{"id":"https://openalex.org/W2587210550","doi":"https://doi.org/10.3390/ijms18020326","title":"Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice","display_name":"Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice","publication_year":2017,"publication_date":"2017-02-04","ids":{"openalex":"https://openalex.org/W2587210550","doi":"https://doi.org/10.3390/ijms18020326","mag":"2587210550","pmid":"https://pubmed.ncbi.nlm.nih.gov/28165393","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5343862"},"language":"en","primary_location":{"id":"doi:10.3390/ijms18020326","doi":"https://doi.org/10.3390/ijms18020326","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18020326","pdf_url":"https://www.mdpi.com/1422-0067/18/2/326/pdf?version=1486194468","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/18/2/326/pdf?version=1486194468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079104869","display_name":"Takeshi Yamamotoya","orcid":"https://orcid.org/0000-0002-4152-6979","observed_orcids":["https://orcid.org/0000-0002-4152-6979"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Yamamotoya","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012416308","display_name":"Yusuke Nakatsu","orcid":"https://orcid.org/0000-0003-3279-1276","observed_orcids":["https://orcid.org/0000-0003-3279-1276"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Nakatsu","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043334395","display_name":"Yasuka Matsunaga","orcid":"https://orcid.org/0000-0003-2154-1642","observed_orcids":["https://orcid.org/0000-0003-2154-1642"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuka Matsunaga","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027632684","display_name":"Toshiaki Fukushima","orcid":"https://orcid.org/0000-0002-0673-9805","observed_orcids":["https://orcid.org/0000-0002-0673-9805"]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Fukushima","raw_affiliation_strings":["CellBiology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259-B16 Nagatsuta, Midori, Yokohama 226-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CellBiology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259-B16 Nagatsuta, Midori, Yokohama 226-8501, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066791807","display_name":"Hiroki Yamazaki","orcid":"https://orcid.org/0000-0001-7788-392X","observed_orcids":["https://orcid.org/0000-0001-7788-392X"]},"institutions":[{"id":"https://openalex.org/I4210087332","display_name":"The Institute of Medical Science, Asahi Life Foundation","ror":"https://ror.org/000hskt11","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210087332"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Yamazaki","raw_affiliation_strings":["Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan","institution_ids":["https://openalex.org/I4210087332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103400692","display_name":"Sunao Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sunao Kaneko","raw_affiliation_strings":["Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112638274","display_name":"Midori Fujishiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Midori Fujishiro","raw_affiliation_strings":["Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076072349","display_name":"Takako Kikuchi","orcid":"https://orcid.org/0000-0002-5099-7203","observed_orcids":["https://orcid.org/0000-0002-5099-7203"]},"institutions":[{"id":"https://openalex.org/I4210087332","display_name":"The Institute of Medical Science, Asahi Life Foundation","ror":"https://ror.org/000hskt11","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210087332"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takako Kikuchi","raw_affiliation_strings":["Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan","institution_ids":["https://openalex.org/I4210087332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087631777","display_name":"Akifumi Kushiyama","orcid":"https://orcid.org/0000-0003-1385-7487","observed_orcids":["https://orcid.org/0000-0003-1385-7487"]},"institutions":[{"id":"https://openalex.org/I4210087332","display_name":"The Institute of Medical Science, Asahi Life Foundation","ror":"https://ror.org/000hskt11","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210087332"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akifumi Kushiyama","raw_affiliation_strings":["Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1385-7487","affiliations":[{"raw_affiliation_string":"Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Chuo-ku, Tokyo 103-0002, Japan","institution_ids":["https://openalex.org/I4210087332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083421911","display_name":"Fuminori Tokunaga","orcid":"https://orcid.org/0000-0003-3626-9119","observed_orcids":["https://orcid.org/0000-0003-3626-9119"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fuminori Tokunaga","raw_affiliation_strings":["Laboratory of Pathobiochemistry, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka City, Osaka 545-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathobiochemistry, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka City, Osaka 545-8585, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101660112","display_name":"Tomoichiro Asano","orcid":"https://orcid.org/0000-0002-9480-7408","observed_orcids":["https://orcid.org/0000-0002-9480-7408"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tomoichiro Asano","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8551, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078941067","display_name":"Hideyuki Sakoda","orcid":"https://orcid.org/0000-0001-9126-2329","observed_orcids":["https://orcid.org/0000-0001-9126-2329"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideyuki Sakoda","raw_affiliation_strings":["Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5078941067","https://openalex.org/A5101660112"],"corresponding_institution_ids":["https://openalex.org/I113306721","https://openalex.org/I118574687"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.1526,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.71716426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"2","first_page":"326","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sharpin","display_name":"SHARPIN","score":0.875},{"id":"https://openalex.org/keywords/lubac","display_name":"LUBAC","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hoip","display_name":"HOIP","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hoil-1l","display_name":"HOIL-1L","score":0.9959999918937683},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9240000247955322},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hepatocyte-viability","display_name":"hepatocyte