{"id":"https://openalex.org/W2587816765","doi":"https://doi.org/10.1021/acs.orglett.7b00052","title":"Nickel-Catalyzed Synthesis of Quinazolinediones","display_name":"Nickel-Catalyzed Synthesis of Quinazolinediones","publication_year":2017,"publication_date":"2017-02-13","ids":{"openalex":"https://openalex.org/W2587816765","doi":"https://doi.org/10.1021/acs.orglett.7b00052","mag":"2587816765","pmid":"https://pubmed.ncbi.nlm.nih.gov/28253632"},"language":"en","primary_location":{"id":"doi:10.1021/acs.orglett.7b00052","doi":"https://doi.org/10.1021/acs.orglett.7b00052","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.7b00052","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051345830","display_name":"Gregory L. Beutner","orcid":"https://orcid.org/0000-0001-8779-1404","observed_orcids":["https://orcid.org/0000-0001-8779-1404"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory L. Beutner","raw_affiliation_strings":["Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States"],"raw_orcid":"https://orcid.org/0000-0001-8779-1404","affiliations":[{"raw_affiliation_string":"Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037621","display_name":"Yi Hsiao","orcid":"https://orcid.org/0009-0000-2528-0844","observed_orcids":["https://orcid.org/0009-0000-2528-0844"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Hsiao","raw_affiliation_strings":["Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012633139","display_name":"Thomas M. Razler","orcid":"https://orcid.org/0000-0002-8704-7682","observed_orcids":["https://orcid.org/0000-0002-8704-7682"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Razler","raw_affiliation_strings":["Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028469979","display_name":"Eric M. Simmons","orcid":"https://orcid.org/0000-0002-3854-1561","observed_orcids":["https://orcid.org/0000-0002-3854-1561"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Simmons","raw_affiliation_strings":["Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072262505","display_name":"William C. Wertjes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Wertjes","raw_affiliation_strings":["Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051345830"],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.6298,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.89742899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"5","first_page":"1052","last_page":"1055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.1817999929189682,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13115","display_name":"Axial and Atropisomeric Chirality Synthesis","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinazolinedione","display_name":"quinazolinedione","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nickel-catalysis","display_name":"nickel catalysis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nickel-0-catalysis","display_name":"nickel(0) catalysis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/isatoic-anhydride","display_name":"isatoic anhydride","score":0.9860000014305115},{"id":"https://openalex.org/keywords/isocyanates","display_name":"isocyanates","score":1.0},{"id":"https://openalex.org/keywords/xantphos-ligand","display_name":"Xantphos ligand","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ligand-screening","display_name":"ligand screening","score":0.8889999985694885},{"id":"https://openalex.org/keywords/substrate-inhibition-kinetics","display_name":"substrate inhibition kinetics","score":0.9139999747276306},{"id":"https://openalex.org/keywords/reaction-kinetics","display_name":"reaction kinetics","score":0.6769999861717224},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9189363121986389},{"id":"https://openalex.org/C2778499101","wikidata":"https://www.wikidata.org/wiki/Q2135551","display_name":"Xantphos","level":4,"score":0.7871223092079163},{"id":"https://openalex.org/C2780534471","wikidata":"https://www.wikidata.org/wiki/Q408365","display_name":"Isocyanate","level":3,"score":0.7743765115737915},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.7384722232818604},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.7172322273254395},{"id":"https://openalex.org/C504270822","wikidata":"https://www.wikidata.org/wiki/Q744","display_name":"Nickel","level":2,"score":0.7167714834213257},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6419290900230408},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6230931282043457},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.27225691080093384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0950143039226532},{"id":"https://openalex.org/C502130503","wikidata":"https://www.wikidata.org/wiki/Q1089","display_name":"Palladium","level":3,"score":0.07524216175079346},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C2779578285","wikidata":"https://www.wikidata.org/wiki/Q146322","display_name":"Polyurethane","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.orglett.7b00052","doi":"https://doi.org/10.1021/acs.orglett.7b00052","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.7b00052","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:28253632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28253632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1500018395","https://openalex.org/W1537478375","https://openalex.org/W1964755291","https://openalex.org/W1965216397","https://openalex.org/W1967403418","https://openalex.org/W1983028371","https://openalex.org/W1985167716","https://openalex.org/W1987062946","https://openalex.org/W1992509930","https://openalex.org/W1994868109","https://openalex.org/W1996802147","https://openalex.org/W1997376445","https://openalex.org/W2002736621","https://openalex.org/W2007015070","https://openalex.org/W2007539395","https://openalex.org/W2012359522","https://openalex.org/W2014671550","https://openalex.org/W2014996990","https://openalex.org/W2015114966","https://openalex.org/W2016546660","https://openalex.org/W2029512719","https://openalex.org/W2036968033","https://openalex.org/W2040957707","https://openalex.org/W2052784459","https://openalex.org/W2063386441","https://openalex.org/W2072798997","https://openalex.org/W2079167860","https://openalex.org/W2085310493","https://openalex.org/W2093482852","https://openalex.org/W2093721184","https://openalex.org/W2094577439","https://openalex.org/W2096864437","https://openalex.org/W2101826827","https://openalex.org/W2110757461","https://openalex.org/W2111847538","https://openalex.org/W2129856412","https://openalex.org/W2133700687","https://openalex.org/W2150072979","https://openalex.org/W2164073420","https://openalex.org/W2165362590","https://openalex.org/W2203103084","https://openalex.org/W2513274461","https://openalex.org/W2783437170","https://openalex.org/W2950076383","https://openalex.org/W2950529579","https://openalex.org/W2950543924","https://openalex.org/W2951111234","https://openalex.org/W2951336705","https://openalex.org/W2951684823","https://openalex.org/W2951855573","https://openalex.org/W2951887401","https://openalex.org/W2952453177","https://openalex.org/W3004816419"],"related_works":["https://openalex.org/W2803877790","https://openalex.org/W2953064026","https://openalex.org/W2583375530","https://openalex.org/W2914225541","https://openalex.org/W2794873056","https://openalex.org/W2151151865","https://openalex.org/W2950837164","https://openalex.org/W2612407066","https://openalex.org/W2975857529","https://openalex.org/W2315716402"],"abstract_inverted_index":{"A":[0],"nickel(0)-catalyzed":[1],"method":[2],"for":[3,25],"the":[4,22,37,52],"synthesis":[5,59],"of":[6,45,60],"quinazolinediones":[7,62],"from":[8],"isatoic":[9],"anhydrides":[10],"and":[11],"isocyanates":[12],"is":[13],"described.":[14],"High-throughput":[15],"ligand":[16,24],"screening":[17],"revealed":[18],"that":[19],"XANTPHOS":[20],"was":[21],"optimal":[23],"this":[26],"transformation.":[27],"Subsequent":[28],"optimization":[29],"studies,":[30],"supported":[31],"by":[32],"kinetic":[33],"analysis,":[34],"significantly":[35],"expanded":[36],"reaction":[38,41],"scope.":[39],"The":[40],"exhibits":[42],"a":[43],"case":[44],"substrate":[46],"inhibition":[47],"kinetics":[48],"with":[49],"respect":[50],"to":[51],"isocyanate.":[53],"Preliminary":[54],"results":[55],"on":[56],"an":[57],"asymmetric":[58],"atropisomeric":[61],"are":[63],"reported.":[64]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2017-02-24T00:00:00"}