{"id":"https://openalex.org/W2587843364","doi":"https://doi.org/10.1093/ndt/gfw117.01","title":"SO001C1-INHIBITOR ABROGATED ISCHEMIA/REPERFUSION (I/R) INDUCED INFLAMMAGING BY INHIBITING SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) IN TUBULAR EPITHELIAL CELLS (TEC)","display_name":"SO001C1-INHIBITOR ABROGATED ISCHEMIA/REPERFUSION (I/R) INDUCED INFLAMMAGING BY INHIBITING SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) IN TUBULAR EPITHELIAL CELLS (TEC)","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2587843364","doi":"https://doi.org/10.1093/ndt/gfw117.01","mag":"2587843364"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfw117.01","doi":"https://doi.org/10.1093/ndt/gfw117.01","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfw117.01","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086487998","display_name":"Rossana Franzin","orcid":"https://orcid.org/0000-0001-7907-7614","observed_orcids":["https://orcid.org/0000-0001-7907-7614"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossana Franzin","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091403457","display_name":"Alessandra Stasi","orcid":"https://orcid.org/0000-0003-3652-3623","observed_orcids":["https://orcid.org/0000-0003-3652-3623"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Stasi","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048351906","display_name":"Angelica Intini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelica Intini","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036503080","display_name":"Chiara Divella","orcid":"https://orcid.org/0000-0003-2717-3158","observed_orcids":["https://orcid.org/0000-0003-2717-3158"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Divella","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025640800","display_name":"Margherita Gigante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Margherita Gigante","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081075808","display_name":"Simona Simone","orcid":"https://orcid.org/0000-0002-2569-3558","observed_orcids":["https://orcid.org/0000-0002-2569-3558"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Simone","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048512133","display_name":"Paola Pontrelli","orcid":"https://orcid.org/0000-0002-7654-8318","observed_orcids":["https://orcid.org/0000-0002-7654-8318"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Pontrelli","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034349357","display_name":"Antonio Crovace","orcid":"https://orcid.org/0000-0002-1391-339X","observed_orcids":["https://orcid.org/0000-0002-1391-339X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Crovace","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031961999","display_name":"Michele Battaglia","orcid":"https://orcid.org/0000-0002-2453-2349","observed_orcids":["https://orcid.org/0000-0002-2453-2349"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Battaglia","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068737784","display_name":"Beatrijs D. Oortwijn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116086","display_name":"Pharming Group (Netherlands)","ror":"https://ror.org/0233s3730","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210116086"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Beatrijs Oortwijn","raw_affiliation_strings":["Pharming Group NV, Pharming Technologies NV, Leiden, THE NETHERLANDS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharming Group NV, Pharming Technologies NV, Leiden, THE NETHERLANDS","institution_ids":["https://openalex.org/I4210116086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002689245","display_name":"Edwin V Amersfoort","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116086","display_name":"Pharming Group (Netherlands)","ror":"https://ror.org/0233s3730","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210116086"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Edwin V. Amersfoort","raw_affiliation_strings":["Pharming Group NV, Pharming Technologies NV, Leiden, THE NETHERLANDS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharming Group NV, Pharming Technologies NV, Leiden, THE NETHERLANDS","institution_ids":["https://openalex.org/I4210116086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024426681","display_name":"Giuseppe Grandaliano","orcid":"https://orcid.org/0000-0003-1213-2177","observed_orcids":["https://orcid.org/0000-0003-1213-2177"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Grandaliano","raw_affiliation_strings":["University of Foggia, Department of Medical and Surgical Sciences, Foggia, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Foggia, Department of Medical and Surgical Sciences, Foggia, ITALY","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001391327","display_name":"Loreto Gesualdo","orcid":"https://orcid.org/0000-0002-4861-0911","observed_orcids":["https://orcid.org/0000-0002-4861-0911"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Loreto