{"id":"https://openalex.org/W2587722872","doi":"https://doi.org/10.3389/fimmu.2017.00053","title":"B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis","display_name":"B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis","publication_year":2017,"publication_date":"2017-02-07","ids":{"openalex":"https://openalex.org/W2587722872","doi":"https://doi.org/10.3389/fimmu.2017.00053","mag":"2587722872","pmid":"https://pubmed.ncbi.nlm.nih.gov/28223983","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5293837"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2017.00053","doi":"https://doi.org/10.3389/fimmu.2017.00053","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2017.00053","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.00053/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.00053/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013406612","display_name":"S\u00e9bastien Sanges","orcid":"https://orcid.org/0000-0003-0280-411X","observed_orcids":["https://orcid.org/0000-0003-0280-411X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Sanges","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078933893","display_name":"Manel Jendoubi","orcid":"https://orcid.org/0000-0002-1047-1274","observed_orcids":["https://orcid.org/0000-0002-1047-1274"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manel Jendoubi","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059590167","display_name":"Niloufar Kavian","orcid":"https://orcid.org/0000-0003-2829-3311","observed_orcids":["https://orcid.org/0000-0003-2829-3311"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Niloufar Kavian","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Institut Cochin INSERM U1016 et Laboratoire d'immunologie biologique, AP-HP H\u00f4pital Cochin, Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Institut Cochin INSERM U1016 et Laboratoire d'immunologie biologique, AP-HP H\u00f4pital Cochin, Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061430350","display_name":"Carine Hauspie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carine Hauspie","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","INSERM, U995, Lille, France","Institut d'Immunologie, CHU Lille, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006239682","display_name":"Silvia Speca","orcid":"https://orcid.org/0000-0001-8494-3329","observed_orcids":["https://orcid.org/0000-0001-8494-3329"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Silvia Speca","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111852008","display_name":"Jean\u2010Charles Crave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122572","display_name":"Octapharma (France)","ror":"https://ror.org/02xqq7c82","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210087655","https://openalex.org/I4210122572"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Charles Crave","raw_affiliation_strings":["Octapharma France SAS, Medical Department, Boulogne-Billancourt, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Octapharma France SAS, Medical Department, Boulogne-Billancourt, France","institution_ids":["https://openalex.org/I4210122572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005053257","display_name":"Thomas Guerrier","orcid":"https://orcid.org/0000-0001-8232-9405","observed_orcids":["https://orcid.org/0000-0001-8232-9405"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Guerrier","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028044238","display_name":"Guillaume Lef\u00e8vre","orcid":"https://orcid.org/0000-0002-9427-7267","observed_orcids":["https://orcid.org/0000-0002-9427-7267"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Lef\u00e8vre","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","INSERM, U995, Lille, France","Institut d'Immunologie, CHU Lille, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016242138","display_name":"Vincent Sobanski","orcid":"https://orcid.org/0000-0003-3083-2441","observed_orcids":["https://orcid.org/0000-0003-3083-2441"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Sobanski","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113896530","display_name":"Ariel Savina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107416","display_name":"Roche (France)","ror":"https://ror.org/01mqmer16","country_code":"FR","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210107416"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ariel Savina","raw_affiliation_strings":["Institut Roche, Boulogne-Billancourt, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Roche, Boulogne-Billancourt, France","institution_ids":["https://openalex.org/I4210107416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018486655","display_name":"Eric HACHULLA","orcid":"https://orcid.org/0000-0001-7432-847X","observed_orcids":["https://orcid.org/0000-0001-7432-847X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Hachulla","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108100485","display_name":"Pierre\u2010Yves Hatron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Yves Hatron","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041359686","display_name":"Myriam Labalette","orcid":"https://orcid.org/0000-0002-1524-9891","observed_orcids":["https://orcid.org/0000-0002-1524-9891"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Myriam Labalette","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","INSERM, U995, Lille, France","Institut d'Immunologie, CHU Lille, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038293102","display_name":"Fr\u00e9d\u00e9ric