{"id":"https://openalex.org/W2587103232","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1027.2","title":"Alterations in the Gut Microbiome Can Elicit Hypertension in WKY Rats","display_name":"Alterations in the Gut Microbiome Can Elicit Hypertension in WKY Rats","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2587103232","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1027.2","mag":"2587103232"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.1027.2","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1027.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.1027.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sareema Adnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sareema Adnan","raw_affiliation_strings":["Anesthesiology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James W Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W Nelson","raw_affiliation_strings":["Anesthesiology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072518517","display_name":"David J. Durgan","orcid":"https://orcid.org/0000-0002-3358-1935","observed_orcids":["https://orcid.org/0000-0002-3358-1935"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J Durgan","raw_affiliation_strings":["Anesthesiology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046974353","display_name":"Robert M. Bryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M Bryan","raw_affiliation_strings":["Anesthesiology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11660964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9950000047683716},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8289999961853027},{"id":"https://openalex.org/keywords/wistar-kyoto-rats","display_name":"Wistar-Kyoto rats","score":0.7860000133514404},{"id":"https://openalex.org/keywords/microbiota-transfer","display_name":"microbiota transfer","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cecal-contents","display_name":"cecal contents","score":0.6060000061988831},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6570000052452087},{"id":"https://openalex.org/keywords/16s-rrna-gene-sequencing","display_name":"16S rRNA gene sequencing","score":0.843999981880188},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.5839999914169312},{"id":"https://openalex.org/keywords/gut-heart-axis","display_name":"gut-heart axis","score":0.44999998807907104},{"id":"https://openalex.org/keywords/gut-liver-axis","display_name":"gut-liver axis","score":0.4440000057220459},{"id":"https://openalex.org/keywords/gut-kidney-axis","display_name":"gut-kidney axis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/gut-lung-axis","display_name":"gut-lung axis","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.8655512928962708},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7509359121322632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42155835032463074},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4119020998477936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36195504665374756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36135333776474},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2778136432170868}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.1027.2","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.1027.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.1027.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389024401","https://openalex.org/W4280649807","https://openalex.org/W3174391334","https://openalex.org/W3156014157","https://openalex.org/W2136344314","https://openalex.org/W3208857447","https://openalex.org/W2972221261","https://openalex.org/W3016700075","https://openalex.org/W4309075856","https://openalex.org/W2904052395"],"abstract_inverted_index":{"Introduction":[0],"Gut":[1],"dysbiosis":[2,33],"or":[3,65,494],"an":[4,29,156],"unhealthy":[5],"change":[6],"in":[7,58,67,116,169,262,324,386,405,428,444,476,503],"the":[8,51,79,83,110,124,132,180,185,190,202,209,215,229,246,263,286,290,295,330,351,373,417,441,466,482,485,504],"gut":[9,32,80,442,486],"microbiota":[10,81,187,287,443,461],"(bacteria)":[11],"is":[12,500],"linked":[13],"to":[14,122,138,183,289,312,336],"a":[15,39,59,68,240,391,501],"number":[16],"of":[17,62,71,109,131,179,192,196,208,285,361,415,484],"pathological":[18],"conditions":[19],"including":[20],"gastrointestinal":[21],"disorders,":[22],"type":[23],"II":[24],"diabetes,":[25],"and":[26,