{"id":"https://openalex.org/W2587746742","doi":"https://doi.org/10.1182/blood.v104.11.3060.3060","title":"Keratinocyte Growth Factor Ameliorates Acute Graft-versus-Host Disease in a Novel Nonmyeloablative Haploidentical Transplantation Model.","display_name":"Keratinocyte Growth Factor Ameliorates Acute Graft-versus-Host Disease in a Novel Nonmyeloablative Haploidentical Transplantation Model.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2587746742","doi":"https://doi.org/10.1182/blood.v104.11.3060.3060","mag":"2587746742"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.3060.3060","doi":"https://doi.org/10.1182/blood.v104.11.3060.3060","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3060.3060","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082157943","display_name":"Gerard M.J. Bos","orcid":"https://orcid.org/0000-0002-6835-5241","observed_orcids":["https://orcid.org/0000-0002-6835-5241"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerard M.J. Bos","raw_affiliation_strings":["Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057871537","display_name":"Ariane Vancl\u00e9e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ariane Vanclee","raw_affiliation_strings":["Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080395902","display_name":"Ellis B. H. Oving","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ellis Oving","raw_affiliation_strings":["Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043249660","display_name":"Ludy C.H.W. Lutgens","orcid":"https://orcid.org/0000-0002-2942-8858","observed_orcids":["https://orcid.org/0000-0002-2942-8858"]},"institutions":[{"id":"https://openalex.org/I4210161616","display_name":"Maastro Clinic","ror":"https://ror.org/059wkzj26","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210161616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ludy Lutgens","raw_affiliation_strings":["Dept Radiation Oncology, Maastro Clinic, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Radiation Oncology, Maastro Clinic, Maastricht, Netherlands","institution_ids":["https://openalex.org/I4210161616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073459667","display_name":"Nicolaas E.P. Deutz","orcid":"https://orcid.org/0000-0001-5845-6447","observed_orcids":["https://orcid.org/0000-0001-5845-6447"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nicolaas Deutz","raw_affiliation_strings":["Dept Surgery, University of Maastricht, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Surgery, University of Maastricht, Maastricht, Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034779401","display_name":"Harry C. Schouten","orcid":"https://orcid.org/0000-0002-2384-4797","observed_orcids":["https://orcid.org/0000-0002-2384-4797"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Harry Schouten","raw_affiliation_strings":["Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Int Medicine, University Hospital Maastricht, Maastricht, Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36228865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"3060","last_page":"3060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratinocyte-growth-factor","display_name":"keratinocyte growth factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/haploidentical-transplantation","display_name":"haploidentical transplantation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nonmyeloablative-conditioning","display_name":"nonmyeloablative conditioning","score":0.9959999918937683},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/low-dose-total-body-irradiation","display_name":"low-dose total body irradiation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/donor-chimerism","display_name":"donor chimerism","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.968999981880188},{"id":"https://openalex.org/keywords/mouse-transplantation-model","display_name":"mouse transplantation model","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2778615670","wikidata":"https://www.wikidata.org/wiki/Q3811988","display_name":"Keratinocyte growth factor","level":4,"score":0.7129604816436768},{"id":"https://openalex.org/C2778880498","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Total body irradiation","level":4,"score":0.6597950458526611},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6561013460159302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5724634528160095},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5640222430229187},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5525093078613281},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.537379264831543},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48146381974220276},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3823612332344055},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3704744875431061},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.32133832573890686},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.24035033583641052},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.3060.3060","doi":"https://doi.org/10.1182/blood.v104.11.3060.3060","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3060.3060","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W70404253","https://openalex.org/W1515588499","https://openalex.org/W116285681","https://openalex.org/W2913699784","https://openalex.org/W2533400011","https://openalex.org/W1969400043","https://openalex.org/W2980933708","https://openalex.org/W2099519160","https://openalex.org/W2559675100","https://openalex.org/W2028471290"],"abstract_inverted_index":{"Abstract":[0],"Allogeneic":[1],"stem":[2],"cell":[3,230],"transplantations":[4,199],"(SCT)":[5],"are":[6,47],"currently":[7],"being":[8],"used":[9],"as":[10,129,165,185],"a":[11,77,82,134,166],"therapy":[12],"for":[13,152,169],"hematological":[14],"malignancies,":[15],"some":[16],"solid":[17],"tumors":[18],"and":[19,38,60,98,121,133,147,203,239],"non-malignant":[20],"bone":[21],"marrow":[22],"deficiencies.":[23],"Nevertheless,":[24],"clinical":[25,219],"applicability":[26],"is":[27],"limited":[28],"due":[29],"to":[30,52,66,156,187,209],"toxicity":[31],"of":[32,41,58,63,92,112,115,137,211],"conditioning":[33,51,79],"regimens,":[34],"graft-versus-host":[35],"disease":[36],"(GVHD)":[37],"the":[39,61,110,157],"scarcity":[40],"HLA-identical":[42],"family":[43],"donors.":[44],"New":[45],"concepts":[46],"based":[48],"on":[49],"nonmyeloablative":[50,78,197,216],"reduce":[53],"toxicity,":[54],"prevention":[55],"or":[56],"amelioration":[57],"GVHD":[59],"use":[62],"haploidentical":[64,83,198,236],"donors":[65],"increase":[67],"donor":[68,105],"availability.":[69],"To":[70],"meet":[71],"these":[72],"requirements,":[73],"we":[74],"have":[75],"developed":[76],"regimen":[80],"in":[81,102,109,125,140,181,235],"F1":[84,86],"\u2192":[85],"mouse":[87],"model.":[88],"These":[89,193],"mini-transplantations,":[90],"consisting":[91],"low":[93],"dose":[94],"total":[95],"body":[96],"irradiation":[97],"cyclophosphamide-based":[99],"chemotherapy,":[100],"resulted":[101,124],"stable":[103],"full":[104],"chimerism,":[106],"but":[107],"also":[108,214],"development":[111],"GVHD.":[113],"Administration":[114],"keratinocyte":[116],"growth":[117],"factor":[118],"(KGF)":[119],"before":[120],"after":[122,174,215],"SCT":[123],"reduced":[126,130,153,241],"GVHD,":[127,213],"evident":[128],"weight":[131],"loss":[132],"lesser":[135],"degree":[136],"dermatitis":[138],"than":[139],"saline-treated":[141],"controls.":[142],"KGF":[143,205],"preserved":[144],"plasma":[145],"citrulline":[146],"TNF-a":[148],"levels,":[149],"both":[150],"indicative":[151],"radiation-induced":[154],"injury":[155],"gastrointestinal":[158,170],"tract.":[159],"Citruline":[160],"has":[161],"recently":[162],"been":[163],"described":[164],"new":[167],"marker":[168],"toxicity.":[171],"Six":[172],"months":[173],"transplantation,":[175],"survival":[176],"rates":[177,243],"were":[178],"significantly":[179],"higher":[180],"KGF-treated":[182],"animals":[183],"(57%":[184],"compared":[186],"PBS-treated":[188],"controls":[189],"(5.3%).":[190],"Figure":[191,192],"data":[194],"indicate":[195],"that":[196,204],"might":[200,206,232],"be":[201,225,233,245],"feasible":[202],"contribute":[207],"substantially":[208],"reduction":[210],"lethal":[212],"procedures.":[217],"For":[218],"transplantation":[220,237],"such":[221],"an":[222],"effect":[223],"would":[224],"significant":[226],"if":[227],"intensive":[228],"T":[229],"depletion":[231],"prevented":[234],"protocols":[238],"therefore":[240],"infection":[242],"can":[244],"obtained.":[246]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-02-17T00:00:00"}
