{"id":"https://openalex.org/W2587775643","doi":"https://doi.org/10.21873/anticanres.11375","title":"Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema","display_name":"Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema","publication_year":2017,"publication_date":"2017-02-10","ids":{"openalex":"https://openalex.org/W2587775643","doi":"https://doi.org/10.21873/anticanres.11375","mag":"2587775643","pmid":"https://pubmed.ncbi.nlm.nih.gov/28179328"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.11375","doi":"https://doi.org/10.21873/anticanres.11375","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.11375","pdf_url":"http://ar.iiarjournals.org/content/37/2/765.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://ar.iiarjournals.org/content/37/2/765.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073371073","display_name":"Ken\u2019ichi Takeda","orcid":"https://orcid.org/0000-0001-9982-439X","observed_orcids":["https://orcid.org/0000-0001-9982-439X"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENICHI TAKEDA","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan takedake@med.tottori-u.ac.jp","Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan takedake@med.tottori-u.ac.jp","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101570878","display_name":"Akira Yamasaki","orcid":"https://orcid.org/0000-0001-5175-2729","observed_orcids":["https://orcid.org/0000-0001-5175-2729"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"AKIRA YAMASAKI","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084973794","display_name":"Tadashi Igishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TADASHI IGISHI","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101132898","display_name":"Yuji Kawasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUJI KAWASAKI","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","Tsuyama Daiichi Hospital, Tsuyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Tsuyama Daiichi Hospital, Tsuyama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022778504","display_name":"Shizuka Nishii\u2010Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHIZUKA ITO-NISHII","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005405732","display_name":"Hiroki Izumi","orcid":"https://orcid.org/0000-0002-9566-4859","observed_orcids":["https://orcid.org/0000-0002-9566-4859"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROKI IZUMI","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075485481","display_name":"Tomohiro Sakamoto","orcid":"https://orcid.org/0000-0002-2791-3294","observed_orcids":["https://orcid.org/0000-0002-2791-3294"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOMOHIRO SAKAMOTO","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000833399","display_name":"Hirokazu Touge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROKAZU TOUGE","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075227198","display_name":"Masahiro Kodani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAHIRO KODANI","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109514681","display_name":"Haruhiko Makino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HARUHIKO MAKINO","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052720657","display_name":"Masaaki Yanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAAKI YANAI","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071739128","display_name":"Natsumi Tanaka","orcid":"https://orcid.org/0000-0002-7019-7748","observed_orcids":["https://orcid.org/0000-0002-7019-7748"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NATSUMI TANAKA","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000703352","display_name":"Shingo Matsumoto","orcid":"https://orcid.org/0000-0003-2698-0839","observed_orcids":["https://orcid.org/0000-0003-2698-0839"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]},{"id":"https://openalex.org/I4405286036","display_name":"National Cancer Center Exploratory Oncology Research & Clinical Trial Center","ror":"https://ror.org/00zwh4w61","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405286036"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHINGO MATSUMOTO","raw_affiliation_strings":["Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan","Translational Research Unit, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]},{"raw_affiliation_string":"Translational Research Unit, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan","institution_ids":["https://openalex.org/I4405286036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110047882","display_name":"Kunio Araki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123591","display_name":"Tottori University Hospital","ror":"https://ror.org/03wa1wy25","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123591"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KUNIO ARAKI","raw_affiliation_strings":["Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Japan","institution_ids":["https://openalex.org/I4210123591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108763007","display_name":"Hiroshige Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123591","display_name":"Tottori University Hospital","ror":"https://ror.org/03wa1wy25","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123591"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROSHIGE NAKAMURA","raw_affiliation_strings":["Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Japan","institution_ids":["https://openalex.org/I4210123591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053435376","display_name":"Eiji Shimizu","orcid":"https://orcid.org/0000-0002-6741-9338","observed_orcids":["https://orcid.org/0000-0002-6741-9338","https://orcid.org/0000-0002-6867-0727"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"EIJI