34,42,85,120,136,149,165,223,236,254,326,348,423,431,437],"obesity.":[27],"Although":[28,329,439],"association":[30],"between":[31,82,346],"hypertension":[35,54],"has":[36,45],"been":[37,47],"reported,":[38],"direct":[40],"cause":[41],"effect":[43,394],"relationship":[44],"not":[46,354],"established.":[48],"We":[49,479],"tested":[50],"hypothesis":[52],"that":[53,341,455,481],"could":[55],"be":[56,337],"induced":[57],"normotensive":[60],"strain":[61,70],"rats":[63,72,75,95,105,151,217,256,270,378,458],"(WKY)":[64],"attenuated":[66],"hypertensive":[69,74],"[spontaneously":[73],"(SHR)]":[76],"by":[77,293],"exchanging":[78],"WKY":[84,104,148,235,247,253,269,327,387,406,409,429,432,457,477],"SHR":[86,94,150,230,237,255,276,325,333,342,365,376,445,460],"rats.":[87,143,238,277,328,478],"Methods":[88],"Cecal":[89,226],"contents":[90,100,274,483],"from":[91,101,129,228,245,275],"20":[92],"wk":[93,103],"were":[96,106,134,152,280,353,471],"pooled;":[97],"similarly,":[98],"cecal":[99,210,243,273,313],"9":[102],"pooled.":[107],"Each":[108],"pooled":[111],"samples":[112,133],"was":[113,182,212,232,250,304,322,367,379,390,419],"diluted":[114],"1:20":[115],"buffer,":[117],"thoroughly":[118],"mixed,":[119],"centrifuged":[121],"remove":[123],"particulate":[125],"matter.":[126],"The":[127,177],"supernatants":[128],"each":[130],"aliquoted":[135],"frozen":[137],"use":[139],"for":[140,173,219,283,332,364,375,473],"inoculating":[141,456],"recipient":[142,147,216],"Three":[144],"week":[145],"old":[146],"gavaged":[153,197,213,233,251,271],"daily":[154,218],"with":[155,189,272,399,459],"antibiotic":[157,204],"cocktail":[158],"[ampicillin,":[159],"gentamycin,":[160],"metronidazole,":[161],"neomycin":[162],"(all":[163],"3mg/day)":[164],"vancomycin":[166],"(1.5":[167],"mg/day)":[168],"1":[170],"ml":[171,207],"buffer]":[172],"10":[174,347],"consecutive":[175,221],"days.":[176],"purpose":[178],"antibiotics":[181],"reduce":[184],"native":[186],"load":[188],"idea":[191],"allowing":[193],"easier":[194],"colonization":[195],"microbiota.":[198],"Two":[199],"days":[200,222],"after":[201],"last":[203],"administration,":[205],"0.75":[206],"supernatant":[211,227,244],"into":[214,234,252],"four":[220],"weekly":[224,282,306],"thereafter.":[225],"donors":[231],"In":[239],"similar":[241,323],"manner,":[242],"donor":[248,393],"pool":[249],"(n=7/group).":[257],"Group":[258],"designation":[259],"are":[260],"indicated":[261],"following":[264],"example:":[265],"\u201cWKY":[266],"g\u2010SHR\u201d":[267],"represents":[268],"Fecal":[278],"pellets":[279],"collected":[281],"identification":[284],"(down":[288],"genus":[291],"level)":[292],"sequencing":[294],"16s":[296],"ribosomal":[297],"RNA":[298],"gene.":[299],"Systolic":[300],"blood":[301,491],"pressure":[302],"(SBP)":[303],"measured":[305],"using":[307],"tail\u2010cuff":[308],"plethysmography.":[309],"Results":[310],"Prior":[311],"gavages":[314],"(age":[315],"=":[316],"4":[317],"wks),":[318],"SBP":[319,331,363,374,400,418,475],"(~143":[320],"mmHg)":[321],"g\u2010WKY":[334,377,410],"tended":[335],"12\u201317":[338],"mmHg":[339,371,383,403,427],"less":[340],"g\u2010SHR":[343,366,407,430,433],"at":[344,358],"ages":[345],"16":[349],"wks,":[350],"differences":[352],"significant.":[355],"For":[356],"example,":[357],"12":[359,413],"wks":[360,414],"age,":[362],"202":[368],"\u00b1":[369,381,421,425],"6":[370],"while":[372],"185":[380],"7":[382],"(p=0.118).":[384],"However,":[385],"rats,":[388],"there":[389],"significant":[392,448],"(p=0.02,":[395],"2\u2010way":[396],"RM":[397],"ANOVA)":[398],"running":[401],"15\u201325":[402],"higher":[404],"than":[408],"().":[411],"At":[412],"age":[416],"182":[420],"8":[422,426],"156":[424],"respectively":[434],"(p=0.02).":[435],"Summary":[436],"Conclusion":[438],"altering":[440],"had":[446],"no":[447],"effects":[449],"on":[450],"SBP,":[451],"we":[452],"did":[453],"find":[454],"significantly":[462],"increased":[463],"SBP.":[464],"Therefore,":[465],"gavage":[467],"contents,":[468],"presumably":[469],"microbiota,":[470],"responsible":[472],"increasing":[474],"conclude":[480],"can":[487],"directly":[488],"affect":[489],"systemic":[490],"pressure.":[492],"Support":[493],"Funding":[495],"Information":[496],"R01NS080531;":[497],"S.":[498],"Adnan":[499],"fellow":[502],"APS":[505],"Undergraduate":[506],"Summer":[507],"Research":[508],"Program.":[509]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-02-17T00:00:00"}