viability","score":0.6480000019073486},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.839066207408905},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7010293006896973},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.6906681060791016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3688731789588928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34978193044662476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3362235724925995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2830163836479187},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.28243502974510193},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.27928322553634644},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms18020326","doi":"https://doi.org/10.3390/ijms18020326","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18020326","pdf_url":"https://www.mdpi.com/1422-0067/18/2/326/pdf?version=1486194468","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:28165393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28165393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5343862","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5343862/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:00897:0004106525","doi":null,"is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100786918","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"journal article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006726758","doi":null,"is_oa":true,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2011367","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal article"},{"id":"pmh:oai:t2r2.star.titech.ac.jp:50458354","doi":null,"is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100786918","pdf_url":null,"source":{"id":"https://openalex.org/S4377196385","display_name":"Tokyo Tech Research Repository (Tokyo Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114531698","host_organization_name":"Tokyo Institute of Technology","host_organization_lineage":["https://openalex.org/I114531698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms18020326","doi":"https://doi.org/10.3390/ijms18020326","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18020326","pdf_url":"https://www.mdpi.com/1422-0067/18/2/326/pdf?version=1486194468","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5448852090","display_name":"Roles of Nedd4-IRS complexes in the development of diabetes and cancer","funder_award_id":"26460369","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6553915035","display_name":"Prolyl isomerase Pin1 suppresses thermogenesis","funder_award_id":"16K09784","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2587210550.pdf","grobid_xml":"https://content.openalex.org/works/W2587210550.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1450614876","https://openalex.org/W1505516041","https://openalex.org/W1523706442","https://openalex.org/W1558228229","https://openalex.org/W1614484620","https://openalex.org/W1975042222","https://openalex.org/W1976799770","https://openalex.org/W2001879129","https://openalex.org/W2008646773","https://openalex.org/W2009008191","https://openalex.org/W2010484395","https://openalex.org/W2025421728","https://openalex.org/W2026585836","https://openalex.org/W2031021050","https://openalex.org/W2032195857","https://openalex.org/W2042694297","https://openalex.org/W2059042590","https://openalex.org/W2090903823","https://openalex.org/W2093222101","https://openalex.org/W2097775330","https://openalex.org/W2110495098","https://openalex.org/W2118436527","https://openalex.org/W2129070184","https://openalex.org/W2131079894","https://openalex.org/W2135332272","https://openalex.org/W2142225943","https://openalex.org/W2143053936","https://openalex.org/W2257231415","https://openalex.org/W2345241074","https://openalex.org/W2399455635","https://openalex.org/W2409425812","https://openalex.org/W2566052805","https://openalex.org/W6628560600"],"related_works":["https://openalex.org/W1505516041","https://openalex.org/W1987625904","https://openalex.org/W2725550952","https://openalex.org/W2790995801","https://openalex.org/W2581484584","https://openalex.org/W2809689994","https://openalex.org/W4255611349","https://openalex.org/W2964714526","https://openalex.org/W2897901019","https://openalex.org/W2809812501"],"abstract_inverted_index":{"Linear":[0],"ubiquitin":[1,21,30],"chain":[2],"assembly":[3],"complex":[4],"(LUBAC),":[5],"composed":[6],"of":[7,16,54,61,70,128,138,150,163,181,189,203],"SHARPIN":[8,43,83],"(SHANK-associated":[9],"RH":[10],"domain-interacting":[11],"protein),":[12,27],"HOIL-1L":[13],"(longer":[14],"isoform":[15],"heme-oxidized":[17],"iron-regulatory":[18],"protein":[19],"2":[20],"ligase-1),":[22],"and":[23,38,45,108,183],"HOIP":[24,158],"(HOIL-1L":[25],"interacting":[26],"forms":[28],"linear":[29],"on":[31],"nuclear":[32],"factor-\u03baB":[33],"(NF-\u03baB)":[34],"essential":[35,177],"modulator":[36],"(NEMO)":[37],"induces":[39],"NF-\u03baB":[40],"pathway":[41],"activation.":[42],"expression":[44,84],"LUBAC":[46,175,190],"formation":[47],"were":[48],"significantly":[49],"reduced":[50],"in":[51,87,115,141,146,166,197],"the":[52,59,73,94,116,134,179,200],"livers":[53],"mice":[55,88],"24":[56],"h":[57],"after":[58,99],"injection":[60],"either":[62],"carbon":[63],"tetrachloride":[64],"(CCl\u2084)":[65],"or":[66,157],"acetaminophen":[67],"(APAP),":[68],"both":[69],"which":[71,130],"produced":[72],"fulminant":[74],"hepatitis":[75],"phenotype.":[76],"To":[77],"elucidate":[78],"its":[79],"pathological":[80],"significance,":[81],"hepatic":[82],"was":[85,124],"suppressed":[86],"by":[89],"injecting":[90],"shRNA":[91,159],"adenovirus":[92,160],"via":[93],"tail":[95],"vein.":[96],"Seven":[97],"days":[98],"this":[100],"transduction,":[101],"without":[102],"additional":[103],"inflammatory":[104],"stimuli,":[105],"substantial":[106],"inflammation":[107],"fibrosis":[109],"with":[110,126,144,154],"enhanced":[111],"hepatocyte":[112,195],"apoptosis":[113,162],"occurred":[114],"livers.":[117],"A":[118],"similar":[119],"but":[120],"more":[121],"severe":[122],"phenotype":[123],"observed":[125],"suppression":[127],"HOIP,":[129],"is":[131,176,185,191],"responsible":[132],"for":[133,178],"E3":[135],"ligase":[136],"activity":[137],"LUBAC.":[139],"Furthermore,":[140],"good":[142],"agreement":[143],"these":[145,164],"vivo":[147],"results,":[148],"transduction":[149],"Hepa1-6":[151],"hepatoma":[152],"cells":[153,165],"SHARPIN,":[155],"HOIL-1L,":[156],"induced":[161],"response":[167],"to":[168,199],"tumor":[169],"necrosis":[170],"factor-\u03b1":[171],"(TNF\u03b1)":[172],"stimulation.":[173],"Thus,":[174],"survival":[180],"hepatocytes,":[182],"it":[184],"likely":[186],"that":[187],"reduction":[188],"a":[192],"factor":[193],"promoting":[194],"death":[196],"addition":[198],"direct":[201],"effect":[202],"drug":[204],"toxicity.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-02-17T00:00:00"}