SHIMIZU","raw_affiliation_strings":["Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0284,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77049101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"37","issue":"2","first_page":"765","last_page":"772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/smokers","display_name":"smokers","score":0.6600000262260437},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.6209999918937683},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7688422203063965},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6985118389129639},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6455481648445129},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6104781627655029},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5106497406959534},{"id":"https://openalex.org/C2992836489","wikidata":"https://www.wikidata.org/wiki/Q188605","display_name":"Pulmonary emphysema","level":3,"score":0.4950689375400543},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.48196908831596375},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4608006775379181},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4547147750854492},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43652820587158203},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4356764256954193},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3728576898574829},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2616958022117615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2203434407711029},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.21873/anticanres.11375","doi":"https://doi.org/10.21873/anticanres.11375","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.11375","pdf_url":"http://ar.iiarjournals.org/content/37/2/765.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:28179328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28179328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/anticanres.11375","doi":"https://doi.org/10.21873/anticanres.11375","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.11375","pdf_url":"http://ar.iiarjournals.org/content/37/2/765.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2587775643.pdf","grobid_xml":"https://content.openalex.org/works/W2587775643.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1965294032","https://openalex.org/W1966738726","https://openalex.org/W1976487567","https://openalex.org/W1996444037","https://openalex.org/W2007328352","https://openalex.org/W2007528734","https://openalex.org/W2012815363","https://openalex.org/W2016455125","https://openalex.org/W2028003302","https://openalex.org/W2031674791","https://openalex.org/W2033400446","https://openalex.org/W2041594765","https://openalex.org/W2050619503","https://openalex.org/W2069870642","https://openalex.org/W2088039296","https://openalex.org/W2093921175","https://openalex.org/W2098759257","https://openalex.org/W2104224322","https://openalex.org/W2107826773","https://openalex.org/W2110573194","https://openalex.org/W2114642822","https://openalex.org/W2119376527","https://openalex.org/W2132391118","https://openalex.org/W2132542518","https://openalex.org/W2133281088","https://openalex.org/W2134881779","https://openalex.org/W2135642217","https://openalex.org/W2143859186","https://openalex.org/W2147415859","https://openalex.org/W2161876687","https://openalex.org/W2163798887","https://openalex.org/W2163814837","https://openalex.org/W2168691181","https://openalex.org/W2316434240","https://openalex.org/W2487751012","https://openalex.org/W2604596332","https://openalex.org/W4244776394","https://openalex.org/W4255483444"],"related_works":["https://openalex.org/W2157509881","https://openalex.org/W2112455687","https://openalex.org/W1834160465","https://openalex.org/W4404099390","https://openalex.org/W2736864655","https://openalex.org/W2053050910","https://openalex.org/W1557031563","https://openalex.org/W1774664476","https://openalex.org/W3028652053","https://openalex.org/W4416567752"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"obstructive":[2],"pulmonary":[3],"disease":[4],"is":[5,10],"a":[6,121],"smoking-related":[7],"disease,":[8],"and":[9,15,26,72,126,140],"categorized":[11,57],"into":[12,58],"the":[13,21,59,92],"emphysema":[14,60,102],"airway":[16],"dominant":[17],"phenotypes.":[18],"We":[19],"examined":[20],"relationship":[22,122],"between":[23,123],"emphysematous":[24,124,143],"changes":[25,79,125],"epidermal":[27],"growth":[28],"factor":[29,107],"receptor":[30],"(EGFR)":[31],"mutation":[32,87,113,128],"status":[33],"in":[34,69,75,82,91],"patients":[35,47,55],"with":[36,48],"lung":[37,49],"adenocarcinoma.":[38],"PATIENTS":[39],"AND":[40],"METHODS:":[41],"The":[42],"medical":[43],"records":[44],"for":[45,108,138],"250":[46],"adenocarcinoma":[50],"were":[51,56,80],"retrospectively":[52],"reviewed.":[53],"All":[54],"or":[61],"non-emphysema":[62,93],"group.":[63],"RESULTS:":[64],"Wild-type":[65],"EGFR":[66,74,86,112,127],"was":[67,88,103],"detected":[68],"136":[70],"(54%)":[71],"mutant":[73],"48":[76],"(19%).":[77],"Emphysematous":[78],"observed":[81],"87":[83],"(36%)":[84],"patients.":[85],"highly":[89],"frequent":[90],"group":[94],"(p=0.0014).":[95],"Multivariate":[96],"logistic":[97],"regression":[98],"analysis":[99],"showed":[100,120],"that":[101],"an":[104],"independent":[105],"risk":[106,136],"reduced":[109],"frequency":[110],"of":[111,142],"(Odds":[114],"Ratio=3.47,":[115],"p=0.005).":[116],"CONCLUSION:":[117],"Our":[118],"data":[119],"status.":[129],"There":[130],"might":[131],"be":[132],"mutually":[133],"exclusive":[134],"genetic":[135],"factors":[137],"carcinogenesis":[139],"development":[141],"changes.":[144]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-02-24T00:00:00"}