Gesualdo","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063287766","display_name":"Giuseppe Castellano","orcid":"https://orcid.org/0000-0002-0153-3795","observed_orcids":["https://orcid.org/0000-0002-0153-3795"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Castellano","raw_affiliation_strings":["University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Department of Emergency and Organ Transplantation, Bari, ITALY","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"suppl_1","first_page":"i1","last_page":"i1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.18930000066757202,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.859000027179718},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.902999997138977},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tubular-epithelial-cells","display_name":"tubular epithelial cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.5410000085830688},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.8830000162124634},{"id":"https://openalex.org/keywords/kidney-aging","display_name":"kidney aging","score":0.5},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.6660000085830688},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/graft-function","display_name":"graft function","score":0.6919999718666077},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.7570000290870667},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.652999997138977},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8562487363815308},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7246938943862915},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6821873784065247},{"id":"https://openalex.org/C176379880","wikidata":"https://www.wikidata.org/wiki/Q18031939","display_name":"TEC","level":3,"score":0.6470354199409485},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5500994920730591},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46826818585395813},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4414258599281311},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30677908658981323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10665279626846313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10573095083236694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08138182759284973},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C116403925","wikidata":"https://www.wikidata.org/wiki/Q162219","display_name":"Ionosphere","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfw117.01","doi":"https://doi.org/10.1093/ndt/gfw117.01","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfw117.01","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2958829951","https://openalex.org/W2096895041","https://openalex.org/W2057787998","https://openalex.org/W2587975190","https://openalex.org/W2749957791","https://openalex.org/W2771783467","https://openalex.org/W2774840784","https://openalex.org/W2521429693","https://openalex.org/W4415334209","https://openalex.org/W2160082379"],"abstract_inverted_index":{"Introduction":[0],"and":[1,41,90,108,127,132,145,150],"Aims:":[2],"Inflammaging":[3],"describes":[4],"a":[5,31],"low-grade,":[6],"subclinical":[7],"inflammation":[8],"that":[9],"occurs":[10],"during":[11],"tissue":[12],"aging.":[13],"This":[14],"pathogenic":[15],"process":[16],"is":[17,50],"usually":[18],"associated":[19],"with":[20,75],"chronic":[21],"kidney":[22],"disease":[23],"such":[24,102],"as":[25,103],"diabetic":[26],"nephropathy":[27],"where":[28],"TEC":[29,118],"have":[30],"diminished":[32],"regenerative":[33],"potential.":[34],"However,":[35],"the":[36],"link":[37],"between":[38],"Complement-induced":[39],"inflammaging":[40],"deterioration":[42],"of":[43,60,67,100,134],"graft":[44],"function":[45],"after":[46,91,130],"renal":[47,61],"Ischemia/Reperfusion":[48],"injury":[49],"not":[51],"known.":[52],"Methods:":[53],"Ten":[54],"pigs":[55,72],"underwent":[56],"to":[57,121],"30":[58],"min":[59,80],"warm":[62],"Ischemia,":[63],"followed":[64],"by":[65,110,147],"24h":[66,92,131],"Reperfusion":[68],"(T24":[69,83],"CTRL).":[70],"Five":[71],"were":[73,96,119],"treated":[74],"C1-Inhibitor":[76],"(C1-Inh,":[77],"500U/Kg,":[78],"5":[79],"before":[81],"reperfusion)":[82],"C1-INH).":[84],"Biopsies":[85],"at":[86],"T0":[87],"(before":[88],"ischemia)":[89],"from":[93],"reperfusion":[94],"(T24)":[95],"analyzed":[97,129],"for":[98,123,139],"markers":[99],"SASP":[101],"SA-\u03b2Gal":[104,140],"(colorimetric":[105],"staining),":[106],"p16INK4a":[107],"IL-6":[109],"Immunohistochemistry":[111],"(IHC,":[112],"Aperio":[113],"Scan":[114],"Scope).":[115],"In":[116],"addition,":[117],"exposed":[120],"C5a":[122],"3h":[124],"(10-7":[125],"M)":[126],"then":[128],"48h":[133],"culture":[135],"in":[136],"normal":[137],"medium":[138],",":[141],"p53,":[142],"IL-8,":[143],"TNF\u03b1,":[144],"MCP1":[146],"Western":[148],"Blot":[149],"qPCR.":[151]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2017-02-24T00:00:00"}