex.org/W3011610724","https://openalex.org/W1538232906","https://openalex.org/W3171978303"],"abstract_inverted_index":{"Background":[0],"Novel":[1],"vaccine":[2,29,76,154,215],"strategies":[3],"are":[4,251],"required":[5],"to":[6,131],"provide":[7],"protective":[8],"immunity":[9],"in":[10,85,94,100,202,235],"tuberculosis":[11,42],"(TB)":[12],"and":[13,23,45,66,102,111,140,162,180,223,259,268],"prevent":[14],"development":[15],"of":[16,25,36,40,73,128,192,200,227,257,262],"active":[17],"disease.":[18],"We":[19],"investigated":[20],"the":[21,74,145,170,205,246],"safety":[22,125,221],"immunogenicity":[24],"a":[26,37,95,124],"novel":[27,213],"TB":[28,97,214],"candidate,":[30,216],"H4:IC31":[31,75,118,153,193],"(AERAS-404)":[32],"that":[33,165,245],"is":[34],"composed":[35],"fusion":[38],"protein":[39],"M.":[41],"antigens":[43],"Ag85B":[44],"TB10.4":[46],"combined":[47],"with":[48,58,123,204],"an":[49,219],"IC31\u00ae":[50],"adjuvant.":[51],"Methods":[52],"BCG-vaccinated":[53,237],"healthy":[54,238],"subjects":[55,105],"were":[56,106,186],"immunized":[57],"various":[59],"antigen":[60],"(5,":[61],"15,":[62,196,253],"50,":[63],"150":[64],"\u03bcg)":[65],"adjuvant":[67,209],"(0,":[68],"100,":[69],"500":[70,206,260],"nmol)":[71],"doses":[72,191],"(n":[77,82],"=":[78,83],"106)":[79],"or":[80,197,254],"placebo":[81],"18)":[84],"two":[86,190],"randomized,":[87],"double-blind,":[88],"placebo-controlled":[89],"phase":[90],"I":[91],"studies":[92],"conducted":[93],"low":[96],"endemic":[98],"setting":[99],"Sweden":[101],"Finland.":[103],"The":[104,152,212],"followed":[107],"for":[108],"adverse":[109],"events":[110],"CD4":[112,157,173,182,230],"+":[113,158,174,183,231],"T":[114,159,175,232],"cell":[115,160,176,233],"responses.":[116],"Results":[117],"vaccination":[119],"was":[120,224],"well":[121],"tolerated":[122],"profile":[126,222],"consisting":[127],"mostly":[129],"mild":[130],"moderate":[132],"self-limited":[133],"injection":[134,150],"site":[135],"pain,":[136],"myalgia,":[137],"arthralgia,":[138],"fever":[139],"post-vaccination":[141],"inflammatory":[142],"reaction":[143],"at":[144],"screening":[146],"tuberculin":[147],"skin":[148],"test":[149],"site.":[151],"elicited":[155],"antigen-specific":[156],"proliferation":[161],"cytokine":[163],"production":[164,179],"persisted":[166],"18":[167],"weeks":[168],"after":[169,189],"last":[171],"vaccination.":[172],"expansion,":[177],"IFN-\u03b3":[178],"multifunctional":[181,229],"Th1":[184],"responses":[185,234],"most":[187],"prominent":[188],"containing":[194],"5,":[195,252],"50":[198,255],"\u03bcg":[199,256],"H4":[201,258],"combination":[203],"nmol":[207,261],"IC31":[208],"dose.":[210],"Conclusions":[211],"H4:IC31,":[217],"demonstrated":[218],"acceptable":[220],"immunogenic,":[225],"capable":[226],"triggering":[228],"previously":[236],"individuals.":[239],"These":[240],"dose-escalation":[241],"trials":[242],"provided":[243],"evidence":[244],"optimal":[247],"antigen-adjuvant":[248],"dose":[249],"combinations":[250],"IC31.":[263],"Trial":[264],"registration:":[265],"ClinicalTrials.gov,":[266],"NCT02066428":[267],"NCT02074956":[269],".":[270]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-02-24T00:00:00"}