Batteux","orcid":"https://orcid.org/0000-0002-1265-7996","observed_orcids":["https://orcid.org/0000-0002-1265-7996"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Batteux","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Institut Cochin INSERM U1016 et Laboratoire d'immunologie biologique, AP-HP H\u00f4pital Cochin, Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Institut Cochin INSERM U1016 et Laboratoire d'immunologie biologique, AP-HP H\u00f4pital Cochin, Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210141964","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089697500","display_name":"Sylvain Dubucquoi","orcid":"https://orcid.org/0000-0002-8962-3719","observed_orcids":["https://orcid.org/0000-0002-8962-3719"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Dubucquoi","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","INSERM, U995, Lille, France","Institut d'Immunologie, CHU Lille, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut d'Immunologie, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014020914","display_name":"David Launay","orcid":"https://orcid.org/0000-0003-1840-1817","observed_orcids":["https://orcid.org/0000-0003-1840-1817"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"David Launay","raw_affiliation_strings":["U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","INSERM, U995, Lille, France","U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U995, LIRIC - Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France; INSERM, U995, Lille, France; D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France; Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques et Auto-immunes Rares (Scl\u00e9rodermie Syst\u00e9mique), Lille, France","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, CHU Lille, Lille, France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"INSERM, U995, Lille, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"U995, LIRIC \u2013 Lille Inflammation Research International Center, Universit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210128436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5014020914"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.4303,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.62656738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":null,"first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/b-cell-homeostasis","display_name":"B cell homeostasis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.6819999814033508},{"id":"https://openalex.org/keywords/transitional-b-cells","display_name":"transitional B cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/regulatory-b-cells","display_name":"regulatory B cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8019999861717224},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ccl3","display_name":"CCL3","score":0.9340000152587891},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.871999979019165},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8529999852180481},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/b-cell-targeted-therapy","display_name":"B cell-targeted therapy","score":0.6150000095367432},{"id":"https://openalex.org/keywords/splenic-b-cells","display_name":"splenic B cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.4749999940395355},{"id":"https://openalex.org/keywords/b-1-cells","display_name":"B-1 cells","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C2781438807","wikidata":"https://www.wikidata.org/wiki/Q18393925","display_name":"Regulatory B cells","level":4,"score":0.7165080904960632},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5756551027297974},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5752893090248108},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5190492272377014},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5003199577331543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4643208384513855},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.46345990896224976},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4543076157569885},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.4442753791809082},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42626726627349854},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.40887731313705444},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3340461254119873},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.27621060609817505},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20797953009605408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2017.00053","doi":"https://doi.org/10.3389/fimmu.2017.00053","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2017.00053","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.00053/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4174321","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5293837","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5293837","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5293837","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:28223983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28223983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05032935v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05032935","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 2017, 8, pp.53. &#x27E8;10.3389/fimmu.2017.00053&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2017.00053","doi":"https://doi.org/10.3389/fimmu.2017.00053","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2017.00053","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.00053/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G645047804","display_name":null,"funder_award_id":"U1151","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"}],"funders":[{"id":"https://openalex.org/F4320316137","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320323296","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37"},{"id":"https://openalex.org/F4320324952","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2587722872.pdf","grobid_xml":"https://content.openalex.org/works/W2587722872.