{"id":"https://openalex.org/W2587701010","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.10513","title":"Evaluation of the safety and efficacy of pathotropic nanoparticles bearing a dominant negative cyclin G1 construct for chemoresistant osteosarcoma and other sarcomas: Phase I, II, and III studies","display_name":"Evaluation of the safety and efficacy of pathotropic nanoparticles bearing a dominant negative cyclin G1 construct for chemoresistant osteosarcoma and other sarcomas: Phase I, II, and III studies","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W2587701010","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.10513","mag":"2587701010"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2009.27.15_suppl.10513","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.10513","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2009.27.15_suppl.10513","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073906112","display_name":"Sant P. Chawla","orcid":"https://orcid.org/0000-0002-9522-6744","observed_orcids":["https://orcid.org/0000-0002-9522-6744"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. P. Chawla","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007128913","display_name":"Victoria S. Chua","orcid":"https://orcid.org/0009-0009-2651-3625","observed_orcids":["https://orcid.org/0009-0009-2651-3625"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. S. Chua","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109457425","display_name":"Luis Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Fernandez","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072718710","display_name":"Doris M Quon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Quon","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074048996","display_name":"A. Saralou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Saralou","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058286316","display_name":"William C. Blackwelder","orcid":"https://orcid.org/0000-0001-8174-9643","observed_orcids":["https://orcid.org/0000-0001-8174-9643","https://orcid.org/0000-0003-1655-5003"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. C. Blackwelder","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111794072","display_name":"Frederick L. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. L. Hall","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018623286","display_name":"Erlinda Maria Gordon","orcid":"https://orcid.org/0000-0003-2599-7188","observed_orcids":["https://orcid.org/0000-0003-2599-7188"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210104185","display_name":"Sarcoma Oncology Center","ror":"https://ror.org/01k15w004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. M. Gordon","raw_affiliation_strings":["Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Oncology Center, Santa Monica, CA; University of Maryland, Baltimore, MD; Epeius Biotehnologies Corporation, San Marino, CA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4210104185"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"15_suppl","first_page":"10513","last_page":"10513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.1720000058412552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6489999890327454},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9480000138282776},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9940000176429749},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9192037582397461},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7988549470901489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6239187717437744},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.622714102268219},{"id":"https://openalex.org/C2778594517","wikidata":"https://www.wikidata.org/wiki/Q2260058","display_name":"Chills","level":2,"score":0.5799891948699951},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5460118055343628},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5341234803199768},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5069773197174072},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46756821870803833},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46532556414604187},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4607819616794586},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32814982533454895},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14984527230262756}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2009.27.15_suppl.10513","doi":"https://doi.org/10.1200/jco.2009.27.15_suppl.10513","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2009.27.15_suppl.10513","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066159416","https://openalex.org/W2019894759","https://openalex.org/W4240229635","https://openalex.org/W2607810319","https://openalex.org/W2063654089","https://openalex.org/W4283831690","https://openalex.org/W4402768926","https://openalex.org/W2339412711","https://openalex.org/W2758151211","https://openalex.org/W7162505682"],"abstract_inverted_index":{"10513":[0],"Background:":[1],"(1)":[2],"To":[3],"evaluate":[4],"the":[5,21,35,43,65,95,167,174,193],"safety/anti-tumor":[6],"potential":[7],"of":[8,23,83,90],"intravenous":[9,224],"(i.v.)":[10],"Rexin-G":[11,25,52,155,190,225,232],"in":[12,26,34,42,173,192,243,247],"chemotherapy-resistant":[13,27,248],"sarcoma":[14,98,197],"(Phase":[15,29],"I/II),":[16],"and":[17,39,87,117,139,154,160,189,198,228,230,236,240,250],"(2)":[18],"to":[19],"confirm":[20],"efficacy/safety":[22],"i.v.":[24],"osteosarcoma":[28,201,249],"II).":[30],"Methods:":[31],"Twenty":[32],"patients":[33,41,101,126,171,208],"Phase":[36,44,96,175,195,199],"I/II":[37,97,196],"study":[38,46,177],"22":[40],"II":[45,176,200],"received":[47],"1\u20132":[48,92],"\u00d7":[49],"10e11":[50],"cfu":[51],"i.v.,":[53],"2\u20133":[54],"times":[55],"a":[56,149,183,244],"week":[57],"for":[58,169,178,215],"4":[59],"weeks.":[60,144,217],"Treatment":[61],"was":[62,114,121,136,142],"continued":[63],"if":[64],"patient":[66],"had":[67,102,127],"<":[68],"Grade":[69,84,91],"1":[70,85],"toxicity.":[71],"Results:":[72],"Treatment-related":[73],"adverse":[74],"events":[75],"included":[76],"chills":[77],"(n=1),":[78,80],"presyncope":[79],"photophobia":[81],"(n=1)":[82],"severity,":[86],"fatigue":[88],"(n=4)":[89],"severity.":[93],"In":[94],"study,":[99],"3/6":[100],"stable":[103,128],"disease":[104,129],"at":[105,130],"Dose":[106,131],"Level":[107,132],"0,":[108],"median":[109,134,140],"progression":[110],"free":[111],"survival":[112,119,188,239,242],"(PFS)":[113],"5":[115],"weeks,":[116,123],"overall":[118,187,241],"(OS)":[120],"14":[122],"while":[124],"10/14":[125],"I-II,":[133],"PFS":[135],"16":[137],"weeks":[138],"OS":[141],"34":[143],"Cox":[145],"regression":[146],"analysis":[147,181],"showed":[148],"dose-response":[150,184],"relationship":[151,185],"between":[152,186],"PFS/OS":[153],"dosage":[156,191],"(p":[157,203],"=":[158,204],"0.02":[159],"0.005,":[161],"respectively).":[162],"The":[163],"Table":[164],"below":[165],"shows":[166,182],"results":[168],"evaluable":[170],"(n=17)":[172],"osteosarcoma.":[179],"Kaplan-Meier":[180],"combined":[194],"studies":[202,220],"0.02;":[205],"n=42).":[206],"Two":[207],"achieved":[209],"surgical":[210],"remissions":[211],"which":[212],"are":[213],"sustained":[214],">26":[216],"Conclusions:":[218],"These":[219],"suggest":[221],"that":[222],"(i)":[223],"is":[226],"safe":[227],"well-tolerated,":[229],"(ii)":[231],"controls":[233],"tumor":[234],"growth":[235],"prolongs":[237],"progression-free":[238],"dose-dependent":[245],"manner":[246],"sarcoma.":[251],"[Table:":[252,255],"see":[253,256],"text]":[254,257]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-02-17T00:00:00"}