{"id":"https://openalex.org/W2587814367","doi":"https://doi.org/10.1111/exd.13315","title":"Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration","display_name":"Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration","publication_year":2017,"publication_date":"2017-02-13","ids":{"openalex":"https://openalex.org/W2587814367","doi":"https://doi.org/10.1111/exd.13315","mag":"2587814367","pmid":"https://pubmed.ncbi.nlm.nih.gov/28191674"},"language":"en","primary_location":{"id":"doi:10.1111/exd.13315","doi":"https://doi.org/10.1111/exd.13315","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.13315","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yu Kishimoto","orcid":"https://orcid.org/0000-0002-8876-0500","observed_orcids":["https://orcid.org/0000-0002-8876-0500"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Kishimoto","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8876-0500","affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103734991","display_name":"Sanki Asakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sanki Asakawa","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080374104","display_name":"Taiki Sato","orcid":"https://orcid.org/0000-0002-6437-8630","observed_orcids":["https://orcid.org/0000-0002-6437-8630"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiki Sato","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112222024","display_name":"Takayuki Takano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Takano","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003768812","display_name":"Takahisa Nakajyo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Nakajyo","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084197890","display_name":"Natsumi Mizuno","orcid":"https://orcid.org/0000-0001-7161-266X","observed_orcids":["https://orcid.org/0000-0001-7161-266X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsumi Mizuno","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055734758","display_name":"Ryosuke Segawa","orcid":"https://orcid.org/0000-0002-7332-2428","observed_orcids":["https://orcid.org/0000-0002-7332-2428"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Segawa","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024105175","display_name":"Takeo Yoshikawa","orcid":"https://orcid.org/0000-0002-7056-6021","observed_orcids":["https://orcid.org/0000-0002-7056-6021"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Yoshikawa","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090833783","display_name":"Masahiro Hiratsuka","orcid":"https://orcid.org/0000-0002-3767-7686","observed_orcids":["https://orcid.org/0000-0002-3767-7686"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Hiratsuka","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035847289","display_name":"Kazuhiko Yanai","orcid":"https://orcid.org/0000-0001-9068-7907","observed_orcids":["https://orcid.org/0000-0001-9068-7907"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Yanai","raw_affiliation_strings":["Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074167675","display_name":"Hiroshi Ohtsu","orcid":"https://orcid.org/0000-0003-3261-8828","observed_orcids":["https://orcid.org/0000-0003-3261-8828"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ohtsu","raw_affiliation_strings":["Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012209368","display_name":"Noriyasu Hirasawa","orcid":"https://orcid.org/0000-0002-8062-4838","observed_orcids":["https://orcid.org/0000-0002-8062-4838"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Noriyasu Hirasawa","raw_affiliation_strings":["Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012209368"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.4752,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58111398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"10","first_page":"868","last_page":"874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/histidine-decarboxylase","display_name":"histidine decarboxylase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.921999990940094},{"id":"https://openalex.org/keywords/histamine-h2-receptor","display_name":"histamine H2 receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.593999981880188},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nickel-allergy","display_name":"nickel allergy","score":0.4880000054836273},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8662208318710327},{"id":"https://openalex.org/C192233252","wikidata":"https://www.wikidata.org/wiki/Q421869","display_name":"Histidine decarboxylase","level":4,"score":0.6653491854667664},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.617134153842926},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5857076048851013},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5012307167053223},{"id":"https://openalex.org/C187507357","wikidata":"https://www.wikidata.org/wiki/Q18027062","display_name":"Histamine N-methyltransferase","level":5,"score":0.4618474841117859},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.45008155703544617},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.44975700974464417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43345892429351807},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.425730437040329},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3931681513786316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3883051574230194},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37042754888534546},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32582592964172363},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32103434205055237},{"id":"https://openalex.org/C34400551","wikidata":"https://www.wikidata.org/wiki/Q311568","display_name":"Histamine