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W83674029","https://openalex.org/W996329053","https://openalex.org/W1490888491","https://openalex.org/W1597336200","https://openalex.org/W1705692489","https://openalex.org/W1835218586","https://openalex.org/W1989963870","https://openalex.org/W1996971331","https://openalex.org/W1999862702","https://openalex.org/W2008227366","https://openalex.org/W2011045499","https://openalex.org/W2012194350","https://openalex.org/W2018343945","https://openalex.org/W2020910429","https://openalex.org/W2022270470","https://openalex.org/W2023466691","https://openalex.org/W2027949435","https://openalex.org/W2045164784","https://openalex.org/W2052079772","https://openalex.org/W2054254671","https://openalex.org/W2065153244","https://openalex.org/W2083141507","https://openalex.org/W2113313714","https://openalex.org/W2130932769","https://openalex.org/W2143819380","https://openalex.org/W2146438051","https://openalex.org/W2156105259","https://openalex.org/W2158070434","https://openalex.org/W2166225174","https://openalex.org/W2171593203","https://openalex.org/W2274176326","https://openalex.org/W2299688666","https://openalex.org/W2311414536","https://openalex.org/W2339825275","https://openalex.org/W2397929769","https://openalex.org/W2429841788","https://openalex.org/W6603408894"],"related_works":["https://openalex.org/W2052409824","https://openalex.org/W2784054063","https://openalex.org/W2771545643","https://openalex.org/W3186332012","https://openalex.org/W2311414536","https://openalex.org/W4316363600","https://openalex.org/W2346034534","https://openalex.org/W2396075471","https://openalex.org/W2323657213","https://openalex.org/W2027949435"],"abstract_inverted_index":{"Introduction.":[0],"During":[1],"systemic":[2],"sclerosis":[3],"(SSc),":[4],"peripheral":[5],"B":[6,47,124,144,170,188,206,284,335],"cells":[7,120,145],"display":[8],"alterations":[9],"in":[10,35,51,202,215,272,283,290,317,342],"subset":[11,199],"homeostasis":[12,49,286],"and":[13,16,65,85,116,122,154,162,200,204,228,230,241,252,259,287,319,337],"functional":[14,66,141,288],"properties,":[15],"are":[17,32,210],"a":[18,63,192,221,327],"promising":[19],"therapeutic":[20],"target.":[21],"However,":[22],"there":[23],"is":[24],"only":[25],"few":[26],"data":[27],"regarding":[28],"whether":[29],"these":[30],"anomalies":[31,209,270,282,304],"accurately":[33],"reproduced":[34],"animal":[36,292],"models":[37],"of":[38,55,71,81,106,150,165,186,195,224,233,239,245,255,281,294,309,334],"SSc.":[39,274,343],"Objective.":[40],"In":[41],"this":[42],"work,":[43],"we":[44],"assessed":[45,136,157],"the":[46,69,72,104,107,196,248,262,269,279,307,310,324,332],"cell":[48,110,125,171,285],"modifications":[50],"an":[52,183,231,253,291],"experimental":[53,329],"model":[54,293,330],"SSc":[56,216,295,301],"(hypochlorous":[57],"acid":[58],"(HOCl)-induced":[59],"mouse),":[60],"both":[61],"at":[62,89,247,261],"phenotypic":[64,102],"level,":[67],"during":[68],"course":[70,308],"disease.":[73],"Methods.":[74],"Balb/c":[75],"mice":[76],"underwent":[77],"daily":[78],"intradermal":[79],"injections":[80],"HOCl":[82,325],"(or":[83],"PBS),":[84],"were":[86,146,174],"then":[87],"sacrificed":[88],"day":[90,96],"21":[91],"(early":[92],"inflammatory":[93,250,318],"stage)":[94],"or":[95],"42":[97],"(late":[98],"fibrotic":[99,264,320],"stage).":[100],"For":[101,140],"studies,":[103,142],"distribution":[105],"main":[108],"spleen":[109],"subsets":[111,126],"(B":[112],"cells,":[113,118,189,336],"T":[114],"CD4":[115],"CD8":[117],"NK":[119],"macrophages)":[121],"splenic":[123,143],"(immature,":[127],"mature":[128,197],"na\u00efve,":[129],"germinal":[130],"center,":[131],"antibody-secreting,":[132],"memory,":[133],"B1)":[134],"was":[135,156],"by":[137,160,167,176,191,300],"flow":[138,177],"cytometry.":[139,178],"immediately":[147],"MACS-sorted.":[148],"Production":[149],"IL-6,":[151],"CCL3,":[152],"IL-10":[153,240],"TGF-\u03b2":[155],"ex":[158],"vivo":[159],"RT-PCR":[161],"after":[163],"48h":[164],"culture":[166],"ELISA.":[168],"Regulatory":[169],"(Breg)":[172],"counts":[173],"quantified":[175],"Results.":[179],"Phenotypic":[180],"analyses":[181,219],"showed":[182],"early":[184,249],"expansion":[185,194],"transitional":[187],"followed":[190],"late":[193,263],"naive":[198],"decrease":[201],"plasmablasts":[203],"memory":[205],"cells.":[207],"These":[208,266,303],"similar":[211],"to":[212],"those":[213,298],"encountered":[214],"patients.":[217,302],"Functional":[218],"revealed":[220],"B-cell":[222,339],"overproduction":[223,254],"pro-inflammatory":[225],"cytokines":[226,257],"(IL-6":[227],"CCL3)":[229],"impairment":[232],"their":[234,315],"anti-inflammatory":[235],"capacities":[236],"(decreased":[237],"production":[238],"TGF-\u03b2,":[242],"reduced":[243],"levels":[244],"Bregs)":[246],"stage;":[251],"profibrotic":[256],"(TGF-\u03b2":[258],"IL-6)":[260],"stage.":[265],"results":[267],"approximate":[268,297],"observed":[271],"human":[273],"Conclusion.":[275],"This":[276,322],"work":[277],"reports":[278],"existence":[280],"properties":[289],"that":[296],"displayed":[299],"vary":[305],"over":[306],"disease,":[311],"which":[312],"pleads":[313],"for":[314,331],"participation":[316],"events.":[321],"makes":[323],"mouse":[326],"relevant":[328],"study":[333],"therefore":[338],"targeted":[340],"therapies,":[341]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}
