{"id":"https://openalex.org/W2587100970","doi":"https://doi.org/10.1182/blood.v118.21.2529.2529","title":"Microdeletions at Apparently Balanced Translocation Breakpoints Are Biomarkers for Heightened Genomic Instability in Patients with Non-MLL Acute Myeloid Leukemia","display_name":"Microdeletions at Apparently Balanced Translocation Breakpoints Are Biomarkers for Heightened Genomic Instability in Patients with Non-MLL Acute Myeloid Leukemia","publication_year":2011,"publication_date":"2011-11-18","ids":{"openalex":"https://openalex.org/W2587100970","doi":"https://doi.org/10.1182/blood.v118.21.2529.2529","mag":"2587100970"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v118.21.2529.2529","doi":"https://doi.org/10.1182/blood.v118.21.2529.2529","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.2529.2529","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020033287","display_name":"Roger Alan Schultz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Roger A. Schultz","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Theresa C. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theresa C. Brown","raw_affiliation_strings":["Cytogenetics, CSI Laboratories, Alpharetta, GA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytogenetics, CSI Laboratories, Alpharetta, GA, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041511479","display_name":"Lynda J. Campbell","orcid":"https://orcid.org/0000-0002-0222-6156","observed_orcids":["https://orcid.org/0000-0002-0222-6156"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lynda J. Campbell","raw_affiliation_strings":["Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, Fitzroy, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, Fitzroy, Australia,","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064752314","display_name":"Meaghan Wall","orcid":"https://orcid.org/0000-0001-9711-0705","observed_orcids":["https://orcid.org/0000-0001-9711-0705"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Meaghan Wall","raw_affiliation_strings":["Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, Fitzroy, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, Fitzroy, Australia,","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053675952","display_name":"Jacqueline Schoumans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jacqueline Schoumans","raw_affiliation_strings":["Cancer Cytogenetic Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Cytogenetic Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland,","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026978255","display_name":"Jin\u2010Yeong Han","orcid":"https://orcid.org/0000-0003-0280-2739","observed_orcids":["https://orcid.org/0000-0003-0280-2739"]},"institutions":[{"id":"https://openalex.org/I51226738","display_name":"Dong-A University","ror":"https://ror.org/03qvtpc38","country_code":"KR","type":"education","lineage":["https://openalex.org/I51226738"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Yeong Han","raw_affiliation_strings":["Laboratory Medicine, Dong-A University College of Medicine, Busan, South Korea,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine, Dong-A University College of Medicine, Busan, South Korea,","institution_ids":["https://openalex.org/I51226738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054573446","display_name":"Urvashi Surti","orcid":"https://orcid.org/0000-0003-4283-9018","observed_orcids":["https://orcid.org/0000-0003-4283-9018"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210106153","display_name":"Magee-Womens Hospital","ror":"https://ror.org/01fbdn283","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210106153","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Urvashi Surti","raw_affiliation_strings":["University of Pittsburgh, Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA,","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210106153","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102164330","display_name":"Eric C. Crawford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eric Crawford","raw_affiliation_strings":["Cytogenetics, Genetics Associates Inc., Nashville, TN, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytogenetics, Genetics Associates Inc., Nashville, TN, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020043629","display_name":"S. Dwanna