H2 receptor","level":4,"score":0.27507248520851135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23009783029556274},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22099027037620544},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.19153878092765808},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006640","descriptor_name":"Histidine Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006640","descriptor_name":"Histidine Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/exd.13315","doi":"https://doi.org/10.1111/exd.13315","is_oa":false,"landing_page_url":"https://doi.org/10.1111/exd.13315","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:28191674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28191674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1451138522","display_name":"Importance of histamine metabolizing enzyme in the brain","funder_award_id":"16K18389","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8124318828","display_name":"Analysis of histamine system through genetically modified mice","funder_award_id":"26253016","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W148017066","https://openalex.org/W1518773720","https://openalex.org/W1927794679","https://openalex.org/W1936763432","https://openalex.org/W1963700481","https://openalex.org/W1977200332","https://openalex.org/W1988155417","https://openalex.org/W1990953761","https://openalex.org/W1994813233","https://openalex.org/W2020342012","https://openalex.org/W2026726022","https://openalex.org/W2032243243","https://openalex.org/W2033019036","https://openalex.org/W2039931465","https://openalex.org/W2044863907","https://openalex.org/W2045200013","https://openalex.org/W2045891124","https://openalex.org/W2053975843","https://openalex.org/W2057254743","https://openalex.org/W2068531845","https://openalex.org/W2074063603","https://openalex.org/W2077904915","https://openalex.org/W2080604513","https://openalex.org/W2083511611","https://openalex.org/W2083923246","https://openalex.org/W2087421650","https://openalex.org/W2091697570","https://openalex.org/W2098574165","https://openalex.org/W2100225253","https://openalex.org/W2103907018","https://openalex.org/W2124547035","https://openalex.org/W2140855200","https://openalex.org/W2150142455","https://openalex.org/W2150355163","https://openalex.org/W2287018822","https://openalex.org/W2330858555","https://openalex.org/W2407151353","https://openalex.org/W2419103144","https://openalex.org/W2499476955"],"related_works":["https://openalex.org/W2026726022","https://openalex.org/W2287018822","https://openalex.org/W3167942879","https://openalex.org/W1518773720","https://openalex.org/W2057233487","https://openalex.org/W4238418641","https://openalex.org/W1970276392","https://openalex.org/W2030714517","https://openalex.org/W1970106442","https://openalex.org/W2090154874"],"abstract_inverted_index":{"Abstract":[0],"Histamine":[1,143],"regulates":[2],"various":[3],"inflammatory":[4,87],"reactions.":[5],"We":[6,44],"have":[7,39],"reported":[8],"that":[9,124,187],"the":[10,26,48,69,74,115,188,198],"expression":[11,130,212],"of":[12,21,30,50,62,73,201],"histidine":[13],"decarboxylase":[14],"(HDC)":[15],"was":[16,120,131,158,176],"induced":[17,65],"by":[18],"subcutaneous":[19],"implantation":[20],"nickel":[22],"(Ni)":[23],"wire.":[24],"However,":[25],"source":[27],"and":[28,35,58,77,79,94,175,195,213],"functions":[29],"histamine":[31,54,134,204],"in":[32,68,80,108,125,133,146,169,178,192,197],"Ni":[33,36,59,63,70,104,116,164,189,206],"elution":[34,165],"wire\u2010induced":[37,117],"inflammation":[38],"not":[40,141,159],"been":[41],"completely":[42],"studied.":[43],"aimed":[45],"to":[46],"elucidate":[47],"effects":[49],"de":[51],"novo":[52],"synthesized":[53],"on":[55],"leucocyte":[56,171],"infiltration":[57,172],"elution.":[60],"Implantation":[61],"wire":[64,105,190],"an":[66],"increase":[67,118],"ion":[71],"content":[72],"surrounding":[75],"tissues":[76],"serum":[78],"themRNAlevels":[81],"ofHDC,":[82],"a":[83,90,99],"histamine\u2010producing":[84],"enzyme,":[85],"macrophage":[86],"protein\u20102":[88],"(MIP\u20102),":[89],"chemoattractant":[91,96,100],"for":[92,101],"neutrophils,":[93],"monocyte":[95],"protein\u20101":[97],"(MCP\u20101),":[98],"monocytes.":[102],"The":[103],"inducedHDCexpression":[106,191],"even":[107],"mast":[109],"cell\u2010deficientWBB6F1\u2010W/WVmice.":[110],"InHDCknockout":[111],"(HDC":[112],"KO)":[113],"mice,":[114],"inMIP\u20102mRNAexpression":[119],"significantly":[121],"higher":[122],"than":[123],"wild\u2010type":[126,154],"mice":[127,139,179],"but":[128,140],"notMCP\u20101.MIP\u20102":[129],"enhanced":[132],"H2":[135],"receptor":[136],"knockout":[137],"(H2RKO)":[138],"inWBB6F1\u2010W/WVmice.":[142],"inhibited":[144],"NiCl2\u2010inducedMIP\u20102mRNAexpression":[145],"mouse":[147],"bone":[148],"marrow\u2010derived":[149],"macrophages":[150],"(BMDMs)":[151],"obtained":[152],"from":[153,162],"mice;":[155],"this":[156],"inhibition":[157],"observed":[160],"inBMDMs":[161],"H2RKOmice.":[163],"increased":[166],"inHDC":[167],"KOmice,":[168],"which":[170],"also":[173],"increased,":[174],"suppressed":[177],"treated":[180],"with":[181],"neutrophil\u2010specific":[182],"antibody.":[183],"These":[184],"results":[185],"suggest":[186],"non\u2010mast":[193],"cells":[194],"that,":[196],"chronic":[199],"phase":[200],"inflammation,":[202],"endogenous":[203],"reduced":[205],"elution,":[207],"probably":[208],"through":[209],"regulation":[210],"ofMIP\u20102":[211],"neutrophil":[214],"migration.":[215]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-02-24T00:00:00"}