Stewart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Dwanna Stewart","raw_affiliation_strings":["Cytogenetics, Genetics Associates Inc., Nashville, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytogenetics, Genetics Associates Inc., Nashville, TN,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111494144","display_name":"Raymond R. Tubbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond R. Tubbs","raw_affiliation_strings":["Molecular Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066731616","display_name":"James R. Cook","orcid":"https://orcid.org/0000-0003-0456-8085","observed_orcids":["https://orcid.org/0000-0003-0456-8085"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James R. Cook","raw_affiliation_strings":["Molecular Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081535615","display_name":"Aaron M. Gruver","orcid":"https://orcid.org/0000-0001-7735-3320","observed_orcids":["https://orcid.org/0000-0001-7735-3320"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron M. Gruver","raw_affiliation_strings":["Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064248808","display_name":"Asad Dean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800124591","display_name":"Texas Oncology","ror":"https://ror.org/02ketev28","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800124591"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Asad Dean","raw_affiliation_strings":["Texas Oncology, Fort Worth, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Oncology, Fort Worth, TX, USA,","institution_ids":["https://openalex.org/I2800124591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111974265","display_name":"Haluk Tezcan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163289","display_name":"Kootenai Medical Center","ror":"https://ror.org/0513nfd47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210163289"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haluk Tezcan","raw_affiliation_strings":["Kootenai Cancer Center, Coeur d\u2018Alene, ID, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kootenai Cancer Center, Coeur d\u2018Alene, ID, USA","institution_ids":["https://openalex.org/I4210163289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028766011","display_name":"Aubry Furrow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aubry Furrow","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070769975","display_name":"Lisa G. Shaffer","orcid":"https://orcid.org/0000-0002-2848-8103","observed_orcids":["https://orcid.org/0000-0002-2848-8103"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa G. Shaffer","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018127934","display_name":"Blake C. Ballif","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Blake C. Ballif","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer Inc., Spokane, WA, USA,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5018127934","https://openalex.org/A5020033287","https://openalex.org/A5020043629","https://openalex.org/A5028766011","https://openalex.org/A5053675952","https://openalex.org/A5054573446","https://openalex.org/A5064248808","https://openalex.org/A5066731616","https://openalex.org/A5070769975","https://openalex.org/A5081535615","https://openalex.org/A5102164330"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I170201317","https://openalex.org/I2800124591","https://openalex.org/I2802229882","https://openalex.org/I4210106153","https://openalex.org/I4210134769"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38001672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"21","first_page":"2529","last_page":"2529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/balanced-translocation","display_name":"balanced translocation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/translocation-breakpoints","display_name":"translocation breakpoints","score":0.765999972820282},{"id":"https://openalex.org/keywords/microdeletion","display_name":"microdeletion","score":0.847000002861023},{"id":"https://openalex.org/keywords/copy-number-abnormalities","display_name":"copy number abnormalities","score":0.8240000009536743},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mll-translocation","display_name":"MLL translocation","score":0.5180000066757202},{"id":"https://openalex.org/keywords/21-q22","display_name":"21)(q22","score":0.9879999756813049},{"id":"https://openalex.org/keywords/inv-16-p13q22","display_name":"inv(16)(p13q22)","score":0.9860000014305115},{"id":"https://openalex.org/keywords/11-p22","display_name":"11)(p22","score":0.9990000128746033},{"id":"https://openalex.org/keywords/9-p23","display_name":"9)(p23","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.8821115493774414},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.7735323905944824},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6728668212890625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5432094931602478},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42691951990127563},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33048051595687866},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3265782296657562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32120564579963684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.301277756690979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15132957696914673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v118.21.2529.2529","doi":"https://doi.org/10.1182/blood.v118.21.2529.2529","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.2529.2529","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2587222030","https://openalex.org/W2003320353","https://openalex.org/W2555515572","https://openalex.org/W2981138031","https://openalex.org/W1974646709","https://openalex.org/W2583784898","https://openalex.org/W2591160326","https://openalex.org/W2979644866","https://openalex.org/W2019146724","https://openalex.org/W2031303146"],"abstract_inverted_index":{"Abstract":[0,1],"2529":[2],"The":[3,533],"clinical":[4],"heterogeneity":[5],"of":[6,16,24,27,64,92,113,118,173,221,248,264,321,349,429,457,469,476,514,518,524,536,546,564,575,592],"acute":[7],"myeloid":[8],"leukemia":[9],"(AML)":[10],"is":[11,20],"well":[12],"established":[13],"and":[14,50,72,116,177,180,201,274,276,307,317,324,333,353,358,368,382,399,410,452,491,506,554,561,616,623],"identification":[15,63,117],"specific":[17],"balanced":[18,96,133,550],"translocations":[19,31,97,134,257,586,615],"a":[21,99,136,328,362,390,439,515,521,598,603],"critical":[22],"component":[23],"the":[25,62,157,206,246,351,372,379,402,436,480,484,525,540,562,572,589],"classification":[26],"AML.":[28],"Patients":[29,167],"with":[30,84,94,103,234,245,279,331,336,414,438,479,486,549,588],"are":[32,242],"assigned":[33],"to":[34,78,130,147,314,620],"prognostic":[35,71],"groups":[36],"generally":[37],"defined":[38],"as":[39],"good":[40],"[e.g.,":[41,47,52],"t(8;21)(q22;q22),":[42],"inv(16)":[43,325,470],"(p13q22),":[44],"t(15;17)(q24;q21)],":[45],"intermediate":[46],"t(3;5)(q25;q34),":[48],"t(9;11)(p22;q23)]":[49],"poor":[51],"other":[53,461,509],"MLL":[54,256,593],"translocations,":[55,86],"inv(3)(q21q26.2),":[56],"t(6;9)(p23;q34)].":[57],"Further":[58],"refinement":[59],"based":[60,377],"on":[61,378],"new":[65,80],"genetic":[66],"markers":[67,82],"may":[68,613,617],"help":[69],"tailor":[70],"treatment":[73,318,621],"decisions.":[74],"In":[75,261,401,543],"an":[76],"effort":[77],"identify":[79,148],"molecular":[81,573,605],"associated":[83],"recurrent":[85],"we":[87],"have":[88],"analyzed":[89],"30":[90,207],"cases":[91,141,223,233,258,267,281,406,418,432,462,471,510,548],"AML":[93,547,608],"apparently":[95],"using":[98],"microarray-based":[100],"technology":[101],"coupled":[102],"linear":[104],"DNA":[105],"amplification":[106],"[translocation-CGH":[107],"(tCGH)],":[108],"providing":[109],"high":[110],"resolution":[111],"mapping":[112],"translocation":[114,216,551],"breakpoints":[115,124],"copy":[119,152],"number":[120,153],"abnormalities":[121,154],"at":[122,287,394],"those":[123],"(BkPt-CNAs).":[125],"Analysis":[126],"can":[127],"be":[128],"multiplexed":[129],"interrogate":[131],"14":[132],"in":[135,212,270,474,483,489,498,607],"single":[137,329,512],"test.":[138],"Additionally,":[139],"all":[140,169],"were":[142,165,168,570],"assayed":[143],"by":[144,366,384,552],"high-density":[145],"aCGH":[146,555],"additional":[149,225,238,277,340,576],"clinically":[150,226,250],"relevant":[151,227,251,313,541,619],"(CNAs)":[155],"throughout":[156],"genome.":[158],"For":[159,342],"each":[160,326],"sample":[161],"these":[162,222,334],"test":[163],"results":[164],"compared.":[166],"adults":[170],"(>40":[171],"years":[172],"age),":[174],"10":[175],"males":[176],"20":[178],"females,":[179],"included":[181],"t(15;17)(q24;q21)":[182],"(8":[183],"cases),":[184,188,191,194,197],"t(8;21)":[185,323,431],"(q22;q22)":[186],"(6":[187],"inv(16)(p13q22)":[189],"(5":[190,193],"t(9;11)(p22;q23)":[192],"t(3;5)(q25;q34)":[195,266],"(4":[196],"t(6;11)(q27;q23)":[198],"(1":[199,203],"case)":[200],"t(6;9)(p23;q34)":[202],"case).":[204],"Of":[205],"cases,":[208,478],"6":[209,219],"showed":[210,237,268,327,346,419],"BkPt-CNAs":[211,236,241,269,332,487,560,569,596],"one":[213],"or":[214,425,465,520,611],"both":[215,271,288,350],"partners.":[217],"All":[218],"(100%)":[220],"exhibited":[224,433,445],"CNAs,":[228,278,434],"whereas":[229],"only":[230,539],"11/24":[231],"(46%)":[232],"no":[235,255,415],"CNAs.":[239,341,566],"Thus,":[240],"significantly":[243],"correlated":[244,335],"presence":[247,563],"secondary":[249,565],"alterations":[252],"(p=0.0208).":[253],"Importantly,":[254],"revealed":[259,556],"BkPt-CNAs.":[260],"contrast,":[262],"3":[263,411,475],"4":[265],"genes":[272,355],"(NPM1":[273],"MLF1)":[275],"two":[280,417],"showing":[282],"large":[283],"deletions":[284,502],"(>0.5":[285],"Mb)":[286],"breakpoints.":[289],"Alterations":[290],"involved":[291],"RSRC1":[292],"(mRNA":[293],"splicing),":[294],"FBXW11":[295],"(E3":[296],"ubiquitin":[297],"protein":[298],"ligase),":[299],"STK10":[300],"(serine/threonine":[301],"kinase),":[302],"FGFR3":[303],"(growth":[304],"factor":[305],"receptor)":[306],"MGMT":[308],"(O-6-methylguanine-DNA":[309],"methyltransferase),":[310],"findings":[311],"potentially":[312,531],"disease":[315],"progression":[316],"response.":[319],"Cases":[320],"t(15;17),":[322,343],"case":[330,345,387,437,485,535],"greater":[337,446],"complexity":[338,447,482,574],"for":[339,448,602],"that":[344,370],"partial":[347],"duplication":[348],"PML":[352,380],"RARA":[354],"(47":[356],"kb":[357,442],"39":[359],"kb)":[360],"yielding":[361],"cryptic":[363],"fusion":[364],"(missed":[365],"karyotype":[367],"FISH)":[369],"produced":[371],"\u201clong\u201d":[373],"form":[374],"(bcr1)":[375,424],"transcript":[376],"breakpoint":[381],"confirmed":[383],"rtPCR.":[385],"This":[386,580],"also":[388],"had":[389,511,538],"24.56":[391],"Mb":[392],"deletion":[393,517,523],"13q14.2->q21.33":[395],"involving":[396,493,504],"RB1,":[397],"MIR15A":[398],"MIR16-1.":[400],"7":[403],"remaining":[404],"PML-RARA":[405],"[4":[407],"short":[408],"(bcr3)":[409],"long":[412],"(bcr1)]":[413],"BkPt-CNAs,":[416],"non-complex":[420],"CNAs":[421,449,473,577],"[(e.g.,":[422],"-Y":[423],"+8":[426,464],"(bcr3)].":[427],"Five":[428],"six":[430],"but":[435],"BkPt-CNA":[440],"(39":[441],"within":[443],"RUNX1)":[444],"(multiple":[450],"gains":[451],"losses":[453],"over":[454],">70":[455],"MB":[456],"distal":[458],"9q)":[459],"than":[460],"(e.g.,":[463],"+15).":[466],"Similarly,":[467],"analysis":[468,545],"demonstrated":[472],"5":[477],"greatest":[481],"[deletion":[488],"CBFB":[490],"MYH11":[492],"ABCC1":[494],"(anion":[495],"transporter":[496],"implicated":[497],"multiple":[499],"drug":[500],"resistance),":[501],"9q34.13":[503],"ABL1":[505],"NUP214],":[507],"while":[508],"changes":[513],"homozygous":[516],"GSTT1":[519],"heterozygous":[522],"16p11.2":[526],"microdeletion":[527],"syndrome":[528],"region,":[529],"either":[530],"inherited.":[532],"sole":[534],"t(6;9)":[537],"translocation.":[542],"conclusion,":[544],"t-CGH":[553],"significant":[557],"correlation":[558],"between":[559],"Moreover,":[567],"when":[568],"present,":[571],"was":[578],"increased.":[579],"observation":[581],"held":[582],"true":[583],"across":[584],"various":[585],"evaluated,":[587],"notable":[590],"exception":[591],"translocations.":[594],"Thus":[595],"provide":[597],"broadly":[599],"applicable":[600],"signature":[601],"subtle":[604],"instability":[606],"that,":[609],"acquired":[610],"inherited,":[612],"predate":[614],"prove":[618],"response":[622],"outcome.":[624],"Disclosures:":[625],"Schultz:":[626],"Signature":[627],"Genomic":[628,635,639,643],"Laboratories:":[629,636,640,644],"Employment.":[630,637,641,645],"Campbell:Abbott":[631],"Molecular:":[632],"Honoraria.":[633],"Furrow:Signature":[634],"Shaffer:Signature":[638],"Ballif:Signature":[642]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-02-17T00:00:00"}
